Article
Pediatrics
Camilla Rigotti, Daniela Doni, Emanuela Zannin, Abedulrhman S. Abdelfattah, Maria Luisa Ventura
Summary: By evaluating the trajectory of left ventricular diastolic function through serial echocardiographic evaluations and its association with respiratory outcomes, we found that abnormalities in left ventricular diastolic function may contribute to the pathophysiology of bronchopulmonary dysplasia. Serial echocardiographic measurements could help identify infants at risk of worse respiratory outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Sanne Arjaans, Elvira. A. H. Zwart, Marc Roofthooft, Elisabeth M. W. Kooi, Arend F. Bos, Rolf M. F. Berger
Summary: Pulmonary hypertension is a frequent complication in extremely preterm infants with significant impact on outcomes. Despite its clinical importance, there is a lack of standardized guidelines for screening and follow-up of PH in extremely preterm infants in the Netherlands.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Junfang Sun, Bowen Weng, Xiaoyue Zhang, Xiaoyun Chu, Cheng Cai
Summary: The study revealed that PDA and birth weight are specific risk factors for BPD-PH in VLBWIs, with low birth weight and the presence of PDA increasing the risk of developing BPD-PH.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Pediatrics
Han-Pi Chang, Reyin Lien, Shih-Ming Chu, Jainn-Jim Lin, Ming-Chou Chiang
Summary: This study aimed to investigate the associated factors, clinical characteristics, and outcomes of bronchopulmonary dysplasia (BPD) with pulmonary hypertension (PH) in very low birth weight (VLBW) preterm infants. The results showed that a higher positive end-expiratory pressure (PEEP) setting and surgical closure of patent ductus arteriosus (PDA) were associated with BPD-PH. Infants with BPD and PH had longer hospitalization, higher incidence of oxygen support after discharge, retinopathy of prematurity (ROP), and tracheostomy compared to those without PH.
FRONTIERS IN PEDIATRICS
(2023)
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Arie Nakhmani, Premananda Indic, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: Early identification of infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) is crucial due to the higher risk of death. We investigated the intermittent hypoxemia (IH) patterns in infants with BPD-PH and compared them with infants with BPD alone. Our findings showed that infants with BPD-PH had longer duration of hypoxemic events, which was associated with both the diagnosis of BPD-PH and death in these infants.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Pediatrics
Christina L. Herrera, Priyanka S. Kadari, Jessica E. Pruszynski, Imran Mir
Summary: Maternal infection does not appear to be directly linked to neurodevelopmental impairment or death at 2 years of age in extremely preterm infants. However, acute histologic chorioamnionitis is associated with this outcome, suggesting the need for further research into the impact of infection and immune response on outcomes in extremely preterm infants.
PEDIATRIC RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Masato Ito, Shin Kato, Makoto Saito, Naoyuki Miyahara, Hirokazu Arai, Fumihiko Namba, Erika Ota, Hidehiko Nakanishi
Summary: This scoping review aimed to screen available evidence regarding perinatal risk factors associated with the development and severity of bronchopulmonary dysplasia (BPD). The results identified several risk factors for BPD, including male sex, maternal hypertensive disorders of pregnancy, low gestational age, small-for-gestational-age birth weight, and mechanical ventilation. Rating: 8 out of 10.
Article
Pediatrics
Haoting Yu, Jianhua Fu, Yong Feng
Summary: This study in preterm infants in northeast China found a high prevalence of vitamin D deficiency and an increased risk of developing bronchopulmonary dysplasia (BPD). The established nomogram can effectively predict the occurrence of BPD, with a 25(OH)D concentration below 15.7 ng/ml being predictive of BPD.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Kacie Dillon, Vineet Lamba, Ranjit R. Philip, Mark F. Weems, Ajay J. Talati
Summary: This study aimed to assess the efficacy of sildenafil in infants with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH). The study found that sildenafil treatment led to improvement in PH as evaluated by transthoracic echocardiography (TTE), and infants showed improvement in their respiratory severity score (RSS) and FiO2 after prolonged therapy. However, TTE improvements did not correlate with clinical improvements.
Article
Environmental Sciences
Kenneth Strommen, Jan Ludvig Lyche, Sissel Jennifer Moltu, Mette H. B. Muller, Elin Wahl Blakstad, Astrid Nylander Almaas, Amrit Kaur Sakhi, Cathrine Thomsen, Britt Nakstad, Arild Erlend Ronnestad, Christian A. Drevon, Per Ole Iversen
Summary: Very low birth weight infants are exposed to high concentrations of parabens and BPA from pharmaceuticals and medical equipment, with lower gestational age and certain conditions associated with higher levels.
Article
Cardiac & Cardiovascular Systems
B. A. Madden, M. R. Conaway, S. A. Zanelli, M. A. McCulloch
Summary: Premature infants with severe BPD were found to have a 34% incidence of BPD-PH at discharge. Echocardiographic screening at 36 weeks PMA was not predictive of PH at discharge, but the presence of ASD, RV dilation, hypertrophy, or reduced function, especially in combination, were associated with BPD-PH at discharge. Further prospective studies are needed to validate these findings.
PEDIATRIC CARDIOLOGY
(2022)
Article
Pediatrics
Dara Torgerson, Miguel Guardado, Martina Steurer, Cheryl Chapin, Ryan D. Hernandez, Philip L. Ballard
Summary: There is no information on the metabolic consequences of hydrocortisone therapy in extremely premature infants who are at risk for circulatory collapse or respiratory failure.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Maria V. Fraga, Kevin C. Dysart, Jason Z. Stoller, Matthew Huber, Anysia Fedec, Laura Mercer-Rosa, Haresh Kirpalani
Summary: This study aimed to determine the efficacy of inhaled nitric oxide (iNO) in reducing pulmonary artery pressure in infants with severe bronchopulmonary dysplasia (BPD) as measured by echocardiography. The results showed that iNO significantly reduced pulmonary arterial hypertension (PAH) in infants with severe BPD.
Article
Pediatrics
Irina Branescu, Sandeep Shetty, Justin Richards, Simona Vladareanu, Anay Kulkarni
Summary: This study aimed to describe the clinical characteristics of pulmonary hypertension (PH) associated with moderate to severe bronchopulmonary dysplasia (MSBPD) in premature infants. The incidence of BPD-associated PH (BPD PH) was 12.6%, with 41% of infants having severe PH. The need for positive pressure respiratory support at 36 weeks post menstrual age (PMA) was independently associated with PH. Babies with MSBPD and PH had a higher mortality rate.
Article
Pediatrics
Chenhong Wang, Xiaolu Ma, Yanping Xu, Zheng Chen, Liping Shi, Lizhong Du
Summary: The study aimed to establish a prediction model for bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) in preterm infants. Four independent predictive factors were identified, and a prediction model was developed with high accuracy in predicting the development of BPD-PH.
FRONTIERS IN PEDIATRICS
(2022)
