Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 19, Pages 9330-9337Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am4026455
Keywords
electric double layer; nanopore surface charge; nanopore conductance; nanopore shape; silicon nitride nanopore; silicon oxide nanopore; biomimetic nanopore; single-molecule sensing
Funding
- NSF CAREER [CBET-1150085]
- University of Rhode Island
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1150085] Funding Source: National Science Foundation
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The performance of nanopore single-molecule sensing elements depends intimately on their physical dimensions and surface chemical properties. These factors underpin the dependence of the nanopore ionic conductance on electrolyte concentration, yet the measured, or modeled, dependence only partially illuminates the details of geometry and surface chemistry. Using the electrolyte-dependent conductance data before and after selective surface functionalization of solid-state nanopores, however, introduces more degrees of freedom and improves the performance of conductance-based nanopore characterizations. Sets of representative nanopore profiles were used to generate conductance data, and the nanopore shape and exact dimensions were identified, through conductance alone, by orders-of-magnitude reductions in the geometry optimization metrics. The optimization framework could similarly be used to evaluate the nanopore surface coating thickness.
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