Article
Endocrinology & Metabolism
Megan Rodgers, Alexandra L. Migdal, Tahereh Ghorbani Rodriguez, Zsu-Zsu Chen, Anjali K. Nath, Robert E. Gerszten, Natasha Kasid, Elena Toschi, Juliet Tripaldi, Brent Heineman, Minh Phan, Long Ngo, Eleftheria Maratos-Flier, Jody Dushay
Summary: In this study, long-term weight loss with exenatide treatment was similar to that achieved with a hypocaloric diet in a population of early high responders. Weight loss at 3 months of treatment predicted super responder status in both treatment groups, with individual variability observed in weight loss outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Alejandra Mera-Charria, Francisco Nieto-Lopez, Manel Pacareu Frances, Priscila Marques Arbex, Laura Vila-Vecilla, Valentina Russo, Carolina Costa Vicente Silva, Gustavo Torres De Souza
Summary: This study evaluates the association of 102 SNPs with BMI and weight loss treatment response in a multi-ethnic population. The findings provide valuable insights into personalized weight management approaches based on individual genetic profiles.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Karen E. Elkind-Hirsch, N. Chappell, Ericka Seidemann, John Storment, Drake Bellanger
Summary: EQW/DAPA and PHEN/TPM showed the most significant reduction in weight and body fat, as well as improvements in blood glucose levels and insulin sensitivity. All drugs resulted in decreases in fasting glucose, testosterone, FAI, and blood pressure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Surgery
Liang Wang, Guangzhong Xu, Chenxu Tian, Qing Sang, Chengyuan Yu, Qiqige Wuyun, Zheng Wang, Weijian Chen, Buhe Amin, Dezhong Wang, Guanyang Chen, Dongbo Lian, Nengwei Zhang
Summary: This study aimed to predict weight loss after laparoscopic sleeve gastrectomy among Chinese patients with BMI >= 32.5 kg/m2, and found that CGRS was superior in prediction compared to using GRS or CRS alone.
Article
Gastroenterology & Hepatology
Dinghui Liu, Juan Pang, Weijuan Shao, Jianqiu Gu, Yong Zeng, Housheng Hansen He, Wenhua Ling, Xiaoxian Qian, Tianru Jin
Summary: This study suggests that liraglutide-stimulated hepatic Fgf21 expression may require GLP-1R to be expressed in extrahepatic organs and reveals that hepatic FGF21 is necessary for liraglutide to lower body weight and improve hepatic lipid homeostasis. These findings advance our understanding of the mechanisms behind the function of GLP-1-based drugs in NAFLD.
Article
Endocrinology & Metabolism
Fioralba Pindozzi, Carlo Socci, Massimiliano Bissolati, Monica Marchi, Elisabetta Devecchi, Alessandro Saibene, Caterina Conte
Summary: This study found that nutritional ketosis is associated with greater weight loss and better metabolic status in patients undergoing bariatric metabolic surgery. Patients with better metabolic status have a higher capacity for ketogenesis, leading to more significant weight loss.
WORLD JOURNAL OF DIABETES
(2022)
Article
Health Care Sciences & Services
Anastasia Ponasenko, Maxim Sinitsky, Varvara Minina, Anna Vesnina, Maria Khutornaya, Alexander Prosekov, Olga Barbarash
Summary: More than two billion people worldwide are overweight or obese, and even apparently healthy individuals are affected by obesity. This study found that polymorphisms in immune response and lipid metabolism genes may be associated with changes in obesity risk in the Caucasian population.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Physiology
Igor B. Mekjavic, Mojca Amon, Elizabeth J. Simpson, Roger Koelegard, Ola Eiken, Ian A. Macdonald
Summary: This study aimed to investigate the effect of hypoxia on metabolism in men with excess weight. The results showed that hypoxia increased energy expenditure and levels of PYY, potentially leading to appetite inhibition and weight loss, but it also indicated the development of insulin resistance.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyo Bin Lee, Ah Young Lee, Yumi Jang, Young Hye Kwon
Summary: This study investigated the distinctive effects of soy protein components on adiposity and circulating miRNA profiles in obese mice. The results showed that soy isoflavones are the main contributor to the health-beneficial effects of soy protein in diet-induced obesity. The dysregulation of circulating miRNAs coincided with obesity.
Article
Biochemistry & Molecular Biology
Qiang-Ming Li, Xue-Qiang Zha, Wei-Nan Zhang, Jian Liu, Li-Hua Pan, Jian-Ping Luo
Summary: The study demonstrates that Laminaria japonica polysaccharide has a significant effect on inhibiting atherosclerosis and improving insulin resistance induced by high-fat diet in mice, along with reducing obesity, inflammation, metabolic endotoxemia, and gut permeability. Additionally, it can regulate gut microbiota, especially Akkermansia, to achieve these effects.
Review
Nutrition & Dietetics
Elena Gangitano, Noelia Martinez-Sanchez, Maria Irene Bellini, Irene Urciuoli, Stefania Monterisi, Stefania Mariani, David Ray, Lucio Gnessi
Summary: Sleep is important for survival, but the time dedicated to sleep has been reduced in industrialized countries. This reduction may contribute to the increase in obesity, diabetes, and cardiovascular disease. Conversely, obesity is associated with sleep disorders. Understanding the physiological and molecular pathways involved in sleep regulation and metabolic homeostasis could improve metabolic health. Strategies aimed at weight loss may benefit both cardiometabolic risk and sleep quality.
Review
Chemistry, Medicinal
Agni Kakouri, Georgia Kanti, Efthymios Kapantais, Alexandros Kokkinos, Leonidas Lanaras, Paul Farajian, Christos Galanakis, Georgios Georgantopoulos, Nikos F. Vlahos, George Mastorakos, Alexandra Bargiota, Georgios Valsamakis
Summary: The global trend of increasing obesity rates presents challenges in finding effective long-term treatments. Current anti-obesity drugs have limited effectiveness and potential side effects, leading researchers to explore the use of combined medications targeting multiple pathways for better outcomes in obesity management.
Article
Medicine, General & Internal
Sabine Julia Maria Sag, Stephanie Mueller, Stefan Wallner, Christina Strack, Ute Hubauer, Margareta Mohr, Judith Zeller, Thomas Loew, Michael Rehli, Julia Wimmer, Martina Erika Zimmermann, Lars Siegfried Maier, Marcus Fischer, Andrea Baessler
Summary: A study showed that a genetic risk score (GRS) can differentiate between obese and lean individuals and is associated with body mass index (BMI) and its related metabolic alterations, but with small effect sizes.
Article
Endocrinology & Metabolism
Eiichi Yoshimura, Yuka Hamada, Yoichi Hatamoto, Takashi Nakagata, Hinako Nanri, Yui Nakayama, Takanori Hayashi, Ippei Suzuki, Takafumi Ando, Kazuko Ishikawa-Takata, Shigeho Tanaka, Rei Ono, Jonguk Park, Koji Hosomi, Kenji Mizuguchi, Jun Kunisawa, Motohiko Miyachi
Summary: Short-term energy loads have dynamic effects on the diversity and composition of gut microbiota. Energy excretion rates via urine and urine plus feces are lower under OF conditions compared to CON and UF conditions, while energy excretion rates via feces show no difference among conditions.
Article
Multidisciplinary Sciences
Carolina Lopez-Cano, Maria Dolores Santos, Enric Sanchez, Raquel Marti, Marta Bueno, Liliana Gutierrez-Carrasquilla, Albert Lecube
Summary: The combination therapy of exenatide and dapagliflozin appears to be a strategic option for reducing the waiting list for bariatric surgery and achieving weight loss and BMI reduction in patients with type 2 diabetes.
SCIENTIFIC REPORTS
(2022)
Article
Biophysics
Alejandra N. Torres, Ludgero Tavares, Maria J. Pereira, Jan W. Eriksson, John G. Jones
Summary: This study characterized the fatty acid composition and positional distribution of triglycerides in human subcutaneous adipose tissue using C-13 NMR spectroscopy. The study found that the sn2 position of triglycerides is enriched with monounsaturated fatty acids, while the sn1,3 position is enriched with saturated fatty acids. Furthermore, the study revealed a significant positive correlation between palmitoleic acid levels and both BMI and insulin sensitivity.
NMR IN BIOMEDICINE
(2023)
Article
Transplantation
Phil McEwan, Rebecca Boyce, Juan Jose Garcia Sanchez, C. David Sjostrom, Bergur Stefansson, Stephen Nolan, Ricardo Correa-Rotter, Peter Rossing, Glenn M. Chertow, John J. McMurray, David C. Wheeler, Hiddo J. L. Heerspink
Summary: The DAPA-CKD trial demonstrated that dapagliflozin has significant benefits in patients with chronic kidney disease and albuminuria. Using a Markov model, it was predicted that dapagliflozin treatment would lead to longer time in lower CKD stages, reduced mortality, and fewer complications such as heart failure and kidney function decline.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Meir Schechter, Niels Jongs, Glenn M. Chertow, Ofri Mosenzon, John J. McMurray, Ricardo Correa-Rotter, Peter Rossing, Anna Maria Langkilde, C. David Sjostrom, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Summary: This study aimed to determine the effects of dapagliflozin on hospitalizations in patients with chronic kidney disease (CKD). The results showed that dapagliflozin reduced the risk of hospitalization for any cause in patients with CKD, regardless of whether they had type 2 diabetes or not.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maria J. Pereira, Ayesha Azim, Susanne Hetty, Bipasha Nandi Jui, Joel Kullberg, Martin H. Lundqvist, Jan W. Eriksson
Summary: This study aims to investigate the expression of interleukin-33 (IL-33) in subcutaneous adipose tissue (SAT) of type 2 diabetes (T2D) subjects and its effects on human adipocyte glucose uptake. The results showed that T2D subjects had higher IL-33 gene and protein expression in SAT, which was associated with insulin resistance and reduced gene expression of markers related to lipid storage and adipogenesis. Additionally, IL-33 treatment reduced adipocyte glucose uptake.
Article
Endocrinology & Metabolism
Jelle M. Beernink, Frederik Persson, Niels Jongs, Gozewijn D. Laverman, Glenn M. Chertow, John J. V. McMurray, Anna Maria Langkilde, Ricardo Correa-Rotter, Peter Rossing, C. David Sjostrom, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Summary: This study aimed to determine whether the benefits of dapagliflozin varied by background glucose-lowering therapy (GLT) in patients with type 2 diabetes and chronic kidney disease (CKD). The results demonstrated consistent effects of dapagliflozin on both primary and secondary endpoints across different baseline GLT classes or combinations. Therefore, dapagliflozin has significant clinical implications in reducing kidney and cardiovascular events.
Article
Endocrinology & Metabolism
Annemarie B. van der Aart-van Der Beek, Ellen Apperloo, Niels Jongs, Dennis B. Rouw, C. David Sjostrom, Iris Friedli, Lars Johansson, Daniel H. van Raalte, Klaas Hoogenberg, Hiddo J. L. Heerspink
Summary: This study evaluated the effects of dapagliflozin, exenatide, and the combination of dapagliflozin and exenatide on reducing albuminuria in patients with type 2 diabetes and microalbuminuria or macroalbuminuria. The study found that all three treatments could reduce albuminuria, with the combination therapy showing the most significant reduction.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Kamlesh Khunti, Volker Schnecke, Christiane Lundegaard Haase, Nina M. Harder-Lauridsen, Naveen Rathor, Kasper Sommer, Camilla S. Morgen
Summary: This study aimed to investigate the association between weight loss/gain and the risk of developing 13 obesity-related complications (ORCs), according to baseline body mass index (BMI). The study included adults with obesity (>30 kg/m(2)) from the UK Clinical Practice Research Datalink GOLD database, and the associations were examined using Cox proportional hazard models. The results revealed four distinct patterns of association between degree of weight change, baseline BMI, and the 13 ORCs.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Nayyar Iqbal, Philip Ambery, Jennifer Logue, Ashwini Mallappa, C. David Sjostrom
Summary: Treatment of T2D and obesity should include glycemic control, sustained weight loss, and organ protection. SGLT2i and GLP-1-glucagon dual agonists are two classes of drugs that can facilitate this approach by addressing the underlying pathophysiology, increasing periods of catabolic energy consumption, and potentially providing long-term cardio-renal benefits.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Ruifeng Shi, Jing Cen, Gunilla T. Westermark, Sheng Zhao, Nils Welsh, Zilin Sun, Joey Lau
Summary: This study aimed to explore the expression of C-type lectin domain containing 11A (CLEC11A) in human islets and its effects on beta-cell function and proliferation. It was found that CLEC11A was expressed in beta-cells and alpha-cells in human islets, and its introduction enhanced glucose-stimulated insulin secretion, insulin content, and proliferation in both human islets and EndoC-beta H1 cells. However, its improvement on impaired beta-cell function caused by chronic palmitate exposure was only partial. Based on these findings, CLEC11A may serve as a potential therapeutic target for maintaining beta-cell function in patients with diabetes.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Glenn M. Chertow, Ricardo Correa-Rotter, Priya Vart, Niels Jongs, John J. V. McMurray, Peter Rossing, Anna Maria Langkilde, C. David Sjostrom, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Summary: In the DAPA-CKD trial, dapagliflozin was found to reduce the risk of kidney and cardiovascular events in patients with chronic kidney disease and albuminuria. The treatment effect of dapagliflozin was consistent regardless of baseline cardiovascular medication use.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Martin H. Lundqvist, Maria J. Pereira, Kristina Almby, Susanne Hetty, Jan W. Eriksson
Summary: Counter-regulatory hormonal responses to glucose variations differ in individuals with type 2 diabetes, prediabetes, and normoglycemia, and may contribute to the progression of the disease by promoting insulin resistance and dysglycemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Jessica A. Regan, Robert J. Mentz, Maggie Nguyen, Jennifer B. Green, Lauren K. Truby, Olga Ilkayeva, Christopher B. Newgard, John B. Buse, Harald Sourij, C. David Sjostrom, Naveed Sattar, Robert W. Mcgarrah, Yinggan Zheng, Darren K. Mcguire, Eberhard Standl, Paul Armstrong, Eric D. Peterson, Adrian F. Hernandez, Rury R. Holman, Svati H. Shah
Summary: This study reveals the heterogeneity of major adverse cardiovascular event (MACE) risk in individuals with type 2 diabetes mellitus (T2D) and identifies circulating metabolites reflecting mitochondrial dysfunction that can predict incident MACE. These metabolites remain associated with MACE in multivariate models and show favorable changes with exenatide therapy. The findings suggest that these biomarkers may improve cardiovascular risk prediction models and highlight emerging risk mechanisms.
Article
Endocrinology & Metabolism
Martin H. Lundqvist, Maria J. Pereira, Jan W. Eriksson
Summary: This study investigates whether inflammatory responses to glycemic and insulinemic variations are altered in obese individuals. The results show that hyperinsulinemia, hypoglycemia, and hyperglycemia lead to a decrease in multiple inflammatory markers, and the inflammatory response is more pronounced in obese individuals during hypoglycemia and hyperglycemia.
Article
Endocrinology & Metabolism
Fozia Ahmed, Milica Vranic, Susanne Hetty, Argyri Mathioudaki, Vagia Patsoukaki, Giovanni Fanni, Maria J. Pereira, Jan W. Eriksson
Summary: This study investigated the association of organic cation transporter 3 (OCT3) mRNA levels in subcutaneous adipose tissue with aging and markers of insulin resistance. The results showed that mRNA and protein levels of OCT3 increased with aging and were negatively associated with markers of insulin resistance. In addition, estradiol treatment resulted in a reduction in OCT3 mRNA levels.
Article
Endocrinology & Metabolism
Milica Vranic, Fozia Ahmed, Robin Kristofi, Susanne Hetty, Dariush Mokhtari, Maria K. Svensson, Jan W. Eriksson, Maria J. Pereira
Summary: This study evaluates the dopaminergic signaling in human adipose tissue in the context of obesity and type 2 diabetes (T2D) and its potential implications in adipose tissue metabolism. The results suggest that protein expression of DRD2 in subcutaneous adipose tissue is up-regulated with hyperglycemia and T2D, possibly as a compensatory mechanism. Additionally, dopamine receptor agonists inhibit adipocyte lipolysis and may have beneficial effects on lipid metabolism.