Article
Chemistry, Multidisciplinary
Xiaoqing Wei, Dan Mu, Yingping Li, Jingya Zhao, Shaobing Zhou
Summary: Researchers have developed a magnetic exosome that responds to bacteria associated with tumors, enabling sensitive tumor imaging. The magnetic exosome can rapidly respond in the tumor microenvironment and release iron oxide nanoparticles for dynamic MRI of tumors. After MRI, the iron oxide nanoparticles can be eliminated through renal clearance to avoid potential toxicity.
Article
Chemistry, Physical
Asim Mushtaq, Han Zhang, Mingyue Cui, Xiaoqing Lin, Shuqi Huang, Zhe Tang, Yike Hou, M. Zubair Iqbal, Xiangdong Kong
Summary: In this study, ultrathin magnetic hydroxyapatite nanorods loaded with ROS-responsive chlorin e6 and silk fibroin were successfully synthesized for T1-magnetic resonance imaging and photodynamic therapy. These self-assembled nanoparticles showed excellent biocompatibility, cellular uptake, and ROS generation ability, making them a promising strategy for cancer diagnosis and treatment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Multidisciplinary
Jingjing Liu, Xiaodong Yu, Hui Jun Ting, Xiaoyuan Wang, Shidang Xu, Yuanbo Wang, Sitong Zhang, Jiong-Wei Wang, Bin Liu
Summary: Nonalcoholic steatohepatitis (NASH) is a critical stage in the development of nonalcoholic fatty liver disease (NAFLD) and its diagnosis is important for preventing its progress into a fatal condition. The expression of the oxidative enzyme myeloperoxidase (MPO) is higher in NASH than in nonalcoholic fatty liver (NAFL), making it a potential target for NASH diagnosis. A nanoparticle platform based on ultrasmall iron oxide (USIO) nanoparticles was designed to achieve MPO-sensitive NASH diagnosis, showing promise for improving NASH MR imaging diagnostic accuracy and sensitivity.
Article
Chemistry, Multidisciplinary
Kun Liu, Bilun Kang, Xiangjie Luo, Zhaoxuan Yang, Chengjie Sun, Ao Li, Yifan Fan, Xiaoyuan Chen, Jinhao Gao, Hongyu Lin
Summary: The study introduces a novel type of nanomaterial as redox-activated probes for real-time visualization of GSH-mediated liver biotransformation using MRI. The technique reveals periodic variations in GSH concentration during the degradation of the nanoparticles, providing direct imaging evidence for carrier-mediated processes in GSH metabolism. This methodology offers a feasible means for in-depth investigations of GSH-related biological processes in liver and real-time assessment of liver functions for early diagnosis of diseases and toxicity evaluation of pharmaceuticals.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zihan Ning, Shuo Chen, Zhensen Chen, Hualu Han, Huiyu Qiao, Nan Zhang, Rui Wang, Rui Shen, Xihai Zhao
Summary: The proposed SAMURAI technique allows for simultaneous quantification of T-1 and perfusion in the kidneys with high time-efficiency, demonstrating feasibility and repeatability.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Di Giuliano Francesca, Minosse Silvia, Picchi Eliseo, Ferrazzoli Valentina, Da Ros Valerio, Muto Massimo, Pistolese Chiara Adriana, Garaci Francesco, Floris Roberto
Summary: The study compared brain MRI using different sequences and found that while BRAVO had higher image quality scores than Silent qualitatively, the diagnostic use of Silent images was similar to BRAVO. Quantitatively, the contrast-to-noise ratio for grey matter and cerebrospinal fluid was comparable in the two sequences, with the signal-to-noise ratio in cerebrospinal fluid being higher in Silent than BRAVO. The acoustic noise of the Silent sequence was significantly lower compared to BRAVO.
Review
Materials Science, Biomaterials
Dorian Foster, Jessica Larsen
Summary: Imaging plays a critical role in brain diagnostics and treatment monitoring. T1-weighted magnetic resonance imaging is preferred, but commercially available contrast agents have toxicity concerns. Recent advancements in nanotechnology have allowed for the development of new contrast agents that integrate potentially harmful metals with reduced toxicity and improved transport. This review summarizes the research on polymeric nanomedicine designs for T1-weighted contrast agents in the brain.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Biomedical
Gary Stinnett, Nasim Taheri, Jake Villanova, Arash Bohloul, Xiaoting Guo, Edward P. Esposito, Zhen Xiao, Deanna Stueber, Carolina Avendano, Paolo Decuzzi, Robia G. Pautler, Vicki L. Colvin
Summary: This study introduces shape-engineered plate-like nanocrystals with sulfonated surface polymers that promote second-sphere relaxation processes, providing remarkable contrast even at high fields. These noncytotoxic materials release no detectable free Gadolinium even under mild acidic conditions, and have a circulation half-life in the liver 50% longer than commercial agents. These features enable the first-time application of T-1 MRI contrast agents to the ex vivo detection of nonalcoholic fatty liver disease in mice.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Shi-Hui Chen, Lu-Yao Huang, Biao Huang, Mingxi Zhang, Hao Li, Dai-Wen Pang, Zhi-Ling Zhang, Ran Cui
Summary: This study synthesizes ultrasmall MnSe nanoparticles and demonstrates their potential as T-1-MRI contrast agents for clinical tumor imaging. The nanoparticles exhibit high relaxivity and a long MRI acquisition window, while also showing no appreciable toxicity to cells and organisms.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Chunyu Zhang, Wentao Huang, Chen Huang, Chengqian Zhou, Wei Wei, Yongsheng Li, Yukuan Tang, Yu Luo, Quan Zhou, Wenli Chen
Summary: Magnetic resonance imaging (MRI) is a potential diagnostic modality for early rheumatoid arthritis (RA). A peptide called UVHP was synthesized as a contrast agent, which targets the overexpression of VCAM-1 in RA cells and generates high contrast in MRI, with the characteristics of simplicity, low cost, and low toxicity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Xiuqi Hou, Xi Yang, Yanwen Xu, Jiayin Lin, Fang Zhang, Xiaohui Duan, Sitong Liu, Jie Liu, Jun Shen, Xintao Shuai, Zhong Cao
Summary: This study developed a theranostic nanodrug that combines MRI and cancer therapy, which released specific drugs and metal ions in the tumor microenvironment and achieved high sensitivity MRI monitoring and gas therapy, while synergistically targeting tumor-promoting macrophages.
Article
Chemistry, Physical
Xiuqi Hou, Xi Yang, Yanwen Xu, Jiayin Lin, Fang Zhang, Xiaohui Duan, Sitong Liu, Jie Liu, Jun Shen, Xintao Shuai, Zhong Cao
Summary: A multifunctional nanodrug combining MRI imaging and cancer therapy has been developed, which can release drugs and achieve sensitive MRI imaging in tumor microenvironment, as well as achieve synergistic antitumor effects through immune activation and gas therapy.
Article
Clinical Neurology
Subin Lee, Ki Woong Kim
Summary: Texture analysis of MRI brain scans may be a useful tool in early diagnosis of Alzheimer's disease, with regional tau burden and cytoarchitecture showing associations with certain texture features. This study highlights the potential of using MRI texture to detect microstructural changes in AD.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Isabelle Riederer, Mark Muehlau, Claus Zimmer, Magaly Gutbrod-Fernandez, Nico Sollmann, Jan S. Kirschke
Summary: The study found that pre-contrast T1-w imaging does not significantly increase diagnostic confidence or detection rate of contrast-enhancing lesions in spinal cord MRI follow-up exams for patients with multiple sclerosis (MS).
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Bottcher, Roberto Lorbeer, Sophia Stocklein, Ebba Beller, Cajetan I. Lang, Marc-Andre Weber, Felix G. Meinel
Summary: The global and regional reproducibility of native T1 and T2 mapping in cardiac MRI was investigated in healthy volunteers, revealing good to excellent reproducibility with significant regional differences, providing valuable insights for the diagnosis and risk stratification of cardiac diseases.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)