Article
Pharmacology & Pharmacy
Rabia Ashfaq, Bianka Sisa, Anita Kovacs, Szilvia Berko, Maria Szecsenyi, Katalin Burian, Peter Valyi, Maria Budai-Szucs
Summary: Periodontitis is a common bacterial infectious oral disease that affects a large number of people worldwide. In this study, the formulation of chlorhexidine medicated in situ gel for periodontal treatment was optimized using factorial design. The effects of gel formation and structure characteristics were investigated, and the optimal concentrations of gel agent, crosslinker, and pH were determined. The optimized gel showed good mucoadhesion, antimicrobial activity, and drug release properties.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Avinash Tekade, Pratiksha Ghodke, Ashvini Patange, Pravin Patil
Summary: The purpose of this research was to develop a cubosomal in situ nasal gel using a novel mucoadhesive agent and to enhance the availability of sumatriptan succinate in brain with better CNS targeting potential for the efficient treatment of migraine. The cubosomal in situ nasal gel was prepared using glycerol monooleate (GMO) and Poloxamer 407 (P407). It showed a significantly higher concentration of sumatriptan succinate in the brain compared to intravenous solution, indicating its potential as a promising carrier for CNS-acting drugs through the intranasal route.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Surabhi V. Boraste, Sanjay B. Patil
Summary: The present study aims to develop mucoadhesive thermosensitive nasal in situ gel to improve the residence and bioavailability of the drug in the nasal mucosa. Nasal administration offers advantages of larger surface area, higher drug absorption rate, and avoidance of first pass effect.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Bence Sipos, Ildiko Csoka, Nimrod Szivacski, Maria Budai-Szucs, Zsuzsanna Schelcz, Istvan Zupko, Piroska Szabo-Revesz, Balazs Volk, Gabor Katona
Summary: Intranasally administered NSAIDs can be effective in pain management, and nanoemulsions can enhance drug absorption and bioavailability, providing an advanced drug delivery system.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Environmental
Hongyao Yin, Xin Yin, Ruibo Cao, Peiyun Zeng, Jing Wang, Dianguo Wu, Xinjie Luo, Youyi Zhu, Zhuo Zheng, Yujun Feng
Summary: This study reports on polymer-based in situ cross-linked gels with adjustable gelation times, which can be used for water shutoff and conformance control, improving sweep efficiency and oil recovery in oil reservoirs.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Shilpa Dawre, Simran Waghela, Gaurav Saraogi
Summary: The study developed PLGA microspheres loaded with vitamin D3 and enhanced nasal permeation by using a thermoreversible in-situ gel. The system showed good release performance and high mucoadhesive property. Through a series of tests, the system was found to be suitable for the nasal delivery of vitamin D3.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Eileen Hulambukie, Hani Abdeltawab, Sanjukta Duarah, Darren Svirskis, Manisha Sharma
Summary: This study aims to develop an NRT formulation that offers sustained nicotine release. Thermoresponsive in situ gelling systems containing nicotine were successfully prepared using poloxamer. The optimized formulation demonstrated prolonged release of nicotine.
Article
Pharmacology & Pharmacy
Tarek M. Ibrahim, Margrit M. Ayoub, Hany M. El-Bassossy, Hanan M. El-Nahas, Eman Gomaa
Summary: The aim of this study was to design injectable long-acting poly (lactide-co-glycolide) (PLGA)-based in situ gel implants (ISGI) loaded with the anti-diabetic alogliptin. By providing sustained therapeutic exposures and improving the pharmacological responses of alogliptin, the study aimed to reduce dosing frequency and enhance treatment outputs. The researchers conducted a preliminary study to select a suitable solvent for ISGI preparation based on its physicochemical characteristics. They then used an optimization technique and compared the blood glucose levels of diabetic rats after a single injection with the optimized formulation to those who received daily oral alogliptin. N-methyl-2-pyrrolidone (NMP) and dimethyl sulfoxide (DMSO) were found to be effective solvents for successful ISGI preparation and controlling the burst alogliptin release. The optimized formulation showed a remarkable decrease in blood glucose levels throughout the study period compared to oral alogliptin solution. The study demonstrated the feasibility of using long-acting alogliptin-loaded ISGI systems for treating type 2 diabetes with reduced dosing frequency and improved patient compliance.
Article
Pharmacology & Pharmacy
Vaishnavi Gattani, Shilpa Dawre
Summary: The aim of this study was to develop Favipiravir loaded PLGA nanoparticles and entrapped them in a thermosensitive gel to increase permeation through the nasal route. The nanoparticles exhibited good homogeneity and stability with a particle size of 175.6 +/- 2 nm and >70 +/- 0.5% EE. The gel showed good gelling properties and mucoadhesion properties. Dissolution study showed sustained release of Favipiravir from the nanoparticles and the gel. Ex-vivo permeation through nasal mucosa of a goat demonstrated significantly higher permeation with the nanoparticles dispersed gel. This formulation has potential for combating Covid-19 infection with high patient compliance.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Avantika Dalvi, Punna Rao Ravi, Chandra Teja Uppuluri
Summary: A thermoresponsive nasal in situ gel loaded with Rufinamide (Rufi) nanocrystals was developed to improve nose-to-brain distribution. The optimized Rufi nanocrystals had reproducible and reliable manufacturing process with small particle size. The combination of nanometric size and in situ gelling properties of Rufi nanocrystals contributed to higher brain distribution and sustained drug concentrations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biophysics
Barnabas Aron Szilagyi, Benjamin Gyarmati, Eszter L. Kiss, Maria Budai-Szucs, Anil Misra, Erzsebet Csanyi, Krisztina Laszlo, Andras Szilagyi
Summary: Efficient topical treatment of ocular diseases requires a prolonged residence time of drug formulations. An in situ gelling, mucoadhesive system can provide improved residence time while keeps the installation of the formulation easy and accurate due to its low initial viscosity. Furthermore, a prolonged release of ofloxacin was observed at pH = 7.4 compared to a conventional liquid formulation, supporting the potential of the developed biopolymers in ophthalmic drug delivery.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Vishwa J. Kalaria, S. Saisivam, Anas Alshishani, Jameel S. Aljariri S. Alhesan, Sumit Chakraborty, Mohamed Rahamathulla
Summary: Traditional eye drops have poor bioavailability due to eye barriers. This study aimed to develop nanoparticles of Gemifloxacin Mesylate and incorporate them into an in situ gel to improve drug delivery. The optimized formulation showed a particle size of 71 nm and 81.11% entrapment efficiency. The nanoparticles exhibited biphasic release and when incorporated into the gel, sustained drug release with efficient antimicrobial activity was observed.
Article
Pharmacology & Pharmacy
Zeinab Fathalla, Wesam W. Mustafa, Hamdy Abdelkader, Hossam Moharram, Ahmed Mohamed Sabry, Raid G. Alany
Summary: The purpose of this study was to develop an effective and long-lasting ophthalmic drug delivery system for corneal wound healing using a combination of thermo-gelling polymer poloxamer 407 and mucoadhesive polymers chitosan and methyl cellulose. The results showed that the poloxamer 407/chitosan system exhibited superior gelation time and temperature, mucoadhesion, and rheological characteristics suitable for corneal wound healing.
Article
Engineering, Chemical
Yaolei Zhu, Wei Di, Mengyuan Song, Bimal Chitrakar, Zhenbin Liu
Summary: Thermo-responsive food inks play an important role in 3D food printing materials. This study provides new insights into 3D printing of thermo-responsive food inks by correlating with sol-gel transition.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Elisa Corazza, Massimiliano Pio di Cagno, Annette Bauer-Brandl, Angela Abruzzo, Teresa Cerchiara, Federica Bigucci, Barbara Luppi
Summary: The objective of this study was to optimize a thermosensitive in situ gelling formulation to improve the intranasal and nose-to-brain delivery of the antiepileptic drug carbamazepine (CBZ). The formulation consisted of poloxamer 407 (P407), poloxamer 188 (P188), and hydroxypropylmethylcellulose (HPMC) and exhibited suitable properties for nasal delivery. The mucoadhesive properties of the formulation were enhanced by adding different grades of HPMC, and the formulation showed promising mucoadhesive potential. Furthermore, the formulation was able to increase drug solubility, control drug release, and promote drug permeation across barrier membranes.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Maram Suresh Gupta, Tegginamath Pramod Kumar, Robert Davidson, Guruprasad Rao Kuppu, Kamla Pathak, Devegowda Vishakante Gowda
Summary: Orodispersible film (ODF) formulations are promising and progressive drug delivery systems, with printed orodispersible films (POFs) being a modern and rapidly developing method. The review provides an overview of printing methods for fabricating POFs, highlighting patenting trends and future market potential.
Review
Chemistry, Organic
Yogesh Murti, Devender Pathak, Kamla Pathak
Summary: Flavonoids are a diverse family of aromatic compounds in nature with reported biological activities, making them potential targets for nutraceuticals and pharmaceuticals. Green Chemistry advancements have enabled eco-friendly synthesis of chalcones, a precursor to flavonoids, reducing hazards to human health and the environment. Bulk production of various flavonoids using green chemistry techniques has been successfully achieved in the pharmaceutical field.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Polymer Science
Kamla Pathak, Shashi Kiran Misra, Aayush Sehgal, Sukhbir Singh, Simona Bungau, Agnieszka Najda, Robert Gruszecki, Tapan Behl
Summary: Chitosan, a natural polymer, is extensively used for versatile drug delivery systems, with quaternized chitosan being preferred in pharmaceutical industries due to its superior properties. Quaternized chitosan has been widely applied in tissue engineering, wound healing, gene, and vaccine delivery.
Review
Biotechnology & Applied Microbiology
Girish Kumar, Tarun Virmani, Kamla Pathak, Abdulsalam Alhalmi
Summary: Hypertension is a major cause of mortality globally, imposing significant health and economic burdens. Nanotechnology offers a promising approach in the treatment of cardiovascular diseases by providing novel drug delivery systems.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Biotechnology & Applied Microbiology
Tarun Virmani, Girish Kumar, Reshu Virmani, Ashwani Sharma, Kamla Pathak
Summary: This article provides updated information on the treatment of COPD, with a focus on nanocarrier-based approaches and the potential of gene therapy and stem cell therapy to combat COPD.
Review
Biotechnology & Applied Microbiology
Ashwani Sharma, Tarun Virmani, Vipluv Pathak, Anjali Sharma, Kamla Pathak, Girish Kumar, Devender Pathak
Summary: This article discusses the development of COVID-19 vaccines and emphasizes the significance of using artificial intelligence in the research and development process.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Ashwani Sharma, Tarun Virmani, Anjali Sharma, Vaishnavi Chhabra, Girish Kumar, Kamla Pathak, Abdulsalam Alhalmi
Summary: Dipeptidyl-peptidase-4 (DPP-4) is an enzyme with various properties and physiological roles. Up-regulation of hepatic DPP-4 expression may be the cause of glucose intolerance in individuals with liver conditions. This review focuses on the cleavage of alanine or proline-containing peptides by DPP-4 and its implications in glucose intolerance and liver diseases.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Review
Polymer Science
Akhilesh Kumar Tewari, Satish Chandra Upadhyay, Manish Kumar, Kamla Pathak, Deepak Kaushik, Ravinder Verma, Shailendra Bhatt, Ehab El Sayed Massoud, Md Habibur Rahman, Simona Cavalu
Summary: Polymeric nanocarriers have great potential as a delivery vehicle in biomedical applications, but only a few have been approved by regulations. This review discusses the historical development, applications, safety issues, and future research directions of polymeric nanocarriers.
Article
Chemistry, Medicinal
Girish Kumar, Tarun Virmani, Kamla Pathak, Omkulthom Al Kamaly, Asmaa Saleh
Summary: The present study aimed to improve the solubility and intestinal permeability of azilsartan medoxomil by designing a nanoemulsion formulation. The optimized formulation exhibited desired droplet size, transmittance, and cumulative drug release, resulting in enhanced drug permeability compared to the drug suspension in rat experiments.
Review
Biochemistry & Molecular Biology
Shashi Kiran Misra, Jessica M. Rosenholm, Kamla Pathak
Summary: Metallic nanoparticles have been explored as a novel therapeutic tool for the treatment and diagnosis of mitochondria-based disorders. They have the ability to alter the structure of mitochondria, disrupt metabolic homeostasis, inhibit ATP production, and induce oxidative stress. However, the biocompatibility, safety, and efficacy of using metal nanoparticles are still debated among researchers.
Review
Pharmacology & Pharmacy
Ruchi Tiwari, Kamla Pathak
Summary: Wound healing is a specific biological process connected to growth and tissue regeneration. The present review paper focuses on the physiology of wound healing, medications used for treatment, and local drug delivery systems for skin wound therapy. Various cellular and matrix elements work together to restore injured tissue integrity. Enhanced local delivery methods, such as innovative systems and nanoparticles, may provide faster wound healing agents.
Review
Pharmacology & Pharmacy
Girish Kumar, Tarun Virmani, Ashwani Sharma, Kamla Pathak
Summary: Monotherapy with anticancer drugs is inefficient for treating cancer due to its heterogeneous nature, drug resistance, and adverse effects. Plant-based phytochemicals offer a better alternative to traditional chemotherapy due to their lower adverse effects, diverse action pathways, and lower costs. Combining phytochemicals with conventional anticancer drugs has shown greater efficacy in preclinical studies. However, poor solubility and bioavailability of phytochemicals need to be addressed. Therefore, nanotechnology-based carriers, such as nanoemulsion, nanosuspension, and polymeric nanoparticles, are employed for co-delivery of phytochemicals and anticancer drugs to improve the treatment of cancer.
Article
Pharmacology & Pharmacy
Maram Suresh Gupta, Tegginamath Pramod Kumar, Dinesh Reddy, Kamla Pathak, Devegowda Vishakante Gowda, A. V. Naresh Babu, Alhussain H. Aodah, El-Sayed Khafagy, Hadil Faris Alotaibi, Amr Selim Abu Lila, Afrasim Moin, Talib Hussin
Summary: Iron deficiency is a major health problem, especially during pregnancy. This study developed and characterized pullulan-based iron-loaded orodispersible films (i-ODFs) which showed good physicochemical properties, excellent disintegration time, and optimal stability at specified storage conditions.
Review
Chemistry, Physical
Shashi Kiran Misra, Kamla Pathak
Summary: Non-invasive and patient-friendly nose-to-brain pathway is the best route for brain delivery of therapeutics, bypassing the blood-brain barrier. The olfactory and trigeminal pathways provide a direct route for the entry of therapeutics into the brain, facilitating better biodistribution and bypassing BBB issues.
COLLOIDS AND INTERFACES
(2023)
Review
Environmental Sciences
Syam Mohan, Pranay Wal, Kamla Pathak, Madhusmruti Khandai, Tapan Behl, Hassan A. Alhazmi, Gulrana Khuwaja, Asaad Khalid
Summary: Naturally sourced polysaccharides show promise as wound dressings due to their availability, cost-effectiveness, and biocompatibility. Nanosilver, known for its broad antimicrobial effects and low drug resistance, is widely incorporated into wound dressings, offering an affordable option for chronic wound healing. This review covers the preparation, classification, and antibacterial performance of nanosilver wound dressings, as well as potential research areas for nanosilver-functionalized polysaccharide dressings.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
