Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Eight-Color Multiplex Immunohistochemistry for Simultaneous Detection of Multiple Immune Checkpoint Molecules within the Tumor Microenvironment

(2017) Mark A. J. Gorris et al.   JOURNAL OF IMMUNOLOGY

Expression of PD-L1 and presence of CD8-positive T cells in pre-treatment specimens of locally advanced cervical cancer

(2017) Emeka K Enwere et al.   MODERN PATHOLOGY

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

(2017) Julienne L. Carstens et al.   Nature Communications

A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non–Small Cell Lung Cancer

(2017) David L. Rimm et al.   JAMA Oncology

Differential intratumoral distributions of CD8 and CD163 immune cells as prognostic biomarkers in breast cancer

(2017) Sotirios P. Fortis et al.   Journal for ImmunoTherapy of Cancer

Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy

(2017) Sacha Gnjatic et al.   Journal for ImmunoTherapy of Cancer

Gene expression markers of Tumor Infiltrating Leukocytes

(2017) Patrick Danaher et al.   Journal for ImmunoTherapy of Cancer

Clinical Significance of Programmed Death Ligand‑1 and Intra-Tumoral CD8+ T Lymphocytes in Ovarian Carcinosarcoma

(2017) Jun Zhu et al.   PLoS One

Advances in the Treatment of Non–small Cell Lung Cancer: Focus on Nivolumab, Pembrolizumab, and Atezolizumab

(2016) Konstantinos Leventakos et al.   BIODRUGS

Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment

(2016) James H Park et al.   BRITISH JOURNAL OF CANCER

Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers

(2016) Marie-Caroline Dieu-Nosjean et al.   IMMUNOLOGICAL REVIEWS

Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study

(2016) Alexander M. Lesokhin et al.   JOURNAL OF CLINICAL ONCOLOGY

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

(2016) Danny N. Khalil et al.   Nature Reviews Clinical Oncology

Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma

(2016) Theodore S. Nowicki et al.   Cancer Immunology Research

Targeting CD73 in the tumor microenvironment with MEDI9447

(2016) Carl M. Hay et al.   OncoImmunology

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

(2016) Sonja Althammer et al.   Journal for ImmunoTherapy of Cancer

Metastatic spread in patients with non-small cell lung cancer is associated with a reduced density of tumor-infiltrating T cells

(2015) Philipp Müller et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Classifying Cancers Based on T-cell Infiltration and PD-L1

(2015) Michele W.L. Teng et al.   CANCER RESEARCH

Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

(2015) Alex T. Ritter et al.   IMMUNITY

CD8+CD103+Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

(2015) Fayçal Djenidi et al.   JOURNAL OF IMMUNOLOGY

The prognostic influence of tumor infiltrating Foxp3+CD4+, CD4+ and CD8+ T cells in resected non-small cell lung cancer

(2015) Jurgita Jackute et al.   Journal of Inflammation-London

Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens

(2015) Marina K Baine et al.   Oncotarget

Tumor infiltrating CD8+T lymphocyte count is independent of tumor TLR9 status in treatment naïve triple negative breast cancer and renal cell carcinoma

(2015) Mikko Mella et al.   OncoImmunology

Consensus nomenclature for CD8+T cell phenotypes in cancer

(2015) Lionel Apetoh et al.   OncoImmunology

Large B-Cell Lymphomas Poor in B Cells and Rich in PD-1+ T Cells Can Mimic T-Cell Lymphomas

(2014) Robert S. Ohgami et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

The Kinematics of Cytotoxic Lymphocytes Influence Their Ability to Kill Target Cells

(2014) Purnima Bhat et al.   PLoS One

Critical role of spatial interaction between CD8+ and Foxp3+ cells in human gastric cancer: the distance matters

(2013) Anita Feichtenbeiner et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Automatic Cell Detection in Bright-Field Microscope Images Using SIFT, Random Forests, and Hierarchical Clustering

(2013) Firas Mualla et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

The additional facet of immunoscore: immunoprofiling as a possible predictive tool for cancer treatment

(2013) Paolo A Ascierto et al.   Journal of Translational Medicine

The immune score as a new possible approach for the classification of cancer

(2012) Jérôme Galon et al.   Journal of Translational Medicine

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors

(2011) S. R. Mattarollo et al.   CANCER RESEARCH

Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy

(2011) N. Halama et al.   CANCER RESEARCH

Robust Segmentation of Overlapping Cells in Histopathology Specimens Using Parallel Seed Detection and Repulsive Level Set

(2011) Xin Qi et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

(2009) Y. Lee et al.   BLOOD

Automated Analysis and Detailed Quantification of Biomedical Images Using Definiens Cognition Network Technology®

(2009) Martin Baatz et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING