Article
Biochemistry & Molecular Biology
Kantaporn Kheawfu, Pattaraporn Panraksa, Pensak Jantrawut
Summary: The study developed a nicotine microemulsion (NCT-ME) and incorporated it into a fast-dissolving film. The results showed that almost all NCT-MEs presented droplet sizes of less than 100 nm with a spherical form, narrow size distribution, and zeta potentials of -10.6 to -73.7 mV. The mechanical properties of films varied with changes in the type of surfactant, and NCT40-Smix[P-80(1:1)]10 film showed the highest dissolution rate.
Article
Pharmacology & Pharmacy
Kiramat Ali Shah, Guifeng Li, Lina Song, Binbin Gao, Linyu Huang, Dazhi Luan, Haroon Iqbal, Qingri Cao, Farid Menaa, Beom-Jin Lee, Sulaiman M. Alnasser, Sultan M. Alshahrani, Jinghao Cui
Summary: In this study, orally disintegrating films (ODFs) of Rizatriptan (RZT) were developed using maltodextrin (MTX) and pullulan (PUL) as film-forming polymers and propylene glycol (PG) as a plasticizer. The optimized film showed rapid disintegration time and remarkable mechanical properties, and demonstrated improved drug release and absorption compared to traditional oral formulations.
Article
Biochemistry & Molecular Biology
Kantaporn Kheawfu, Adchareeya Kaewpinta, Wisinee Chanmahasathien, Pornchai Rachtanapun, Pensak Jantrawut
Summary: The study found that nicotine extracted from the upper part of tobacco leaves using acid-base extraction method had the highest content, and the fast dissolving film formulation showed rapid and effective nicotine release.
Article
Chemistry, Physical
Kiramat Ali Shah, Binbin Gao, Robia Kamal, Anam Razzaq, Sun Qi, Qiu-Ning Zhu, Song Lina, Linyu Huang, Grainne Cremin, Haroon Iqbal, Farid Menaa, Jing-Hao Cui
Summary: Migraine treatment with oral fast-dissolving films (OFDFs) containing ZMT showed rapid dissolution and fast disintegration time, improving patient compliance and shortening the onset time of ZMT. The optimized formulation displayed excellent mechanical characteristics and enhanced drug release. This study offers a promising strategy for developing ZMT-OFDFs using the solvent casting method, with the potential to provide an auspicious alternative approach for migraine headache treatment.
Article
Polymer Science
Adel F. Alghaith, Gamal M. Mahrous, Gamal A. Shazly, Diaa Eldin Z. Zidan, Abdullah S. Alhamed, Mohammed Alqinyah, Mohammed M. Almutairi, Saeed A. Syed
Summary: This study aimed to improve the aqueous solubility and bioavailability of flibanserin by incorporating it into orally fast dissolving films containing beta hydroxypropyl cyclodextrin. The optimized film showed good physical and mechanical properties and released 98% of the drug within 10 minutes.
Article
Engineering, Chemical
Emoke-Margit Redai, Paula Antonoaea, Nicoleta Todoran, Robert Alexandru Vlad, Magdalena Birsan, Anamaria Tataru, Adriana Ciurba
Summary: The study developed and evaluated orodispersible films for pediatric patients containing fluoxetine formulated in the polymeric matrix. FX1 and FX2 were found to have better drug release, and FX ODFs followed first-order release kinetic.
Article
Pharmacology & Pharmacy
Ibrahim Ashraf, Pierre A. Hanna, Shadeed Gad, Fathy I. Abd-Allah, Khalid M. El-Say
Summary: This study developed a fast-dissolving film (FDF) formulation of rosuvastatin (RSV) and compared it with a conventional tablet. The optimized RSV-FDF showed a faster onset of action and improved lipid-lowering effects, highlighting its potential for enhancing the bioavailability and therapeutic efficacy of rosuvastatin in treating dyslipidemia.
Article
Pharmacology & Pharmacy
Apoorva Panda, Purnendu Kumar Sharma, H. N. Shivakumar, Michael A. Repka, S. Narasimha Murthy
Summary: This study explored the feasibility of delivering nicotine through microneedles via the transdermal route, showing immediate and effective release in pharmacokinetic studies. Nicotine loaded microneedles could potentially provide a pain-free and minimally invasive treatment option for nicotine replacement therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Deepali N. Tapre, Sachin P. Borikar, Shirish P. Jain, Sheelpriya R. Walde, Ganesh G. Tapadiya, Vishal C. Gurumukhi
Summary: The present study developed and evaluated a novel famotidine (FMD) loaded fast-dissolving sublingual film using a quality-by-design approach. The optimized film showed stability for 3 months and demonstrated enhanced dissolution and permeation compared to buccal and oral films. In vivo studies in rabbits showed a 2.05-fold increase in bioavailability, with systemic circulation achieved within 15 minutes. This fast-dissolving sublingual film potentially overcomes biopharmaceutical challenges and is a promising alternative for FMD administration in peptic ulcer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Neha Vishal Gandhi, Uday Arvind Deokate, Sachidanand Shankar Angadi
Summary: This study aimed to develop nanoparticles incorporating fast dissolving film to enhance the solubility and bioavailability of nitrendipine. The nanoparticles and fast dissolving film were optimized and evaluated for various parameters, showing increased drug release and improved pharmacokinetics compared to conventional tablets. The development of nanoparticulate orodispersible film represents a promising approach to enhance the efficacy of nitrendipine for treating hypertension and angina pectoris.
Article
Polymer Science
Emrah Ozakar, Rukiye Sevinc-Ozakar, Bilal Yilmaz
Summary: Oral Thin Films (OTFs) are a new drug delivery system that can help patients who have difficulty swallowing or chewing solid dosage forms. In this study, OTFs containing pregabalin and methylcobalamin were developed successfully using solvent pouring method. The OTFs showed good flexibility, transparency, fast disintegration time, and acceptable taste and appearance.
Article
Chemistry, Applied
Chi-Hui Tsou, Zheng-Lu Ma, Manuel Reyes De Guzman, Lei Zhao, Juan Du, Wilfred Emori, Chen Gao, Yanchun Zhao, Tao Yang, Jintian Wu
Summary: In this study, exfoliated carboxylated graphene was used to prepare nanocomposite films of modified polyvinyl alcohol incorporated with maleic anhydride. The resulting films exhibited improved mechanical and barrier properties, as well as conductivity at high and low temperatures. The addition of carboxylated graphene also enhanced the water resistance and durability of the nanocomposite films.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Polymer Science
Chang-Lei Qu, Shang-Ming Lin, Pranut Potiyaraj, Lei Meng, Chin-San Wu, Li Yuan, Xin Luo, Fei-Fan Ge, Chi-Hui Tsou
Summary: This research focuses on developing a LDPE/TOS blend by incorporating thermally treated oyster shell powder (TOS) into low-density polyethylene (LDPE) to enhance food packaging materials. The blend exhibits advantageous characteristics in terms of mechanical strength, thermostability, water absorption, hydrophobicity, as well as improved barrier properties against water vapor transmission and antibacterial properties.
Article
Pharmacology & Pharmacy
Hiraku Onishi, Osamu Sakata
Summary: Etilefrine hydrochloride is an important drug for treating hypotension. The compacted buccal film containing ET demonstrated rapid absorption, maintained effective plasma levels for a long period, and had a satisfactory plasma concentration-time profile with a smaller standard error.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Biswajit Basu, Ankur Mankad, Ayon Dutta
Summary: This study aimed to design and optimize a methylphenidate hydrochloride mouth dissolving film for treating ADHD and narcolepsy. The results showed that different polymer amounts had complex effects on the drug release, disintegration time, and tensile strength of the film. The final formulation demonstrated rapid drug release and good tensile strength.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Umberto M. Musazzi, Chiara G. M. Gennari, Silvia Franz, Paola Minghetti, Francesco Cilurzo
Summary: Topical propranolol has been used for treating cutaneous infantile haemangiomas, but frequent applications are needed. This study developed propranolol patches using hot-melt ram extrusion printing, with formulations releasing the drug in a reasonable time and exhibiting suitable adhesive properties. The patch made of Eudragit RL and TBC with 1% propranolol hydrochloride is the most promising for superficial haemangiomas, while the patch made of Eudragit RL and ATEC with 1% propranolol base can be used for deep haemangiomas.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Silvia Franze, Francesco Rama, Paolo Rocco, Michela Debernardi, Valeria Bincoletto, Silvia Arpicco, Francesco Cilurzo
Summary: This study demonstrates the potential of controlling drug delivery in the skin by adjusting the amount of HA on the vesicle surface. Different phosphatidylethanolamine-HA conjugates impact the deformability of liposomes and the transdermal permeation of drugs, with higher HA extent favoring drug retention in the skin.
MOLECULAR PHARMACEUTICS
(2021)
Article
Instruments & Instrumentation
Michele Schlich, Umberto M. Musazzi, Virginia Campani, Marco Biondi, Silvia Franze, Francesco Lai, Giuseppe De Rosa, Chiara Sinico, Francesco Cilurzo
Summary: The skin is an important site for drug absorption, and recent research has supported the design of innovative nanosystems to improve the absorption of poorly skin-permeable drugs. However, topically applied liposomal systems face several challenges, making their clinical application difficult.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Virology
Rafaela Milan Bonotto, Francesco Boni, Mario Milani, Antonio Chaves-Sanjuan, Silvia Franze, Francesca Selmin, Tommaso Felicetti, Martino Bolognesi, Soultana Konstantinidou, Monica Poggianella, Chantal L. Marquez, Federica Dattola, Monica Zoppe, Giuseppe Manfroni, Eloise Mastrangelo, Alessandro Marcello
Summary: Pyridobenzothiazolone derivatives are a promising class of antiviral compounds with broad-spectrum activity. The HeE1-17Y derivative has been shown to be potent against flaviviruses and West Nile virus. It interacts directly with viral particles, compromising their infectivity. This compound alters the viral membrane and exhibits virucidal activity.
Article
Medicine, Research & Experimental
Stefano Bellosta, Francesca Selmin, Giulia Magri, Silvia Castiglioni, Patrizia Procacci, Patrizia Sartori, Edoardo Scarpa, Valerio Tolva, Clara Rossi, Francesco Puoci, Loris Rizzello, Francesco Cilurzo
Summary: This study demonstrates the use of grafting caffeic acid or resveratrol on a poly(lactide-co-glycolide) backbone (g-CA-PLGA or g-RV-PLGA) and fluvastatin as a drug for drug-eluting nanoparticles, which can effectively prevent restenosis after angioplasty.
MOLECULAR PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Francesca Selmin, Silvia Franze, Antonella Casiraghi, Francesco Cilurzo
Summary: Psoriasis is a complex disease that requires lifelong treatment, and combination therapy can improve its safety and efficacy. Fixed-dose topical formulations can simplify treatment and improve patient compliance. This review provides an overview of Cal/BD fixed-dose combination products on the market and discusses the differences among different formulations.
Article
Pharmacology & Pharmacy
Silvia Franze, Liliana Angelo, Antonella Casiraghi, Paola Minghetti, Francesco Cilurzo
Summary: The administration of drug fixed combinations by nanocarriers is an attractive approach to enhance the skin penetration and synergistic effects of drugs. This study investigated the use of deformable liposomes to deliver the combination of lidocaine and cannabidiol in the deeper layers of the skin. Results showed that the DiMiL formulation had higher skin permeation and dermal retention compared to the G-liposomes formulation, and both were more effective than control formulations carrying free drugs.
Article
Pharmacology & Pharmacy
Antonella Casiraghi, Andrea Gentile, Francesca Selmin, Chiara Grazia Milena Gennari, Eleonora Casagni, Gabriella Roda, Gloria Pallotti, Pierangela Rovellini, Paola Minghetti
Summary: In the past 20 years, the interest in medicinal cannabis oily extracts has grown, leading to the need for high quality preparations. This study systematically investigated the use of an ultrasonic homogenizer as an alternative extraction method and found that it can provide equivalent content in CBD and THC compared to the traditional hot maceration method, with the advantage of a faster process. The qualitative characteristics of the oil remained constant for both treatments.
Article
Medicine, Research & Experimental
Silvia Franze, Caterina Ricci, Elena Del Favero, Francesco Rama, Antonella Casiraghi, Francesco Cilurzo
Summary: This study investigated the advantages of combining proliposomes and DiMiL as drug carriers to enhance the skin penetration of CBD. Sucrose and trehalose were found to be the best carriers for spray-dried and slurried proliposomes, respectively. Cryo-EM images showed the presence of micelles in the aqueous core of lipid vesicles in the DiMiL system, and the presence of sugars did not alter the structural organization. CBD permeation through human epidermis was significantly improved when carried by DiMiL systems, and trehalose further increased the flux.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Giuseppe Francesco Racaniello, Monica Pistone, Chiara Meazzini, Angela Lopedota, Ilaria Arduino, Rosanna Rizzi, Antonio Lopalco, Umberto M. Musazzi, Francesco Cilurzo, Nunzio Denora
Summary: The aim of this study is to develop and produce novel oral mucoadhesive films delivering Clobetasol propionate (CBS) through Direct Powder Extrusion (DPE) 3D printing technique for paediatric treatment of Oral Lichen Planus (OLP). Different polymeric materials, such as hydroxypropylmethylcellulose or polyethylene oxide blended with chitosan (CS), were tested to obtain suitable mucoadhesive films. Hydroxypropyl-& beta;-cyclodextrin was added to enhance CBS solubility. The DPE-printed films showed strong adhesion, improved drug characteristics, and significant drug exposure time on the mucosa.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Umberto M. Musazzi, Silvia Franze, Fabrizio Condorelli, Paola Minghetti, Paolo Caliceti
Summary: New and innovative nanomedicines have revolutionized the prognosis of many human diseases. However, their peculiar physicochemical properties pose new challenges in regulatory approval. This article critically discusses the current open issues regarding regulatory qualification and physicochemical characterization of nanosystems, considering the current European regulatory framework on nanomedicine products. Practicable paths for improving their quality assurance and predicting their fate in vivo are also proposed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Venera R. Timergalieva, Chiara G. M. Gennari, Francesco Cilurzo, Francesca Selmin, Rouslan I. Moustafine
Summary: The aim of this study was to compare three different dissolution methods for drug release assessment in oral lyophilisates. Interpolyelectrolyte complexes (IPECs) were prepared using two different polymers and two model drugs. The drug release kinetics were evaluated using artificial saliva and three different set-ups. The results showed that the choice of set-up significantly influenced the drug release profiles.
SCIENTIA PHARMACEUTICA
(2023)
