Journal
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
Volume 25, Issue 2, Pages 404-408Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1078155217752535
Keywords
Food timing; oral oncology drugs; bioavailability; efficacy
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Funding
- National Natural Science Foundation of China [81603209]
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Many oral anticancer agents are recommended to be given either at least 1 h before or 2 h after a meal, according to the prescribing information. However, the effect of dosage timing of an oral anticancer agent with reference to food intake on anticancer treatment remains unclear. As shown by the literature survey and labeling analysis for oral anticancer drugs approved by the US Food and Drug Administration from 2010 to 2016, labeling information regarding dosage timing for several anticancer drugs appeared not be optimum, leading to suboptimal bioavailability and plasma drug concentrations. This supports a call to regularly recalibrate the labeling information for dosage timing of oral anticancer medications to minimize the risks of compromised efficacy or unintended toxicities.
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