Article
Emergency Medicine
Vera Bzhilyanskaya, Daniel Najafali, Olivia M. Torre, Leenah Afridi, Tiffany Cao, Bhakti Panchal, Fernando Albelo, Allison Karwoski, Ikram Afridi, Quincy K. Tran
Summary: This retrospective study analyzed patients with spontaneous intracranial hemorrhage (sICH) and found that blood pressure variability is associated with neurological deterioration during the patient's stay in the emergency department and during interhospital transport. The study identified maximum systolic blood pressure in the emergency department as the strongest predictive factor, with other components of blood pressure variability also being significant.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Xin-Ni Lv, Jing Cheng, Xue-Yun Liu, Jin-Cheng Liu, Lan Deng, Zuo-Qiao Li, Ming-Jun Pu, Chu Chen, Qi Li
Summary: This study found that ultraearly intraventricular hemorrhage growth is associated with early neurologic deterioration and poor functional outcomes in patients with intracerebral hemorrhage.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Eva Giralt-Steinhauer, Joan Jimenez-Balado, Isabel Fernandez-Perez, Lucia Rey Alvarez, Ana Rodriguez-Campello, Angel Ois, Elisa Cuadrado-Godia, Jordi Jimenez-Conde, Jaume Roquer
Summary: This review summarizes the advances in genetics and epigenetics of intracerebral hemorrhage (ICH), shedding light on the understanding of ICH pathophysiology and the potential for developing therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Daiquan Gao, Xiaojuan Zhang, Yunzhou Zhang, Rujiang Zhang, Yuanyuan Qiao
Summary: The aim of this study was to explore factors related to neurological deterioration (ND) after spontaneous intracerebral hemorrhage (sICH) and establish a prediction model based on random forest analysis in evaluating the risk of ND. The results indicated that time of onset to the emergency department (ED), baseline hematoma volume, serum sodium, and serum calcium were independently associated with the risk of ND. A random forest model was developed and showed good predicting performance with an area under the curve value of 0.795 in the training set and 0.713 in the testing set. Overall, this study identified factors related to ND and developed a predictive model for acute sICH patients.
FRONTIERS IN SURGERY
(2022)
Article
Clinical Neurology
Jiaxin Liu, Ning Li, Zhiyuan Zhu, Karrie Mei-Yee Kiang, Anson Cho Kiu Ng, Celia M. Dong, Gilberto Ka-Kit Leung
Summary: This study found that vitamin D promotes the differentiation of reparative macrophages, facilitates hematoma clearance, and improves neurological function after intracerebral hemorrhage. These findings suggest that vitamin D could be a potentially promising treatment for intracerebral hemorrhage.
Article
Clinical Neurology
Zhe Kang Law, Rob Dineen, Timothy J. England, Lesley Cala, Amit K. Mistri, Jason P. Appleton, Serefnur Ozturk, Daniel Bereczki, Alfonso Ciccone, Philip M. Bath, Nikola Sprigg
Summary: The study analyzed data from the TICH-2 trial to investigate predictors and effects of neurological deterioration following intracerebral hemorrhage. Tranexamic acid was found to reduce the risk of early neurological deterioration, but had no effect on late deterioration. Larger hematoma size, intraventricular and subarachnoid extension were identified as risk factors for neurological deterioration.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Medicine, Research & Experimental
Eugenia-Maria Muresan, Adela Golea, Stefan Cristian Vesa, Manuela Lenghel, Csaba Csutak, Lacramioara Perju-Dumbrava
Summary: Spontaneous intracerebral hemorrhage (sICH) is associated with high morbidity and mortality rates. This study investigated the relationship between emergency department point-of-care blood biomarkers and day 90 functional outcome in patients with acute sICH. The results showed that admission D-dimer levels were associated with functional outcome, severity, and early neurological worsening.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Medical Laboratory Technology
Yingrui Gu, Xiaodong Deng, Chong Liang, Yi Chen, Hongbing Lei, Qi Zhang
Summary: The study suggests that serum sTREM-1 can be used as a biomarker for assessing and predicting inflammation, severity, early neurologic deterioration (END), and outcome after intracerebral hemorrhage (ICH). Elevated serum sTREM-1 levels are associated with more severe disease, END, and poor outcome.
CLINICA CHIMICA ACTA
(2021)
Review
Clinical Neurology
Xianqi Li, Li Zhang, Charles D. A. Wolfe, Yanzhong Wang
Summary: According to recent epidemiological data, the number of hemorrhagic stroke cases has increased significantly worldwide in the past 20 years. This study systematically evaluated the incidence and long-term survival of intracerebral hemorrhage (ICH) in countries with different income levels. The results showed that lower-middle-income countries had the highest incidence of ICH, and the 1-year and 5-year survival rates for ICH patients were relatively low. More population-based studies are needed to help prevent ICH.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Federico Marrama, Maeva Kyheng, Marco Pasi, Matthieu Pierre Rutgers, Solene Moulin, Marina Diomedi, Didier Leys, Charlotte Cordonnier, Hilde Henon, Barbara Casolla
Summary: This study found a high incidence of early-onset delirium in patients with spontaneous intracerebral hemorrhage, which is associated with markers of pre-existing brain vulnerability. Predictors of early-onset delirium included pre-existing dementia, heavy alcohol intake, and lobar location of intracerebral hemorrhage. Early-onset delirium was associated with higher mortality rates, but did not predict higher dementia rates during long-term follow-up.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Cardiac & Cardiovascular Systems
Quanwei He, Hongxiu Guo, Rentang Bi, Shaoli Chen, Jing Shen, Chunnan Long, Man Li, Yuanpeng Xia, Lei Zhang, Zhou Sun, Xiaolu Chen, Zhaowei Wang, Daokai Gong, Jingwen Xu, Dondya Zhu, Yan Wan, Bo Hu
Summary: The study developed a new scoring tool (SIGNALS score) for predicting the risk of in-hospital neurological deterioration in patients with intracerebral hemorrhage.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, Research & Experimental
EUGENIA-MARIA MURESAN, A. D. E. L. A. GOLEA, S. T. E. F. A. N. C. R. I. S. T. I. A. N. VESA, I. U. L. I. A. GIVAN, L. A. C. R. A. M. I. O. A. R. A. PERJU-DUMBRAVA
Summary: This study aimed to assess the impact of emergency department point-of-care biomarkers on early mortality in patients with acute intracerebral hemorrhage (sICH). The study found that these biomarkers could serve as a readily available and simple to use prognostic tool, helping to predict the mortality rate of patients.
Review
Neurosciences
Hongxiu Guo, Mingfeng You, Jiehong Wu, Anqi Chen, Yan Wan, Xinmei Gu, Senwei Tan, Yating Xu, Quanwei He, Bo Hu
Summary: This article summarizes the current knowledge of genetic variations in spontaneous intracerebral hemorrhage (ICH), with a focus on location distribution and outcome. Investigations have shown that certain genetic variants are associated with lobar ICH or deep ICH, and some variations in genes may contribute to the outcome of ICH.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Lorena M. Schenk, Matthias Schneider, Christian Bode, Erdem Gueresir, Christoph Junghanns, Marcus Mueller, Christian Putensen, Hartmut Vatter, Julian Zimmermann, Patrick Schuss, Felix Lehmann
Summary: This retrospective study analyzed 87 patients with deep-seated intracerebral hemorrhage, finding that early development of acute kidney injury within 48 hours of admission and elevated levels of procalcitonin upon admission are independent predictors for the need for continuous renal replacement therapy. Further research is needed to identify these vulnerable patients early for appropriate treatment.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Ellis S. van Etten, Kanishk Kaushik, Wilmar M. T. Jolink, Emma A. Koemans, Merel S. Ekker, Ingeborg Rasing, Sabine Voigt, Floris H. B. M. Schreuder, Suzanne C. Cannegieter, Gabriel J. E. Rinkel, Willem M. Lijfering, Catharina J. M. Klijn, Marieke J. H. Wermer
Summary: This study identifies several trigger factors, such as caffeine consumption, lifting weights, sexual activity, and Valsalva maneuvers, that increase the risk of spontaneous intracerebral hemorrhage (ICH). These findings provide new insights into the pathophysiology of vessel rupture resulting in ICH.