Article
Dermatology
L. Techasatian, P. Kiatchoosakun
Summary: This study suggests that in a tropical climate, applying emollients to the skin of at-risk neonates on an 'as needed' basis, depending on environmental factors and level of skin dryness, rather than daily, can significantly prevent AD.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Plant Sciences
Gakyung Lee, Jinyoung Park, Hyunbeom Lee, Kyeong Seok Kim, Jae Hyeon Park, So Young Kyung, Hyung Sik Kim, Hyun Ok Yang, Byung Hwa Jung
Summary: This study evaluated the therapeutic effects of BS012 on AD and investigated the underlying metabolic mechanisms. Results showed that BS012 exerted strong anti-atopic activity by reducing Th2-specific inflammatory response and improving skin barrier function. This novel combination could be a potential alternative for AD treatment and provide crucial information for the development of natural products.
Article
Dermatology
A. Hoyer, E. M. Rehbinder, M. Fardig, S. Asad, K. C. Lodrup Carlsen, K. M. A. Endre, B. Granum, G. Haugen, G. Hedlin, C. Monceyron Jonassen, S. Katayama, J. R. Konradsen, L. Landro, M. LeBlanc, C. A. Olsson Magi, K. Rudi, H. O. Skjerven, A. C. Staff, R. Vettukattil, M. Bradley, B. Nordlund, C. Soderhall
Summary: In this study, FLG gene mutations were found to be associated with eczema and dry skin in infancy, but not with impaired skin barrier function or dry skin in general at 3 months of age.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Trinidad Montero-Vilchez, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Maria Salazar-Nievas, Jesus Tercedor-Sanchez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: The study aimed to evaluate the impact of dupilumab on skin barrier function in patients with atopic dermatitis (AD) and compare it with other treatments. The study found that dupilumab was more effective in improving barrier function in both eczematous lesions and non-lesioned skin compared to topical corticosteroids and cyclosporine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Instruments & Instrumentation
Behnam Dasht Bozorg, Sonalika A. Bhattaccharjee, Mahadevabharath R. Somayaji, Ajay K. Banga
Summary: The study investigated the impact of non-infectious skin diseases on skin characteristics and drug permeation in healthy, eczematous, and psoriatic human tissue. It found that psoriasis skin samples had a damaged barrier function and significantly higher drug retention. Anodal iontophoresis resulted in greater drug distribution into deeper skin layers, regardless of skin condition.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Veterinary Sciences
Jihee Kim, Ji-Hye Lee, Yunji Song, Ha-Jung Kim
Summary: This study analyzed the correlation between indoor house dust mite (HDM) concentration, canine atopic dermatitis (CAD) severity, and residential environments in 35 CAD dogs and 13 healthy dogs. The results showed that Der f 1 concentration had a negative association with transepidermal water loss (TEWL), but no association with CAD severity index-04 (CADESI-04) and pruritus visual analog scale (PVAS). Der f 1 concentration was significantly higher in the group living near green areas and with indoor relative humidity (RH) ≥40%. The study suggests that living near green areas and maintaining appropriate indoor climate may improve CAD clinical symptoms, and high concentrations of HDM may enhance the skin barrier function.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Medicine, General & Internal
Trinidad Montero-Vilchez, Maria-Victoria Segura-Fernandez-Nogueras, Isabel Perez-Rodriguez, Miguel Soler-Gongora, Antonio Martinez-Lopez, Ana Fernandez-Gonzalez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: This study compared skin barrier function between healthy skin, psoriatic skin, and atopic dermatitis skin, finding that TEWL was higher at psoriatic and AD lesions, while SCH was lower. Specific TEWL and temperature values may help clinicians determine disease severity and treatment needs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mariam M. Amin, Hossam M. Elkady
Summary: This study investigated the sensitization to aeroallergens in 132 patients with atopic dermatitis and found that multiple aeroallergens can worsen the severity of the disease.
Article
Pediatrics
Martin Fardig, Hrefna Katrin Gudmundsdottir, Angela Hoyer, Karen Eline Stensby Bains, Catarina Almqvist, Christine Monceyron Jonassen, Eva Maria Rehbinder, Havard O. Skjerven, Anne Cathrine Staff, Riyas Vettukattil, Cilla Soderhall, Karin C. Lodrup Carlsen, Bjorn Nordlund
Summary: This study aimed to investigate the association between high transepidermal water loss (TEWL), eczema, Filaggrin (FLG) mutations and lung function in three-month-old infants. The results showed that high TEWL was associated with lower lung function, while eczema or FLG mutations were not.
Article
Dermatology
Luise Rauer, Matthias Reiger, Madhumita Bhattacharyya, Patrick M. M. Brunner, James G. G. Krueger, Emma Guttman-Yassky, Claudia Traidl-Hoffmann, Avidan U. U. Neumann
Summary: This study investigated the skin microbiome of 48 adult patients with moderate-to-severe atopic dermatitis (AD) and found that the diversity of the skin microbiome is associated with patients' demographic and clinical cofactors, as well as disease severity. Specifically, the relative abundance of Staphylococcus aureus and the evenness of the microbiome were associated with AD severity. These findings are important for the development of personalized treatments for AD.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Pharmacology & Pharmacy
Silvia Ferrucci, Maurizio Romagnuolo, Carlo Alberto Maronese, Francesca Germiniasi, Simona Tavecchio, Luisa Angileri, Giovanni Casazza, Angelo Valerio Marzano, Giovanni Genovese
Summary: The study aimed to assess skin barrier status in nonlesional skin of severe AD patients treated with dupilumab, by evaluating the association between TEWL variation and EASI75 achievement over time. During dupilumab treatment, TEWL on nonlesional skin tends to significantly improve 4 months after treatment initiation, serving as a useful tool for monitoring therapy response.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Food Science & Technology
Emilia Alves, Joao Gregorio, Andre Rolim Baby, Patricia Rijo, Luis M. Rodrigues, Catarina Rosado
Summary: Diet plays a fundamental role in maintaining the balance of bodily functions, including skin health, through the gut-skin axis. Probiotics in kefir have potential therapeutic benefits for inflammatory skin diseases like atopic dermatitis. The intake of homemade kefir has been shown to improve skin barrier function and severity of atopic dermatitis, particularly in terms of skin hydration.
Review
Allergy
Razvigor Darlenski, Anita L. Kozyrskyj, Joachim W. Fluhr, Luis Caraballo
Summary: Atopic diathesis is a prevalent condition with a wide range of clinical manifestations and age of onset, characterized by a common inherited epidermal barrier dysfunction. Microbiome diversity and contact with nonpathogenic microbes play a key role in immune system maturation and may impact the development of the disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Plant Sciences
Risako Kishimoto, Narumi Kato, Mayuka Koike, Naoki Iwashita, Yoshiichi Takagi, Tomoki Fukuyama
Summary: The study focused on developing preventive and supportive options for skin allergies using a natural product called Mastic. Results showed that topical treatment with mastic significantly improved inflammatory and pruritic responses in mouse models of allergic dermatitis and atopic dermatitis. Mastic treatment reduced skin thickness, AD score, transepidermal water loss, itch behavior, and pro-inflammatory cytokine production.
Article
Medicine, Research & Experimental
Charles F. Schuler, Kelly M. O'Shea, Jonathan P. Troost, Bridgette Kaul, Christopher M. Launius, Jayme Cannon, David M. Manthei, George E. Freigeh, Georgiana M. Sanders, Simon P. Hogan, Nicholas W. Lukacs, James R. Baker Jr
Summary: The study found that an increase in TEWL during OFCs could predict positive clinical challenges. TEWL provides a monitoring modality that may predict food anaphylaxis and facilitate improvements in OFC safety and tolerability.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Multidisciplinary
Nur Izzah Md Fadilah, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Suet Lin Chia, Shiow-Fern Ng, Sze Wei Leong
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2020)
Article
Biochemistry & Molecular Biology
Evelyn Yun Xi Loh, Mh. Busra Fauzi, Min Hwei Ng, Pei Yuen Ng, Shiow Fern Ng, Mohd Cairul Iqbal Mohd Amin
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Review
Nanoscience & Nanotechnology
Anis Syauqina Mohd Zaffarin, Shiow-Fern Ng, Min Hwei Ng, Haniza Hassan, Ekram Alias
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Masoud Rezvanian, Shiow-Fern Ng, Taradokht Alavi, Waqas Ahmad
Summary: The study demonstrated that the novel hydrogel film wound dressing showed significant efficacy in accelerating diabetic wound healing, with pro-angiogenic effects, faster re-epithelialization, and increased collagen deposition.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Thiviya Sunmugam, Hanisah Azhari, Shiow-Fern Ng, Fazren Azmi
Summary: This study showed that the release of sea cucumber extract in the cream formulations was influenced by different types of oil phase, with lemongrass oil enhancing skin permeation and olive oil working synergistically with sea cucumber extract. The formulated creams demonstrated significant wound healing efficacy on excision wounds in rats, with the highest rate of wound closure observed in the F1 cream.
Article
Pharmacology & Pharmacy
Rathapon Asasutjarit, Nawarat Sooksai, Adryan Fristiohady, Kriyapa Lairungruang, Shiow-Fern Ng, Asira Fuongfuchat
Summary: The active compound Andrographolide was isolated from Andrographis paniculata, but its low water solubility posed challenges for product development. An AG-loaded nanoemulsion was prepared to address this issue. The study found that the optimized AG-NE had cytotoxic effects on skin cancer cells and improved skin disorders caused by UVB radiation.
Article
Polymer Science
Payal Bhatnagar, Jia Xian Law, Shiow-Fern Ng
Summary: The study developed a chitosan and kenaf nanocrystalline cellulose hydrogel composite to stabilize platelet lysate (PL) and control its release onto the wound site for prolonged action. The composite hydrogel exhibited excellent water retention capacity, sustained release of PL, promotion of wound healing, and enhanced fibroblast proliferation in vitro.
Review
Chemistry, Multidisciplinary
Anis Syauqina Mohd Zaffarin, Shiow-Fern Ng, Min Hwei Ng, Haniza Hassan, Ekram Alias
Summary: Nano-hydroxyapatite (nHA) is effective in promoting bone regeneration as a delivery system, inducing bone regeneration successfully and enhancing osteogenesis when conjugated with other bioactive molecules.
Review
Pharmacology & Pharmacy
Payal Bhatnagar, Jia Xian Law, Shiow-Fern Ng
Summary: Platelet-rich plasma (PRP) has therapeutic potential in wound healing and tissue regeneration due to its abundance of growth factors (GFs). However, GFs have a short half-life and need frequent administration to be effective. Novel drug delivery systems are being studied to stabilize and control the release of GFs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Lay-Hong Chuah, Hooi-Leong Loo, Choon Fu Goh, Ju-Yen Fu, Shiow-Fern Ng
Summary: Atopic dermatitis is a chronic inflammatory skin disease that has significant impact on patients' quality of life. Recent research has focused on the development of chitosan-based drug delivery systems for AD treatment, taking advantage of its antimicrobial, antioxidative, and inflammatory response modulation properties.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sharifah Shakirah Syed Omar, Hazrina Hadi, Nadzira Mohd Hanif, Hawa Mas Azmar Ahmad, Shiow-Fern Ng
Summary: The study aimed to develop an effective skin-lightening cream containing PBL, which showed significant reduction in melanin content and improvement in skin tone. Both base and PBL creams demonstrated acceptable properties with no phase separation, and the in vivo study indicated a healthier skin barrier and supple skin with consistent use.
Article
Education, Scientific Disciplines
Shiow-Fern Ng, Dorothy Diliana Shalilan Anak Dawie, Wei-Wen Chong, Jamia Azdina Jamal, Siti Noraisyah Abd.Abd Ahman, Jazmi Izwan Jamal
Summary: This study investigated the preferences and perceptions of serious games among local pharmacy students in Malaysia. The results showed that pharmacy students have a positive attitude towards serious games, with limited awareness and knowledge of them. The most preferred game genres were role-playing and strategy among the students.
CURRENTS IN PHARMACY TEACHING AND LEARNING
(2021)
Article
Materials Science, Multidisciplinary
Siaw-Kim Chua, Ju-Yen Fu, Mohd Hanif Zulfakar, Mei-Han Ng, Zafarizal Aldrin Azizul Hasan, Shiow-Fern Ng
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2020)
Article
Materials Science, Textiles
Chai-Yee Chin, Shiow-Fern Ng
FIBERS AND POLYMERS
(2020)
Article
Polymer Science
Hafiz Muhammad Basit, Mohd Cairul Iqbal Mohd Amin, Shiow-Fern Ng, Haliza Katas, Shefaat Ullah Shah, Nauman Rahim Khan