Article
Radiology, Nuclear Medicine & Medical Imaging
Ronnie Sebro, S. Sharon Ashok
Summary: This study compared the accuracy of PET/CT parameters with CT parameters for directing bone biopsies. It found that metabolic 2-[F-18]FDG PET/CT parameters have more clinical impact for planning bone biopsies than CT parameters, with SUVmax and lesion size being important factors in detecting malignancy.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lijuan Feng, Xu Yang, Xia Lu, Ying Kan, Chao Wang, Dehui Sun, Hui Zhang, Wei Wang, Jigang Yang
Summary: This study developed and validated a radiomics nomogram based on F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for non-invasive prediction of bone marrow involvement (BMI) in pediatric neuroblastoma. The radiomics nomogram incorporated radiomics signature and independent clinical risk factors, and showed good predictive performance in predicting BMI.
INSIGHTS INTO IMAGING
(2022)
Review
Oncology
Federica Matteucci, Giovanni Paganelli, Giovanni Martinelli, Claudio Cerchione
Summary: Recent advances in the diagnosis and treatment of multiple myeloma have emphasized the importance of imaging methods, particularly PET/CT, in providing accurate information for disease localization, prognosis, and therapy response evaluation. While 18F-FDG tracer is commonly used and has high sensitivity, limitations such as physiological uptake in the bone marrow and brain have prompted research on other PET tracers for improved accuracy in multiple myeloma management.
FRONTIERS IN ONCOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Koa, Austin J. Borja, Mahmoud Aly, Sayuri Padmanabhan, Joseph Tran, Vincent Zhang, Chaitanya Rojulpote, Sheila K. Pierson, Mark-Avery Tamakloe, Johnson S. Khor, Thomas J. Werner, David C. Fajgenbaum, Abass Alavi, Mona-Elisabeth Revheim
Summary: Castleman disease is a rare hematologic condition involving lymphadenopathy and clinical abnormalities, classified into UCD and MCD; MCD is further divided based on etiological driver; FDG-PET/CT plays an important role in differential diagnosis and monitoring treatment responses.
INSIGHTS INTO IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kailin Qiao, Xueting Qin, Shuai Fu, Jiazhong Ren, Jing Jia, Xinying Hu, Yuanyuan Tao, Shuanghu Yuan, Yuchun Wei
Summary: The uptake of [F-18]AlF-NOTA-FAPI-04 and [F-18]FDG imaging tracers varies in malignant and inflammatory lung lesions, with lower uptake observed in inflammatory lesions. This difference in uptake can be valuable for distinguishing between malignancy and various inflammatory findings.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lijuan Feng, Xu Yang, Xia Lu, Ying Kan, Chao Wang, Hui Zhang, Wei Wang, Jigang Yang
Summary: This study developed and validated a radiomics nomogram based on 18F-FDG PET/CT for the diagnosis of bone marrow involvement in pediatric neuroblastoma. The nomogram showed good diagnostic performance and could improve the diagnostic accuracy without additional medical costs and radiation exposure.
ACADEMIC RADIOLOGY
(2023)
Article
Oncology
Maxwell W. G. Miner, Heidi Liljenback, Jenni Virta, Semi Helin, Olli Eskola, Petri Elo, Jarmo Teuho, Kerttu Seppala, Vesa Oikonen, Guangli Yang, Andrea Kindler-Roehrborn, Heikki Minn, Xiang-Guo Li, Anne Roivainen
Summary: This study investigated the imaging capabilities of three PET imaging compounds in orthotopic BT4C gliomas in BDIX rats and compared two imaging systems. Results indicated that [F-18]FGln may offer improved imaging compared to [C-11]Met and [F-18]FDG, with similar end-result ratios between Inveon and Molecubes camera systems. Pharmacokinetic modeling suggested both reversible and irreversible uptake play an important role in the uptake of [F-18]FGln in BDIX rat pharmacokinetics.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Bing Zhang, Qiao He, Yali Long, Yuying Zhang, Xiaoyan Wang, Zhifeng Chen, Jianbo Liu, Xiangsong Zhang
Summary: This study compared the diagnostic efficacies of F-18-FDG PET/CT and Ga-68-DOTANOC PET/CT in patients with EAS. The results showed that Ga-68-DOTANOC PET/CT imaging may be more suitable for identifying the primary tumor, while F-18-FDG PET/CT may be more advantageous for patients with suspected metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan P. M. Souza, Fernanda C. Frasson, Maria Emilia S. Takahashi, Gislaine B. O. Duarte, Vania P. Castro, Fernando V. Pericole, Licio A. Velloso, Carmino A. De Souza, Irene Lorand-Metze, Allan O. Santos, Celso D. Ramos
Summary: The aim of this study was to compare [F-18]FDG and [Ga-68]Ga-PSMA-11 PET/CT image findings in patients with multiple myeloma (MM). The study found that both methods can detect most lesions, but half of the lesions can only be identified by one tracer, suggesting their possible complementary role in MM.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Virginia Liberini, Michael Messerli, Lars Husmann, Ken Kudura, Hannes Grunig, Alexander Maurer, Stephan Skawran, Erika Orita, Daniele A. Pizzuto, Desiree Deandreis, Reinhard Dummer, Joanna Mangana, Daniela Mihic-Probst, Niels Rupp, Martin W. Huellner
Summary: BSREM detects significantly more ITM than OSEM, with higher SUVmax, higher TBR, and less blurring. BSREM is particularly helpful in small and less avid lesions, which are more often missed with OSEM.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Soon Ho Yoon, Jin Mo Goo, Jae-Joon Yim, Takashi Yoshiyama, JoAnne L. Flynn
Summary: This article critically reviews the CT and PET findings of incipient tuberculosis without X-ray abnormalities, revealing pauci-nodular infiltrations and metabolic uptake in asymptomatic close contacts. These findings challenge the validity of simply dichotomizing cases of tuberculosis based on X-ray abnormalities and suggest the need for advanced imaging tools to stratify contacts on a continuous spectrum. Identifying incipient tuberculosis would provide an opportunity for earlier treatment.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fernando U. Kay, Vinh Ho, Edmund B. Dosunmu, Avneesh Chhabra, Keenan Brown, Xinhui Duan, Orhan K. Oz
Summary: Low bone mineral density (BMD) was found to be common in oncologic patients undergoing F-18-FDG PET/CT. Decreased F-18-FDG avidity of bone marrow correlated with decreased BMD, validating the link between osteoporosis and bone marrow fat. CT attenuation value of L1 vertebrae could serve as a simple and accurate approach for detecting patients at risk for osteoporosis-related fractures using PET/CT data.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xueqi Chen, Pengcheng Hu, Haojun Yu, Hui Tan, Yibo He, Shuangliang Cao, Yun Zhou, Hongcheng Shi
Summary: This study compares the lesion-detecting ability of 2-[F-18]FDG total-body PET/CT and conventional digital PET/CT. The results show that TB PET/CT is more sensitive in detecting small or low-uptake lesions compared to conventional PET/CT.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuki Onozato, Takekazu Iwata, Yasufumi Uematsu, Daiki Shimizu, Takayoshi Yamamoto, Yukiko Matsui, Kazuyuki Ogawa, Junpei Kuyama, Yuichi Sakairi, Eiryo Kawakami, Toshihiko Iizasa, Ichiro Yoshino
Summary: This study developed and validated multiple machine learning models using radiomic features from preoperative [F-18]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) images to predict the pathological invasiveness of lung cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Pharmacology & Pharmacy
Gaelle Hugon, Sebastien Goutal, Ambre Dauba, Louise Breuil, Benoit Larrat, Alexandra Winkeler, Anthony Novell, Nicolas Tournier
Summary: Focused ultrasound in combination with microbubbles enhances therapeutics delivery to the brain by increasing blood-brain barrier permeability. PET imaging using [F-18]FDS is evaluated as a marker for BBB integrity, showing significantly increased distribution in the brain after FUS. These findings demonstrate the potential of [F-18]FDS PET as a sensitive and reproducible marker for noninvasive monitoring of BBB disruption induced by FUS in vivo.
Article
Multidisciplinary Sciences
Amir Emamifar, Torkell Ellingsen, Anne Pernille Hermann, Soren Hess, Oke Gerke, Ziba Ahangarani Farahani, Per Syrak Hansen, Inger Marie Jensen Hansen, Peter Thye-Ronn
Summary: The study revealed that in the treatment process of patients with PMR/GCA, arterial stiffness decreased, and body composition changed, with a decrease in bone mineral content and an increase in fat mass, while lean body mass did not significantly change.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jesper A. S. Andersen, Anders D. Spatzek, Mie H. Vilstrup, Peter Grupe, Soren Hess, Paw C. Holdgaard, Lars Bastholt, Oke Gerke, Malene G. Hildebrandt
Summary: This study evaluated the diagnostic accuracy and clinical impact of FDG-PET/CT in detecting recurrence in high-risk malignant melanoma patients during the first year after surgery. The results showed a high rate of recurrence and a moderately low specificity, indicating a high number of false-positive results.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mia Daugaard Jorgensen, Ronald Antulov, Soren Hess, Simon Lysdahlgaard
Summary: The study compared the diagnostic accuracy of convolutional neural networks with radiologists in diagnosing intracranial hemorrhages. It found that in retrospective studies, the performance of CNNs was equivalent to that of radiologists, but when combined with external validation studies, CNN performance was slightly worse.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Respiratory System
Ayse Dudu Altintas Dogan, Ole Hilberg, SOren Hess, Torben Tranborg Jensen, Else-Marie Bladbjerg, Claus Bogh Juhl
Summary: This study investigated the effect of liraglutide on pulmonary function in individuals with obesity and COPD. The results showed that liraglutide use led to weight loss, improved pulmonary function, and reduced clinical impact of COPD.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
M. W. Kusk, J. Stowe, S. Hess, O. Gerke, S. Foley
Summary: A study was conducted to evaluate the automatic measurement method using a 3D-printed heart phantom. The results showed that the phantom closely mimicked the real scans and the automatic algorithm reliably measured left ventricular volume.
Review
Medicine, General & Internal
Soren Hess
Summary: Bacteremia is a complex and potentially dangerous medical condition characterized by viable bacteria in the bloodstream. Treatment differs between simple and complex cases, with complex cases requiring more advanced treatment including long-term antibiotics or invasive drainage. This review highlights the potential role of [F-18]FDG-PET/CT in detecting metastatic infections in patients with bacteremia, which can have a significant impact on patient management, treatment strategy, and patient outcome.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Shashi B. Singh, Sadikshya Bhandari, Shisir Siwakoti, Rabi Bhatta, William Y. Raynor, Thomas J. Werner, Abass Alavi, Soren Hess, Mona-Elisabeth Revheim
Summary: This study evaluates the limitations of positron emission tomography (PET) in diagnosing bacterial infections. Although [F-18]FDG-PET can visualize inflammation caused by bacterial infections, its lack of specificity makes it unsuitable for direct visualization of bacteria. Therefore, researchers are exploring more specific radiotracers and have used several radiotracers to image microorganisms. However, there has been no progress in translating these results for routine clinical use, as feasibility and other factors have constrained their success in clinical settings. Nonetheless, [F-18]FDG-PET remains important as the only option for detecting evidence of infection.
Article
Mathematics
Simon Lysdahlgaard, Sandi Baressi Segota, Soren Hess, Ronald Antulov, Martin Weber Kusk, Zlatan Car
Summary: The authors propose a system based on convolutional neural networks for automatic quality classification of X-ray examinations. The system significantly reduces erroneous classification and simplifies the process. They tested different approaches and achieved the best results using a hybrid approach with the Xception network architecture.
Article
Rheumatology
Amir Emamifar, Soren Hess, Torkell Ellingsen, Oke Gerke, Ziba Ahangarani Farahani, Per Syrak Hansen, Inger Marie Jensen Hansen, Peter Thye-Ronn
Summary: The study showed that many clinical symptoms significantly improved within 4 weeks and remained at lower levels as time progressed. Some clinical features, such as female biological sex, younger age, fewer relapses, and lower baseline ESR levels, were significantly associated with better treatment response.
RHEUMATOLOGY ADVANCES IN PRACTICE
(2021)
Article
Surgery
O. S. Bjerring, S. Hess, H. Petersen, C. W. Fristrup, L. Lundell, M. B. Mortensen
Summary: EUS outperformed PET-CT in detecting locoregional and isolated locoregional recurrences; PET-CT had moderate to high sensitivity for overall recurrence detection, but low specificity; The concomitant use of PET-CT and EUS had high accuracy in detecting recurrences.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Lars Christian Gormsen, Soren Hess
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
S. Hess, R. Horvat, E. H. Jakobsen, P. C. Holdgaard
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
S. Hess, R. Horvat
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
P. Holdgaard, S. T. Nygaard, E. H. Jakobsen, S. Hess
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moozhan Nikpanah, Sanaz Katal, Thomas Q. Christensen, Thomas J. Werner, Soren Hess, Ashkan A. Malayeri, Ali Gholamrezanezhad, Abass Alavi, Babak Saboury
