Article
Biochemistry & Molecular Biology
Lorena Perez-Carrillo, Isaac Gimenez-Escamilla, Luis Martinez-Dolz, Ignacio Jose Sanchez-Lazaro, Manuel Portoles, Esther Rosello-Lleti, Estefania Tarazon
Summary: Disturbances in sphingolipid metabolism contribute to the development of heart failure by causing an accumulation of ceramide and S1P in cardiac tissue, as well as an increase in the ceramide/S1P ratio. Therapeutic gene modulation aimed at restoring ceramide levels or reversing the ceramide/S1P ratio could be a potential treatment strategy for heart failure patients.
Review
Cell Biology
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo
Summary: Psoriasis is a chronic skin condition that lacks a complete cure. Recent studies have identified sphingolipid metabolites as significant contributors to psoriasis, particularly ceramide and sphingosine-1-phosphate (S1P). The modulation of S1P and its receptor has shown potential in improving psoriasis inflammation.
Review
Biochemistry & Molecular Biology
Mateusz Matwiejuk, Hanna Mysliwiec, Adrian Chabowski, Iwona Flisiak
Summary: Psoriasis is a complex, chronic, immunologically mediated disease that is associated with numerous other diseases. It can cause impairment of quality of life and may be associated with depressive disorders. The pathophysiology of psoriasis and its comorbidities is not fully understood yet, and disrupted metabolism of sphingolipids may be the link between them.
Review
Urology & Nephrology
Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni, Sandra Merscher
Summary: Recent studies have shown that sphingolipids and sphingolipid metabolites play important roles in the pathogenesis and progression of kidney diseases by influencing the intracellular sphingolipid composition of renal cells and the integrity of the glomerular filtration barrier. The sphingolipid metabolite S1P plays a crucial role in renal cells, and aberrant S1P signaling contributes to the pathogenesis and progression of kidney diseases.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Oncology
Antonia Piazzesi, Sumaiya Yasmeen Afsar, Gerhild Van Echten-Deckert
Summary: Cancer development is a complex process involving overcoming obstacles such as unrestricted proliferation, invasion, nutrient supply, and metastasis, while evading the immune system. Inflammation plays a role in cancer development, with sphingolipid metabolism impacting cells' progression from healthy to cancerous phenotypes.
MOLECULAR ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Yanfei Qi, Wei Wang, Ziyu Song, Gulibositan Aji, Xin Tracy Liu, Pu Xia
Summary: Sphingolipids play a crucial role in cell membrane structure and intracellular signaling pathways. Sphingosine kinase (SphK) is an important enzyme in sphingolipid metabolism, with implications in both physiological and pathological processes, including type 2 diabetes mellitus (T2D). There is ongoing debate about the specific role of SphK in T2D, but it is believed to be a potential target for future anti-diabetes therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Chiara D'Aprile, Simona Prioni, Laura Mauri, Alessandro Prinetti, Sara Grassi
Summary: Lipid rafts are specialized membrane domains enriched in gangliosides, sphingomyelin, cholesterol, and proteins involved in signal transduction, modulating cell homeostasis. Sphingosine 1-phosphate participates in various signal transduction processes, with enzymes and receptors often localized in lipid rafts.
CELLULAR SIGNALLING
(2021)
Review
Pharmacology & Pharmacy
Gerhild van Echten-Deckert
Summary: Lipids are essential components of the CNS, and sphingolipids, a type of lipid, are highly concentrated in the brain. Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, has complex effects on the brain, which can be both beneficial and detrimental. However, the role of S1P in brain development and various brain pathologies is still controversial.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Colin Niaudet, Bongnam Jung, Andrew Kuo, Steven Swendeman, Edward Bull, Takahiro Seno, Reed Crocker, Zhongjie Fu, Lois E. H. Smith, Timothy Hla
Summary: This study reveals the significance of S1P in vascular development. Activation of endothelial S1PR1 by circulating HDL-S1P can suppress neovascularization in retinopathy. These findings suggest that circulating HDL-S1P activation of endothelial S1PR1 serves as a protective mechanism against neovascular retinopathy.
EMBO MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Leiye Yu, Licong He, Bing Gan, Rujuan Ti, Qingjie Xiao, Hongli Hu, Lizhe Zhu, Sheng Wang, Ruobing Ren
Summary: This study reveals the activation and regulation mechanism of human S1PR1 receptor through cryo-electron microscopy analysis. The S1PR1 receptor plays an essential role in the immune and vascular systems, and understanding its function in depth contributes to the development of related therapeutic approaches.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Albena Momchilova, Roumen Pankov, Galya Staneva, Stefan Pankov, Plamen Krastev, Evgenia Vassileva, Rusina Hazarosova, Nikolai Krastev, Bozhil Robev, Biliana Nikolova, Adriana Pinkas
Summary: Resveratrol regulates sphingolipid metabolism in lung cancer cells, leading to changes in CER and S1P levels, and showing anti-cancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Albena Momchilova, Georgi Nikolaev, Stefan Pankov, Evgenia Vassileva, Nikolai Krastev, Bozhil Robev, Dimo Krastev, Adriana Pinkas, Roumen Pankov
Summary: This study analyzed the effects of quercetin and fingolimod on sphingolipid metabolism in HepG2 cells. The results showed that quercetin and fingolimod, alone or in combination, can reduce sphingolipid levels and activate certain enzymes. The up-regulation and down-regulation of specific enzymes and proteins by quercetin have important implications for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Michela Terlizzi, Chiara Colarusso, Giusy Ferraro, Anna Falanga, Maria Chiara Monti, Pasquale Somma, Ilaria De Rosa, Luigi Panico, Aldo Pinto, Rosalinda Sorrentino
Summary: Sex is a biological variable that can affect the activity of the lipid mediator S1P in lung conditions. This study found sex differences in circulating S1P levels among lung cancer patients, with ADK patients having lower levels compared to SCC patients. Additionally, the expression of S1P receptors and metabolic enzymes differed between male and female patients with different lung cancer types. These findings highlight the importance of considering sex differences when studying S1P as a prognostic mediator in lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jae-Hwi Song, Goon-Tae Kim, Kyung-Ho Park, Woo-Jae Park, Tae-Sik Park
Summary: Atherosclerosis is characterized by plaque deposition in major arteries and involves inflammation, macrophages, endothelial cells, and various sphingolipids such as ceramides, glycosphingolipids, and S1P. Inhibition of de novo ceramide biosynthesis and regulation by S1P receptor (S1PR) can impact the development of atherosclerosis. S1PR1 and S1PR3 have anti-atherosclerotic properties, with ceramide and S1P playing crucial roles in the atherogenic process.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
David Montefusco, Maryam Jamil, Melissa A. Maczis, William Schroeder, Moshe Levi, Suman Ranjit, Jeremy Allegood, Dipankar Bandyopadhyay, Reuben Retnam, Sarah Spiegel, L. Ashley Cowart
Summary: Men with NAFLD are more likely to progress to NASH and liver fibrosis than women. This study revealed a novel pathway involving estrogen-mediated cross-talk between hepatocytes and HSCs that may contribute to sex differences in NAFLD through the anti-fibrogenic function of the S1P/S1PR3 axis.
MOLECULAR METABOLISM
(2022)
