Article
Chemistry, Physical
Huaxin Zhang, Honglin Wang, Hongmei Yang, Dan Zhou, Qinghua Xia
Summary: Water-soluble amino-terminated SiQDs were successfully synthesized without extra reductants or catalysts, showing excellent fluorescence properties and stability. SiQDs could stably bind with human serum albumin and have potential biomedical applications.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Rongzheng Zhao, Shuhao Liu, Xuewen Zhao, Yonghong Cheng, Jinying Zhang
Summary: A new molecular probe has been developed to measure the local environments of biomaterials. This probe can effectively distinguish temperature and pH variations based on fluorescence intensity and lifetime.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Optics
Yide Zhang, Ian H. Guldner, Evan L. Nichols, David Benirschke, Cody J. Smith, Siyuan Zhang, Scott S. Howard
Summary: Instant FLIM is a method of analog signal processing that allows real-time streaming of fluorescence intensity, lifetime, and phasor imaging data, improving the efficiency and real-time capabilities of FLIM techniques. By upgrading existing two-photon microscopes with cost-effective components and open-source software, this technology can be easily implemented, along with enhancements in functionality through phasor segmentation, adaptive optics, and super-resolution techniques.
Article
Biophysics
Yong-Qiang Xu, Liu-Yuan Zang, Hai-Yu Gao, Jin Peng, Dong-Yun Zheng, Chao Liu, Xiao-Jun Liu, Dong-Bing Cheng, Chun-Nan Zhu
Summary: Ingeniously designed Cu-In-S/ZnS:Gd3+ quantum dots were successfully prepared in the aqueous phase, allowing for the balance between fluorescence and paramagnetic properties. These high-performance quantum dots showed significant potential in in vivo tumor FL/MR dual-modality imaging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yongwei Guo, Jie Hu, Peiyuan Wang, Hongyi Yang, Sisi Liang, Dejian Chen, Kunyuan Xu, Yingping Huang, Qinglai Wang, Xiaolong Liu, Haomiao Zhu
Summary: Second near infrared (NIR-II) fluorescence lifetime imaging in the range of 1000-1700 nm has versatile applications in biosensing, anti-counterfeiting, and multiplex imaging. However, the low photoluminescence quantum yield (PLQY) of fluorescence probes hinders its data collecting efficiency, especially in vivo multiplex molecular imaging. To address this issue, lanthanide-doped nanoparticles with high PLQY and tunable PL lifetime were developed. By utilizing these nanoparticles in a homebuilt fluorescence lifetime imaging system, fast and high signal-to-noise fluorescence lifetime imaging was achieved, enabling multiplex molecular imaging of atherosclerosis.
Article
Nanoscience & Nanotechnology
Xinyuan Sun, Mengyao Shi, Chun Zhang, Jinting Yuan, Min Yin, Shichao Du, Shuai Yu, Bowei Ouyang, Fumin Xue, Sheng-Tao Yang
Summary: In this study, fluorescent Ag-In-S/ZnS quantum dots (AIS/ZnS QDs) with red emission were developed for fast tumor drainage lymph node imaging in vivo. The AIS/ZnS QDs were shown to migrate efficiently to sentinel lymph nodes, enabling effective imaging within 10 minutes upon intratumoral injection. Overall, AIS/ZnS QDs demonstrated high performance as an imaging reagent for tumor drainage lymph nodes.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Analytical
Yajie Chi, Qing Hu, Shuxiao Yi, Huijiao Qu, Yan Xiao
Summary: In this study, a novel strategy was proposed for developing an activatable silver chalcogenide QDs nanoprobe for NIR-II fluorescence imaging of hypochlorous acid (HClO) in vivo. The nanoprobe was constructed by mixing an Au-precursor solution with Ag2Te@Ag2S QDs to achieve cation exchange and release Ag ions, and then reducing the released Ag ions on the QDs surface to form an Ag shell for quenching the QDs emission. The Ag shell of QDs was oxidized and etched in the presence of HClO, resulting in the reactivation of the QDs emission. This study provides a promising tool for NIR-II imaging of HClO in vivo.
Article
Chemistry, Physical
Liang Wang, Ming Li, Yongle Li, Bin Wu, Hailong Chen, Ruining Wang, Tao Xu, Huazhang Guo, Weitao Li, Jarin Joyner, Xingcan Shen, Mengying Le, Robert Vajtai, Pulickel M. Ajayan, Wei Ren, Minghong Wu
Summary: A molecular fusion route was designed to synthesize bright orange fluorescent graphene quantum dots (GQDs), which exhibited excellent optical properties and targeting capability for cell nucleus imaging. Enriched nitrogen doping in GQDs facilitated their penetration through the cell membrane to target the nucleus, providing a basis for designing nucleus-targeting probes in the future.
Article
Chemistry, Physical
Wenhua Su, Dan Yang, Yulan Wang, Yawei Kong, Wanlu Zhang, Jing Wang, Yiyan Fei, Ruiqian Guo, Jiong Ma, Lan Mi
Summary: Intracellular pH plays a critical role in biological functions and diseases. This study reports on the use of an intracellular pH sensor, AIS/ZnS quantum dots, for live cell imaging and distinguishing between cancer cells and normal cells. The method offers potential for noninvasive cervical cancer screening.
Article
Materials Science, Biomaterials
Bingjie Li, Guohe Wang, Yujie Tong, Yujie Zhang, Shao-Kai Sun, Chunshui Yu
Summary: The combination of high-resolution CT and real-time sensitive NIR-II fluorescence bioimaging can provide complementary information for the diagnosis, progression, and prognosis of gastrointestinal disorders. The synthesized BSA-Ag2Te QDs have shown excellent properties for CT/NIR-II dual-modal imaging, high spatiotemporal resolution, and sensitivity.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Analytical
Feng Ren, Tuanwei Li, Tingfeng Yao, Guangcun Chen, Chunyan Li, Qiangbin Wang
Summary: The pathological process involves intrinsic biochemical markers, and precise diagnostic information on diseases requires the detection of multiple biological parameters. In vivo multichannel fluorescence biosensing using near-infrared-II (NIR-II) fluorophores enables rapid acquisition of biochemical information at different levels with high sensitivity and resolution. This review summarizes the versatile designs and functions of NIR-II fluorophores for in vivo multichannel biosensing in various scenarios, and discusses desirable traits for their clinical translation.
Article
Chemistry, Physical
Rahul Bhuyan, Bramhaiah Kommula, Lopamudra Bishwal, Srayee Mandal, Santanu Bhattacharyya
Summary: This study investigates the stepwise growth process of zero-dimensional N-functionalized carbon dots (CDs) and gains in-depth molecular insight into their evolution of chromophore centers. Structural and elemental features of the CDs are illustrated using various analytical techniques, such as proton nuclear magnetic resonance, Fourier-transform infrared, X-ray photoelectron spectroscopy, and high-resolution transmission electron microscopy. The photophysical properties and chemical transformations of the CDs are studied using steady-state and time-resolved spectroscopy. The extent of aromaticity and internal rigidity during the growth process are also illustrated through temperature-dependent fluorescence spectroscopy.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Alexander M. Saeboe, Alexey Y. Nikiforov, Reyhaneh Toufanian, Joshua C. Kays, Margaret Chern, J. Paolo Casas, Keyi Han, Andrei Piryatinski, Dennis Jones, Allison M. Dennis
Summary: This report showcases the reddest emitting indium phosphide quantum dots to date, demonstrating tunable near-infrared photoluminescence and PL multiplexing in the first optical tissue window while avoiding toxic constituents. By utilizing an inverted QD heterostructure, the synthesis overcomes the growth bottleneck and extends the emission peak of the nanoparticles into the deeper optical tissue window.
Article
Chemistry, Multidisciplinary
Ting Meng, Zifei Wang, Ting Yuan, Xiaohong Li, Yunchao Li, Yang Zhang, Louzhen Fan
Summary: This study presents a gram-scale synthesis of red/green/blue solid-state fluorescent carbon quantum rings with high quantum yields, offering a potential alternative to REE-free phosphor-converted white LEDs. These R/G/B-SBF-CQRs-based LEDs emit warm white light with low CCT, high CRI, and high luminous efficiency, comparable to REE-phosphor-based LEDs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Spectroscopy
Ju Yang, Yunhan Yang, Lijiao Su, Xin Tao, Juntong Zhang, Yan Chen, Lijuan Yang
Summary: Diethylenetriamine-ll-cyclodextrin-modified carbon quantum dots (3N-CQDs) were synthesized via a one-step hydrothermal method and showed good anti-interference capability. The prepared carbon quantum dots had low cytotoxicity, good biocompatibility, and excellent cellular imaging capability for HeLa cells. They were ideal fluorescent probes for the detection of Hg2+ and Fe3+ in water, with a relative fluorescence quantum yield of 67.2%.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)