Journal
ROYAL SOCIETY OPEN SCIENCE
Volume 5, Issue 3, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsos.171364
Keywords
graphene foam; biocompatibility; human stem cells; human cortical neurons
Categories
Funding
- University of Melbourne
- Australian Research Council
- ARC Centre of Excellence for Integrative Brain Function
- Australian Research Council Future Fellowship
- Saudi Arabian Ministry of Higher Education (Saudi Arabia)
- Clifford Chair in Neural Engineering
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In this study, we explore the use of electrically active graphene foam as a scaffold for the culture of human-derived neurons. Human embryonic stein cell (hESC)-derived cortical neurons fated as either glutamatergic or GABAergic neuronal phenotypes were cultured on graphene foam. We show that graphene foam is biocompatible for the culture of human neurons, capable of supporting cell viability and differentiation of hESC-derived cortical neurons. Based on the findings, we propose that graphene foam represents a suitable scaffold for engineering neuronal tissue and warrants further investigation as a model for understanding neuronal maturation, function and circuit formation.
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