Review
Biochemistry & Molecular Biology
Severa Bunda, Jeffrey A. Zuccato, Mathew R. Voisin, Justin Z. Wang, Farshad Nassiri, Vikas Patil, Sheila Mansouri, Gelareh Zadeh
Summary: Liquid biopsy is a non-invasive technique for cancer diagnosis, providing a major advancement in conquering tumors. It enables rapid, precise, and real-time cancer detection, prognosis, and treatment monitoring, particularly for central nervous system tumors. Major components include circulating tumor cells, circulating tumor nucleic acids, and exosomes, with samples obtained from cerebrospinal fluid, plasma, and serum of patients with CNS malignancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Linjuan He, Jiyan Liu, Xiaoyue Wang, Yuanzhao Wang, Jiawen Zhu, Xuexue Kang
Summary: The pathological mechanism of childhood asthma is complex, and timely diagnosis is crucial for prevention and control. By analyzing serum miRNA biomarkers, four miRNAs were found to effectively distinguish childhood asthma from healthy subjects, with high specificity and sensitivity.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Matyas Bukva, Gabriella Dobra, Juan Gomez-Perez, Krisztian Koos, Maria Harmati, Edina Gyukity-Sebestyen, Tamas Biro, Adrienn Jenei, Sandor Kormondi, Peter Horvath, Zoltan Konya, Almos Klekner, Krisztina Buzas
Summary: The study explored the potential role of serum-derived small extracellular vesicles (sEVs) in diagnosing CNS tumors through Raman spectroscopic analyses. The results showed that Raman spectroscopic analysis of sEV-sized particles could distinguish different tumor types with high sensitivity and specificity, suggesting it is a promising liquid-biopsy-based method for CNS tumor diagnosis.
Article
Genetics & Heredity
Xiaotong Duan, Simiao Qiao, Dianhe Li, Shangbiao Li, Zhihao Zheng, Qin Wang, Xiaoxia Zhu
Summary: The combination of miR-492, miR-590-3p, and miR-631 can effectively distinguish healthy individuals from early-stage NSCLC patients, making them promising serum biomarkers for the early diagnosis of NSCLC.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Mohsen Karami Fath, Jalil Azami, Alireza Masoudi, Reza Mosaddeghi Heris, Elnaz Rahmani, Fatemeh Alavi, Armina Alagheband Bahrami, Zahra Payandeh, Bahman Khalesi, Masoomeh Dadkhah, Navid Pourzardosht, Vahideh Tarhriz
Summary: This review focuses on the role of exosomes in glioblastoma, highlighting their involvement in creating an immunosuppressive tumor microenvironment and their potential as therapeutic and diagnostic tools.
CANCER CELL INTERNATIONAL
(2022)
Review
Cell Biology
Ilaria Conti, Carolina Simioni, Gabriele Varano, Cinzia Brenna, Eva Costanzi, Luca Maria Neri
Summary: Advancements in cancer screening methods and treatments have increased life expectancy for cancer patients and led to a rapid growth in the community of cancer survivors. Research has highlighted the regulatory role of extracellular circulating miRNAs (ECmiRNAs) in cancer diagnosis and prognosis, suggesting their potential as biomarkers for controlling follow-up care for cancer survivors.
Article
Medicine, Research & Experimental
Simone Agostini, Roberta Mancuso, Lorenzo Agostino Citterio, Gabriela Alexandra Mihali, Beatrice Arosio, Mario Clerici
Summary: The concentration of miR-451a in serum was significantly increased in frail patients, while the concentrations of miR-93-5p and miR-495-3p were reduced, and miR-155-5p was increased. The multicomponent exercise program was able to improve physical performance and muscle strength in frail patients and modulate the expression of miRNAs in serum.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Stefan Bittner, Jiwon Oh, Eva Kubala Havrdova, Mar Tintore, Frauke Zipp
Summary: Blood-based serum neurofilament light chain (sNfL) is being investigated as a biomarker for prognosis and treatment response in multiple sclerosis patients. It reflects ongoing inflammatory-driven neuroaxonal damage and has the potential to guide individualized clinical decision-making.
Review
Urology & Nephrology
Ricardo Leao, Maarten Albersen, Leendert H. J. Looijenga, Torgrim Tandstad, Christian Kollmannsberger, Matthew J. Murray, Stephane Culine, Nicholas Coleman, Gazanfer Belge, Robert J. Hamilton, Klaus-Peter Dieckmann
Summary: Circulating microRNA levels, especially miR-371a-3p, show promise for clinical use in testicular germ cell tumors, with high sensitivity and specificity in various clinical scenarios, potentially aiding in clinical decision-making.
Article
Infectious Diseases
Qiu-Yue Ning, Na Liu, Ji-Zhou Wu, Die-Fei Hu, Qi Wei, Jin-Ai Zhou, Jun Zou, Ning Zang, Guo-Jian Li
Summary: This study investigated serum exosomal miRNAs in AIDS patients with TM infection, identifying three potential biomarkers and exploring their biological functions and pathways.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Oncology
Konstantinos Evmorfopoulos, Panagiotis J. Vlachostergios, Petros Sountoulides, Vassilios Tzortzis
Summary: This review discusses the advances in understanding the biology of testicular germ cell tumors (TGCT) and the discovery of biomarkers for diagnosis and treatment evaluation. Serum biomarkers play a significant role in TGCT diagnosis and treatment response evaluation, while molecular biomarkers potentially have important implications for future disease diagnosis, treatment selection, and prognosis assessment.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Medical Laboratory Technology
Rongkang Li, Chong Lu, Weiqiang Yang, Yaqi Zhou, Jiatao Zhong, Xuan Chen, Xinji Li, Guocheng Huang, Xiqi Peng, Kaihao Liu, Chunduo Zhang, Hongyi Hu, Yongqing Lai
Summary: MicroRNAs are stable in serum and specific to different tumor types, making them a potential non-invasive biomarker for cancer detection. A three-miRNA panel has been shown to have high diagnostic efficiency for nasopharyngeal carcinoma. Further analysis suggests potential target genes for this miRNA panel.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Chemistry, Inorganic & Nuclear
Shuai Zhang, Feilong Rong, Chuanpan Guo, Fenghe Duan, Linghao He, Minghua Wang, Zhihong Zhang, Mengmeng Kang, Miao Du
Summary: Metal-organic frameworks (MOFs) have emerged as promising porous crystalline materials with various applications due to their large surface areas, tunable pore scales, and good adsorption capabilities. They have been utilized for developing highly sensitive and selective biosensors, particularly for early cancer diagnosis and treatment monitoring, by anchoring diverse probes for construction of electrochemical biosensors.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Respiratory System
Xintong Zhang, Jinjing Tan, Yan Chen, Shang Ma, Wanqiu Bai, Yanjing Peng, Guangli Shi
Summary: Serum miRNAs miR-3149 and miR-4769.3p are up-regulated in NSCLC and may serve as potential biomarkers for early diagnosis of lung cancer when combined with tumor markers CEA and Cyfra21-1.
BMC PULMONARY MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Zodwa Dlamini, Mzwandile Mbele, Tshepiso J. Makhafola, Rodney Hull, Rahaba Marima
Summary: Globally, HIV/AIDS and cancer are significant public health problems, with sub-Saharan Africa bearing the largest burden. While AIDS-defining cancers are decreasing, non-AIDS defining cancers are on the rise in HIV-positive individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
Gianluca Russo, Francesco Pepe, Pasquale Pisapia, Lucia Palumbo, Mariantonia Nacchio, Elena Vigliar, Pierlorenzo Pallante, Paola Parente, Matteo Fassan, Paolo Graziano, Claudio Bellevicine, Giancarlo Troncone, Umberto Malapelle, Antonino Iaccarino
Summary: This article reviews the results of microsatellite instability (MSI) evaluation using a customized workflow and microfluidic system in a diagnostic routine practice over a period of 4 years. The results showed that the majority of patients with metastatic colorectal cancer (mCRC) had microsatellite stability (MSS) profile, while a minority had microsatellite high (MSI-H) profile. Similarly, in patients without colorectal cancer, both MSS and MSI-H profiles were observed.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Valentina Mari, Valentina Angerilli, Giada Munari, Marco Scarpa, Quoc Riccardo Bao, Salvatore Pucciarelli, Matteo Fassan, Gaya Spolverato
Summary: This review outlines the molecular pathways involved in peritoneal metastatic dissemination in gastric cancer, highlighting the lack of comprehensive understanding of the complex molecular landscape of this disease. The integration of molecular profiling and histological evaluation is recommended for risk prediction assessment of peritoneal dissemination.
DIGESTIVE DISEASES
(2023)
Article
Pathology
Federica Grillo, Luca Carlin, Andrea Remo, Matteo Fassan, Claudia Mescoli, Michela Campora, Luigi Caserta, Fabrizio Mazza, Luca Mastracci
Summary: Dasatinib-induced colitis may present histological features similar to Crohn's disease, including microgranulomas and active inflammation, and complete remission can be achieved after treatment interruption.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Surgery
Gianluca Businello, Valentina Angerilli, Sara Lonardi, Francesca Bergamo, Michele Valmasoni, Fabio Farinati, Edoardo Savarino, Gaya Spolverato, Matteo Fassan
Summary: The comprehensive molecular characterization of gastric and gastroesophageal junction adenocarcinomas has improved targeted and effective treatments, introducing biomarkers into clinical practice. The evaluation mainly relies on limited biopsy material, making pathologists essential in patient selection for precision medicine approaches.
UPDATES IN SURGERY
(2023)
Article
Oncology
Alessandra A. Prete, Paolo Manca, Marco Messina, Vincenzo Formica, Giovanni L. Frassineti, Maria G. Zampino, Domenico C. Corsi, Corrado Orciuolo, Michele Prisciandaro, Francesca Bergamo, Valentina Angerilli, Mario Scartozzi, Mariaelena Casagrande, Gianluca Masi, Monica Ronzoni, Federica Morano, Valentina Vettore, Roberta Salmaso, Cosimo Rasola, Giulia Maddalena, Paola del Bianco, Massimo Milione, Chiara Cremolini, Matteo Fassan, Filippo Pietrantonio, Sara Lonardi
Summary: This study found that patients with high PD-L1 and high TMB had better survival outcomes when treated with immune checkpoint inhibitors for advanced squamous cell anal carcinoma.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Margherita Rimini, Carles Fabregat-Franco, Mara Persano, Valentina Burgio, Francesca Bergamo, Monica Niger, Mario Scartozzi, Ilario Giovanni Rapposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Mario Rizzato, Federico Nichetti, Eleonora Lai, Alessandro Cappetta, Teresa Macarulla, Matteo Fassan, Filippo De Braud, Andrea Pretta, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Andrea Casadei-Gardini
Summary: This study investigated the prognostic impact of IDH1 mutations in patients with advanced iCCA after progression on first-line therapies. The presence of IDH1 mutations was associated with worse overall survival and worse objective response rate in second-line therapy. IDH1 mutations were confirmed as an independent negative prognostic factor.
Review
Health Care Sciences & Services
Alessandro Mangogna, Giada Munari, Francesco Pepe, Edoardo Maffii, Pierluigi Giampaolino, Giuseppe Ricci, Matteo Fassan, Umberto Malapelle, Stefania Biffi
Summary: Homologous recombination deficiency (HRD) refers to the inability to efficiently repair DNA double-strand breaks using the homologous recombination repair pathway. It serves as a predictive biomarker for the clinical use of poly (adenosine diphosphate [ADP]-ribose) polymerase inhibitors and platinum-based chemotherapy in ovarian cancers. However, HRD is a complex genomic signature, and various methods of analysis have been developed for HRD testing in the clinical setting.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Grazia Vernaci, Edoardo Vincenzo Savarino, Ilaria Patuzzi, Sonia Facchin, Fabiana Zingone, Davide Massa, Giovanni Faggioni, Tommaso Giarratano, Federica Miglietta, Gaia Griguolo, Matteo Fassan, Marcello Lo Mele, Elisa Gasparini, Giancarlo Bisagni, Valentina Guarneri, Maria Vittoria Dieci
Summary: This article evaluates the feasibility of analyzing the gut microbiome in patients with early stage triple-negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy, and explores its impact on treatment response and clinicopathologic factors. The study suggests that analyzing the gut microbiome may have potential significance in early TNBC, but further investigation is needed to understand its complex correlation with immunity and cancer.
Article
Pathology
Federica Zannier, Valentina Angerilli, Gaya Spolverato, Stefano Brignola, Daniele Sandona, Mariangela Balistreri, Marianna Sabbadin, Sara Lonardi, Francesca Bergamo, Claudia Mescoli, Marco Scarpa, Quoc Riccardo Bao, Angelo Paolo Dei Tos, Salvatore Pucciarelli, Emanuele L. D. Urso, Matteo Fassan
Summary: This study aimed to compare the pathological and clinical characteristics of MMR-deficient (MMRd) tumors and MMR proficient (MMRp) cases, with a particular focus on the relationship between these molecular subgroups and lymph node ratio (LNR). The study found significant differences between MMRd and MMRp tumors in terms of sex, age, size, growth pattern, inflammatory infiltrate, perineural invasion, stage, grade, and LNR. In conclusion, MMRd tumors are a distinct molecular subtype of colorectal cancer characterized by a significantly lower LNR, further supporting the prognostic impact of MMRd status in early-stage CRC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Valentina Angerilli, Paola Parente, Gianluca Businello, Alessandro Vanoli, Michele Paudice, Giovanni Perrone, Giada Munari, Ilaria Govoni, Giuseppe Neri, Elena Rebellato, Paola Parrella, Federica Grillo, Luca Mastracci, Matteo Fassan
Summary: Colorectal adenosquamous carcinoma (ASC) is a rare and aggressive disease with a higher metastatic rate and worse outcome than conventional colorectal adenocarcinoma. The molecular profile of this type of cancer needs further investigation.
Editorial Material
Genetics & Heredity
Kunqi Chen, Ernesto Picardi, Xiao Han, Giovanni Nigita
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Federica Miglietta, Moira Ragazzi, Bethania Fernandes, Gaia Griguolo, Davide Massa, Fabio Girardi, Michele Bottosso, Alessandra Bisagni, Giovanni Zarrilli, Francesca Porra, Daniela Iannaccone, Leocadia Dore, Mariangela Gaudio, Giacomo Santandrea, Matteo Fassan, Marcello Lo Mele, Rita De Sanctis, Alberto Zambelli, Giancarlo Bisagni, Valentina Guarneri, Maria Vittoria Dieci
Summary: The prognostic significance of tumor-infiltrating lymphocyte on residual disease (RD-TIL) in HER2+ patients with breast cancer who failed to achieve pathologic complete response (pCR) after anti-HER2+ chemotherapy (CT)-based neoadjuvant treatment (NAT) was evaluated. The study found that both RCB and RD-TIL were significantly associated with overall survival (OS) and could be used to predict patient prognosis. Additionally, a new composite prognostic score, RCB+TIL, was developed and found to be more informative than the isolated evaluation of RCB and RD-TILs.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Laura Bonanno, Martina Lorenzi, Davide Massa, Mattia De Nuzzo, Valentina Angerilli, Fabiana Zingone, Brigida Barberio, Alberto Russi, Fabio Girardi, Alessandra Ferro, Alessandro Dal Maso, Stefano Frega, Giulia Pasello, Angelo Paolo Dei Tos, Marina Coppola, Matteo Fassan, Edoardo Vincenzo Savarino, Valentina Guarneri
Summary: This study collected real-world data on the occurrence of immune-mediated diarrhea and colitis in patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors, and assessed the clinical impact of a multidisciplinary approach on the management of this adverse event.
Review
Oncology
Alessandro Massano, Luisa Bertin, Fabiana Zingone, Andrea Buda, Pierfrancesco Visaggi, Lorenzo Bertani, Nicola de Bortoli, Matteo Fassan, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Cristina Bezzio, Valentina Casini, Davide Giuseppe Ribaldone, Edoardo Vincenzo Savarino, Brigida Barberio
Summary: This review summarizes the evidence on the association between inflammatory bowel disease (IBD) and extraintestinal cancers (EICs), as well as the safety and management of immunomodulators and biologics for IBD patients with prior or current EICs.
Article
Oncology
Daniela Brina, Adele Ponzoni, Martina Troiani, Bianca Cali, Emiliano Pasquini, Giuseppe Attanasio, Simone Mosole, Michela Mirenda, Mariantonietta D'Ambrosio, Manuel Colucci, Ilaria Guccini, Ajinkya Revandkar, Abdullah Alajati, Toma Tebaldi, Deborah Donzel, Fabio Lauria, Nahjme Parhizgari, Aurora Valdata, Martino Maddalena, Arianna Calcinotto, Marco Bolis, Andrea Rinaldi, Simon Barry, Jan Hendrik Rueschoff, Marianna Sabbadin, Semini Sumanasuriya, Mateus Crespo, Adam Sharp, Wei Yuan, Mathew Grinu, Alexandra Boyle, Cynthia Miller, Lloyd Trotman, Nicolas Delaleu, Matteo Fassan, Holger Moch, Gabriella Viero, Johann de Bono, Andrea Alimonti
Summary: In prostate cancer, the secretome is rewired at the translational level to recruit MDSCs, with Hgf, Spp1, and Bgn identified as key regulators. By inhibiting the MNK/eIF4E and AKT pathways, this study provides a therapeutic strategy that combines translation inhibition with immunotherapy to restore immune surveillance in prostate cancer.