Influenza vaccination of cancer patients during PD-1 blockade induces serological protection but may raise the risk for immune-related adverse events

Immune-Related Adverse Events Associated with Immune Checkpoint Blockade

(2018) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

MA14.06 Nivolumab in Never Smoker Patients with Advanced Squamous NSCLC: Results from the Italian Expanded Access Programme (EAP)

(2017) Giuseppe Lo Russo et al.   Journal of Thoracic Oncology

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

Is autoimmunity the Achilles' heel of cancer immunotherapy?

(2017) Carl H June et al.   NATURE MEDICINE

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2017) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

(2017) Joaquim Bellmunt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

(2017) Michel Enamorado et al.   Nature Communications

Comprehensive Meta-analysis of Key Immune-Related Adverse Events from CTLA-4 and PD-1/PD-L1 Inhibitors in Cancer Patients

(2017) Guillermo De Velasco et al.   Cancer Immunology Research

The T cell repertoire in tumors overlaps with pulmonary inflammatory lesions in patients treated with checkpoint inhibitors

(2017) Heinz Läubli et al.   OncoImmunology

Cerebral vasculitis mimicking intracranial metastatic progression of lung cancer during PD-1 blockade

(2017) Heinz Läubli et al.   Journal for ImmunoTherapy of Cancer

Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire

(2016) David Y. Oh et al.   CANCER RESEARCH

Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy

(2016) Lars Hofmann et al.   EUROPEAN JOURNAL OF CANCER

T cell epitope redundancy: cross-conservation of the TCR face between pathogens and self and its implications for vaccines and autoimmunity

(2016) Leonard Moise et al.   Expert Review of Vaccines

Influenza Vaccination

(2016) John J. Treanor   NEW ENGLAND JOURNAL OF MEDICINE

Fulminant Myocarditis with Combination Immune Checkpoint Blockade

(2016) Douglas B. Johnson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serologic response and clinical efficacy of influenza vaccination in children and young adults on chemotherapy for cancer

(2016) Daniel K. Choi et al.   PEDIATRIC BLOOD & CANCER

Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

(2016) Sumit K. Subudhi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved immunogenicity of high-dose influenza vaccine compared to standard-dose influenza vaccine in adult oncology patients younger than 65 years receiving chemotherapy: A pilot randomized clinical trial

(2016) Saad Jamshed et al.   VACCINE

Immunogenicity and safety of high-dose trivalent inactivated influenza vaccine compared to standard-dose vaccine in children and young adults with cancer or HIV infection

(2016) Hana Hakim et al.   VACCINE

Immunogenicity of trivalent influenza vaccine in patients with lung cancer undergoing anticancer chemotherapy

(2016) Kei Nakashima et al.   Human Vaccines & Immunotherapeutics

Influenza vaccination for patients with chronic obstructive pulmonary disease: understanding immunogenicity, efficacy and effectiveness

(2016) Farzaneh Sanei et al.   Therapeutic Advances in Respiratory Disease

Acute rhabdomyolysis with severe polymyositis following ipilimumab-nivolumab treatment in a cancer patient with elevated anti-striated muscle antibody

(2016) Mehmet Asim Bilen et al.   Journal for ImmunoTherapy of Cancer

Immunogenicity of Influenza Vaccination in Patients With Cancer

(2015) Saiama N. Waqar et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

(2015) Julie Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunization in cancer patients: Where we stand

(2015) Christine Robin et al.   PHARMACOLOGICAL RESEARCH

Accumulation of Memory Precursor CD8 T Cells in Regressing Tumors following Combination Therapy with Vaccine and Anti-PD-1 Antibody

(2014) L. Karyampudi et al.   CANCER RESEARCH

PD-1 Blockade in Rhesus Macaques: Impact on Chronic Infection and Prophylactic Vaccination

(2014) A. C. Finnefrock et al.   JOURNAL OF IMMUNOLOGY

Programmed Death-1 Impairs Secondary Effector Lung CD8+T Cells during Respiratory Virus Reinfection

(2014) John J. Erickson et al.   JOURNAL OF IMMUNOLOGY

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

(2013) J. Duraiswamy et al.   CANCER RESEARCH

PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response

(2013) Nuriban Valero-Pacheco et al.   Clinical & Developmental Immunology

Manipulating the PD-1 pathway to improve immunity

(2013) Alice O Kamphorst et al.   CURRENT OPINION IN IMMUNOLOGY

Local Blockade of Epithelial PDL-1 in the Airways Enhances T Cell Function and Viral Clearance during Influenza Virus Infection

(2013) Beth McNally et al.   JOURNAL OF VIROLOGY

Viral acute lower respiratory infections impair CD8+ T cells through PD-1

(2012) John J. Erickson et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking of PDL-1 Interaction Enhances Primary and Secondary CD8 T Cell Response to Herpes Simplex Virus-1 Infection

(2012) Rudragouda Channappanavar et al.   PLoS One

Blockade of programmed death receptor-1 signaling restores expression of mostly proinflammatory cytokines in anergic cytomegalovirus-specific T cells

(2012) J. Dirks et al.   Transplant Infectious Disease

Severe novel influenza A (H1N1) infection in cancer patients

(2010) L. A. Hajjar et al.   ANNALS OF ONCOLOGY

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice

(2010) Scott N. Mueller et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

(2008) Sang-Jun Ha et al.   JOURNAL OF EXPERIMENTAL MEDICINE