Article
Biophysics
Ibrahima Youm, Matthew B. West, Xiangping Huang, Wei Li, Richard D. Kopke
Summary: The effects of sucrose on the physical stability, cellular entry pathways, and functional efficacy of PLGA-NPs were investigated in this study. The results showed that the addition of 10% sucrose significantly improved the physical stability and cellular uptake of HEI-101-NPs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is widely used in various biomedical applications due to its biodegradability and biocompatibility. This study successfully developed a method to synthesize syndioenriched, alternating PLGA from racemic methyl-glycolide (rac-MeG), and confirmed the high degree of alternation of the comonomer sequence and moderate syndiotacticity within the polymer backbone stereoconfiguration through NMR investigations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer used in biomedical applications. This study presents a method for synthesizing syndioenriched, alternating PLGA from racemic methyl-glycolide with the use of an optimized racemic aluminum catalyst. The resulting material has a high degree of alternation in copolymer sequence and moderate syndiotacticity, and is amorphous, making it suitable for drug complexation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Lei Gao, Jing Li, Tianhang Song
Summary: Cancer immunotherapy is a promising strategy that has revolutionized cancer therapy, with a particular emphasis on cancer vaccines and tumor microenvironment modulation.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Feipeng Yang, Maleen Cabe, Hope A. Nowak, Kelly A. Langert
Summary: In this study, different size groups of poly(lactic-co-glycolic) acid (PLGA) nanoparticles and chitosan-PLGA nanoparticle counterparts were prepared by adjusting key formulation parameters. The effects of size and surface modification on drug loading and release were investigated, and changes in mucoadhesion were quantified.
Review
Materials Science, Biomaterials
Jagan Mohan Dodda, Tomas Remis, Sadiku Rotimi, Yi-Cheun Yeh
Summary: This article provides an overview of PLGA-based conjugates in cancer research, focusing on their roles as targeted drug carriers and sustained drug controllers. The preparation and drug encapsulation of PLGA nanoparticles and FA-PEG-PLGA conjugates are discussed, with emphasis on the associated chemistries and biocompatibility. This review offers a deeper understanding of PLGA-conjugated materials for successful material design and biomedical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Physical
Guangliang Liu, Roberto Martinez, Anika Bhatnagar, Kathleen McEnnis
Summary: PLGA is a commonly used drug carrier in nanomedicines due to its biodegradability, biocompatibility, and low toxicity. The glass transition temperature (T-g), which is an indicator of drug release behavior, is often overlooked in the physico-chemical characterization and study of drug release. This study investigated the influence of polymeric (PVA) and ionic (DMAB) surfactants on the T-g of PLGA nanoparticles and found that the choice and residual amount of surfactant are crucial parameters in designing the physico-chemical properties of PLGA particles.
Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Review
Biotechnology & Applied Microbiology
Nasrullah Jan, Asadullah Madni, Safiullah Khan, Hassan Shah, Faizan Akram, Arshad Khan, Derya Ertas, Mohammad F. Bostanudin, Christopher H. Contag, Nureddin Ashammakhi, Yavuz Nuri Ertas
Summary: This article discusses the preparation methods and applications of cell membrane-coated PLGA nanoparticles, as well as their role in cancer therapy, inflammation management, cardiovascular disease treatment, and infection control. It also highlights the challenges and future research directions of cell membrane-camouflaged nanoparticles.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Victoria L. Messerschmidt, Uday Chintapula, Aneetta E. Kuriakose, Samantha Laboy, Thuy Thi Dang Truong, LeNaiya A. Kydd, Justyn Jaworski, Zui Pan, Hashem Sadek, Kytai T. Nguyen, Juhyun Lee
Summary: Notch signaling is crucial for embryonic development and organ regeneration, with loss of signal resulting in maldevelopment. Encapsulating Notch plasmid in nanoparticles made of poly(lactic-co-glycolic acid) can reestablish downstream signaling, showing non-toxicity, stability, compatibility with blood, and successful transfection of HUVECs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Dong-Hyun Kim, Thu Nhan Nguyen, Young-Min Han, Phuong Tran, Jinhyung Rho, Jae-Young Lee, Hwa-Young Son, Jeong-Sook Park
Summary: In this study, an intratympanic delivery system using PLGA nanoparticles and thermosensitive gels was developed for sustained release of dexamethasone. The system showed potential as a drug delivery system for the inner ear, with efficient drug release and minimal inflammatory response after administration.
Article
Materials Science, Multidisciplinary
Akhand Pratap Singh, Om Prakash, Sunil Kumar, Aparna Shukla, Pralay Maiti
Summary: The study demonstrates the suitability of poly(lactic acid-co-glycolic acid) (PLGA) as a sustained drug delivery vehicle for melanoma treatment. PLGA nanoparticles (NPs) and PLGA film encapsulated with paclitaxel (PTX) show greater efficacy in inhibiting melanoma cell proliferation and reducing tumor volume, compared to pure drug and control group. The sustained drug delivery systems also result in minimal damage to vital organs and fewer side effects.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Polymer Science
Jie Yan, Paula Facal Marina, Anton Blencowe
Summary: Poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) (PEG-PLGA) block copolymers and their thermoresponsive hydrogels have been widely studied for sustained drug delivery. The microstructure of these copolymers is highly sensitive to the reaction conditions, such as temperature and catalyst loading, which influence the occurrence and extent of side reactions during ring-opening polymerization. Our detailed study revealed that increasing the catalyst loading had negligible effects on side reactions but surprisingly increased the polymerization rate of lactide relative to glycolide. These findings provide valuable insights for the improved synthesis of PLGA-PEG-PLGA copolymers and their hydrogels.
Article
Pharmacology & Pharmacy
Anita Kirti Ghosh, Rubina Thapa, Harsh Nilesh Hariani, Michael Volyanyuk, Sean David Ogle, Karoline Anne Orloff, Samatha Ankireddy, Karen Lai, Agne Ziniauskaite, Evan Benjamin Stubbs Jr, Giedrius Kalesnykas, Jenni Johanna Hakkarainen, Kelly Ann Langert, Simon Kaja
Summary: This study demonstrated the pharmacological efficacy of xanthohumol in preclinical models for dry eye disease by promoting the transcription of phase II antioxidant enzymes. Xanthohumol-encapsulating PLGA nanoparticles showed cytoprotective effects against oxidative stress in vitro and reduced ocular surface damage in vivo, suggesting their potential as future therapeutic options for dry eye disease.
Review
Chemistry, Multidisciplinary
Linye Jiang, Jie Luo, Dawei Hong, Shuhong Guo, Shuyi Wang, Bizhong Zhou, Shiyu Zhou, Jingyan Ge
Summary: The research summarizes passive tumor-targeting strategies through the EPR effect and active tumor-targeting strategies through ligand modifications based on PLGA NPs for tumor-targeted drug delivery. Furthermore, new challenges and possible research opportunities are also discussed.
