Journal
ACADEMIC RADIOLOGY
Volume 15, Issue 10, Pages 1259-1263Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.acra.2008.04.018
Keywords
liposome; long circulating; blood pool contrast agent; MR, gadolinium
Funding
- NIH/NCRR National Biomedical Technology Resource Center [P41 RR005959, NCI R24 CA092656, NHLBI RO1 HL055348]
- American Society of Neuroradiology
Ask authors/readers for more resources
Rationale and Objectives. Long circulating core-encapsulated gadolinium (CE-Gd) liposomal nanoparticles that have surface face Conjugated polyethylene glycol are a promising platform technology for use as blood pool T1-based magnetic resonance (MR) contrast agents. The objective of this study was to investigate the effect of liposome size and internal (core) Gd concentration on the T1 relaxivity of CE-Gd liposomes. Materials and Methods. Twelve different liposomal formulations were synthesized and characterized, resulting in a size (50, 100, 200, and 400 nm) and core Gd-concentration (200, 350, and 500 mM) matrix of test samples. Subsequently, CE-Gd liposomes were diluted in deionized water (four diluted samples) and molar T1 relaxivity (H) measurements were performed at 2- and 7-T MR field strengths. Results. The r1 of CE-Gd liposomes was inversely related to the liposome size. The largest change in r1 was observed between liposomes that were extruded through 50- and 100-nm filter membranes. At both field strengths, the variation in internal gadolinium concentration did not show any significant correlation (alpha <= 0.05) with r1. Conclusions. The size of CE-Gd liposomal nanoparticles significantly affects the T1 relaxivity. An inverse relation was observed between liposome size and T1 relaxivity. The T1 relaxivity did not change significantly with core Gd concentration over the measured concentration range.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available