Article
Medicine, General & Internal
Jacco J. A. S. Smeets, Kim Rijkers, Linda Ackermans, Olaf Schijns, Ghislaine A. P. G. van Mastrigt, Rob Rouhl, G. Louis Wagner, Sander van Kuijk, Jeske Nelissen, Ilse E. C. W. van Straaten, Kuan Kho, Francesca Snoeijen-Schouwenaars, Anne-Marthe Meppelink, Sylvia Klinkenberg, H. J. M. Majoie
Summary: Epilepsy is a common neurological disorder, and neuromodulation can be an option for drug-resistant patients. This study aims to determine the change in quality of life after neuromodulation and study the cost-effectiveness of these treatments.
Review
Medicine, General & Internal
Shiraz El Adam, Colene Bentley, Lisa McQuarrie, Paulos Teckle, Stuart Peacock
Summary: This paper describes a scoping review protocol to examine the effect of a cancer diagnosis on the income of adults, with the aim of summarizing existing evidence and identifying future research priorities.
Article
Medicine, General & Internal
Ruth Tulleners, Robin Blythe, Sasha Dionisio, Hannah Carter
Summary: The study aims to quantify the health service use and cost of epilepsy in Queensland, Australia, explore differences across population and disease subgroups, and investigate the associations between health service use and common comorbidities. Data linkage will be used to identify health service utilisation and costs associated with epilepsy, with findings to be disseminated through conferences, presentations, and publications.
Review
Medicine, General & Internal
Priyanka Chandrakant Barathe, Herosh T. Haridas, Priya Soni, Krithi Kariya Kudiya, Jisha B. Krishnan, Vijay Shree Dhyani, Ambigai Rajendran, Andria J. N. Sirur, Prachi Pundir
Summary: Breast cancer is the leading cause of death among women, imposing significant economic burden on communities. This study aims to map the current direct and indirect expenses of breast cancer in India and identify research gaps and future research directions.
Review
Clinical Neurology
Anne Kitschen, Milda Aleknonyte-Resch, Gabija Sakalyte, Freya Diederich
Summary: This systematic review aims to evaluate the cost-effectiveness of surgical treatment compared to medical treatment for drug-refractory epilepsy patients. The findings suggest that surgical treatment is more cost-effective, especially when considering a long-term perspective.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Anne Kitschen, Milda Aleknonyte-Resch, Gabija Sakalyte, Freya Diederich
Summary: Surgical treatment is cost-effective compared to medical treatment for patients with drug-refractory epilepsy, especially when considering a lifetime perspective. All disease-specific costs should be taken into account when assessing the cost-effectiveness of epilepsy treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Palvi Gotra, Nidhi Bhardwaj, Abhilash Ludhiadch, Gagandeep Singh, Anjana Munshi
Summary: Epilepsy and migraine share common clinical and pathophysiological mechanisms, with genetic variations playing a role in susceptibility. Alterations in ion channel-encoding genes may be a common risk factor for both conditions. The potential for targeting common genes and molecular mechanisms in future treatment strategies is discussed.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, General & Internal
David Livingstone Ejalu, Aaron Irioko, Rhoda Kirabo, Aggrey David Mukose, Elizabeth Ekirapa, Joseph Kagaayi, Juliana Namutundu
Summary: This study investigated the cost-effectiveness of Xpert Omni compared with Xpert MTB/Rif for diagnosing tuberculosis in a low-resource, high burden facility. The results showed that Xpert Omni was more effective but more expensive than Xpert MTB/Rif when used at a point-of-care health facility.
Article
Medicine, General & Internal
Mehdi Ammi, Jonas Fooken, Jill Klein, Anthony Scott
Summary: Personality differences between doctors and patients can affect treatment outcomes. Doctors tend to be more agreeable, conscientious, extroverted, and neurotic compared to the general population and patients. Patients are more open than doctors. Doctors also have a more external locus of control compared to the general population but not compared to patients. There are minor differences in personality traits among doctors with different specialities.
Article
Medicine, General & Internal
Xin Che, Jiajia Li, Wenhao Fu, Feng Fang
Summary: This study aimed to examine the association between livelihood capital and catastrophic health expenditure (CHE) among households with critically ill patients in rural areas. The results indicated that better livelihood capital was significantly associated with a lower incidence of CHE. The study suggested that attention should be paid to the ability of rural families with critically ill patients to create and preserve livelihood capital, in addition to providing health insurance.
Article
Medicine, General & Internal
Andreas Kohler, Linda Vinci, Renato Mattli
Summary: The objective of this study is to provide estimates of the price elasticity of demand for cigarettes in Europe to support public health policies on tobacco taxation. The study uses secondary data on cigarette sales, prices, tobacco control measures, and income from 2010 to 2020 in 27 European countries. The results show that the demand for cigarettes in Europe has remained relatively inelastic during this period, and taxation can still be an effective policy to reduce cigarette consumption.
Article
Medicine, General & Internal
Lata Vadlamudi, Carmen Maree Bennett, Melanie Tom, Ghusoon Abdulrasool, Kristian Brion, Ben Lundie, Hnin Aung, Chiyan Lau, Jonathan Rodgers, Kate Riney, Louisa Gordon
Summary: This study demonstrated the diagnostic yield and management impact of genomic testing on patients with drug-resistant epilepsy. The multi-disciplinary team (MDT) approach increased neurologists' confidence in genomic testing and was highly valued by them.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ian Ross, Giulia Greco, Zaida Adriano, Rassul Nala, Joe Brown, Charles Opondo, Oliver Cumming
Summary: This study evaluates the impact of a shared sanitation intervention on quality of life and mental well-being. It found that the intervention significantly improved sanitation-related quality of life and mental well-being, especially in terms of privacy and safety.
Article
Medicine, General & Internal
Padraig Dixon, William Hollingworth, Katie Pike, Rosy Reynolds, Margaret Stoddart, Alasdair MacGowan
Summary: This study assessed the cost-effectiveness of rapid microbial identification by MALDI-TOF mass spectrometry for bloodstream infections. The results indicate that adjunctive MALDI-TOF diagnosis may not be cost-effective when measured as cost per death avoided at 28 days.
Article
Medicine, General & Internal
Kurt Boman, Krister Lindmark, Jan Stalhammar, Mona Olofsson, Madlaina Costa-Scharplatz, Ana Filipa Fonseca, Stina Johansson, Vincent Heller, Michael Tornblom, Gerhard Wikstrom
Summary: This study examined healthcare resource use and costs among heart failure patients in Sweden using population data. The findings suggest that costs and healthcare resource utilization are high, especially in the first year following diagnosis, driven by high hospitalization rates. Understanding the characteristics of patients who are more resource-intensive can help in managing and allocating resources effectively.
Article
Rheumatology
David J. J. Hunter, Jocelyn L. L. Bowden, Rana S. S. Hinman, Thorlene Egerton, Andrew M. M. Briggs, Stephen J. J. Bunker, Simon D. D. French, Marie Pirotta, Rupendra Shrestha, Deborah J. J. Schofield, Karen Schuck, Nicholas A. A. Zwar, S. Sandun M. Silva, Gillian Z. Z. Heller, Kim L. L. Bennell, PARTNER Study Team
Summary: This study evaluated the effectiveness and health costs of a new primary care service delivery model (the PARTNER model) compared to usual care for patients with knee osteoarthritis. The results showed that the PARTNER model improved knee pain and function more than usual care, although the clinical significance was limited to function improvement.
ARTHRITIS CARE & RESEARCH
(2023)
Editorial Material
Biochemistry & Molecular Biology
Bronwyn Terrill, Lauren McKnight, Angela Pearce, Heather Gordon, William Lo, I-Chieh Jennifer Lee, Monica Runiewicz, Alex Palmer, Lesley Andrews, Edwin Kirk, Daniel Goldberg, John Tucker, David Murray, Warren Kaplan, Sarah Kummerfeld, Leslie Burnett
Summary: A community genetics carrier screening program for the Jewish community in Sydney has adapted to the challenges posed by the COVID-19 pandemic by implementing online education, contactless telehealth, and a novel patient and specimen identification protocol. These strategies have allowed for the uninterrupted operation and delivery of complex genetic testing and screening programs during the pandemic.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Review
Cell Biology
John S. S. Mattick, Paulo P. P. Amaral, Piero Carninci, Susan Carpenter, Howard Y. Y. Chang, Ling-Ling Chen, Runsheng Chen, Caroline Dean, Marcel E. E. Dinger, Katherine A. A. Fitzgerald, Thomas R. R. Gingeras, Mitchell Guttman, Tetsuro Hirose, Maite Huarte, Rory Johnson, Chandrasekhar Kanduri, Philipp Kapranov, Jeanne B. B. Lawrence, Jeannie T. T. Lee, Joshua T. T. Mendell, Timothy R. R. Mercer, Kathryn J. J. Moore, Shinichi Nakagawa, John L. L. Rinn, David L. L. Spector, Igor Ulitsky, Yue Wan, Jeremy E. E. Wilusz, Mian Wu
Summary: Genes encoding lncRNAs are abundant in complex organisms and are transcribed by RNA polymerase I, II, and III, as well as processed introns. The classification and annotation of lncRNAs are challenging due to their various functions, isoforms, and interactions with other genes. These lncRNAs evolve rapidly, are cell type-specific, and regulate multiple cellular processes, including gene expression and translation control.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lucinda Freeman, Martin B. Delatycki, Jackie Leach Scully, Nancy Briggs, Edwin P. Kirk
Summary: A survey conducted among healthcare providers in Australia and New Zealand shows that genes associated with non-syndromic hearing loss are believed to be appropriate for inclusion in reproductive genetic carrier screening. However, concerns were raised about potential discrimination and the complexity of defining the severity of deafness.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Genetics & Heredity
Deborah Schofield, Evelyn Lee, Jayamala Parmar, Simon Kelly, Matthew Hobbs, Nigel Laing, Jan Mumford, Rupendra Shrestha
Summary: The purpose of this study was to evaluate the cost effectiveness of population-based, expanded reproductive carrier screening. The results showed that expanded screening was cost effective and could avert a significant number of affected births and save healthcare resources.
GENETICS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Deborah Schofield, Joshua Kraindler, Owen Tan, Rupendra N. Shrestha, Sarah West, Natalie Hart, Liny Tan, Alan Ma, John R. Grigg, Robyn Jamieson
Summary: This study estimated the healthcare and societal costs of inherited retinal diseases (IRDs) in Australia. The total estimated lifetime cost per person with an IRD was $5.2 million, with 87% being societal costs and 13% healthcare costs. The highest cost items were lost income, both for individuals with IRDs and their carers and spouses.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Anesthesiology
Anonnya Rizwana Chowdhury, Deborah Schofield, Rupendra Shrestha, Michael Nicholas
Summary: The economic evaluation shows that the interdisciplinary intervention of Active Day Patient Treatment can lead to improvements in labor force participation, reduction in healthcare costs, and better health outcomes for chronic pain patients.
Letter
Oncology
Arthavan Selvanathan, C. Forwood, J. Russell, K. Batten, S. Thompson, E. E. Palmer, R. Macintosh, S. Nightingale, R. Mitchell, F. Alvaro, T. Dudding-Byth, S. Lunke, J. Christodoulou, Z. Stark, F. White, S. A. Jones, K. Bhattacharya
PEDIATRIC BLOOD & CANCER
(2023)
Editorial Material
Clinical Neurology
Arthavan Selvanathan, Rebecca Macintosh, Alexandra Johnson, Vanessa Sarkozy, Kristen Neville, Rani Sachdev
EPILEPTIC DISORDERS
(2023)
Article
Health Care Sciences & Services
Rebecca Daly, Kate Hetherington, Emily Hazell, Bethany R. Wadling, Vanessa Tyrrell, Katherine M. Tucker, Glenn M. Marshall, David S. Ziegler, Loretta Lau, Toby N. Trahair, Tracey A. O'Brien, Kiri Collins, Andrew J. Gifford, Michelle Haber, Mark Pinese, David Malkin, Mark J. Cowley, Jonathan Karpelowsky, Donna Drew, Chris Jacobs, Claire E. Wakefield
Summary: Precision medicine programs aim to identify personalized treatments for children with cancer, but the various professional groups involved in delivering these programs are understudied. This study explored the experiences of professionals involved in Australia's first precision medicine trial for children with poor-prognosis cancer. The professionals expressed both complexity in their roles and positive views about the impact of precision medicine on their profession.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemical Research Methods
Mahdi Zeraati, Samuel E. Ross, Behnaz Aghaei, Alvaro Gonzalez Rajal, Cecile King, Marcel E. Dinger
Summary: Intercalated motifs or i-Motifs (iMs) are nucleic acid structures formed by cytosine-rich sequences, which can regulate cellular processes and have broad applications in nanotechnology due to their pH-dependent nature. We have developed an iM-specific nanobody (iMbody) that can recognize iM DNA structures regardless of their sequences, making it a versatile research tool. In this article, we provide a protocol for the bacterial expression and purification of iMbody, as well as procedures for performing ELISA and immunostaining using iMbody.