Review
Nutrition & Dietetics
Michael D. Thompson, Brian J. DeBosch
Summary: With the increasing consumption of fructose in the diet, the impact of fructose exposure during pregnancy and lactation has gained significance. While human studies have established the effect of fructose consumption on maternal health, little is known about its impact on offspring. Animal models have shown an association between maternal fructose exposure and chronic diseases in offspring.
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, Chih-Yao Hou, Wei-Hsuan Hsu, You-Lin Tain
Summary: Metabolic syndrome (MetS) has developmental origins, which can be programmed by adverse early-life conditions. Early interventions have potential to prevent MetS, and mechanism-targeted strategies including antioxidants and probiotics are being explored. Further research is needed to determine insults, mechanisms, and reprogramming strategies for clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Hiroaki Itoh, Megumi Ueda, Misako Suzuki, Yukiko Kohmura-Kobayashi
Summary: Metabolic syndrome, associated with obesity, increases the risk of type 2 diabetes, coronary diseases, stroke, and other disabilities. The Developmental Origins of Health and Disease (DOHaD) theory suggests that early developmental environmental imbalance affects health and predisposes individuals to non-communicable diseases, including metabolic syndrome. The 'Thrifty Phenotype' hypothesis proposes that undernourished fetuses develop evolutionary advantageous traits for survival in a hangry environment after birth, but this phenotype increases the risk of metabolic syndrome under an obesogenic diet. Chronic inflammation, referred to as 'Metaflammation', is believed to mediate the connection between obesity and metabolic disorders in metabolic syndrome. However, the contribution of evolutionary maladaptation to the pathophysiology of 'Metaflammation' remains understudied. Investigating 'Metaflammation' from the perspective of selective advantages and mismatches to contemporary lifestyles can provide valuable insights, considering the concept of evolutionarily conserved nutrient sensing and immune signaling systems.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: The cardiovascular system can be programmed by early-life insults, potentially leading to cardiovascular disease in adulthood. Hydrogen sulfide plays a crucial role in the pathogenesis of cardiovascular disease of developmental origins, with early interventions based on H2S showing benefits in preventing adult-onset CVD. Understanding cardiovascular programming and recent advances in H2S-based interventions may help lower the global burden of CVD.
Article
Biochemistry & Molecular Biology
Chien-Ning Hsu, Julie Y. H. Chan, Kay L. H. Wu, Hong-Ren Yu, Wei-Chia Lee, Chih-Yao Hou, You-Lin Tain
Summary: The study found that high-fructose diet and minocycline treatment, both individually and combined, resulted in elevated blood pressure in adult male offspring, with no synergistic effect between the two. Different groups showed distinct enterotypes. Minocycline treatment increased the F/B ratio but decreased the abundance of genera Lactobacillus, Ruminococcus, and Odoribacter. Additionally, minocycline treatment led to lower levels of plasma acetic acid and butyric acid.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: The developmental origins of health and disease theory suggests that many adult-onset diseases can originate in early life. Oxidative stress plays a crucial role in renal programming, and perinatal use of antioxidants can reverse programming processes and prevent adult-onset diseases.
Article
Nutrition & Dietetics
Chien-Ning Hsu, Hong-Ren Yu, Julie Y. H. Chan, Kay L. H. Wu, Wei-Chia Lee, You-Lin Tain
Summary: Excessive or insufficient maternal nutrition can affect fetal development and the susceptibility of offspring to adult diseases. Maternal fructose intake has an increasing relevance to offspring health, as it can alter the gut microbiome and lead to metabolic disorders. Animal models have shown that maternal fructose consumption causes various metabolic syndrome components in adult offspring. However, the involvement of gut microbiome in fructose-induced developmental programming and the risks for chronic disease in offspring are not well understood.
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Hypertension is a significant global disease burden and can originate in early life. Melatonin, a hormone with multifaceted biological functions, plays important roles in pregnancy, fetal development, and blood pressure regulation. Early melatonin therapy as a reprogramming strategy can protect against the early life origins of hypertension.
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: Animal models are essential for investigating the causal relationship between early-life exposure and the developmental programming of hypertension, providing insights into how early interventions can reprogram disease processes and prevent hypertension.
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, Chih-Yao Hou, You-Lin Tain
Summary: This review highlights the link between cardiovascular and renal programming with developmental origins of CVD and kidney disease, discussing the positive influence of resveratrol on these diseases and its role as a reprogramming agent in animal studies. Further research is needed to clarify the reprogramming effects of resveratrol before clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ying-Hua Huang, You-Lin Tain, Chien-Ning Hsu
Summary: This review summarizes the research on the impact of environmental factors on the development of metabolic syndrome and the interaction between gut microbiota and other mechanisms. It also discusses experimental animal models of gut microbiota-targeted interventions and their potential in preventing metabolic syndrome. Although the effects on pregnant women are still unclear, gut microbiota-targeted therapies show promise in early intervention against metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Chien-Ning Hsu, You-Lin Tain
Summary: To reduce the global burden of kidney disease and hypertension, urgent action is needed to identify toxic chemicals in the environment, avoid harmful chemical exposure during pregnancy and lactation, and translate effective reprogramming interventions from animal studies into clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: This review discusses the innovative use of animal models in studying the mechanisms behind developmental origins of hypertension. Research has found that early maternal stress can alter the gut microbiota, leading to adverse outcomes in offspring. Dysbiosis of the gut microbiota is involved in the developmental origins of hypertension, while targeted therapy for the gut microbiota can prevent hypertension in later life.
Review
Physiology
Daniel J. Hoffman, Theresa L. Powell, Emily S. Barrett, Daniel B. Hardy
Summary: Nearly 2 billion adults worldwide are overweight, with over half classified as obese, and nearly one-third of global children experience poor growth and development. The global epidemic of obesity and double burden of malnutrition, where overweight coexists with underweight and micronutrient deficiencies, poses a significant challenge to human health. Understanding the developmental origins of health and disease (DOHaD) is crucial in addressing the global issues of obesity and chronic diseases.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Oxidative stress plays a crucial role in the developmental origins of hypertension, as early-life oxidative stress leads to developmental programming in key blood pressure-controlled organs and subsequently results in hypertension in adulthood. Antioxidant therapy has the potential to lower blood pressure and serves as a novel preventive strategy for hypertension with developmental origins.
Article
Medicine, General & Internal
Wei-Chia Lee, Kay L. H. Wu, You -Lin Tain, Steve Leu, Yuan-Tso Cheng, Julie Y. H. Chan
Summary: This study investigated the common mechanisms between metabolic syndrome and overactive bladder caused by fructose exposure in rats. Dysregulated insulin signaling was found at the bladder mucosa, leading to bladder overactivity in rats with fructose-induced metabolic syndrome. These findings highlight the importance of understanding the role of insulin signaling in bladder function.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Environmental Sciences
Li-Yuan Bai, Kay Li-Hui Wu, Chang-Fang Chiu, Hong-Chu Chao, Wei-Yu Lin, Jing-Lan Hu, Bo-Rong Peng, Jing-Ru Weng
Summary: Oral squamous cell carcinoma (OSCC) is a common type of cancer that requires new therapeutic strategies. In this study, the anti-proliferative effects of Ficus septica bark extract (FSB) on OSCC cells were examined. The results showed that FSB could reduce the viability of OSCC cells in a concentration-dependent manner, induce apoptosis, increase reactive oxygen species generation, inhibit cell migration, and modulate the levels of cell adhesion molecules. Furthermore, a lignan compound isolated from FSB showed antitumor effects on OSCC cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Behavioral Sciences
Mu-Hui Fu, Chih-Cheng Huang, Kay L. H. Wu, Ying-Fa Chen, Yu-Chih Kung, Cheng-Chang Lee, Jia-Shou Liu, Min-Yu Lan, Yung-Yee Chang
Summary: This study found that the presence of NPH-like MRI features is higher in PSP patients, and this tendency is associated with the determination of parkinsonism subtype. This suggests that these two diseases have common pathophysiological characteristics. More diagnostic tools are needed to better differentiate the two diseases and determine the treatment.
BRAIN AND BEHAVIOR
(2023)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Oxidative stress occurs when the production of reactive oxygen or nitrogen species exceeds the capacity of antioxidant systems. It has a significant impact on kidney development and can lead to kidney disease in adulthood. Evaluating biomarkers allows us to assess oxidative stress in fetuses and neonates. Animal models have provided valuable insights into the mechanisms of renal programming related to oxidative stress and interventions to prevent kidney disease. This comprehensive review examines the effects of perinatal oxidative stress on renal programming, the role of antioxidant strategies in kidney disease prevention, and the challenges in translating findings from animal models to clinical practice.
Article
Pediatrics
You-Lin Tain, Chien-Ning Hsu
Summary: The disruption of gut microbiota composition and structure, known as dysbiosis, plays a crucial role in the development of kidney diseases. Understanding the connection between dysbiotic gut microbiota and pediatric renal diseases is important for the prevention and treatment of these conditions. This review explores the link between dysbiotic gut microbiota and various pediatric renal diseases and discusses potential gut microbiota-targeted therapies.
Review
Biochemistry & Molecular Biology
Yu-Chen Chen, Wei-Chia Lee, Yao-Chi Chuang
Summary: Urinary tract infections (UTIs) are common bacterial infections in healthcare settings, with a high rate of recurrence. Conventional antibiotic management may lead to multidrug-resistant uropathogens. Therefore, alternative non-antibiotic solutions targeting the pathogenicity of UTIs and inadequate host defenses are being explored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kuo-Shu Tang, Chun-Yi Ho, Chien-Ning Hsu, You-Lin Tain
Summary: Melatonin, a hormone released by the pineal gland at night, has various functions and plays a crucial role in kidney health and disease. As the prevalence of chronic kidney disease continues to rise, it is important to find a strategy to not only treat but also prevent it. This review examines the effect of melatonin on kidney development, its clinical uses in early life, preventive applications in animal models, and considerations for melatonin supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Biochemistry & Molecular Biology
I. Chun Lin, Chih-Wei Wu, You-Lin Tain, I-Chun Chen, Chun-Ying Hung, Kay L. H. Wu
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Hsi-Yun Liu, Chen-Hao Lee, Chien-Ning Hsu, You-Lin Tain
Summary: A balanced diet during gestation is crucial for fetal development, and excessive intake of saturated fats during this period is linked to increased risk of offspring kidney disease. Maternal high-fat diet influences kidney health and disease in offspring through renal programming. This review summarizes preclinical research on the connection between maternal high-fat diet during gestation and lactation and offspring kidney disease, the molecular mechanisms behind renal programming, and early-life interventions to mitigate adverse programming effects. Animal models suggest that perinatal supplementation with polyunsaturated fatty acids, changes in gut microbiota, and modulation of nutrient-sensing signals can improve offspring kidney health. These findings emphasize the importance of a balanced maternal diet for offspring kidney health.
Article
Nutrition & Dietetics
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Hong-Tai Tzeng, Wei-Chia Lee, Kay L. H. Wu, Hong-Ren Yu, Julie Y. H. Chan, Chien-Ning Hsu
Summary: Maternal nutrition plays a crucial role in adult disease development. Excessive fructose intake by mothers contributes to hypertension in their offspring. New evidence suggests a connection between early-life gut microbiota and later hypertension. This study aimed to investigate if maternal supplementation of butyrate or propionate can prevent hypertension in offspring exposed to a high-fructose diet.
Article
Biochemistry & Molecular Biology
You-Lin Tain, Hung-Wei Yang, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
Summary: This study investigated the use of Cu/ZIF-8 nanoparticles to deliver GSNO and effectively reduce hypertension and improve kidney function in a pediatric CKD model. The nanoparticles enhanced endogenous NO generation, reduced renal oxidative stress, and downregulated the renin-angiotensin system. This research has the potential to improve the treatment of pediatric CKD.
Article
Nutrition & Dietetics
You-Lin Tain, Guo-Ping Chang-Chien, Sufan Lin, Chih-Yao Hou, Chien-Ning Hsu
Summary: This study demonstrates that treatment with Antrodia cinnamomea improves kidney function, proteinuria, and hypertension in children with chronic kidney disease. Low-dose treatment with Antrodia cinnamomea also increases plasma concentrations of short-chain fatty acids and enriches beneficial bacteria in the gut.
Article
Medicine, General & Internal
Wei-Ling Chen, Wei-Ting Liao, Chien-Ning Hsu, You-Lin Tain
Summary: Cardiovascular disease is a major cause of mortality and morbidity in children with chronic kidney disease (CKD). The causes of pediatric CKD differ from adults, with congenital anomalies in the kidney and urinary tract being the leading causes in childhood. This study identified pregnancy zone protein (PZP) as a potential marker for cardiovascular risk in CKD children and found associations between PZP and arterial stiffness, blood pressure abnormalities, and nitric oxide levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zong-Sheng Wu, Hung-Jen Wang, Wei-Chia Lee, Hou Lun Luo, Tsu-Kung Lin, Yao-Chi Chuang
Summary: Low-energy shock wave (LESW) treatment has therapeutic effects on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and this study investigated its mechanism of action. In a rat model of carrageenan-induced prostatitis, LESW treatment suppressed prostatic pain, inflammatory reaction, and expression of sensory molecules. These findings suggest a link between the neuroinflammatory effects of LESW in CP/CPPS and imbalances in mitochondrial dynamics in the prostate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)