Article
Cell Biology
Dylan Jones, Clarissa A. Whitehead, Marija Dinevska, Samuel S. Widodo, Liam M. Furst, Andrew P. Morokoff, Andrew H. Kaye, Katharine J. Drummond, Theo Mantamadiotis, Stanley S. Stylli
Summary: Glioblastoma is a highly invasive and destructive brain tumor, and current standard treatments often fail to effectively eliminate it. In this study, we investigate the effects of several FDA-approved drugs on the invasion and viability of GBM cells. We found that these drugs can reduce cell invasion and viability, suggesting their potential as therapeutic options for GBM.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Haotian Li, Tingting Li, Liangsheng Zhang, Qiao Hu, Xia Liao, Qinggen Jiang, Xiuxiu Qiu, Lu Li, Roger R. Draheim, Qi Huang, Rui Zhou
Summary: This study identified five compounds from the FDA-approved drug library that showed high antimicrobial activity against Streptococcus suis, with floxuridine displaying potent in vivo efficacy, indicating its potential for further development.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mahsa Vaezzadeh, Ehsan Kachooei, Shivani Krishnamurthy, Preeti Manandhar, Annemarie Nadort, Gilles J. Guillemin, Antonio Di Ieva, Marina Santiago, Benjamin Heng, Anna Guller
Summary: Combination drug therapy is a promising strategy to improve treatment outcomes for glioblastoma patients. However, there is a lack of clarity in drug testing using 3D in vitro models of glioblastoma. This review explores the available literature on the application of temozolomide (TMZ) in 3D in vitro models of glioblastoma, providing a roadmap for future combination treatment research.
ADVANCED THERAPEUTICS
(2023)
Article
Immunology
Linda Voss, Karina Guttek, Annika Reddig, Annegret Reinhold, Martin Voss, Burkhart Schraven, Dirk Reinhold
Summary: Screening FDA-approved drug library identified ADV as a potent compound inhibiting T cell proliferation and affecting various cellular functions. ADV treatment induced DNA damage, cell cycle arrest, and activation of apoptosis pathway, suggesting its potential as a candidate for treating T cell-mediated autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Lucie Peyclit, Sophie Alexandra Baron, Linda Hadjadj, Jean-Marc Rolain
Summary: This study collected a group of multidrug-resistant bacteria and conducted a high-throughput screening of a drug library, finding that multiple drugs have inhibitory effects on these bacteria, some of which also have anticancer activity. Drug repurposing is a promising strategy for specific bacteria.
Review
Medicine, Research & Experimental
Brandon Wee Siang Phon, Muhamad N. A. Kamarudin, Saatheeyavaane Bhuvanendran, Ammu K. Radhakrishnan
Summary: This study analyzed transcriptomic data between 3D and 2D models of GBM, finding that 63% of genes were upregulated in 3D models. These upregulated genes are associated with GBM stemness, epithelial to mesenchymal transition, hypoxia, and migration-related genes, showing similarities to primitive tumor phenotypes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Federica Fabro, Nynke M. Kannegieter, Erik L. de Graaf, Karla Queiroz, Martine L. M. Lamfers, Anna Ressa, Sieger Leenstra
Summary: Glioblastoma is the most deadly brain cancer with poor response to treatment. In this study, 2D and 3D models were used to investigate the effects of small protein kinase inhibitors on patient-derived glioblastoma. The results showed inter-patient variability in drug response, with the ErbB signaling pathway playing a role. It was also observed that the choice of model influenced the analysis of kinases. A new resistance mechanism derived from imatinib treatment was identified in one sample.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Janith Wanigasekara, Lara F. Carroll, Patrick Cullen, Brijesh Tiwari, James Curtin
Summary: Three-dimensional (3D) cell culture models can effectively simulate the natural in vivo environment, shape, tissue stiffness, stressors, gradients, and cellular response, bridging the gap between in vitro cell cultures and in vivo responses, without the associated costs and ethical concerns of animal models.
Article
Environmental Sciences
Mohammad A. Elmorsy, Ahmed M. El-Baz, Nashwa H. Mohamed, Rafa Almeer, Mohamed M. Abdel-Daim, Galal Yahya
Summary: This study involved computational screening of FDA-approved drugs against specific proteins of COVID-19, identifying several antibiotics and mouth rinsing solutions showing promising binding stability with the virus targets. Heartburn drugs did not show significant binding affinity, while angiotensin II blockers used as antihypertensive drugs were suggested to have a therapeutic effect against COVID-19.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Microbiology
Shivani Gargvanshi, William G. Gutheil
Summary: This study screened 1,000 FDA-approved drugs and their metabolites against vancomycin-resistant bacteria and identified potentially synergistic combinations with vancomycin. Several drugs were confirmed to have synergistic effects in follow-up assays.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Medicinal
Zhonglei He, Clara Charleton, Robert W. Devine, Mark Kelada, John M. D. Walsh, Gillian E. Conway, Sebnem Gunes, Julie Rose Mae Mondala, Furong Tian, Brijesh Tiwari, Gemma K. Kinsella, Renee Malone, Denis O'Shea, Michael Devereux, Wenxin Wang, Patrick J. Cullen, John C. Stephens, James F. Curtin
Summary: Pyrazolopyrimidinones are core scaffold in many pharmaceutically relevant compounds and have been demonstrated to be efficient in treating several diseases. This study tested the cytotoxic effects of 15 pyrazolopyrimidinones in combination with cold atmospheric plasma (CAP) on glioblastoma U-251MG cell line, and identified two drugs with enhanced cytotoxicity when combined with CAP. These findings suggest the potential of using CAP combined with pyrazolopyrimidinones as a programmable cytotoxic therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Paschalis Athanasiadis, Balaguru Ravikumar, Richard J. R. Elliott, John C. Dawson, Neil O. Carragher, Paul A. Clemons, Timothy Johanssen, Daniel Ebner, Tero Aittokallio
Summary: Designing a targeted screening library of bioactive small molecules is a challenging task due to the complexity of compound-protein interactions. In this study, we developed analytic procedures to design anticancer compound libraries that consider factors such as library size, cellular activity, chemical diversity, and target selectivity. The resulting compound collections cover a wide range of protein targets and biological pathways implicated in various cancers, making them valuable for precision oncology. In a pilot screening study, we identified patient-specific vulnerabilities using a physical library of compounds, highlighting the heterogeneity of phenotypic responses across patients and glioblastoma subtypes.
Article
Pharmacology & Pharmacy
Zara Ahmad Khan, Yuli Hu, Behafarid Ghalandari, Mashaal Ahmad, Aynur Abdullah, Lai Jiang, Xianting Ding
Summary: This study aimed to investigate the synthetic cytotoxicity interaction between Paxlovid and 100 frequently used small molecule drugs and further explore the structural modulation through molecular docking simulation with Caspase-8.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Scott B. Biering, Erik Van Dis, Eddie Wehri, Livia H. Yamashiro, Xammy Nguyenla, Claire Dugast-Darzacq, Thomas G. W. Graham, Julien R. Stroumza, Guillaume R. Golovkine, Allison W. Roberts, Daniel M. Fines, Jessica N. Spradlin, Carl C. Ward, Teena Bajaj, Dustin Dovala, Ursula Schulze-Gamen, Ruchika Bajaj, Douglas M. Fox, Melanie Ott, Niren Murthy, Daniel K. Nomura, Julia Schaletzky, Sarah A. Stanley
Summary: The COVID-19 pandemic has posed a major global health threat, with an urgent need for safe and effective therapeutic options. By repurposing known clinical compounds, it is possible to rapidly identify drugs effective against SARS-CoV-2.
ACS INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Yujin Park, Kang Moo Huh, Sun-Woong Kang
Summary: The evaluation of drug efficacy and toxicity is crucial for the development of new drugs, with 3D cell culture playing a significant role in simulating human tissue functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anne-Laure Cattin, Jemima J. Burden, Lucie Van Emmenis, Francesca E. Mackenzie, Julian J. A. Hoving, Noelia Garcia Calavia, Yanping Guo, Maeve McLaughlin, Laura H. Rosenberg, Victor Quereda, Denisa Jamecna, Ilaria Napoli, Simona Parrinello, Tariq Enver, Christiana Ruhrberg, Alison C. Lloyd
Article
Biochemistry & Molecular Biology
V. Quereda, E. Porlan, M. Canamero, P. Dubus, M. Malumbres
CELL DEATH AND DIFFERENTIATION
(2016)
Article
Cell Biology
Laura H. Rosenberg, Marie Lafitte, Victor Quereda, Wayne Grant, Weimin Chen, Mathieu Bibian, Yoshihiko Noguchi, Mohammad Fallahi, Chunying Yang, Jenny C. Chang, William R. Roush, John L. Cleveland, Derek R. Duckett
SCIENCE TRANSLATIONAL MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Andrii Monastyrskyi, Napon Nilchan, Victor Quereda, Yoshihiko Noguchi, Claudia Ruiz, Wayne Grant, Michael Cameron, Derek Duckett, William Roush
BIOORGANIC & MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Andrii Monastyrskyi, Simon Bayle, Victor Quereda, Wayne Grant, Michael Cameron, Derek Duckett, William Roush
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Hematology
Esther Rodriguez-Diez, Victor Quereda, Florian Bellutti, Michaela Prchal-Murphy, David Partida, Manuel Eguren, Karoline Kollmann, Marta Gomez de Cedron, Pierre Dubus, Marta Canamero, Dolores Martinez, Veronika Sexl, Marcos Malumbres
Article
Cell Biology
Laura H. Rosenberg, Anne-Laure Cattin, Xavier Fontana, Elizabeth Harford-Wright, Jemima J. Burden, Ian J. White, Jacob G. Smith, Ilaria Napoli, Victor Quereda, Cristina Policarpi, Jamie Freeman, Robin Ketteler, Antonella Riccio, Alison C. Lloyd
Article
Biochemistry & Molecular Biology
Ainhoa Nieto, Makoto R. Hara, Victor Quereda, Wayne Grant, Vanessa Saunders, Kunhong Xiao, Patricia H. McDonald, Derek R. Duckett
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Oncology
Victor Quereda, Simon Bayle, Francesca Vena, Sylvia M. Frydman, Andrii Monastyrskyi, William R. Roush, Derek R. Duckett
Article
Oncology
Francesca Vena, Simon Bayle, Ainhoa Nieto, Victor Quereda, Massimiliano Aceti, Sylvia M. Frydman, Samer S. Sansil, Wayne Grant, Andrii Monastyrskyi, Patricia McDonald, William R. Roush, Mingxiang Teng, Derek Duckett
MOLECULAR CANCER THERAPEUTICS
(2020)
Meeting Abstract
Oncology
Francesca Vena, Max Aceti, Simon Bayle, Victor Quereda, Andrii Monastyrskyi, William Roush, Derek Duckett
Meeting Abstract
Oncology
V. Quereda, S. Bayle, V. Francesca, M. Andrii, R. William, D. Derek
Meeting Abstract
Oncology
S. Bayle, M. Lafitte, V. Quereda, W. R. Roush, D. R. Duckett
Article
Pharmacology & Pharmacy
Vanessa C. Saunders, Marie Lafitte, Isabel Adrados, Victor Quereda, Daniel Feurstein, YuanYuan Ling, Mohammad Fallahi, Laura H. Rosenberg, Derek R. Duckett
MOLECULAR PHARMACOLOGY
(2015)