Article
Chemistry, Physical
Ryan P. Collanton, Christopher J. Ellison, Kevin D. Dorfman
Summary: Block copolymers have been studied for their role in interface thermodynamics at homopolymer interfaces. The research finds that interface thermodynamics are more sensitive to block degree of polymerization than to the number of blocks. In addition, a strong correlation is identified between the spatial uniformity of block junctions on the interface and the reduction of interfacial tension.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Polymer Science
Ilsiya M. Davletbaeva, Alexander Yu. Alentiev, Zulfiya Z. Faizulina, Ilnaz I. Zaripov, Roman Yu. Nikiforov, Victor V. Parfenov, Alexander V. Arkhipov
Summary: In this study, organosubstituted silica derivatives were synthesized and used as modifiers for block copolymers, showing significant influence on the structure and gas transport properties of the modified polymers.
Article
Polymer Science
Henry Foster, Martina H. Stenzel, Robert Chapman
Summary: Compared to conventional techniques, photoinitiated electron/energy transfer-reversible addition-fragmentation chain transfer (PET-RAFT) allows for better control over the polymerization of multiblock star copolymers, avoiding the generation of termination products. This technique is also tolerant to oxygen, enabling the automated synthesis of multiblock star copolymers at short block lengths, providing a useful approach for screening the effect of polymer composition on solution structure.
Article
Polymer Science
Jinseok Park, Anne Staiger, Stefan Mecking, Karen Winey
Summary: This study reveals that by adjusting the structure of multiblock copolymers, the morphology of single-ion conducting polymers can be controlled, leading to improved ion transport efficiency.
Article
Chemistry, Multidisciplinary
Xiaohui Zhang, Weihua Li
Summary: We designed A(m)BCA(n) multiblock terpolymers and studied their self-assembly process. We successfully obtained four stable patchy spheres and clarified the regulation mechanism of the number of patches.
Article
Materials Science, Multidisciplinary
Marc Behl, Maria Balk, Ulrich Mansfeld, Andreas Lendlein
Summary: By modifying the chain length and sequence structure of building blocks in multiblock copolymers, the phase segregation is influenced, which in turn disrupts the crystallization behavior.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2021)
Article
Polymer Science
Tieshuai Zhao, Ben Drain, Gokhan Yilmaz, C. Remzi Becer
Summary: In this study, pentafluoro benzyl bromide was used as a clickable initiator for the cationic ring opening polymerization of poly(2-oxazolines) to synthesize various multiblock copolymers. By combining the para-fluoro-thiol click reaction with terminating agents in a one-pot approach, multiblock copolymers such as PEtOx-mb-PMeOx were successfully prepared. Characterization of the polymers was done using SEC, H-1 NMR, and MALDI-ToF mass spectrometry, and the self-assembly properties were studied using DLS and TEM, which showed nanoparticles with diameters ranging from 184 nm to 250 nm for the PEtOx-mb-PMeOx copolymers.
Article
Polymer Science
Marc Behl, Maria Balk, Karola Luetzow, Andreas Lendlein
Summary: The study investigates the impact of block length and sequence structure on phase segregation and elastic properties of multiblock copolymers, showing that MBCs with strictly alternating sequences favor phase segregation and higher elastic properties, but have lower elongation at break compared to MBCs with random sequences.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jinseok Park, Anne Staiger, Stefan Mecking, Karen Winey
Summary: By investigating the temperature, we explored the phase behavior and interaction parameter of polyethylene-based multiblock copolymers. These copolymers exhibit layered morphologies with semicrystalline polyethylene blocks, showing ultrahigh compatibility between polar ionic and nonpolar polyethylene segments.
Article
Engineering, Manufacturing
Xiaowen Wang, Paul Smith, Zhe Qiang, Qingbao Guan, Zhengwei You, Changhuai Ye, Meifang Zhu
Summary: In this study, conductive composites based on all-aromatic multiblock poly(esterimide)s (BPEI) and multilayer graphene (MLG) with well-defined segregated structure were successfully fabricated. These composites exhibited ultrahigh electrical conductivity and high EMI shielding effectiveness, along with high thermal stability and outstanding flame retardancy.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2022)
Article
Polymer Science
B. A. Drain, V. P. Beyer, B. Cattoz, C. R. Becer
Summary: Multiblock copolymers and cyclic polymers possess unique physical properties but their synthesis poses challenges due to the delicate balance required. The study reveals a surprising solvent dependence on cyclization reactions and provides insight into optimizing reaction conditions for obtaining desired ratios of step-growth and cyclization polymers. By manipulating catalyst concentration, polymer concentration, temperature, and reaction conditions, it is possible to achieve a higher proportion of cyclization over step-growth polymerization in specific systems.
Article
Polymer Science
Julien Morthomas, Veronica Viola, Victor Vallejo-Otero, Guilhem P. Baeza
Summary: In this study, coarse-grained molecular dynamics simulations are used to investigate the influence of chain topology on the structure and properties of crystallizable multiblock copolymers. It is found that the crystallization temperature is primarily determined by the length of the hard segments, regardless of the chain topology or the fraction of crystallizable units. However, the variation in topology results in significant structural differences, with ring and comb molecules forming more small and well-distributed crystallites compared to linear and star counterparts. This research contributes to the understanding of the structure-property relationship in thermoplastic elastomers and extends the fundamental knowledge of polymer crystallization.
Review
Polymer Science
Md. Mushfequr Rahman
Summary: This review focuses on the use of aliphatic polyethers as membrane materials for CO2 separation and discusses the design and structure-property relationships of multiblock copolymers.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Engineering, Chemical
Hortensia Maldonado-Textle, Enrique Javier Jimenez-Regalado, Claude St Thomas
Summary: This study reports the synthesis of thermo-associative water soluble multiblock copolymers and investigates the effect of thermo-responsive blocks on the thickening behavior of aqueous polymer solutions.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Polymer Science
Baotao Huang, Hao Xue, Yangyang Xiang, Yi Pan, Zhaohui Zheng, Xiaobin Ding, Jinni Deng
Summary: This paper discusses the preparation of fluorinated multiblock copolymers with micro-nano structures using macromolecular cross metathesis (MCM) method. The resulting copolymers exhibited good hydrophobicity, processability, and thermal stability. The micro-nano structures were also retained in the blends with polypropylene, leading to enhanced tensile mechanical properties and hydrophobicity. Furthermore, the melt-blending process greatly improved the antifouling durability of the copolymers compared to the solution coating method.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Instruments & Instrumentation
Sara Basile, Essyrose Mathew, Ida Genta, Bice Conti, Rossella Dorati, Dimitrios A. Lamprou
Summary: This study validated an optimized FDM 3D printing method for the manufacturing of personalized medical implants, particularly fistulas. Different types of filaments were produced using hot melt extrusion, and the printed fistulas were characterized using various physicochemical analysis methods. The results demonstrated that TPU material is suitable for 3D printing and successful drug loading. Drug release testing showed sustained release, meeting the requirements for implants in the patient's body.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Chemistry, Organic
Massimo Serra, Marco Terreni, Eric Bernardi, Lino Colombo
Summary: After their first synthesis in 1994, azabicycloalkane amino acids have gained increasing interest and become one of the most important classes of constrained dipeptide mimics. Incorporating them into peptidomimetic structures has allowed the synthesis of a wide range of biologically active compounds. However, methods for obtaining functionalized and easy-to-functionalize derivatives of these amino acids are still limited. This review focuses on the synthesis of functionalized azabicycloalkane amino acids from 2010 to the present, and discusses their recent applications in drug discovery.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Yu Gao, Sara Sparascio, Lorenzo Di Terlizzi, Massimo Serra, Guanglu Yue, Yaru Lu, Maurizio Fagnoni, Xia Zhao, Stefano Protti
Summary: Two visible-light mediated protocols for the synthesis of aryl thiocyanates and aryl selenocyanates from arylazo sulfones are presented. The reactions make use of the unique photoreactivity and redox activity of the substrates, and exhibit high yields and wide scope.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Medicinal
Ersilia De Lorenzi, Francesca Seghetti, Andrea Tarozzi, Letizia Pruccoli, Cecilia Contardi, Massimo Serra, Alessandra Bisi, Silvia Gobbi, Giulio Vistoli, Silvia Gervasoni, Carla Argentini, Giulia Ghirardo, Giulia Guarato, Genny Orso, Federica Belluti, Rita Maria Concetta Di Martino, Morena Zusso
Summary: Simultaneous modulation of multifaceted toxicity arising from neuroinflammation, oxidative stress, and mitochondrial dysfunction represents a valuable therapeutic strategy to tackle Alzheimer's disease. In this study, a small library of hybrid compounds targeting A beta protein oligomerisation and neurotoxic events was developed. Compound 4, bearing a substituted triazole moiety, emerged as a promising lead candidate to counteract A beta aggregation, neuroinflammation, and oxidative stress.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Erika M. M. Tottoli, Laura Benedetti, Enrica Chiesa, Silvia Pisani, Giovanna Bruni, Ida Genta, Bice Conti, Gabriele Ceccarelli, Rossella Dorati
Summary: This study proposes a new electrospun dressing called Biofiber as a solution to prevent hypertrophic scar formation in complex wounds. Biofiber has excellent wetting properties and good absorbency and moisture vapor transmission rate. By controlling the release of the natural antifibrotic agent Naringin, Biofiber can demonstrate prolonged antifibrotic effects on normal human dermal fibroblasts. However, the effect on inhibiting hypertrophic scar formation is not significant.
Article
Biochemistry & Molecular Biology
Mariella Rosalia, Pietro Grisoli, Rossella Dorati, Enrica Chiesa, Silvia Pisani, Giovanna Bruni, Ida Genta, Bice Conti
Summary: Vascular graft infections are a severe complication in vascular surgery, with high morbidity and mortality. Currently, there are no commercially available infection-proof small-diameter vascular grafts. In this study, two prototypes of small-diameter vascular grafts loaded with tobramycin were developed and tested for their antimicrobial activity. The prototypes showed sustained and diffusive driven drug release, with Prototype 1 being more efficient in killing bacterial populations. Overall, both prototypes exhibited good antimicrobial activity over the 5 days of in vitro testing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Silvia Pisani, Deborah Di Martino, Silvia Cerri, Ida Genta, Rossella Dorati, Giulia Bertino, Marco Benazzo, Bice Conti
Summary: In this study, four different active encapsulation methods were compared for loading a model protein into liposomes. Electroporation yielded the highest encapsulation efficiency, but led to a significant increase in liposome size. Freeze-thawing was an effective method, allowing for high encapsulation efficiency while maintaining suitable size. Charged liposomes showed slower in vitro release and good cytocompatibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Giacomo Rossino, Emanuela Marchese, Giovanni Galli, Francesca Verde, Matteo Finizio, Massimo Serra, Pasquale Linciano, Simona Collina
Summary: Peptides have the potential to be potent, selective, and safe therapeutical agents and have reshaped the pharmaceutical landscape. However, traditional peptide synthesis processes are environmentally draining and require sustainable alternatives. This review discusses the importance of applying green chemistry principles to peptide synthesis for achieving a green transition era in the pharmaceutical field.
Article
Polymer Science
Erika Maria Tottoli, Laura Benedetti, Federica Riva, Enrica Chiesa, Silvia Pisani, Giovanna Bruni, Ida Genta, Bice Conti, Gabriele Ceccarelli, Rossella Dorati
Summary: This study proposes a new type of dressing, Biofiber PF, loaded with Pirfenidone, for the treatment of HTSs in complex wounds. It has antifibrotic properties and promotes physiological healing by modulating the fibrotic process.
Article
Pharmacology & Pharmacy
Silvia Pisani, Valeria Mauri, Erika Negrello, Valeria Friuli, Ida Genta, Rossella Dorati, Giovanna Bruni, Stefania Marconi, Ferdinando Auricchio, Andrea Pietrabissa, Marco Benazzo, Bice Conti
Summary: In this study, hybrid scaffolds were developed as a versatile platform for soft tissue regeneration. These scaffolds exhibited favorable cell adhesion and proliferation, and allowed for controlled drug release.
