Application of Native ESI-MS to Characterize Interactions between Compounds Derived from Fragment-Based Discovery Campaigns and Two Pharmaceutically Relevant Proteins

Insight into Signal Response of Protein Ions in Native ESI-MS from the Analysis of Model Mixtures of Covalently Linked Protein Oligomers

(2017) Katharina Root et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination

(2016) Lucy A. Woods et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP

(2015) Gianni Chessari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Screening Carbohydrate Libraries for Protein Interactions Using the Direct ESI-MS Assay. Applications to Libraries of Unknown Concentration

(2014) Elena N. Kitova et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Influence of Dimehylsulfoxide on Protein–Ligand Binding Affinities

(2013) Dragana Cubrilovic et al.   ANALYTICAL CHEMISTRY

Fragment Screening by Native State Mass Spectrometry

(2013) Sally-Ann Poulsen   AUSTRALIAN JOURNAL OF CHEMISTRY

Detergent-free mass spectrometry of membrane protein complexes

(2013) Jonathan T S Hopper et al.   NATURE METHODS

Mass spectrometry of intact membrane protein complexes

(2013) Arthur Laganowsky et al.   Nature Protocols

Fragment-Based Approaches in Drug Discovery and Chemical Biology

(2012) Duncan E. Scott et al.   BIOCHEMISTRY

Quantifying Protein-Ligand Binding Constants using Electrospray Ionization Mass Spectrometry: A Systematic Binding Affinity Study of a Series of Hydrophobically Modified Trypsin Inhibitors

(2012) Dragana Cubrilovic et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Weak affinity chromatography as a new approach for fragment screening in drug discovery

(2011) Minh-Dao Duong-Thi et al.   ANALYTICAL BIOCHEMISTRY

Automated Protein–Ligand Interaction Screening by Mass Spectrometry

(2011) Hannah J. Maple et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein Conformation and Supercharging with DMSO from Aqueous Solution

(2011) Harry J. Sterling et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Quantifying Protein-Fatty Acid Interactions Using Electrospray Ionization Mass Spectrometry

(2011) Lan Liu et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors

(2010) Nyssa Drinkwater et al.   BIOCHEMICAL JOURNAL

A Method for Removing Effects of Nonspecific Binding on the Distribution of Binding Stoichiometries: Application to Mass Spectroscopy Data

(2010) Liat Shimon et al.   BIOPHYSICAL JOURNAL

NMR quantification using an artificial signal

(2010) Roger D. Farrant et al.   MAGNETIC RESONANCE IN CHEMISTRY

Native MS: an ’ESI‚ way to support structure- and fragment-based drug discovery

(2009) Valerie Vivat Hannah et al.   Future Medicinal Chemistry

Electrospray: From ions in solution to ions in the gas phase, what we know now

(2009) Paul Kebarle et al.   MASS SPECTROMETRY REVIEWS

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry

Identification ofN-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design†

(2008) Paul G. Wyatt et al.   JOURNAL OF MEDICINAL CHEMISTRY