Article
Pediatrics
Zhihui Rong, Luxia Mo, Rui Pan, Xiaofang Zhu, Hongbin Cheng, Maojun Li, Lubiao Yan, Yujie Lang, Xiaoshan Zhu, Liping Chen, Shiwen Xia, Jun Han, Liwen Chang
Summary: The study showed that using bovine surfactant (Calsurf) in neonates with neonatal acute respiratory distress syndrome (NARDS) significantly improved oxygenation index, but did not have a significant impact on mortality, duration of ventilator support, or oxygen use. This is the first large randomized controlled trial studying surfactant treatment in neonates with acute respiratory distress syndromes, demonstrating the acute improvement in oxygenation after administration.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Xiaoqin Liu, Chun Pan, Lining Si, Shijun Tong, Yi Niu, Haibo Qiu, Guifen Gan
Summary: This study aimed to determine the value of the Berlin Definition altitude-PaO2/FiO(2)-corrected criteria for ARDS in Xining, Qinghai. The results showed that this criteria can distinguish the severity of ARDS, but further confirmation is needed through larger sample and multicenter clinical studies.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Nadir Yehya, Lincoln J. Smith, Neal J. M. Thomas, Katherine M. Steffen, Jerry Zimmerman, Jan Hau J. Lee, Simon J. L. Erickson, Steven L. Shein
Summary: This article presents the revisions of the definitions for Pediatric Acute Respiratory Distress Syndrome (PARDS) made during the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2). Through the assessment of a large number of research data, 17 consensus-based definition statements were generated to update the definitions of PARDS, Possible PARDS, and At-Risk for PARDS.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Nadir Yehya, Hossein Fazelinia, Gladys G. Lawrence, Lynn A. Spruce, Mark Mai, G. Scott Worthen, Jason D. Christie
Summary: This study found that plasma nucleosomes are associated with the severity of acute respiratory distress syndrome (ARDS) in children, as well as with nonpulmonary organ failures. Nucleosomes were also linked to higher mortality rates and fewer ventilator-free days in the pediatric ARDS patients. Proteomic analysis further showed elevated levels of core nucleosome histones in septic children with ARDS.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Anoopindar K. Bhalla, Margaret J. Klein, Guillaume Emeriaud, Yolanda M. Lopez-Fernandez, Natalie Napolitano, Analia Fernandez, Awni M. Al-Subu, Rainer Gedeit, Steven L. Shein, Ryan Nofziger, Deyin Doreen Hsing, George Briassoulis, Stavroula Ilia, Florent Baudin, Byron Enrique Pineres-Olave, Ledys Maria Izquierdo, John C. Lin, Ira M. Cheifetz, Martin C. J. Kneyber, Lincoln Smith, Robinder G. Khemani, Christopher J. L. Newth
Summary: The study described mechanical ventilation management in pediatric acute respiratory distress syndrome and found that nonadherence to lung-protective ventilation principles is common, potentially impacting outcomes. Modifiable factors exist that may improve adherence.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Darya Rudym, Tai Pham, Craig R. Rackley, Giacomo Grasselli, Michaela Anderson, Matthew R. Baldwin, Jeremy Beitler, Cara Agerstrand, Alexis Serra, Lisle A. Winston, Desiree Bonadonna, Natalie Yip, Logan J. Emerson, Amy Dzierba, Joshua Sonett, Darryl Abrams, Niall D. Ferguson, Matthew Bacchetta, Matthieu Schmidt, Daniel Brodie
Summary: This study investigated the association between obesity and mortality in patients with ARDS receiving ECMO. The results showed that patients with obesity had lower ICU mortality than patients without obesity, supporting the idea that obesity should not be considered a general contraindication to ECMO.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Steven L. Shein, Aline B. Maddux, Margaret J. Klein, Anoopindar Bhalla, George Briassoulis, Mary K. Dahmer, Guillaume Emeriaud, Heidi R. Flori, Rainer Gedeit, Stavroula Ilia, Martin C. J. Kneyber, Natalie Napolitano, Shinichiro Ohshimo, Marti Pons-Odena, Sarah Rubin, Benjamin R. White, Nadir Yehya, Robinder Khemani, Lincoln Smith
Summary: This study aimed to characterize the frequency and outcomes of children meeting at risk for pediatric acute respiratory distress syndrome criteria. The results showed that the criteria identified high-risk critically ill children and were associated with increased mortality and longer treatment durations.
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Giacomo Grasselli, Carolyn S. Calfee, Luigi Camporota, Daniele Poole, Marcelo B. P. Amato, Massimo Antonelli, Yaseen M. Arabi, Francesca Baroncelli, Jeremy R. Beitler, Giacomo Bellani, Geoff Bellingan, Bronagh Blackwood, Lieuwe D. J. Bos, Laurent Brochard, Daniel Brodie, Karen E. A. Burns, Alain Combes, Sonia D'Arrigo, Daniel De Backer, Alexandre Demoule, Sharon Einav, Eddy Fan, Niall D. Ferguson, Jean-Pierre Frat, Luciano Gattinoni, Claude Guerin, Margaret S. Herridge, Carol Hodgson, Catherine L. Hough, Samir Jaber, Nicole P. Juffermans, Christian Karagiannidis, Jozef Kesecioglu, Arthur Kwizera, John G. Laffey, Jordi Mancebo, Michael A. Matthay, Daniel F. McAuley, Alain Mercat, Nuala J. Meyer, Marc Moss, Laveena Munshi, Sheila N. Myatra, Michelle Ng Gong, Laurent Papazian, Bhakti K. Patel, Mariangela Pellegrini, Anders Perner, Antonio Pesenti, Lise Piquilloud, Haibo Qiu, Marco Ranieri, Elisabeth Riviello, Arthur S. Slutsky, Renee D. Stapleton, Charlotte Summers, Taylor B. Thompson, Carmen Valente Barbas, Jesus Villar, Lorraine B. Ware, Bjoern Weiss, Fernando G. Zampieri, Elie Azoulay, Maurizio Cecconi
Summary: The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients' representatives on behalf of the ESICM.
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
V. Marco Ranieri, Gordon Rubenfeld, Arthur S. Slutsky
Summary: The definition of acute respiratory distress syndrome (ARDS) has encountered controversies, especially during the COVID-19 pandemic. The increase in ARDS incidence, new treatment modalities, and difficulty of diagnosis in resource-limited settings have further amplified the debates. This article suggests using a framework developed by psychologists and social scientists to revise the definition of ARDS in a structured manner, focusing on measures of reliability, feasibility, and validity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Jie Guo, Jia Zhu, Qian Wang, Juan Wang, Yaodan Jia
Summary: A study compared the efficacy of seven different Chinese medicine injections in the treatment of ALI/ARDS patients, finding that Xuebijing, Tanreqing, and Huangqi showed certain effects on treating ALI/ARDS in different aspects. Xuebijing was associated with lower mortality, while Tanreqing and Xuebijing had the best effect on improving the Oxygenation Index. In addition, Huangqi, Danshen, Tanreqing, and Xuebijing were effective in reducing certain scores related to the severity of the condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Jerome Rambaud, Ryan P. Barbaro, Duncan J. Macrae, Heidi Dalton
Summary: This article aims to systematically review and synthesize literature on children receiving extracorporeal membrane oxygenation (ECMO) support in pediatric acute respiratory distress syndrome (PARDS), with the goal of updating the recommendations from the Pediatric Acute Lung Injury Consensus Conference. Based on the analysis of 18 studies, six clinical recommendations, three good practice statements, two policy statements, and one research statement were generated.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Pediatrics
Yucai Zhang, Chunxia Wang, Fei Wang, Jingyi Shi, Jiaying Dou, Yijun Shan, Ting Sun, Yiping Zhou
Summary: Lung ultrasound score is a promising tool for predicting the prognosis in patients with ARDS under ECMO support. Moreover, LUS-72 h >= 24 is associated with high risk of PICU mortality in patients with pARDS who received ECMO.
FRONTIERS IN PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Ting-Yu Liao, Sheng-Yuan Ruan, Chien-Heng Lai, Li-Jung Tseng, Li-Ta Keng, You-Yi Chen, Chih-Hsien Wang, Jung-Yien Chien, Huey-Dong Wu, Yih-Sharng Chen, Chong-Jen Yu
Summary: This study aimed to investigate the impact of ventilator settings on patient outcomes in influenza-associated ARDS patients receiving vv-ECMO support. The results showed that a higher respiratory rate was associated with higher mortality. Therefore, adjusting the respiratory rate may improve outcomes in this patient population.
Article
Critical Care Medicine
Oliver Hunsicker, Lukas Beck, Alexander Krannich, Tobias Finger, Vincent Prinz, Claudia Spies, Steffen Weber-Carstens, Stefan Wolf, Jan Adriaan Graw, Mario Menk
Summary: Intracranial hemorrhage is a serious complication in patients receiving venovenous extracorporeal membrane oxygenation during treatment of the acute respiratory distress syndrome. The study found that early occurrence of intracranial hemorrhage is associated with higher 60-day mortality, and adjusting modifiable risk factors may lower the prevalence of this complication.
CRITICAL CARE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Nasrin Khalesi, Farhad Abolhasan Choobdar, Mousa Khorasani, Fatemeh Sarvi, Behzad Haghighi Aski, Mahmoud Khodadost
Summary: The study concluded that the oxygen saturation index (OSI) can accurately predict the severity of respiratory failure in preterm neonates with RDS, with high sensitivity and specificity values.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Pediatrics
Samriti Gupta, Jhuma Sankar, Praveen Narsaria, Saurabh Kumar Gupta, Rakesh Lodha, S. K. Kabra
Summary: The study aimed to determine the association of clinical and laboratory parameters at admission with septic myocardial dysfunction (SMD) in children with septic shock. It was found that prolonged CRT, increased lactate, lower platelet count, increased blood urea, and elevated liver enzymes at admission may be associated with SMD.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Krishna Mohan Gulla, Jhuma Sankar, Kana Ram Jat, Sushil Kumar Kabra, Rakesh Lodha
Summary: This study compared the efficacy of dexmedetomidine and midazolam for sedation in mechanically ventilated children aged 1 month to 15 years, finding no significant difference in the percentage of time spent in the target sedation level between the two groups. However, 17.4% of children in the dexmedetomidine group developed persistent bradycardia.
Article
Critical Care Medicine
Priyanka Gupta, Jhuma Sankar, B. Kiran Kumar, Kana Ram Jat, Aparna Mukherjee, Arti Kapil, Sushil K. Kabra, Rakesh Lodha
Summary: This study aimed to evaluate the prevalence of gastroesophageal reflux and its role in ventilator-associated pneumonia among mechanically ventilated children using 24-hour esophageal pH-metry. The findings showed a high incidence of pathologic gastroesophageal reflux in these children, with a subset developing ventilator-associated pneumonia. Further research on the impact of this reflux on ventilator-associated events is warranted.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Nishanth Dev, Ramesh Chand Meena, D. K. Gupta, Nitesh Gupta, Jhuma Sankar
Summary: The frequency of SARS-CoV-2 infection was 16% among healthcare workers in India. Sanitation workers, inappropriate personal protective equipment (PPE) use, and lack of hydroxychloroquine (HCQ) prophylaxis were significant risk factors for infection.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Pediatrics
Kana Ram Jat, Jhuma Sankar, Rashmi Ranjan Das, Vinod H. Ratageri, Bharat Choudhary, Javeed Iqbal Bhat, Baijayantimala Mishra, Sushma Bhatnagar, Bijayini Behera, Bashir Ahmad Charoo, Jagdish P. Goyal, Aditya Kumar Gupta, Krishna Mohan Gulla, Rani Gera, Shivanand Illalu, S. K. Kabra, Daisy Khera, Balbir Kumar, Rakesh Lodha, Anant Mohan, Pankaj Kumar Mohanty, Amit Kumar Satapathy, Kuldeep Singh, Amitabh Singh, Sumant Vinayak Sharma, Pawan Tiwari, Anjan Trikha, Prakash K. Wari
Summary: This study aimed to describe the clinical profile and risk factors for severe disease in children hospitalized with COVID-19 from India. Results showed that fever was the commonest symptom, with the majority of children being asymptomatic or mildly symptomatic. Abnormal inflammatory markers were associated with moderate to severe disease.
JOURNAL OF TROPICAL PEDIATRICS
(2021)
Review
Pediatrics
Jhuma Mondal Sankar, Rashmi Ranjan Das, Udhaya Vijaya Kumar
Summary: A systematic review compared intermittent and continuous ScvO(2) monitoring in patients with septic shock, finding no significant difference in overall mortality between the two methods. However, one observational study showed an increase in mortality in the intermittent monitoring group, indicating the need for further research in this area.
JOURNAL OF PEDIATRIC INTENSIVE CARE
(2022)
Article
Pediatrics
Amit Pathania, Jhuma Sankar, Rakesh Lodha, Sushil K. Kabra
Summary: This study aimed to evaluate the impact of a quality improvement initiative on the use of noninvasive ventilation (NIV) in critically ill children with respiratory distress. The results showed that implementing a protocol, checklist, and training program for the treating team improved the acceptance and success of NIV.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Editorial Material
Pediatrics
Anshula Tayal, Jhuma Sankar
INDIAN JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Samriti Gupta, Jhuma Sankar
Summary: Shock in children is a major cause of mortality and morbidity, especially in resource-poor settings. The management principles have evolved in the past decade, shifting from protocolized care to personalized management, from liberal to restrictive strategies, and from clinical monitoring to multimodal monitoring. However, uncertainties still exist regarding fluid volume, steroid use, and newer therapies for shock. This article provides a summary of these changes and the evidence to guide evidence-based management of pediatric shock.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Kumar Himanshu Bhadani, Jhuma Sankar, Sudip Kumar Datta, Sagar Tungal, Kana Ram Jat, Sushil K. Kabra, Rakesh Lodha
Summary: The study aimed to evaluate the performance of the empiric tool by Gupta et al. in predicting neurological outcomes in children admitted to the PICU, as well as the association of biomarkers S100B and NSE with these outcomes. The tool showed good discrimination and calibration, with a high prediction rate for favorable outcomes. Higher PCPC scores and organ failure were identified as independent factors associated with unfavorable neurological outcomes. The potential of NSE and S100B as biomarkers requires further evaluation.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Kiran Kumar Banothu, Jhuma Sankar, Mona Pathak, Devasenathipathy Kandasamy, Priyanka Gupta, Sushil Kumar Kabra, Rakesh Lodha
Summary: This study aims to evaluate the sensitivity and specificity of increment IVC and increment Vpeak in predicting fluid responsiveness in ventilated children with shock and determine the best cut-off values for predicting fluid responsiveness.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Critical Care Medicine
Jhuma Sankar, Vaishali Thakral, Kanchan Bharadwaj, Sheetal Agarwal, Sushil Kumar Kabra, Rakesh Lodha, Sumit Rathore
Summary: There are significant alterations in the gut microbiota and metabolome in children with sepsis/septic shock. Further research is needed to confirm these findings and develop potential therapeutic targets that will improve outcomes in children with sepsis/septic shock.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Jagat Jeevan Ghimire, Krishna Mohan Gulla, Kana Ram Jat, Jhuma Sankar, Rakesh Lodha, S. K. Kabra
Summary: The study found that Staphylococcus aureus colonization, especially when combined with Pseudomonas aeruginosa, in children with cystic fibrosis was associated with worsening of forced vital capacity (FVC) and clinical severity score, as well as increased pulmonary exacerbations.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Medicine, General & Internal
Mohsin Raj Mantoo, Jagat Jeevan Ghimire, Sarita Mahopatra, Jhuma Sankar
Summary: A 7-month-old male infant presented with an unusual clinical presentation and responded well to treatment before being discharged. A rare infection of Elizabethkingia anophelis was discovered during the course of the illness.
Article
Critical Care Medicine
Jhuma Sankar, A. Lalitha, Ramachandran Rameshkumar, Subramanian Mahadevan, Sushil K. Kabra, Rakesh Lodha
Summary: This study compared the use of medicated honey dressings with standard care in pediatric intensive care unit for pressure injuries in children, showing that children treated with medicated honey dressings had a shorter time to wound healing.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
