Review
Biochemistry & Molecular Biology
Kornelius Zeth, Enea Sancho-Vaello
Summary: The human cathelicidin LL-37 is a versatile peptide with antimicrobial activity, playing a crucial role in targeting microorganisms. Recent structural studies have revealed the diversity and adaptability of LL-37 in interacting with lipid-like molecules. Complexes of LL-37 with detergents provide insights into mimicking lipids and inducing oligomerization and fibrillation, opening avenues for designing LL-37-derived peptides with enhanced antibiotic properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Gladys Pinilla, Yenifer Tatiana Coronado, Gabriel Chaves, Liliana Munoz, Jeannette Navarrete, Luz Mary Salazar, Carlos Pelleschi Taborda, Julian E. Munoz
Summary: Fungal infections have become a major problem in immunosuppressed or ICU patients, and the resistance of fungi to conventional antifungal treatments is increasing. This study evaluated the in vitro antifungal activity of LL-37 analogue peptides against Candida spp. The results suggest that LL37-1 and AC-2 have the best inhibitory effect on Candida strains.
Article
Biochemical Research Methods
William F. Porto, Sergio A. Alencar
Summary: Cathelicidin antimicrobial peptides, including LL-37, are important host defense peptides with various activities. We investigated the effects of single nucleotide polymorphism (SNP)-driven point mutations on LL-37 structure and activity. Our results suggest that while the mutations had minimal impact on LL-37 activity, some mutations could reduce its antimicrobial activity and alter its structure.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2023)
Article
Polymer Science
Monica A. Marks, Kyriaki Kalaitzidou, Will R. Gutekunst
Summary: A modular strategy for synthesizing dendron-linear polymer hybrids was developed, allowing for the creation of a 12-membered family of materials with variable properties. The physical behavior of these hybrids significantly changed after introducing cationic dendron end-groups, resulting in soft-solid materials with inhibited chain mobility. These hybrids are expected to act as surface-active antimicrobial additives in bulk cross-linked silicone systems.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Infectious Diseases
Malihe Mirzaee, Edita Holaskova, Alzbeta Micuchova, David J. Kopecny, Zhila Osmani, Ivo Frebort
Summary: This study demonstrates stable inheritance and expression of the LL-37 gene in barley over six generations, including two consecutive seasons of experimental field cultivation. The transgenic plants exhibited normal growth and remained fertile, with the produced LL-37 peptide retaining high antibacterial activity based on bacteria viability tests.
Review
Infectious Diseases
Kylen E. Ridyard, Joerg Overhage
Summary: LL-37 shows promise as an alternative to conventional antibiotics due to its broad spectrum antibacterial and immunomodulatory properties, but faces limitations such as high cost and toxicity to human cells.
Article
Biochemistry & Molecular Biology
Paulina Piller, Heimo Wolinski, Robert A. Cordfunke, Jan Wouter Drijfhout, Sandro Keller, Karl Lohner, Nermina Malanovic
Summary: The development of antimicrobial agents against multidrug-resistant bacteria is crucial in the medical field. This study found that SAAP-148, an antimicrobial peptide, showed higher efficiency in killing bacteria and had stronger effects on membranes at both cellular and molecular levels compared to OP-145.
Article
Infectious Diseases
David A. Perez-Perez, Teresa De J. Villanueva-Ramirez, Adriana E. Hernandez-Pedraza, Nestor G. Casillas-Vega, Patricia Gonzalez-Barranco, Xristo Zarate
Summary: The study introduces a novel approach to producing biologically-active LL-37 peptide by tagging it with SmbP, a carrier protein that enhances production in Escherichia coli. The method allows for rapid expression, purification, and evaluation of LL-37's antimicrobial activity, with promising results against Staphylococcus aureus and Escherichia coli.
Article
Biochemistry & Molecular Biology
Francisco Javier Sanchez-Pena, Maria de los Angeles Romero-Tlalolini, Honorio Torres-Aguilar, Diego Sait Cruz-Hernandez, Rafael Baltierrez-Hoyos, Sarai Remedios Sanchez-Aparicio, Alba Soledad Aquino-Dominguez, Sergio Roberto Aguilar-Ruiz
Summary: Research has shown that the antimicrobial peptide LL-37 activates the antimicrobial function of human platelets by increasing receptor expression and secreted antimicrobial molecules. It also enhances the binding of platelets to E. coli, S. aureus, and C. albicans, and inhibits the growth of these microorganisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Aman Kumar, Kashmiri Lal, Nisha Poonia, Ashwani Kumar, Anil Kumar
Summary: A diverse series of imine linked 1,2,3-triazole hybrids were synthesized via Cu(I)-promoted click reaction, and their structures were characterized using various spectral techniques. Among them, 7d exhibited the highest antimicrobial activity against R. oryzae and S. aureus. Docking studies revealed that some triazole hybrids showed high potency towards E. coli DNA gyrase and C. albicans sterol 14-alpha demethylase.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Medicinal
Yingxia Zhang, Jayaram Lakshmaiah Narayana, Qianhui Wu, Xiangli Dang, Guangshun Wang
Summary: The innate immune system in humans is crucial for protection from infections, with the cathelicidin LL-37 playing a key role. The SK-24 peptide, derived from LL-37, exhibits strong antimicrobial activity against bacterial membranes, potentially making it a valuable therapeutic template for human antimicrobial defense.
Article
Engineering, Environmental
Luogen Lai, Wanqing Zou, Yan Zhang, Yuanbiao Tu, Simeng Li, Tongxuan Xin, Tianyue Zhou, Shan Xu, Pengwu Zheng, Qingshan Pan, Wufu Zhu
Summary: Bacterial infections and antibiotic resistance have become a global healthcare crisis. In this study, a novel NIR imaging and synergistic antibacterial nano-system is reported for resistance bacterial infection therapy. The nano-system has the ability to monitor the progress of infection treatment and promote wound healing.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Microbiology
Gianluca Morroni, Laura Di Sante, Oriana Simonetti, Lucia Brescini, Wojciech Kamysz, Elzbieta Kamysz, Marina Mingoia, Andrea Brenciani, Eleonora Giovanetti, Patrizia Bagnarelli, Andrea Giacometti, Oscar Cirioni
Summary: The antimicrobial peptide LL-37 showed good activity against multidrug-resistant Escherichia coli strains, especially when used in combination with colistin, demonstrating synergistic effects and the ability to reduce biofilm formation. This suggests a new possible clinical application for combating antibiotic resistance.
FUTURE MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Alexander Jackson, Eryn L. Werry, James O'Brien-Brown, Paolo Schiavini, Shane Wilkinson, Erick C. N. Wong, Andre D. J. McKenzie, Alexandra Maximova, Michael Kassiou
Summary: Antagonists of the P2X7 receptor have therapeutic potential for diseases involving neuroinflammation. A recently developed structural hybrid compound showed insights into the interaction of antagonists with the P2X7R. LL-37 was found to enhance the ability of ATP to induce dye uptake.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Virology
Celine Chessa, Charles Bodet, Clement Jousselin, Andy Lariviere, Alexia Damour, Julien Garnier, Nicolas Leveque, Magali Garcia
Summary: LL-37 can directly inhibit West Nile virus (WNV), while hBD-3 does not have an inhibitory effect on WNV replication. Both peptides have immunomodulatory properties in WNV-infected keratinocytes.
Article
Nanoscience & Nanotechnology
Christian Kuttner, Martin Mayer, Martin Dulle, Ana Moscoso, Juan Manuel Lopez-Romero, Stephan Foerster, Andreas Fery, Jorge Perez-Juste, Rafael Contreras-Caceres
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Chemistry, Physical
Maria Sanchez-Molina, Amelia Diaz, Maria Valpuesta, Rafael Contreras-Caceres, J. Manuel Lopez-Romero, M. Rosa Lopez-Ramirez
APPLIED SURFACE SCIENCE
(2018)
Review
Chemistry, Multidisciplinary
Rafael Contreras-Caceres, Laura Cabeza, Gloria Perazzoli, Amelia Diaz, Juan Manuel Lopez-Romero, Consolacion Melguizo, Jose Prados
Article
Nanoscience & Nanotechnology
Lazaros Tzounis, Manuel Dona, Juan Manuel Lopez-Romero, Andreas Fery, Rafael Contreras-Caceres
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Nanoscience & Nanotechnology
Alicia Ortega-Rodriguez, Yingli Shen, Irene Zabala Gutierrez, Harrison D. A. Santos, Vivian Torres Vera, Erving Ximendes, Gonzalo Villaverde, Jose Lifante, Christoph Gerke, Nuria Fernandez, Oscar G. Calderon, Sonia Melle, Jose Marques-Hueso, Diego Mendez-Gonzalez, Marco Laurenti, Callum M. S. Jones, Juan Manuel Lopez-Romero, Rafael Contreras-Caceres, Daniel Jaque, Jorge Rubio-Retama
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Physical
Ana Belen Ruiz-Muelle, Christian Kuttner, Carlos Alarcon-Fernandez, Juan Manuel Lopez-Romero, Petra Uhlmann, Rafael Contreras-Caceres, Ignacio Fernandez
APPLIED SURFACE SCIENCE
(2019)
Article
Chemistry, Physical
Manuel Dona, Alicia Ortega-Rodriguez, Carlos Alarcon-Fernandez, Juan Manuel Lopez-Romero, Rafael Contreras-Caceres
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Nanoscience & Nanotechnology
Roland P. M. Hoeller, Christian Kuttner, Martin Mayer, Ruosong Wang, Martin Dulle, Rafael Contreras-Caceres, Andreas Fery, Luis M. Liz-Marzan
Article
Chemistry, Multidisciplinary
David Asmat-Campos, Ana C. Abreu, Manuel S. Romero-Cano, Josue Urquiaga-Zavaleta, Rafael Contreras-Caceres, Daniel Delfin-Narciso, Luisa Juarez-Cortijo, Renny Nazario-Naveda, Roger Rengifo-Penadillos, Ignacio Fernandez
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2020)
Article
Polymer Science
Laura Lozano Chamizo, Yurena Luengo Morato, Karina Ovejero Paredes, Rafael Contreras Caceres, Marco Filice, Marzia Marciello
Summary: Combining chitosan and metal oxide nanoparticles has led to the creation of nanohybrids with enhanced properties for skin repair, demonstrating synergistic antibacterial and tissue regeneration effects.
Article
Biochemistry & Molecular Biology
Cristina Lucena-Serrano, Ana Lucena-Serrano, Amelia Diaz, Maria Valpuesta, Gonzalo Villaverde, J. Manuel Lopez-Romero, Francisco Sarabia, Marco Laurenti, Jorge Rubio-Retama, Rafael Contreras-Caceres
Summary: This study reports the preparation of new hybrid core@shell systems based on SPION nanoparticles coated with a SiO2 shell and functionalized with carboxyl groups, which can be used in nanomedicine and potentially applied in the treatment of central nervous system diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Vivian Torres Vera, Diego Mendez-Gonzalez, Diego J. Ramos-Ramos, Asmae Igalla, Marco Laurenti, Rafael Contreras-Caceres, Enrique Lopez-Cabarcos, Elena Diaz, Jorge Rubio-Retama, Sonia Melle, Oscar G. Calderon
Summary: The study analyzed the effect of Er3+ and Yb3+ dopant concentrations on the luminescence properties of nanoparticles and found that there is a significant increase in luminescence intensity as the Yb/Er ratio increases following a power-law behavior, with greater enhancement at low excitation intensities. Saturation occurs at a Yb/Er ratio of around two, with a slight peak when this ratio is around four.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Multidisciplinary
Arturo Moncho-Jorda, Ana B. Jodar-Reyes, Matej Kanduc, Alicia German-Bellod, Juan M. Lopez-Romero, Rafael Contreras-Caceres, Francisco Sarabia, Miguel Garcia-Castro, Hector A. Perez-Ramirez, Gerardo Odriozola
Article
Nanoscience & Nanotechnology
Carlos Alarcon-Fernandez, Manuel Dona, Antonio Tapia-Fernandez, Gonzalo Villaverde, Maria Rosa Lopez-Ramirez, Juan Manuel Lopez-Romero, Rafael Contreras-Caceres
ACS APPLIED NANO MATERIALS
(2020)
Article
Biotechnology & Applied Microbiology
Beatriz Garcia-Pinel, Alicia Ortega-Rodriguez, Cristina Porras-Alcala, Laura Cabeza, Rafael Contreras-Caceres, Raul Ortiz, Amelia Diaz, Ana Moscoso, Francisco Sarabia, Jose Pradosa, Juan M. Lopez-Romero, Consolacion Melguizo
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2020)