Article
Biotechnology & Applied Microbiology
Monika Jain, Priyanka Yadav, Bhavana Joshi, Abhijeet Joshi, Prashant Kodgire
Summary: The indiscriminate use of organophosphorus (OP)-based insecticides poses a serious threat to human health due to bioaccumulation-induced hazards, necessitating the development of reliable, selective, cost-effective, and sensitive detection methods. Enzymatic sensor systems have gained popularity for their high catalytic activity, enhanced detection limits, and environmentally benign operation.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Ana C. R. Ribeiro, Fay M. Jahr, Elisa Hawkins, Mohamad M. Kronfol, Rabha M. Younis, Joseph L. McClay, Laxmikant S. Deshpande
Summary: Exposure to organophosphate compounds in rats led to an increase in HDAC protein expression and enzyme activity in the hippocampus, as well as a decrease in H3K9ac and BDNF protein levels. Treatment with an HDAC inhibitor showed promising results in reducing immobility time in the Forced Swim Test for rats exposed to organophosphates, suggesting potential new targets for the treatment of GWI symptoms.
Article
Environmental Sciences
Murali Krishna Paidi, Praveen Satapute, Muhammad Salman Haider, Shashikant Shiddappa Udikeri, Yarappa Lakshmikantha Ramachandra, Dai-Viet N. Vo, Muthusamy Govarthanan, Sudisha Jogaiah
Summary: Organophosphorus insecticides (OPIs) occupy a significant share in the global market, leading to increasing contamination of OPIs residues in food chains. Enzymatic degradation methods have been approved by multiple environmental regulatory agencies to neutralize toxic pesticides and insecticides.
ENVIRONMENTAL RESEARCH
(2021)
Article
Microbiology
Xiaofang Zheng, Li Wang, Lihong Qi, Zhiyang Dong
Summary: The newly discovered OPAA114644 enzyme showed excellent alkaline stability and salt tolerance, making it effective in degrading OPCs. It also demonstrated high degradation efficiency for various toxic compounds like soman, dichlorvos, paraoxon, coumaphos, and chlorpyrifos. Its potential applications include decontaminating surfaces and remediation of polluted sites.
Article
Neurosciences
Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy
Summary: In this study, the effectiveness of a mitochondrial-targeted NADPH oxidase inhibitor in reducing oxidative stress and inflammation in rats exposed to organophosphates (OP) was examined. The inhibitor showed promising results in decreasing markers of oxidative stress and inflammation in the serum, but had limited effects in the brain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Patricia G. Izquierdo, Vincent O'Connor, A. Christopher Green, Lindy Holden-Dye, John E. H. Tattersall
Summary: By studying the non-parasitic nematode Caenorhabditis elegans, researchers gain insights into the molecular mechanisms of acetylcholinesterase poisoning, as well as the mode of action of carbamates and organophosphates. The high degree of conservation in cholinergic transmission between C. elegans and mammals makes it an effective model to explore anti-cholinesterase intoxication and recovery, with potential to uncover critical genetic determinants of these neurotoxins' mode of action.
Article
Neurosciences
Clemence Maupu, Julie Enderlin, Alexandre Igert, Myriam Oger, Stephane Auvin, Rahma Hassan-Abdi, Nadia Soussi-Yanicostas, Xavier Brazzolotto, Florian Nachon, Gregory Dal Bo, Nina Dupuis
Summary: Organophosphate pesticides and nerve agents can lead to seizures and neurodegeneration, resulting in neuroinflammation. This study identified distinct neuroinflammatory responses of microglia and astrocytes at different time points after induced seizures, highlighting the importance of targeting specific markers for treatment.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Environmental Sciences
Julia Yamila Santillan, Natalia Lorena Rojas, Elizabeth Sandra Lewkowicz, Adolfo Marcelo Iribarren
Summary: Organophosphorus pesticides have improved agriculture, but their toxicity has negative effects on the environment and health. This study aimed to develop robust biocatalysts for bioremediation and evaluated four fungi as hydrolase sources. The results showed that Penicillium chrysogenum had outstanding activity in degrading organophosphorus pesticides under acidic conditions, making it a potential candidate for eliminating these pesticides in fruit washing processes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hong Lei, Aqu Alu, Jingyun Yang, Xi He, Cai He, Wenyan Ren, Zimin Chen, Weiqi Hong, Li Chen, Xuemei He, Li Yang, Jiong Li, Zhenling Wang, Wei Wang, Yuquan Wei, Shuaiyao Lu, Guangwen Lu, Xiangrong Song, Xiawei Wei
Summary: In this study, a nasal vaccine containing cationic crosslinked carbon dots (CCD) and SARS-CoV-2 antigen, RBD-HR, was prepared. It induces high levels of antibodies with broad-spectrum neutralization against Omicron variants, protecting immunized mice from infection. Moreover, CCD/RBD-HR activates antigen-presenting cells and nasal epithelial cells, promoting antigen presentation. CCD is a promising intranasal vaccine adjuvant for strong mucosal immunity.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Weng Meiqi, Shang Guiming, Wang Jiatai, Li Shenghua, Fan Zhi, Lin Song, Guo Minjie
Summary: This study proposes using paraoxon as an alternative template simulant for organophosphorus nerve agents molecularly imprinted polymers (MIPs). By comparing the stability and binding energy of the complexes formed by paraoxon and 4-nitrophenyl phosphate (BNPP) with various functional monomers, it is confirmed that the combination of 4-merhylacrylamide anlipyrine (MAAP) and methacrylic acid (MAA) is the optimal monomer in this study. Furthermore, SiO2@BNPP core-shell MIPs with desirable adsorption properties were successfully prepared. The adsorption process of MIPs to the template was described using pseudo-second-order kinetic model and Langmuir isothermal adsorption equation. Scatchard equation analysis showed that MIPs had two classes of adsorption sites. The computational simulation was found to be helpful for the design of organophosphorus nerve agent MIPs.
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
(2022)
Article
Polymer Science
Siby Mathew, Yuki Naganawa, Fan Jiang, Raphael Wischert, Stephane Streiff, Pascal Metivier, Yumiko Nakajima
Summary: The Abramov phosphonylation reaction can be used to synthesize organophosphorus polymers by reacting di- or tricarbaldehydes with phosphinic acid in the presence of N,O-bis(trimethylsilyl)acetamide. These polymers have main chain P-C bonds and are linked by bis(alpha-hydroxymethylene)phosphinic acid units, resulting in water-soluble polymers with resilience against hydrolysis and superior thermal stability.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Shuyin Zuo, Xiaorong Lan, Yong Wang, Sai Li, Zhonglan Tang, Yunbing Wang
Summary: In this study, a cross-linked polymer network with anti-biofouling properties was prepared by photopolymerization. The mechanical properties and biocompatibility of the network were adjusted by varying the composition of the materials. The designed network has the potential for commercial applications in the field of biological anti-fouling materials.
Article
Medicine, General & Internal
Gholamreza Poorheidari, Mahdi Mashhadi Akbar Boojar
Summary: The study found that paraoxon at a concentration of 0.1 μM significantly increased twitch amplitude, while higher concentrations induced partial or total contracture. The results indicated that oximes were effective in preventing and reversing the toxic effects of OP on skeletal muscles, with pralidoxime being more potent than obidoxime and HI-6. HI-6, a newer oxime, was unexpectedly less effective than the other two when used in this study.
IRANIAN RED CRESCENT MEDICAL JOURNAL
(2021)
Article
Chemistry, Medicinal
Avinash G. Vishakantegowda, Berehe Solomon Girmay, Jin Soo Shin, Joo-Youn Lee, Sunjoo Ahn, Young-Sik Jung
Summary: This study aimed to explore non-pyridinium oxime acetylcholinesterase (AChE) reactivators for the treatment of neurologic manifestations induced by organophosphorus agents. Compound 13 showed the highest reactivation of AChE and has the potential to be developed into a novel AChE reactivator that can cross the blood-brain barrier.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Review
Pharmacology & Pharmacy
Yeye Hu, Wei Zhang, Xiaozhong Chu, Aoran Wang, Ziliang He, Chuan-Ling Si, Weicheng Hu
Summary: This paper reviews and compares DC surface receptors and their specific coupling natural ligands and antibodies, describes reaction mechanisms, and demonstrates the synergistic effects of immune adjuvants. Moreover, extracellular-targeting antigen-delivery strategies and intracellular stimulus responses are reviewed to promote the rational design of polymer delivery systems.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Kristof Kovacs, Prashanth K. Jayanna, Anna Duke, Brittany Winner, Melaeni Negrito, Siva Angalakurthi, Jorn C. C. Yu, Petra Furedi, Krisztina Ludanyi, Peter Sipos, Gary A. Rockwood, Ilona Petrikovics
CURRENT DRUG DELIVERY
(2016)
Article
Chemistry, Analytical
Tiffany Franklin, Lauren Perry, Wei-Chuan Shih, Jorn Yu
ANALYTICAL METHODS
(2018)
Article
Chemistry, Analytical
Jianbo Zeng, Ji Qi, Fuquan Bai, Jorn Chi Chung Yu, Wei-Chuan Shih
Article
Biochemical Research Methods
Ming Li, Jing Lu, Ji Qi, Fusheng Zhao, Jianbo Zeng, Jorn Chi-Chung Yu, Wei-Chuan Shih
JOURNAL OF BIOMEDICAL OPTICS
(2014)
Article
Medicine, Legal
Patricia A. Contreras, Stephen S. Houck, William M. Davis, Jorn C. -C. Yu
JOURNAL OF FORENSIC SCIENCES
(2013)
Article
Biochemical Research Methods
Sun Yi Li, Ilona Petrikovics, Jorn (Chi Chung) Yu
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2019)
Article
Medicine, Legal
Emily E. Fairbanks, Jennifer Turner, Junkun Ma, Jorn Yu
JOURNAL OF FORENSIC SCIENCES
(2020)
Article
Chemistry, Analytical
Ting-Yu Huang, Jorn Chi Chung Yu
Summary: A new intelligent analytical platform was developed for field identification and classification of gasoline evidence. The pretrained convolutional neural network (CNN) model outperformed other models in various performance benchmarks, demonstrating its superiority in accuracy, precision, recall, F1, Cohen's Kappa, and Matthews correlation coefficient. This nondestructive, automated, and accurate platform successfully processed and classified complex Raman spectral data without feature engineering, showing great potential for accelerating crime scene intelligence based on evidence's chemical signatures detected by hand-held Raman spectrometers.
ANALYTICAL CHEMISTRY
(2021)
Article
Medicine, Legal
Sun Yi Li, Jennifer Turner, Scott Golightly, Pamela Zelbst, Jorn Yu
Summary: In this study, two gun barrels were 3D-printed using a metal alloy material and successfully test-fired with 100 rounds of ammunition each, revealing distinctive striation patterns. These unconventional striation features could be valuable for forensic investigations involving 3D-printed firearms.
JOURNAL OF FORENSIC SCIENCES
(2021)
Article
Medicine, Legal
Sun Yi Li, Madeleine J. Swortwood, Jorn (Chi Chung) Yu
Summary: This study evaluated the effects of small quantity and repeat brewing on opiate concentrations in poppy seed tea. Results showed that brewing with a small quantity of seeds may provide minimal analgesic and euphoric effects, with over 80% of the total opiate yield extracted in the first brew.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Biochemical Research Methods
Ting -Yu Huang, Jorn (Chi Chung) Yu
Summary: A novel carbon nanotube-assisted solid phase microextraction (CNT-SPME) fiber coupled with gas chromatography and mass spectrometry (GC/MS) was proposed for the determination of gasoline residues in fire debris analysis. The CNT-SPME fiber showed promising extraction capabilities for gasoline and its major aromatic groups, with high accuracy and stability. This method has potential applications in the extraction and detection of other ignitable liquids.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Ting-Yu Huang, Jianzhong Wang, Qingzhong Liu, Jorn Yu
Summary: This study proposed an AI approach based on Raman spectra for rapid and automatic detection of gasoline samples from different ignitable liquid samples. The experimental results showed that the established AI model had high accuracy and performance.
Article
Chemistry, Analytical
Sun Yi Li, Ilona Petrikovics, Jorn Yu
Summary: Dispersive-micro solid phase extraction using magnetic carbon nanotubes has shown excellent separation efficiency and adsorption capability, particularly with surface modifications that allow for a one-step derivatization/desorption approach, improving overall extraction efficiency.
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Austin McDaniel, Lauren Perry, Qingzhong Liu, Wei-Chuan Shih, Jorn Yu
FORENSIC CHEMISTRY
(2018)
Meeting Abstract
Chemistry, Multidisciplinary
Lauren Perry, Jorn Yu
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
