Nose-to-Brain Delivery of Antiviral Drugs: A Way to Overcome Their Active Efflux?

In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates

(2018) Alessandro Giuliani et al.   DRUG DELIVERY

Cationic DDA/TDB liposome as a mucosal vaccine adjuvant for uptake by dendritic cells in vitro induces potent humoural immunity

(2018) Wenjing Qu et al.   Artificial Cells Nanomedicine and Biotechnology

Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS Neurodegeneration

(2016) M. K. Mamik et al.   JOURNAL OF NEUROSCIENCE

Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine

(2016) Shital Lungare et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Progress and perspectives on targeting nanoparticles for brain drug delivery

(2016) Huile Gao   Acta Pharmaceutica Sinica B

Nasal chitosan microparticles target a zidovudine prodrug to brain HIV sanctuaries

(2015) Alessandro Dalpiaz et al.   ANTIVIRAL RESEARCH

Multidrug resistance in cancer or inefficacy of neuroactive agents: innovative strategies to inhibit or circumvent the active efflux transporters selectively

(2014) Barbara Pavan et al.   DRUG DISCOVERY TODAY

Chitosan in nasal delivery systems for therapeutic drugs

(2014) Luca Casettari et al.   JOURNAL OF CONTROLLED RELEASE

Brain Uptake of a Zidovudine Prodrug after Nasal Administration of Solid Lipid Microparticles

(2014) Alessandro Dalpiaz et al.   MOLECULAR PHARMACEUTICS

Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing “Generally Recognized As Safe” (GRAS) nanopharmaceuticals: A review

(2013) Alejandro Sosnik   ADVANCED DRUG DELIVERY REVIEWS

Induction of P-Glycoprotein by Antiretroviral Drugs in Human Brain Microvessel Endothelial Cells

(2013) Gary N. Y. Chan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood–brain barrier after CITCO activation

(2013) Julia Lemmen et al.   BRAIN RESEARCH

Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain

(2013) Mansi Krishan et al.   DRUG DELIVERY

Development and characterization of PLGA nanoparticles as delivery systems of a prodrug of zidovudine obtained by its conjugation with ursodeoxycholic acid

(2013) Alessandro Dalpiaz et al.   DRUG DELIVERY

Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting

(2013) Hitendra S. Mahajan et al.   DRUG DELIVERY

Advances in brain targeting and drug delivery of anti-HIV therapeutic agents

(2013) Abeer M Al-Ghananeem et al.   Expert Opinion on Drug Delivery

Specific Increase in MDR1 Mediated Drug-Efflux in Human Brain Endothelial Cells following Co-Exposure to HIV-1 and Saquinavir

(2013) Upal Roy et al.   PLoS One

Homodimers of the antiviral abacavir as modulators of P-glycoprotein transport in cell culture: probing tether length

(2013) Hilda A. Namanja et al.   MedChemComm

Poly(ɛ-caprolactone), Eudragit® RS 100 and poly(ɛ-caprolactone)/Eudragit® RS 100 blend submicron particles for the sustained release of the antiretroviral efavirenz

(2012) Katia P. Seremeta et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Highly Attenuated Recombinant Vesicular Stomatitis Virus VSV-12'GFP Displays Immunogenic and Oncolytic Activity

(2012) A. N. van den Pol et al.   JOURNAL OF VIROLOGY

Zidovudine and Ursodeoxycholic Acid Conjugation: Design of a New Prodrug Potentially Able To Bypass the Active Efflux Transport Systems of the Central Nervous System

(2012) Alessandro Dalpiaz et al.   MOLECULAR PHARMACEUTICS

Effects of Localized Hydrophilic Mannitol and Hydrophobic Nelfinavir Administration Targeted to Olfactory Epithelium on Brain Distribution

(2011) John Douglas Hoekman et al.   AAPS PHARMSCITECH

Brain distribution of ribavirin after intranasal administration

(2011) Gaia Colombo et al.   ANTIVIRAL RESEARCH

Improving Cancer Chemotherapy with Modulators of ABC Drug Transporters

(2011) S. Shukla et al.   CURRENT DRUG TARGETS

Prodrugs and Endogenous Transporters: Are They Suitable Tools for Drug Targeting into the Central Nervous System?

(2011) Barbara Pavan et al.   CURRENT PHARMACEUTICAL DESIGN

Poly(ethylene oxide/propylene oxide) copolymer thermo-reversible gelling system for the enhancement of intranasal zidovudine delivery to the brain

(2011) Parag M. Ved et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells

(2011) Gary N. Y. Chan et al.   JOURNAL OF NEUROCHEMISTRY

Toward Eradicating HIV Reservoirs in the Brain: Inhibiting P-Glycoprotein at the Blood–Brain Barrier with Prodrug Abacavir Dimers

(2011) Hilda A. Namanja et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermosensitive hydrogels for nasal drug delivery: The formulation and characterisation of systems based on N-trimethyl chitosan chloride

(2010) H. Nazar et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Tight junction modulation by chitosan nanoparticles: Comparison with chitosan solution

(2010) Driton Vllasaliu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pharmacokinetic Interaction of Ritonavir-Boosted Elvitegravir and Maraviroc

(2010) Srinivasan Ramanathan et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Nuclear Receptor-Mediated Induction of CYP450 by Antiretrovirals: Functional Consequences of NR1I2 (PXR) Polymorphisms and Differential Prevalence in Whites and Sub-Saharan Africans

(2010) Jenny Svärd et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Trigeminal Pathways Deliver a Low Molecular Weight Drug from the Nose to the Brain and Orofacial Structures

(2010) Neil J. Johnson et al.   MOLECULAR PHARMACEUTICS

Constitutive Androstane Receptor-Mediated Up-Regulation of ATP-Driven Xenobiotic Efflux Transporters at the Blood-Brain Barrier

(2010) X. Wang et al.   MOLECULAR PHARMACOLOGY

The transport of anti-HIV drugs across blood–CNS interfaces: Summary of current knowledge and recommendations for further research

(2009) Lavanya Varatharajan et al.   ANTIVIRAL RESEARCH

Nanoparticles for direct nose-to-brain delivery of drugs

(2009) Alpesh Mistry et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pregnane X Receptor (PXR) Regulates P-Glycoprotein at the Blood-Brain Barrier: Functional Similarities between Pig and Human PXR

(2009) M. Ott et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Mucoadhesive Polymeric Hydrogels for Nasal Delivery of Acyclovir

(2008) Ibrahim A. Alsarra et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

MRP (ABCC) Transporters-Mediated Efflux of Anti-HIV Drugs, Saquinavir and Zidovudine, from Human Endothelial Cells

(2008) Mark Eilers et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Effect of Pretreatment with Toll‐like Receptor Agonists in a Mouse Model of Herpes Simplex Virus Type 1 Encephalitis

(2008) Nicolas Boivin et al.   JOURNAL OF INFECTIOUS DISEASES

Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line

(2008) Jason A. Zastre et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Preclinical assessment of the distribution of maraviroc to potential human immunodeficiency virus (HIV) sanctuary sites in the central nervous system (CNS) and gut-associated lymphoid tissue (GALT)

(2008) D. K. Walker et al.   XENOBIOTICA

In vitro efficacy of ribavirin against canine distemper virus

(2007) Gabriella Elia et al.   ANTIVIRAL RESEARCH

HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis

(2007) Marcus Kaul   Frontiers in Bioscience-Landmark