Article
Emergency Medicine
Tina Dhebaria, Adam Sivitz, Cena Tejani
Summary: This study found that IV acetaminophen did not reduce the amount of morphine administered to pediatric patients with sickle cell VOC pain, and the disposition pain scores for the patients were equivalent. Therefore, the conclusion of this study suggests that IV acetaminophen does not provide an opioid-sparing effect in treating VOC pain in pediatric sickle cell patients.
ACADEMIC EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Stephen Rineer, Patrick S. Walsh, Luke R. Smart, Nusrat Harun, David Schnadower, Matthew J. Lipshaw
Summary: This study investigated the absolute risk, risk factors, and outcomes of bacteremia in children and young adults with sickle cell disease presenting with fever. The study found that the risk of bacteremia during fever in these individuals is low, while a history of invasive bacterial infection, central line-associated bloodstream infection, or central venous catheter use may be associated with bacteremia. Age and sickle cell disease genotype are not associated with bacteremia.
Article
Oncology
Keli D. Coleman, Kenneth McKinley, Angela M. Ellison, Elizabeth R. Alpern, Selena Hariharan, Irina Topoz, Morgan Wurtz, Blake Nielsen, Lawrence J. Cook, Claudia R. Morris, Amanda M. Brandow, Andrew D. Campbell, Robert I. Liem, Rachelle Nuss, Charles T. Quinn, Alexis A. Thompson, Anthony Villella, Allison A. King, Ana Baumann, Warren Frankenberger, David C. Brousseau
Summary: This study examined the return visit rate after ED discharge for pediatric SCD pain treatment. The results showed that nearly 30% of patients had a return visit within 14 days. Younger patients had slightly lower return visit rates, while sex and visits during the pandemic were not associated with the return visit rate.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Multidisciplinary Sciences
Kyle Kidwell, Camila Albo, Michael Pope, Latanya Bowman, Hongyan Xu, Leigh Wells, Nadine Barrett, Niren Patel, Amy Allison, Abdullah Kutlar
Summary: The study revealed differences in biological and psychosocial factors between high-utilization and low-utilization SCD patients. High-utilization patients had higher white blood cell count, absolute neutrophil count, and total bilirubin levels, as well as lower mean corpuscular volume. Additionally, high-utilizers had higher anxiety and depression scores, as well as higher opioid use.
Article
Anesthesiology
Anthony A. Wachnik, Jena L. Welch-Coltrane, Meredith C. B. Adams, Howard A. Blumstein, Manoj Pariyadath, Samuel G. Robinson, Amit Saha, Erik C. Summers, Robert W. Hurley
Summary: The use of a standardized and multimodal ED order set reduced hospital admission rates and improved the timeliness of analgesia without negatively impacting patients' pain levels.
Article
Computer Science, Information Systems
Huilin Jiang, Haifeng Mao, Huimin Lu, Peiyi Lin, Wei Garry, Huijing Lu, Guangqian Yang, Timothy H. Rainer, Xiaohui Chen
Summary: This study compared the performance of four common machine learning models in assisting decision making of triage levels for patients with suspected cardiovascular disease at the emergency department. XGBoost demonstrated a slight advantage over other models, with blood pressure, pulse rate, oxygen saturation, and age being identified as the most significant variables for triage decisions. The models could be used for differential triage of low-risk and high-risk patients to improve efficiency and resource allocation.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2021)
Editorial Material
Hematology
Lidiane S. Torres, Andres Hidalgo
Summary: In this study, Vats et al. reported a mechanism of lung injury in sickle cell disease (SCD) caused by neutrophil extracellular traps (NETs) produced by gasdermin D-driven process in the liver, leading to occlusion in the pulmonary microcirculation.
Editorial Material
Hematology
Enrico M. Novelli
Summary: This study tested the safety and efficacy of the IL-1 beta neutralizing antibody canakinumab in children and young adults with sickle cell anemia, chronic pain, and inflammation. While there was no significant reduction in average daily pain, there was a promising reduction in multiple biomarkers of inflammation, number and duration of hospitalizations, and other patient-reported outcomes of pain and fatigue.
Article
Computer Science, Information Systems
Sayon Dutta, Dustin S. McEvoy, David M. Rubins, Anand S. Dighe, Michael R. Filbin, Chanu Rhee
Summary: A study found that the implementation of clinical decision support (CDS) in the emergency department (ED) led to an increase in blood cultures before intravenous (IV) antibiotics administration, indicating that CDS may improve the process of obtaining blood cultures for ED patients.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Clinical Neurology
Shannon Phillips, Alyssa M. Schlenz, Shannon D'Alton, Mary Johnson, Julie Kanter
Summary: This qualitative study explored the decision-making processes for opioid medications in individuals with sickle cell disease (SCD). The findings highlight the importance of collaboration among patients, families, and providers in managing pain with opioids. These results can inform shared decision-making strategies and future research.
Article
Oncology
Pavitra Parimala Krishnamani, Aiham Qdaisat, Monica Kathleen Wattana, Demis N. Lipe, Marcelo Sandoval, Ahmed Elsayem, Maria Teresa Cruz Carreras, Sai-Ching Jim Yeung, Patrick S. Chaftari
Summary: This study analyzed the use of an observation unit for managing cancer-related pain and found that it provided appropriate care for patients in the emergency department. Pain scores and the need for consultation services were important predictors of hospitalization.
Article
Anesthesiology
Nitya Bakshi, Scott Gillespie, Donna McClish, Courtney McCracken, Wally R. Smith, Lakshmanan Krishnamurti
Summary: This study demonstrates that mean pain intensity alone is insufficient to describe pain phenotypes in sickle cell disease (SCD). The researchers calculated measures of pain variability and pain intensity for 139 participants and found that pain variability was inversely correlated with health-related quality of life, and positively correlated with affective coping, catastrophizing, somatic symptom burden, sickle cell stress, health care utilization, and opioid use. The study also identified 3 subgroups or clusters of pain phenotypes in SCD using k-means clustering.
Article
Medicine, General & Internal
Joshua W. Joseph, Maura Kennedy, Alden M. Landry, Regan H. Marsh, Da'Marcus E. Baymon, Dana E. Im, Paul C. Chen, Margaret E. Samuels-Kalow, Lauren M. Nentwich, Noemie Elhadad, Leon D. Sanchez
Summary: This study found racial disparities in triage scores and physician evaluations in emergency departments, with Black, Hispanic, and other racial and ethnic patients receiving less acute triage scores despite undergoing more involved physician workups. This suggests potential mistriage.
Review
Pharmacology & Pharmacy
Reem A. Hejazi, Nameer A. Mandourah, Aryaf S. Alsulami, Hussain T. Bakhsh, Reem M. Diri, Ahmad O. Noor
Summary: This study provides a narrative literature review of agents used to manage acute pain crisis in SCD patients in Saudi Arabia. The results indicate that morphine is the most commonly used drug for treating vaso-occlusive pain crisis in SCD patients among the included studies.
SAUDI PHARMACEUTICAL JOURNAL
(2021)
Editorial Material
Hematology
Susanna A. Curtis, Enrico M. Novelli
Summary: In this study, researchers found that cannabidiol (CBD), a nonpsychoactive compound in cannabis, can reduce chronic pain and systemic inflammation markers in murine models of sickle cell disease (SCD). The effects of CBD on pain and inflammation markers were influenced by dosage and sex. This study suggests that CBD may be a promising treatment for chronic pain in SCD and could potentially modify the disease progression due to its anti-inflammatory properties.