Review
Urology & Nephrology
Pawel Rajwa, Benjamin Pradere, Fahad Quhal, Keiichiro Mori, Ekaterina Laukhtina, Nicolai A. Huebner, David D'Andrea, Aleksandra Krzywon, Sung Ryul Shim, Pascal A. Baltzer, Raphaele Renard-Penna, Michael S. Leapman, Shahrokh F. Shariat, Guillaume Ploussard
Summary: The study evaluated the diagnostic estimates of serial prostate MRI for PCa progression during AS, suggesting that MRI alone is not accurate enough to reliably rule out or rule in prostate cancer progression. Other clinical factors and biomarkers are needed to tailor the intensity of follow-up biopsies.
Review
Biochemistry & Molecular Biology
Avan Kader, Julia Brangsch, Jan O. Kaufmann, Jing Zhao, Dilyana B. Mangarova, Jana Moeckel, Lisa C. Adams, Ingolf Sack, Matthias Taupitz, Bernd Hamm, Marcus R. Makowski
Summary: This review summarizes recent developments in molecular imaging markers for magnetic resonance imaging of prostate cancer, aiming to improve the molecular characterization of the tumor and enable targeted therapies to suppress tumor growth or reduce tumor size in a non-invasive manner.
Review
Radiology, Nuclear Medicine & Medical Imaging
Moon Hyung Choi, Dong Hwan Kim, Young Joon Lee, Sung Eun Rha, Ji Youl Lee
Summary: This study aimed to evaluate the diagnostic performance of each MRI feature of the PI-RADS for predicting extraprostatic extension in prostate cancer. After screening 1955 studies, 17 studies with a total of 3062 men were included. Among the six MRI features, breach of the capsule with direct tumor extension and tumor-capsule interface > 10 mm were the most predictive of extraprostatic extension with the highest specificity (98.0%) and sensitivity (86.3%), respectively.
INSIGHTS INTO IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Laura Evangelista, Fabio Zattoni, Gianluca Cassarino, Paolo Artioli, Diego Cecchin, Fabrizio dal Moro, Pietro Zucchetta
Summary: This study summarized the diagnostic role of PET/MRI in patients with prostate cancer. The results showed that PET/MRI has high sensitivity for detecting primary PCa, especially when radiolabeled PSMA is used, and also has a high detection rate for recurrent disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Oncology
Jing Wen, Yugang Ji, Jing Han, Xiaocui Shen, Yi Qiu
Summary: The study aimed to assess the inter-reader agreement of the Prostate Imaging Reporting and Data System Version (PI-RADS) v2.1 for detecting prostate cancer (PCa). The results showed substantial inter-reader agreement for both whole gland and transitional zone lesions using PI-RADS v2.1. Furthermore, there was no significant difference in agreement between PI-RADS v2.0 and v2.1.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Avan Kader, Jan O. Kaufmann, Dilyana B. Mangarova, Jana Moeckel, Lisa C. Adams, Julia Brangsch, Jennifer L. Heyl, Jing Zhao, Christine Verlemann, Uwe Karst, Federico Collettini, Timo A. Auer, Bernd Hamm, Marcus R. Makowski
Summary: The constant interactions between tumor cells and the extracellular matrix in prostate cancer influence its progression. Collagen fibers, as key components of the extracellular matrix, play important roles in tissue stiffness, growth, adhesion, proliferation, migration, invasion/metastasis, cell signaling, and immune recruitment of tumor cells. In this study, molecular magnetic resonance imaging (MRI) using a collagen-specific probe was used to explore the molecular marker in prostate cancer. The results showed that there was no significant signal difference between two different tumor volumes, but there was a significant difference in the signal intensity between the peripheral and central areas of the tumor, indicating higher collagen expression in the peripheral area. The MRI data were strongly correlated with the histological data and supported by elemental analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Yi Zhao, Benjamin S. Simpson, Naomi Morka, Alex Freeman, Alex Kirkham, Daniel Kelly, Hayley C. Whitaker, Mark Emberton, Joseph M. Norris
Summary: This study aimed to compare the diagnostic performance of mpMRI and PSMA PET imaging in diagnosing primary prostate cancer. The results showed that PSMA PET/CT was superior in diagnosing patients with prostate cancer over mpMRI, but not in defining the location of the cancer. Early evidence suggests that adding PSMA PET to the diagnostic pathway may enhance the detection of clinically significant prostate cancer.
Review
Oncology
Jing Zeng, Qingqing Cheng, Dong Zhang, Meng Fan, Changzheng Shi, Liangping Luo
Summary: This study aimed to estimate the diagnostic capacity of DCE-MRI for prostate cancer (PCa) and clinically significant prostate cancer (csPCa) in equivocal lesions. The results indicate that the sensitivity and specificity of DCE-MRI in diagnosing csPCa and PCa are relatively low, suggesting limitations in its role in equivocal lesions. Through meta-regression, factors contributing to heterogeneity were identified as study design, magnetic field strength, the definition of csPCa, and the scoring system.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Armando Stabile, Elio Mazzone, Giuseppe O. Cirulli, Francesco De Cobelli, Jeremy Grummet, Harriet C. Thoeny, Mark Emberton, Morgan Pokorny, Peter A. Pinto, Samir S. Taneja
Summary: The study systematically reviewed the relationship between pre-treatment mpMRI and oncological outcomes after primary treatment for PCa. PI-RADS scores were found to predict biochemical recurrence, while tumor volume at mpMRI was not significantly associated with recurrence. Limited data on disease progression and PCa-specific mortality were reported. Substantial heterogeneity among studies was noted.
EUROPEAN UROLOGY ONCOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yajing Wang, Wei Wang, Nuo Yi, Liang Jiang, Xindao Yin, Wenzhen Zhou, Liwei Wang
Summary: This systematic review and meta-analysis evaluated the diagnostic performance of biparametric magnetic resonance imaging (bpMRI) for the detection of intermediate-and high-risk prostate cancer (IHPC). The results showed that bpMRI exhibited a high negative predictive value and accuracy in the diagnosis of IHPC, and may be valuable for detecting prostate cancer with poor prognosis.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yajing Wang, Wei Wang, Nuo Yi, Liang Jiang, Xindao Yin, Wenzhen Zhou, Liwei Wang
Summary: This systematic review and meta-analysis evaluated the diagnostic performance of biparametric magnetic resonance imaging (bpMRI) for the detection of intermediate- and high-risk prostate cancer (IHPC). The results showed that bpMRI exhibited a high negative predictive value and accuracy in the diagnosis of IHPC, and may be valuable for detecting PCa with poor prognosis. However, the bpMRI protocol needs to be standardized further to improve its wider applicability.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Urology & Nephrology
Benjamin D. Besasie, Abhijit G. Sunnapwar, Feng Gao, Dean Troyer, Geoffrey D. Clarke, Hugh White, Peter T. Fox, Anders Dale, Allison Wheeler, Michael A. Liss
Summary: Restriction spectrum imaging-magnetic resonance imaging improves upgrading detection in active surveillance for prostate cancer, especially for predicting Gleason upgrading, by providing a noninvasive radiological biomarker.
JOURNAL OF UROLOGY
(2021)
Letter
Oncology
Amanda Khoo, Lydia Y. Liu, Taylor Y. Sadun, Amirali Salmasi, Aydin Pooli, Ely Felker, Kathleen E. Houlahan, Vladimir Ignatchenko, Steven S. Raman, Anthony E. Sisk, Robert E. Reiter, Paul C. Boutros, Thomas Kislinger
Summary: This study found that the tumors that are invisible on mpMRI closely resemble the histologically normal prostate, indicating that tumor visibility on mpMRI depends on the proteomic differences between the tumor and normal prostate.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Juan Morote, Angel Borque-Fernando, Marina Triquell, Anna Celma, Lucas Regis, Richard Mast, Ines M. de Torres, Maria E. Semidey, Anna Santamaria, Jacques Planas, Luis M. Esteban, Enrique Trilla
Summary: The study confirmed that prostate magnetic resonance imaging (MRI) grades the aggressiveness of prostate cancer (PCa), with its rating significantly related to GG, surgical specimen pathology type, clinical stage, and biochemical recurrence risk after treatment of localized PCa.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lei Hu, Da Wei Zhou, Cai Xia Fu, Thomas Benkert, Chun Yu Jiang, Rui Ting Li, Li Ming Wei, Jun Gong Zhao
Summary: The radiomics signatures based on zoomed diffusion-weighted imaging technology showed better diagnostic accuracy for prostate cancer compared to traditional full-field-of-view DWI technology. The mixed model performed the best in diagnosing PCa and guiding clinical interventions among the studied models.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhicong Li, Jing Zhang, Yang Song, Xiaorui Yin, An Chen, Na Tang, Martin R. Prince, Guang Yang, Han Wang
Summary: A prediction model incorporating T2WI-based radiomics features and clinical parameters can guide radiologists to evaluate MRgFUS treatment for adenomyosis patients who will achieve good response.
EUROPEAN RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yu Fan, Lizhou Lin, Fangfang Yin, Yu Zhu, Mingwu Shen, Han Wang, Lianfang Du, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi
Article
Acoustics
Nan Wu, Guofeng Shen, Xiongfei Qu, Hao Wu, Shan Qiao, Enmin Wang, Yazhu Chen, Han Wang
Summary: The study introduces a novel ultrasound transducer that can be rotated according to different skull geometries, improving treatment efficiency while minimizing the impact of shear waves on the treatment area. Computational tomography model simulations of nine skulls confirm the versatility and feasibility of the new transducer design.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Engineering, Environmental
Fangfang Yin, Yu Fan, Leijing Xu, Fei Yin, Meijuan He, Tingting Xiao, Xiangyang Shi, Han Wang
Summary: Immune cell therapy and nanoparticle-mediated cell-immunotherapy have shown promising potential in the treatment of malignant tumors, particularly in osteosarcoma. Engineered macrophages carrying gold nanoparticles can serve as a theranostic platform for CT imaging-guided cell immunotherapy and chemotherapy, demonstrating a cooperative impact in enhancing cancer treatment.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Acoustics
Xiongfei Qu, Guofeng Shen, Nan Wu, Hao Wu, Shan Qiao, Enmin Wang, Yazhu Chen, Han Wang
Summary: Transcranial focused ultrasound is a novel noninvasive therapeutic modality for brain disorders, but focus-shifting sonication may unintentionally damage healthy brain tissue. To reduce risks, linear frequency-modulated excitation is proposed, which effectively suppresses undesired prefocal grating lobes.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Chemistry, Multidisciplinary
Tingting Xiao, Meijuan He, Fang Xu, Yu Fan, Bingyang Jia, Mingwu Shen, Han Wang, Xiangyang Shi
Summary: The study introduces a multifunctional polymer nanogel camouflaged with macrophage membranes for MR imaging-guided chemotherapy of glioma. The nanogel exhibits dual pH and redox-responsive release profiles, enhancing chemotherapy/CDT efficacy.
Article
Chemistry, Multidisciplinary
Qiuhong Zhang, Meijuan He, Xiaodong Zhang, Hongwei Yu, Jiawei Liu, Yi Guo, Junmin Zhang, Xiangzhong Ren, Han Wang, Yanli Zhao
Summary: This study reports the development of a tumor microenvironment-activable ROS-generating system using a protein-based nanomedicine that undergoes multistage self-assembly. The system offers effective self-protection for normal tissues and achieves tumor-specific therapy, providing a powerful strategy for nanomedicine design and precise cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhiqiang Wang, Yunqi Guo, Yu Fan, Jingwen Chen, Han Wang, Mingwu Shen, Xiangyang Shi
Summary: The study introduces a novel theranostic nanoplatform based on endoplasmic reticulum stress (ERS) amplification, utilizing metal-phenolic network-coated dendrimer-drug conjugates. These nanocomplexes can effectively inhibit cancer cell adaptation by rapidly releasing the drug Toy under the tumor microenvironment, while also generating cytotoxic hydroxyl radicals through a Fenton reaction for improved chemo/chemodynamic therapy. Additionally, the coated network allows for in vivo T-1-weighted tumor magnetic resonance imaging.
ADVANCED MATERIALS
(2022)
Article
Oncology
Xuhui Fan, Ni Xie, Jingwen Chen, Tiewen Li, Rong Cao, Hongwei Yu, Meijuan He, Zilin Wang, Yihui Wang, Hao Liu, Han Wang, Xiaorui Yin
Summary: This study developed and evaluated radiomic models based on multiparametric MRI as a noninvasive diagnostic method to predict various biological characteristics of prostate cancer. The results showed that the RF-based model performed best among the six classifiers for all the groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wenjing Ma, Yue Gao, Zhijun Ouyang, Yu Fan, Hongwei Yu, Mengsi Zhan, Han Wang, Xiangyang Shi, Mingwu Shen
Summary: The development of a dendrimer-based nanomedicine formulation for apoptosis-enhanced ferroptosis therapy shows promise in improving the treatment efficacy of pancreatic carcinoma.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ni Xie, Xuhui Fan, Haoran Xie, Jiawei Lu, Lanting Yu, Hao Liu, Han Wang, Xiaorui Yin, Baiwen Li
Summary: In this study, radiomics models were used to predict extrapancreatic extension in pancreatic cancer patients before surgery. The best classifier was XGBoost, and incorporating the clinical factor of platelet improved the predictive performance.
ACADEMIC RADIOLOGY
(2023)
Article
Engineering, Environmental
Meijuan He, Tingting Xiao, Yihui Wang, Hongwei Yu, Zilin Wang, Xiangyang Shi, Han Wang
Summary: In this study, we developed an immunostimulated nanoplatform for MRI-guided radiotherapy against GBM. The platform effectively enhances the immune response and shows promising therapeutic efficacy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ni Xie, Xuhui Fan, Desheng Chen, Jingwen Chen, Hongwei Yu, Meijuan He, Hao Liu, Xiaorui Yin, Baiwen Li, Han Wang
Summary: The study aims to develop radiomics models based on multiparametric MRI (MP-MRI) to evaluate lymph node metastasis (LNM) and histological grade (HG) in pancreatic cancer.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaorui Yin, Na Tang, Xuhui Fan, Shengping Wang, Junhai Zhang, Jianjun Gu, Han Wang
Summary: This study confirmed that MRgFUS is a non-invasive, effective, and safe modality for treating painful bone metastases. The study also found that the non-perfused volume ratio and the lesion type may affect the mid-term efficacy of MRgFUS.
EUROPEAN RADIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Beilei Zhang, Yue Gao, Rui Yang, Zhijun Ouyang, Hongwei Yu, Han Wang, Xiangyang Shi, Mingwu Shen
Summary: Unobtrusive metastasis and invasion are the major causes of cancer patient death, and the lack of specificity and abrupt release of anticancer drugs applied to primary tumors cause serious side effects in cancer management. Therefore, the development of controlled local drug delivery systems that can effectively treat primary tumors and inhibit tumor metastasis is crucial for improved cancer therapeutics.
ADVANCED FIBER MATERIALS
(2022)