☆ 4.5 Article

New Normative Database of Inner Macular Layer Thickness Measured by Spectralis OCT Used as Reference Standard for Glaucoma Detection

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2018)

Journal

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY

Volume 7, Issue 1, Pages -

Publisher

ASSOC RESEARCH VISION OPHTHALMOLOGY INC

DOI: 10.1167/tvst.7.1.20

Keywords

ganglion cell layer; retinal nerve fiber layer; inner plexiform layer; Spectralis-OCT

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Abstract

Purpose: This study examines the capacity to detect glaucoma of inner macular layer thickness measured by spectral-domain optical coherence tomography (SD-OCT) using a new normative database as the reference standard. Methods: Participants (N = 148) were recruited from Leuven (Belgium) and Zaragoza (Spain): 74 patients with early/moderate glaucoma and 74 age-matched healthy controls. One eye was randomly selected for a macular scan using the Spectralis SD-OCT. The variables measured with the instrument's segmentation software were: macular nerve fiber layer (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) volume and thickness along with circumpapillary RNFL thickness (cpRNFL). The new normative database of macular variables was used to define the cutoff of normality as the fifth percentile by age group. Sensitivity, specificity, and area under the receiver operating characteristic curve (AUROC) of each macular measurement and of cpRNFL were used to distinguish between patients and controls. Results: Overall sensitivity and specificity to detect early-moderate glaucoma were 42.2% and 88.9% for mRNFL, 42.4% and 95.6% for GCL, 42.2% and 94.5% for IPL, and 53% and 94.6 degrees/o for RNFL, respectively. The best macular variable to discriminate between the two groups of subjects was outer temporal GCL thickness as indicated by an AUROC of 0.903. This variable performed similarly to mean cpRNFL thickness (AUROC = 0.845; P = 0.29). Conclusions: Using our normative database as reference, the diagnostic power of inner macular layer thickness proved comparable to that of peripapillary RNFL thickness. Translational Relevance: Spectralis SD-OCT, cpRNFL thickness, and individual macular inner layer thicknesses show comparable diagnostic capacity for glaucoma and RNFL, GCL, and IPL thickness may be useful as an alternative diagnostic test when the measure of cpRNFL shows artifacts.

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Comparison of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness Values Using Spectral-Domain and Swept-Source OCT

Alessandro Rabiolo, Federico Fantaguzzi, Giovanni Montesano, Maria Brambati, Riccardo Sacconi, Francesco Gelormini, Giacinto Triolo, Paolo Bettin, Giuseppe Querques, Francesco Bandello

Summary: This study compared the measurements of pRNFL and mGCIPL thickness obtained with SD-OCT and SS-OCT, and assessed their ability to distinguish among glaucoma patients, glaucoma suspects, and healthy controls. The results showed that both SD-OCT and SS-OCT detected thinning in pRNFL and mGCIPL in glaucoma patients compared to healthy controls and glaucoma suspects. The two devices demonstrated similar diagnostic abilities, and conversion formulas could be used to remove the proportional bias.

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2022)