Article
Medicine, Research & Experimental
Aleksandra Wabik, Elzbieta Trypka, Joanna Bladowska, Mikolaj Statkiewicz, Marek Sasiadek, Anna Zimny
Summary: This study compared the use of DSC-MRI and FDG-PET in the diagnosis of AD and aMCI. Results showed that hypoperfusion was present in AD patients, while aMCI patients showed hypoperfusion in the parietal and temporal cortices, as well as the left PCG region. FDG-PET was more accurate in distinguishing aMCI from the control group. DSC-MRI may be a competitive method to FDG-PET.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Geriatrics & Gerontology
Jennie L. Dorris, Stephen Neely, Lauren Terhorst, Helena M. VonVille, Juleen Rodakowski
Summary: The study demonstrates that active music-making has a small but statistically significant impact on cognitive functioning, emotional well-being, and social engagement for older adults with probable MCI or dementia.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Tommaso Romagnoli, Beatrice Ortolani, Juana Maria Sanz, Alessandro Trentini, Davide Seripa, Edoardo Dalla Nora, Eleonora Capatti, Carlo Cervellati, Angelina Passaro, Giovanni Zuliani, Gloria Brombo
Summary: This study evaluated serum ApoJ levels in 196 MCI subjects and found that low ApoJ levels may be associated with an increased risk of developing dementia. The risk of dementia conversion doubled in subjects with lower ApoJ levels compared to those with higher levels, especially after two years of follow up.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Che Liu, Sang H. Lee, David A. Loewenstein, James E. Galvin, Bonnie E. Levin, Alexander McKinney, Noam Alperin
Summary: This study compared total cerebral blood flow (tCBF), global cerebral perfusion (GCP), and volumes of AD-prone regions between cognitively normal and early amnestic mild cognitive impairment (aMCI) individuals. It was found that tCBF and GCP were significantly reduced in the early aMCI group compared to the cognitively normal group. Furthermore, tCBF and GCP were significantly associated with global cognition and memory scores.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Cell Biology
Michael K. Yeung, Anson Kwok-yun Chau, Jason Yin-chuen Chiu, Jay Tsz-lok Shek, Jody Po-yi Leung, Toby Chun-ho Wong
Summary: The study found significant differences in neuroimaging abnormalities between amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI), with aMCI showing more and more significant abnormalities, while naMCI showing more limited abnormalities, with shared features but unique neuroimaging abnormalities in aMCI.
AGEING RESEARCH REVIEWS
(2022)
Review
Clinical Neurology
Jonathan Blackman, Marta Swirski, James Clynes, Sam Harding, Yue Leng, Elizabeth Coulthard
Summary: Suboptimal sleep can lead to cognitive decline and accelerate Alzheimer's Disease progression. Early intervention in MCI and mild AD is necessary, but there is a lack of evidence for sleep interventions in these stages, highlighting the need for high quality experimental studies exploring alternative interventions.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Environmental Sciences
Teresa Urbano, Annalisa Chiari, Carlotta Malagoli, Andrea Cherubini, Roberta Bedin, Sofia Costanzini, Sergio Teggi, Giuseppe Maffeis, Marco Vinceti, Tommaso Filippini
Summary: Exposure to outdoor air pollutants, particularly PM10, may nonlinearly increase the risk of conversion from MCI to dementia. Higher PM10 levels were associated with increased concentrations of cerebrospinal fluid tau proteins and decreased beta-amyloid levels. The risk of dementia was positively associated with mean PM10 levels above 10 μg/m3 and maximum PM10 levels above 35 μg/m3.
ENVIRONMENTAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Rachel Heutz, Jurgen Claassen, Sanne Feiner, Aaron Davies, Dewakar Gurung, Ronney B. Panerai, Rianne de Heus, Lucy C. Beishon
Summary: Dynamic cerebral autoregulation (dCA) is a key mechanism that regulates cerebral blood flow in response to transient changes in blood pressure. The literature remains conflicted on whether dCA is altered in Alzheimer's disease (AD) and mild cognitive impairment (MCI). A qualitative synthesis of eight studies suggests no significant difference in dCA parameters for spontaneous fluctuations between AD, MCI, and healthy controls. Limited data on induced fluctuations indicate preserved or possibly better autoregulatory functioning in AD and MCI compared to controls. Further research is needed to investigate dCA in dementia with induced fluctuations controlling for changes in end-tidal carbon dioxide.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Julia Schumacher, John-Paul Taylor, Calum A. Hamilton, Michael Firbank, Paul C. Donaghy, Gemma Roberts, Louise Allan, Rory Durcan, Nicola Barnett, John T. O'Brien, Alan J. Thomas
Summary: The study compared resting-state fMRI data of patients with mild cognitive impairment due to Lewy bodies and Alzheimer's disease, finding no significant differences between the mild cognitive impairment groups and controls. The fMRI analyses did not appear sensitive enough to detect early and subtle changes in brain function in these patients.
JOURNAL OF NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Lars Michels, Florian Riese, Rafael Meyer, Andrea M. Kaelin, Sandra E. Leh, Paul G. Unschuld, Roger Luechinger, Christoph Hock, Ruth O'Gorman, Spyros Kollias, Anton Gietl
Summary: The study used EEG-fMRI to evaluate brain activity in patients with mild cognitive impairment (MCI) and found abnormal coupling in multiple networks in MCI patients. Amyloid deposition was associated with abnormal signal coupling in visual, fronto-parietal regions, and some core memory regions.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Hong-Chun Wei, Bing Li, Kok Pin Ng, Qing-Xi Fu, Sheng-Jie Dong, Mao-Wen Ba, Min Kong
Summary: This study compared clinical and biomarker features between A+T+MCI individuals progressing to pMCI and those remaining stable sMCI, identifying CSF and cognitive measures at baseline predictive of dementia progression within 2 years. Subset differences in biomarkers, cognitive assessment, and MRI imaging were observed, with CSF t-tau levels and cognitive scores serving as potential risk factors for dementia progression in A+T+MCI individuals.
CHINESE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
James E. Galvin, Stephanie Chrisphonte, Iris Cohen, Keri K. Greenfield, Michael J. Kleiman, Claudia Moore, Mary Lou Riccio, Amie Rosenfeld, Niurka Shkolnik, Marcia Walker, Lun-Ching Chang, Magdalena I. Tolea
Summary: The study tested the performance of the LBD-MOD module in characterizing Lewy body dementia (DLB) and distinguishing it from Alzheimer's disease (AD). Results showed differences between DLB and AD in various symptoms, as well as differences between MCI-DLB and MCI-AD. The LBD-MOD module provided excellent characterization of core features and supportive features to differentiate DLB from AD and also characterize features of MCI-DLB.
ALZHEIMERS & DEMENTIA
(2021)
Article
Behavioral Sciences
Victor N. Almeida, Marcia Radanovic
Summary: This theoretical review critically examines linguistic and semantic processing in Mild Cognitive Impairment and Alzheimer's disease, focusing on a neurobiological perspective. The authors propose that most linguistic alterations result from inhibited semantic discrimination, caused by a cluster of cholinergic dysfunction, A?? load, and somatostatin-positive cell loss. These changes lead to failures in accurate retrieval, verbal fluency anomalies, semantic interference, dampened N400 effects, and other semantic deviations.
Article
Clinical Neurology
Kirsty E. McAleese, Sean J. Colloby, Alan J. Thomas, Safa Al-Sarraj, Olaf Ansorge, James Neal, Federico Roncaroli, Seth Love, Paul T. Francis, Johannes Attems
Summary: The aged brain often exhibits multiple pathologies, rather than a single pathology, and the presence of multiple pathologies can significantly worsen cognitive decline, increasing the risk of transitioning from mild cognitive impairment to dementia.
ALZHEIMERS & DEMENTIA
(2021)
Article
Biochemistry & Molecular Biology
Patrick Buecker, Henning Richter, Alexander Radbruch, Michael Sperling, Marcus Brand, Markus Holling, Veerle Van Marck, Werner Paulus, Astrid Jeibmann, Uwe Karst
Summary: The study investigated the deposition of lanthanum in two patients who received lanthanum carbonate as a phosphate binder, compared to additionally found gadolinium deposition. Both lanthanum and gadolinium were found to deposit in various tissues of the body, with a significantly increased Gd-to-La ratio in certain organs like the thyroid vasculature and cerebellum.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Haubold, Rene Hosch, Lale Umutlu, Axel Wetter, Patrizia Haubold, Alexander Radbruch, Michael Forsting, Felix Nensa, Sven Koitka
Summary: The required amount of ICM for CT can be reduced by 50% while maintaining image quality and diagnostic accuracy using GANs. The networks achieving 50% reduction in ICM dose reached 100% consistency in the crucial question of pathological consistency. More studies are needed to confirm these initial results.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Paech, Alexander Radbruch
MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA
(2021)
Article
Clinical Neurology
Johannes Kaesmacher, Nuran Abdullayev, Basel Maamari, Tomas Dobrocky, Jan Vynckier, Eike Piechowiak, Raoul Pop, Daniel Behme, Peter B. Sporns, Hanna Styczen, Pekka Virtanen, Lukas Meyer, Thomas R. Meinel, Daniel Cantre, Christoph Kabbasch, Volker Maus, Johanna Pekkola, Sebastian Fischer, Anca Hasiu, Alexander Schwarz, Moritz Wildgruber, David J. Seiffge, Soenke Langner, Nicolas Martinez-Majander, Alexander Radbruch, Marc Schlamann, Dan Mihoc, Remy Beaujeux, Daniel Strbian, Jens Fiehler, Pasquale Mordasini, Jan Gralla, Urs Fischer
Summary: The study found that the administration of intra-arterial fibrinolytics as an adjunct to mechanical thrombectomy is rarely performed but can improve reperfusion, leading to better treatment outcomes. However, there is a possible increased risk of symptomatic intracranial hemorrhage, highlighting the importance of careful patient selection.
Article
Medicine, General & Internal
Matthias Schneider, Niklas Schaefer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Gueresir, Muriel Heimann, Yon-Dschun Ko, Felix Lehmann, Anna-Laura Potthoff, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Hartmut Vatter, Ulrich Herrlinger, Jennifer Landsberg, Patrick Schuss
Summary: Studying preoperative laboratory inflammation markers in melanoma patients with brain metastasis undergoing surgery revealed that elevated CRP levels, higher NLR and PLR, and lower LMR were associated with reduced overall survival rates. These markers could potentially be integrated into preoperative treatment planning for affected patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Clinical Neurology
Laura Fischbach, Tobias Bauer, Theodor Rueber, Marcus Grobe-Einsler, Aileen Sitter, Alexander Radbruch, Oliver Kaut
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Majd Bahna, Muriel Heimann, Christian Bode, Valeri Borger, Lars Eichhorn, Erdem Gueresir, Motaz Hamed, Ulrich Herrlinger, Yon-Dschun Ko, Felix Lehmann, Anna-Laura Potthoff, Alexander Radbruch, Christina Schaub, Rainer Surges, Johannes Weller, Hartmut Vatter, Niklas Schaefer, Matthias Schneider, Patrick Schuss
Summary: Surgical resection is effective for treating tumor-related epilepsy in patients with brain metastases, although some patients may experience postoperative persistent epilepsy. Identifying preoperative risk factors for unfavorable seizure outcomes is crucial, with tumor volume, midline shift, and necrosis/tumor volume ratio being significant factors. Preoperative identification of these factors can help in selecting highly vulnerable patients who may benefit from neuro-oncological expertise during treatment.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Frederic Carsten Schmeel, Simon Jonas Enkirch, Julian Alexander Luetkens, Anton Faron, Nils Lehnen, Alois Martin Sprinkart, Leonard Christopher Schmeel, Alexander Radbruch, Ulrike Attenberger, Guido Matthias Kukuk, Petra Murtz
Summary: The study aimed to compare and combine the diagnostic performance of ADC from DWI and PDFF from CSE-based MRI in distinguishing benign and malignant vertebral bone marrow lesions. Results showed that ADC and PDFF values were significantly lower in malignant lesions compared to benign lesions, and the combination of both parameters improved diagnostic accuracy in differentiating benign and malignant VBMLs, yielding a high diagnostic accuracy.
CLINICAL NEURORADIOLOGY
(2021)
Article
Oncology
Patrick Schuss, Niklas Schaefer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Guresir, Muriel Heimann, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Anna-Laura Potthoff, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Hartmut Vatter, Ulrich Herrlinger, Matthias Schneider
Summary: Postoperative prolonged mechanical ventilation (PMV) is significantly associated with poor overall survival (OS) in patients with surgically treated brain metastasis. PMV can serve as an important prognostic factor and be utilized for optimized patient management early in the postoperative phase.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Nils Christian Lehnen, Robert Haase, Jennifer Faber, Theodor Ruber, Hartmut Vatter, Alexander Radbruch, Frederic Carsten Schmeel
Summary: The study evaluated the diagnostic performance of a convolutional neural network on lumbar spine MRI images, demonstrating high accuracy and consistency in automatically diagnosing various degenerative changes in the lumbar spine.
Letter
Clinical Neurology
Martin Schidlowski, Tobias Bauer, Bastian David, Felix Bitzer, Laura Ostermann, Attila Racz, Randi von Wrede, Alexander Radbruch, Tony Stoecker, Rainer Surges, Theodor Rueber
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Multidisciplinary Sciences
Angelika Maurer, Damian Verma, Annika Reddehase, Lukas Scheef, Alexander Radbruch, Ulrike Attenberger, Andreas Jaeger, Henning Boecker
Summary: This study investigated central pain representations during loading of the periodontium induced by orthodontic and occlusal stress. Functional magnetic resonance imaging showed elevated activation in specific brain regions during tooth clenching with an elastic separator, indicating specific expressions of pain at both behavioral and neuronal network levels. This research contributes to the neuroimaging literature on odontogenic pain.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Matthias Schneider, Niklas Schaefer, Christian Bode, Lars Eichhorn, Frank A. Giordano, Erdem Gueresir, Muriel Heimann, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss
Summary: This study identified several risk factors for reduced overall survival in patients undergoing surgical treatment for non-small cell lung cancer brain metastases, including age, location of metastases, preoperative C-reactive protein levels, intraoperative blood transfusion, postoperative prolonged mechanical ventilation, and postoperative adverse events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Johannes Haubold, Aydin Demircioglu, Jens Matthias Theysohn, Axel Wetter, Alexander Radbruch, Nils Doerner, Thomas Wilfried Schlosser, Cornelius Deuschl, Yan Li, Kai Nassenstein, Benedikt Michael Schaarschmidt, Michael Forsting, Lale Umutlu, Felix Nensa
Summary: This study aimed to generate virtual STIR (vSTIR) images from non-contrast, non-fat-suppressed T1- and T2-weighted images using a conditional generative adversarial network (cGAN) to shorten scanning time in MRI of the spine. Validation tests showed that vSTIR was equivalent to real STIR in most cases, with only slight insignificant differences in some details.
Article
Clinical Neurology
Peter B. Sporns, Marios-Nikos Psychogios, Ronald Straeter, Uta Hanning, Jens Minnerup, Rene Chapot, Hans Henkes, Elina Henkes, Astrid Grams, Franziska Dorn, Omid Nikoubashman, Martin Wiesmann, Georg Bier, Anushe Weber, Gabriel Broocks, Jens Fiehler, Alex Brehm, Daniel Kaiser, Umut Yilmaz, Andrea Morotti, Wolfgang Marik, Richard Nolz, Ulf Jensen-Kondering, Michael Braun, Stefan Schob, Oliver Beuing, Friedrich Goetz, Johannes Trenkler, Bernd Turowski, Markus Mohlembruch, Christina Wendl, Peter Schramm, Patricia L. Musolino, Sarah Lee, Marc Schlamann, Alexander Radbruch, Andre Karch, Nicole Rubsamen, Moritz Wildgruber, Andre Kemmling
Summary: Thrombectomy in pediatric ischemic stroke within an extended time window of up to 24 hours after onset of symptoms appears to be safe and associated with generally good neurologic outcomes when patients are selected based on a mismatch between clinical deficit and infarct.
