Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 12, Pages 5811-5814Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am401391g
Keywords
silicon nanowire; optical endoscope; surface-enhanced Raman spectroscopy; intracellular pH probing; near-infrared spectrum; high sensitive sensor
Funding
- National Basic Research Program of China (973 Program) [2010CB9345000, 2012CB932400]
- Major Research Plan of the National Natural Science Foundation of China [91233110]
- Beijing Natural Science Foundation [2112044]
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Very recently, one-dimensional nanowire (NW) sensors have attracted great attention as smart optical endoscopes to probe and manipulate intracellular biological processes. However, NWs often have limited optical response to the intracellular environment changes. In this work, a near-infrared nanowire optical endoscope for high-resolution intracellular pH detection was developed by integrating the advantages of silicon nanowires and surface-enhanced Raman spectroscopy (SERS). This optical endoscope has a high-resolution, sensitive response to local pH changes over the wide range of pH 4.0-9.0, an important range for most biological processes in cells, with high reproducibility, good reversibility, and at least one-week stability in an aqueous environment. The results indicate the great potential of a single SiNW SERS endoscope for intracellular pH monitoring.
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