Constitutive Activation of STAT3 in Myeloma Cells Cultured in a Three-Dimensional, Reconstructed Bone Marrow Model

Tight Junction Protein 1 Modulates Proteasome Capacity and Proteasome Inhibitor Sensitivity in Multiple Myeloma via EGFR/JAK1/STAT3 Signaling

(2016) Xing-Ding Zhang et al.   CANCER CELL

A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses

(2016) Natividad Gomez-Roman et al.   NEURO-ONCOLOGY

Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells

(2016) Yao Yao et al.   Oncotarget

Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells in vitro and in vivo by modulating multiple cellular pathways

(2016) Tai Yang et al.   Oncotarget

Culture on 3D Chitosan-Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells

(2016) Kui Wang et al.   Advanced Healthcare Materials

3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma

(2015) Pilar de la Puente et al.   BIOMATERIALS

Novel Morphologic and Genetic Analysis of Cancer Cells in a 3D Microenvironment Identifies STAT3 as a Regulator of Tumor Permeability Barrier Function

(2015) M. C. Park et al.   CANCER RESEARCH

Angiopoietin-2 in Bone Marrow milieu promotes Multiple Myeloma-associated angiogenesis

(2015) Daniela Belloni et al.   EXPERIMENTAL CELL RESEARCH

Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells

(2015) U. Rozovski et al.   MOLECULAR CANCER RESEARCH

Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments

(2015) AKINORI WADA et al.   ONCOLOGY REPORTS

Notch signaling deregulation in multiple myeloma: A rational molecular target

(2015) Michela Colombo et al.   Oncotarget

Multiple myeloma induces Mcl-1 expression and survival of myeloid-derived suppressor cells

(2015) Kim De Veirman et al.   Oncotarget

A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations

(2015) Claudia Canino et al.   Oncotarget

Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3

(2015) Shicong Zhu et al.   Oncotarget

New insights into the roles of CHOP-induced apoptosis in ER stress

(2014) Yiming Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors

(2014) Kodappully Sivaraman Siveen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Three-dimensional in vitro tumor models for cancer research and drug evaluation

(2014) Xian Xu et al.   BIOTECHNOLOGY ADVANCES

Targeting the Phosphatidylinositol 3-Kinase/AKT Pathway for the Treatment of Multiple Myeloma

(2014) J. Zhu et al.   CURRENT MEDICINAL CHEMISTRY

IL-6 Activated JAK/STAT3 Pathway and Sensitivity to Hsp90 Inhibitors in Multiple Myeloma

(2014) I. Kolosenko et al.   CURRENT MEDICINAL CHEMISTRY

Phospho-flow detection of constitutive and cytokine-induced pSTAT3/5, pAKT and pERK expression highlights novel prognostic biomarkers for patients with multiple myeloma

(2014) R Brown et al.   LEUKEMIA

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

(2014) Mukti R. Parikh et al.   Jove-Journal of Visualized Experiments

STAT3 in Cancer—Friend or Foe?

(2014) Hai-Feng Zhang et al.   Cancers

Therapeutic Advancements in Multiple Myeloma

(2014) Alessandro Gozzetti et al.   Frontiers in Oncology

Protein Kinase CK2 Inhibition Down Modulates the NF-κB and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells

(2013) Sabrina Manni et al.   PLoS One

Correction: Ex-Vivo Dynamic 3-D Culture of Human Tissues in the RCCS™ Bioreactor Allows the Study of Multiple Myeloma Biology and Response to Therapy

(2013) Marina Ferrarini et al.   PLoS One

Patient-Specific 3D Microfluidic Tissue Model for Multiple Myeloma

(2013) Wenting Zhang et al.   TISSUE ENGINEERING PART C-METHODS

Prolonged early G1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4

(2012) X. Huang et al.   BLOOD

PPAR-alpha is a therapeutic target for chronic lymphocytic leukemia

(2012) D E Spaner et al.   LEUKEMIA

A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells

(2011) Li Lin et al.   INTERNATIONAL JOURNAL OF CANCER

A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells

(2011) T Calimeri et al.   LEUKEMIA

The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma

(2011) Ellen J. Gunn et al.   LEUKEMIA & LYMPHOMA

Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival

(2010) T. Steinbrunn et al.   BLOOD

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells

(2009) Evelyn K.F. Yim et al.   BIOMATERIALS

The imbalance between Survivin and Bim mediates tumour growth and correlates with poor survival in patients with multiple myeloma

(2009) Mathilde Romagnoli et al.   BRITISH JOURNAL OF HAEMATOLOGY

 1 Integrin Adhesion Enhances IL-6-Mediated STAT3 Signaling in Myeloma Cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation

(2009) K. H. Shain et al.   CANCER RESEARCH

A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma

(2008) J. Kirshner et al.   BLOOD