Journal
IMMUNOBIOLOGY
Volume 220, Issue 9, Pages 1107-1112Publisher
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2015.05.003
Keywords
Action potential; Atrium; Heart; Interleukin-6; Stretch
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Funding
- Russian Foundation for Basic Research [12-04-00390-a]
- Ministry of Education and Science of the Russian Federation
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Using the micro-electrode technique we studied the effects of interleukin-6 on bio-electric activity of rat atrial tissue under normal conditions and after gradual stretching. It was shown that IL-6 caused increasing of the duration of the action potential at the levels of 25, 50, and 90% re-polarization. The hump-like depolarization at APD90 appeared 7-10 min after initial stretching and transformed into single extrapotentials after tension removing. Perfusion with IL-6 for more than 20 min led to the appearance of atrial fibrillation even with the application of slight tension. Close observation of the IL-6 induced mechanisms and stretch induced APD alteration, confirmed the existence of a tight link between examined cytokine and stretch induced mechanisms. (C) 2015 Elsevier GmbH. All rights reserved.
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