Article
Biochemistry & Molecular Biology
Yihe Wang, Christine Y. Chuang, Clare L. Hawkins, Michael J. Davies
Summary: Matrix metalloproteinase-9 (MMP9) plays a crucial role in the degradation of extracellular matrix (ECM) proteins. This study demonstrates that MMP9 can be activated by both chloramines and oxidation. The activation of MMP9 and ECM degradation are interdependent processes that may contribute to the progression of diseases.
Article
Cardiac & Cardiovascular Systems
Yu Jia, Dongze Li, Jing Yu, Wenli Jiang, Yi Liu, Fanghui Li, Wentao Li, Rui Zeng, Xiaoyang Liao, Zhi Wan
Summary: This study aimed to investigate the relationship between plasma levels of IL-33, sST2, MPO, and MMP-9 and all-cause mortality in patients with AAD. The results showed that sST2, MPO, and MMP-9 were independently associated with mortality in patients with AAD, suggesting a pathogenic role for the IL-33/ST2/neutrophil granzyme system in these patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Esra Ozkan, Yeliz Celik, Tulay Yucel-Lindberg, Yuksel Peker
Summary: This study investigated the determinants of high levels of oxidative stress marker MPO and destabilizer of plaques MMP-9 in coronary artery disease (CAD) patients with obstructive sleep apnea (OSA). The results showed that current smoking was significantly associated with high levels of MPO and MMP-9, while OSA had no significant effect. These findings suggest that smoking status should be considered when evaluating the impact of OSA on long-term cardiovascular outcomes in CAD adults.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ya-Tang Chiang, Yu-Bai Xiao, Shan-hui Hsu, Shu-Wei Chang, Chia-Ching Chou
Summary: Tannic acid (TA) has antibacterial, antioxidant, and anti-inflammatory properties and acts as an adhesive, hemostatic, and crosslinking agent in hydrogels. TA has been reported to inhibit MMP-2/- 9 activities, thereby improving tissue remodeling and wound healing. In this study, atomistic modeling was used to explore the mechanisms and structures of TA binding with MMP-2 and MMP-9, revealing the specific binding regions and molecular interactions involved. Understanding the binding mechanism and dynamics of TA with these MMPs provides crucial knowledge on the effects of TA on MMPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Article
Oncology
Reetta Peltonen, Jaana Hagstrom, Taina Tervahartiala, Timo Sorsa, Caj Haglund, Helena Isoniemi
Summary: This study found that high expression of MMP-9 in colorectal tumor tissue was associated with better disease-free survival (DFS), while high preoperative MPO in serum was associated with improved DFS and overall survival (OS) in patients undergoing liver resection for colorectal cancer. The prognostic significance varied according to gender, age, and the synchronicity of liver metastases. Low preoperative MPO in serum might identify patients at high risk of recurrence and death after resection of colorectal liver metastases.
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ionut Luchian, Mihaela Moscalu, Ancuta Goriuc, Ludovica Nucci, Monica Tatarciuc, Ioana Martu, Mihai Covasa
Summary: Periodontitis results in destructive effects on periodontium, with increased levels of MMP-9. Periodontal treatment alone or combined with orthodontic treatment can improve clinical parameters and lower MMP-9 levels. The degree of malocclusion affects the treatment's impact on MMP-9 levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Xianda Chen, Shuaixing Wang, Wenli Xu, Mingming Zhao, Youyi Zhang, Han Xiao
Summary: Vulnerable atherosclerotic plaque rupture is the main cause of myocardial infarction and stroke. Metformin, commonly used for type 2 diabetes, has been found to improve plaque vulnerability, but its mechanism is unknown. This study showed that metformin directly interacts with MMP-9, reducing its activity and driving its degradation. In a carotid artery plaque model, metformin treatment decreased local MMP-9 protein level and circulating MMP-9 activity, preserved collagen content in plaque, and reduced plaque vulnerability index.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Zhenshengnan Li, Jia Wei, Bowen Chen, Yaoqi Wang, Shuai Yang, Kehui Wu, Xianying Meng
Summary: Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent proteolytic metalloenzyme that degrades the extracellular matrix (ECM) and has been proven to be elevated in various pathological conditions, including thyroid carcinoma. Its expression level in malignant or metastatic thyroid tumor tissues is higher than in normal or benign tissues, and it correlates closely with clinical features such as lymph node metastasis, TNM stage, and tumor size.
Article
Surgery
Jing Shen, Jian-bo Song, Jun Fan, Zhe Zhang, Zheng-jia Yi, Shuo Bai, Xiao-lin Mu, Yao-bo Yang, Liang Xiao
Summary: This study simulated the process of neointima generation and regression after stent implantation, demonstrating the spatial distribution and dynamic changes of MMP-2, MMP-9, and collagen in ISR. The expression of MMP-2 and MMP-9 decreased and collagen content reached its maximum when ISR occurred, suggesting their potential contribution to ISR.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Clinical Neurology
Giuseppe Cosentino, Vincenzo Di Stefano, Rosalia Lo Presti, Maria Montana, Massimiliano Todisco, Matteo Gastaldi, Andrea Cortese, Enrico Alfonsi, Cristina Tassorelli, Brigida Fierro, Gregorio Caimi, Filippo Brighina
Summary: This study found that the plasmatic levels of MMPs and TIMPs were significantly altered in patients with CIDP, with higher concentrations of MMP-9, downregulation of TIMP-1, and lower concentration of MMP-2. These new biomarkers may have potential usefulness in the clinical setting and further studies are needed to confirm their utility.
NEUROLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yu-Chung Shih, Po-Yuan Chen, Tai-Ming Ko, Po-Hsun Huang, Hsu Ma, Der-Cherng Tarng
Summary: MMP-9 knockout attenuated AV fistula stenosis by reducing perioperative vascular inflammation through decreasing neointima size, increasing lumen area, and inhibiting the expression of inflammatory genes. Experiments showed that MMP-9 knockout also reduced CD44 and RAC-alpha serine/threonine-protein kinase (Akt) and extracellular signal-regulated kinases (ERK) phosphorylation, ultimately leading to a reduction in AV fistula failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Shenghui Chen, Jinghua Wang, Yishu Chen, Yanjun Guo, Qinqiu Wang, Zhening Liu, Hang Zeng, Chengfu Xu
Summary: Olfactomedin-4 is significantly upregulated in ulcerative colitis and may protect against colitis by directly inhibiting matrix metalloproteinase-9 and further decreasing p53-mediated apoptosis via Notch1 signaling.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Harmony R. Reynolds, Ariel Diaz, Derek D. Cyr, Leslee J. Shaw, G. B. John Mancini, Jonathon Leipsic, Matthew J. Budoff, James K. Min, Cameron J. Hague, Daniel S. Berman, Bernard R. Chaitman, Michael H. Picard, Sean W. Hayes, Marielle Scherrer-Crosbie, Raymond Y. Kwong, Renato D. Lopes, Roxy Senior, Sudhanshu K. Dwivedi, Todd D. Miller, Benjamin J. W. Chow, Ramesh de Silva, Gregg W. Stone, William E. Boden, Sripal Bangalore, Sean M. O'Brien, Judith S. Hochman, David J. Maron
Summary: This study investigated the prevalence of ischemia with nonobstructive coronary arteries (INOCA) among patients with at least moderate ischemia and the relationship between ischemia severity and non-obstructive atherosclerosis severity. The results showed that the prevalence of INOCA was 13% and there was no significant association between the severity of ischemia and the severity of nonobstructive atherosclerosis. Female sex was identified as an independent predictor of INOCA.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Hyung-Bok Park, Jina Lee, Yongtaek Hong, So Byungchang, Wonse Kim, Byoung K. Lee, Fay Y. Lin, Martin Hadamitzky, Yong-Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Pedro de A. Goncalves, Jonathon A. Leipsic, Sanghoon Shin, Jung H. Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Peter H. Stone, Daniel S. Berman, Jagat Narula, Leslee J. Shaw, Jeroen J. Bax, James K. Min, Woong Kook, Hyuk-Jae Chang
Summary: This study used the Bayesian quantile regression model to analyze the relationship between multiple cardiovascular risk factors and different stages of coronary artery disease. The results showed that the lumen diameter stenosis of different heart vessels ranged from 41% to 50% and the maximum stenosis change ranged from 5.6% to 7.3%. The study found that angina was associated with a high quantile (90%) of stenosis in the left anterior descending artery, diabetes was associated with higher quantiles (75% and 90%) of stenosis in the left circumflex artery, and dyslipidemia was associated with the highest quantile (90%) of stenosis in the right coronary artery. This study demonstrates the clinical utility of the Bayesian quantile regression model in evaluating the comprehensive relationship between risk factors and baseline-grade coronary artery disease and its progression.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeff Moore, Suvasini Lakshmanan, Venkat Sanjay Manubolu, April Kinninger, George Stojan, Daniel W. Goldman, Michelle Petri, Matthew Budoff, George A. Karpouzas
Summary: This study compared the baseline and progression of coronary plaques in patients with SLE and RA. The results showed that SLE patients had a greater increase in plaque volume, which may explain their higher cardiovascular risk.
CORONARY ARTERY DISEASE
(2023)
Review
Peripheral Vascular Disease
Samuel C. R. Sherratt, Peter Libby, Matthew J. Budoff, Deepak L. Bhatt, R. Preston Mason
Summary: This review examines the effects of omega-3 fatty acids (n3-FAs) on cardiovascular risk reduction. It has been found that high-purity EPA ethyl ester has significant benefits in reducing cardiovascular events and atherosclerosis progression compared to mixed EPA/DHA treatments. Mechanistic differences between n3-FAs, including membrane interactions, metabolic products, cholesterol efflux, antioxidant properties, and tissue distribution, have been explored.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew J. Buckler, Atsushi Sakamoto, Samantha St. Pierre, Renu Virmani, Matthew J. Budoff
Summary: This study demonstrates the accurate discrimination and quantitation of lipid-rich necrotic core, intraplaque hemorrhage, and fibrotic tissues using histopathologic correlates. These markers can be used singly or in combination to optimize patient care and contribute to the development of novel drugs and clinical decision support tools.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lohendran Baskaran, Jing Kai Lee, Michelle Shi Min Ko, Subhi J. Al'Aref, Yu Pei Neo, Jien Sze Ho, Weiting Huang, Yeonyee Elizabeth Yoon, Donghee Han, Rine Nakanishi, Swee Yaw Tan, Mouaz Al-Mallah, Matthew J. Budoff, Leslee J. Shaw
Summary: This study compared the abilities of pooled cohort equations (PCE) and coronary artery calcium (CAC) assessment in predicting major adverse cardiovascular events (MACE) in an Asian population. Age, presence of CAC, and ln(Volume) were significantly associated with MACE in the overall subgroup, while age and PCE score were significantly associated with MACE in the CAC = 0 subgroup. No risk factors were associated with MACE in the CAC > 0 subgroup. The performance of PCE deteriorated in statin versus non-statin users, while the Agatston score performed consistently in both groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Clinical Neurology
Meiyuzhen Qi, Imke Janssen, Emma Barinas-Mitchell, Matthew Budoff, Maria M. Brooks, Arun S. Karlamangla, Carol A. Derby, Chung-Chou H. Chang, Kelly J. Shields, Samar R. El Khoudary
Summary: This study found that the quantity and quality of thoracic perivascular adipose tissue (PVAT) in middle age are related to cognitive performance in later years. Higher thoracic PVAT volume is associated with better future episodic memory, while higher thoracic PVAT radiodensity is related to poorer future working and episodic memories, particularly at higher thoracic PVAT volume.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cardiac & Cardiovascular Systems
Ramzi Dudum, Zeina A. Dardari, David I. Feldman, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, Alan Rozanski, John A. Rumberger, Leslee Shaw, Omar Dzaye, Miguel Cainzos-Achirica, Jaideep Patel, Michael J. Blaha
Summary: Coronary artery calcium is useful for assessing subclinical atherosclerosis and improving risk stratification. The dispersion of calcified vessels and CAC phenotype have different impacts on cause-specific mortality. This study demonstrated that increasing calcium dispersion, characterized by multiple vessel involvement and less dense calcification, is associated with higher all-cause mortality and cardiovascular disease-specific mortality.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Hematology
Shripad Sinari, Juraj Koska, Yueming Hu, Jeremy Furtado, Majken K. Jensen, Matthew J. Budoff, Dobrin Nedelkov, Robyn L. McClelland, Dean Billheimer, Peter Reaven
Summary: The composition of Apo CIII proteoforms is associated with cardiovascular risk and influences plasma lipids. Total apo CIII and CIII2/III1 are positively associated with cardiovascular disease risk, while CIII0b/III1 is inversely associated with cardiovascular disease risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Critical Care Medicine
Anusha G. Bhat, Dhiran Verghese, Sri Harsha Patlolla, Alexander G. Truesdell, Wayne B. Batchelor, Timothy Henry, Robert J. Cubeddu, Matthew Budoff, Quang Bui, Peter Matthew Belford, David X. Zhao, Saraschandra Vallabhajosyula
Summary: This study investigated the relationship between different management strategies for ST-segment-elevation myocardial infarction (STEMI) and in-hospital cardiac arrest (IHCA). The results showed that early percutaneous coronary intervention (PCI) and delayed PCI were associated with lower incidence and mortality of IHCA compared to medical management, but also resulted in more multiorgan damage and cardiogenic shock.
Editorial Material
Cardiac & Cardiovascular Systems
Jairo Aldana-Bitar, Ronald P. Karlsberg, Matthew J. Budoff
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Letter
Cardiac & Cardiovascular Systems
Jairo Aldana-Bitar, Ronald P. Karlsberg, Matthew J. Budoff
Article
Cardiac & Cardiovascular Systems
Ayman Abdelkarim, Sion K. Roy, April Kinninger, Azadeh Salek, Olivia Baranski, Daniele Andreini, Gianluca Pontone, Edoardo Conte, Rachael O'Rourke, Christian Hamilton-Craig, Matthew J. Budoff
Summary: This study evaluates the image quality in patients with heart rates above or equal to 70 bpm using a 16 cm scanner compared to a CT scanner with only 4 cm of coverage. The results show that the 16 cm scanner has superior image quality in terms of contrast-to-noise ratio and signal-to-noise ratio compared to the 4 cm scanner.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Peripheral Vascular Disease
Ryan L. Wallace, Oluseye Ogunmoroti, Di Zhao, Dhananjay Vaidya, Amir Heravi, Eliseo Guallar, Chiadi E. Ndumele, Joao A. C. Lima, Pamela Ouyang, Matthew J. Budoff, Matthew Allison, Isac Thomas, Oluwaseun E. Fashanu, Ron Hoogeveen, Wendy S. Post, Erin D. Michos
Summary: This study examined the associations between urinary isoprostane levels and measures of plaque prevalence, burden, incidence, and progression in different vascular beds. The results showed inconsistent associations between urinary isoprostanes and subclinical atherosclerosis by imaging. Therefore, the urinary isoprostane levels may have limited prognostic value in the development of atherosclerotic cardiovascular disease (ASCVD).
ATHEROSCLEROSIS PLUS
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Nozomi Kotoku, Bjarne L. Norgaard, Scot Garg, Koen Nieman, Marc R. Dweck, Jeroen J. Bax, Juhani Knuuti, Jagat Narula, Divaka Perera, Charles A. Taylor, Jonathon A. Leipsic, Edward D. Nicol, Nicolo Piazza, Carl J. Schultz, Kakuya Kitagawa, Bernard De Bruyne, Carlos Collet, Kaoru Tanaka, Saima Mushtaq, Marta Belmonte, Darius Dudek, Adriana Zlahoda-Huzior, Shengxian Tu, William Wijns, Faisal Sharif, Matthew J. Budoff, Johan de Mey, Daniele Andreini, Yoshinobu Onuma
Summary: Coronary computed tomographic angiography (CCTA) has become the preferred investigation for determining the presence and haemodynamic significance of coronary artery disease. It can rule out atherosclerosis or detect subclinical plaque in patients without significant epicardial obstruction, and provide risk classification. For ischaemic non-obstructive coronary arteries, non-invasive imaging, including CCTA, is also expected. In patients with significant epicardial obstruction, CCTA can assist in planning revascularisation by determining disease complexity, vessel size, lesion length, tissue composition of the atherosclerotic plaque, and the best fluoroscopic viewing angle.
