Article
Multidisciplinary Sciences
Drew C. Schreiner, Christian Cazares, Rafael Renteria, Christina M. Gremel
Summary: Prior experience plays a crucial role in guiding adaptive behavior during decision making. This study demonstrates that mice not only use information from prior actions and rewards, but also selectively incorporate information from recent and longer-term experiences, including checking behavior and the passage of time, to guide self-initiated actions. These experiences are represented in the secondary motor cortex and its projections into the dorsal medial striatum, which influence strategy-level decision-making.
NATURE COMMUNICATIONS
(2022)
Article
Psychiatry
Keitaro Murayama, Hirofumi Tomiyama, Aikana Ohno, Kenta Kato, Akira Matsuo, Suguru Hasuzawa, Kenta Sashikata, Mingi Kang, Tomohiro Nakao
Summary: This study investigated deficits in decision-making in patients with OCD using the PVL model and found that the most recent outcome has a small influence on the expectancy of prospect valence, indicating more impulsive choices.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Cell Biology
Yuki Sakai, Yutaka Sakai, Yoshinari Abe, Jin Narumoto, Saori C. Tanaka
Summary: This study models obsessive-compulsive disorder (OCD) symptoms as implicitly learned maladaptive behaviors using reinforcement learning framework, extends understanding of therapeutic effects of behavioral therapy in OCD, and discovers imbalanced traces in OCD patients and healthy participants.
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Psychiatry
Clark Roberts, Annemieke M. Apergis-Schoute, Annette Bruhl, Magda Nowak, David S. Baldwin, Barbara J. Sahakian, Trevor W. Robbins
Summary: Patients with generalized anxiety disorder (GAD) exhibit heightened physiological responses to threat cues, but show no deficits in instrumental avoidance learning or persistent avoidance habits.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Qiang Luo, Jonathan W. Kanen, Andrea Bari, Nikolina Skandali, Christelle Langley, Gitte Moos Knudsen, Johan Alsio, Benjamin U. Phillips, Barbara J. Sahakian, Rudolf N. Cardinal, Trevor W. Robbins
Summary: This study shows that manipulating serotonin function in rats and humans can affect behavioral flexibility and plasticity. Specifically, increasing serotonin function increases choice repetition ("stickiness") and reward learning rates, while decreasing serotonin function decreases these measures. This finding is clinically relevant for understanding neuropsychiatric disorders.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Alec Solway, Zhen Lin, Ekansh Vinaik
Summary: Real-life decisions are often revisited, especially in individuals with OCD. Both implicit and explicit memories of previous decisions affect subsequent decisions, with a reduction in information transfer effects specifically due to implicit memory in OCD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Hospitality, Leisure, Sport & Tourism
Gabrielle Lin, Michael S. Lin, Haiyan Song
Summary: Prospect theory is a foundational theory in behavioral economics and has received recognition with the Nobel Prize in economic sciences in 2002. Due to the increasing interest in behavioral economics among tourism researchers, there is a need for a systematic assessment of prospect theory and its application in tourism research. This study clarifies the theoretical background of prospect theory, analyzes 93 published studies, evaluates its performance in explaining tourism decision-making, and provides future research directions.
JOURNAL OF TRAVEL RESEARCH
(2023)
Article
Psychology, Biological
Pedro Castro-Rodrigues, Thomas Akam, Ivar Snorasson, Marta Camacho, Vitor Paixao, Ana Maia, J. Bernardo Barahona-Correa, Peter Dayan, H. Blair Simpson, Rui M. Costa, Albino J. Oliveira-Maia
Summary: Explicit information obtained through instruction profoundly shapes human choice behaviour, specifically affecting model-based and model-free systems in complex decision-making tasks. Providing task structure information strongly increases model-based control in both healthy volunteers and individuals with obsessive-compulsive disorder.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Multidisciplinary Sciences
Anne Buot, Cecile Pallares, Alina Oganesyan, Charles Daure, Valerie Bonnelle, Eric Burguiere, Joao Flores Alves Dos Santos, Karim N'Diaye, Michael Ljuslin, Pauline Smith, Vincent Verroust, Benjamin Wyplosz, Margot Morgieve, Luc Mallet
Summary: There has been a renewed interest in using psychedelics to treat OCD in the past 20 years. However, there is limited pre-clinical and clinical evidence, and little is known about the factors that determine the magnitude and persistence of the therapeutic effect. A retrospective online survey was conducted to explore the impact of psychoactive drugs on OCD symptoms in the general population. The survey found that classic psychedelics were the only substances reported to be effective in reducing OCD symptoms.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Yilin Chen, Ying Liu, Zhen Wang, Tianming Yang, Qing Fan
Summary: This study compared OCD patients with a control group and found that OCD patients process evidence differently during decision-making. While their decision-making accuracy was similar to the control group, OCD patients took longer to accumulate evidence, especially in difficult trials with low evidence strength. Model analysis showed that the OCD group was less sensitive to evidence.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neuroimaging
Darsol Seok, Reza Tadayonnejad, Wan-wa Wong, Joseph O'Neill, Jeff Cockburn, Ausaf A. Bari, John P. O'Doherty, Jamie D. Feusner
Summary: This study found differences in the decision-making and arbitration systems between patients with OCD and BDD, which may represent specific neural phenotypes of obsessive-compulsive symptoms. These results provide potential treatment targets for novel circuit-specific treatments.
NEUROIMAGE-CLINICAL
(2022)
Review
Clinical Neurology
Natalia Szejko, Kirsten R. Muller-Vahl
Summary: Tourette syndrome (TS) is characterized by vocal and motor tics, often accompanied by psychiatric comorbidities. Differential diagnosis between tics and OCD-related phenomena can be challenging, as some symptoms may overlap. "Just right" phenomena are common in patients with TS, showing similarities with both tics and OCD. Treatment strategies for tics and OCD in TS patients should take into consideration these complexities.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Medicine, General & Internal
Lilach Rachamim, Hila Mualem-Taylor, Osnat Rachamim, Michael Rotstein, Sharon Zimmerman-Brenner
Summary: This study found that in children and adolescents with tic disorders, both the presence of ADHD and the absence of comorbid ADHD were associated with similar reductions in tic symptoms after internet-delivered, self-help comprehensive behavioral intervention for tics (ICBIT). However, the presence of OCD comorbidity was associated with a lesser response to intervention. Furthermore, the intervention also led to significant reductions in parental reports of inattention, hyperactivity, and impulsivity. Larger studies are needed to further optimize the application of ICBIT in children and teens with both tic disorders and comorbid ADHD and OCD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Francesco Demaria, Paolo Alfieri, Maria Cristina Digilio, Maria Pontillo, Cristina Di Vincenzo, Federica Alice Maria Montanaro, Valentina Ciullo, Giuseppe Zampino, Stefano Vicari
Summary: KBG syndrome is a rare disease characterized by short stature, facial dysmorphism, and other symptoms. This study found that a subset of patients with KBGS exhibited peculiar behaviors related to paper handling, reminiscent of symptoms seen in obsessive compulsive disorder.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Alessandro S. De Nadai, Kate D. Fitzgerald, Luke J. Norman, Stefanie R. Russman Block, Kristin A. Mannella, Joseph A. Himle, Stephan F. Taylor
Summary: This study investigates the heterogeneity in neural activity of OCD patients using unsupervised machine learning and identifies three subgroups. These findings improve precision in patient characterization and provide a starting point for neuroimaging-guided treatment selection.
NEUROPSYCHOPHARMACOLOGY
(2023)
Editorial Material
Neurosciences
Stephan F. Taylor, Meghan E. Martz
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Molly Simmonite, Clara J. Steeby, Stephan F. Taylor
Summary: GABA abnormalities may contribute to the pathophysiology of psychosis spectrum and mood disorders. Lower GABA levels were found in the mid- and posterior medial frontal cortex of schizophrenia patients, while increased GABA levels were observed in the rostral medial frontal cortex of bipolar disorder patients.
BIOLOGICAL PSYCHIATRY
(2023)
Review
Neurosciences
Cynthia Z. Burton, Emily O. Garnett, Emily Capellari, Soo-Eun Chang, Ivy F. Tso, Benjamin M. Hampstead, Stephan F. Taylor
Summary: A systematic review and meta-analysis showed that combined cognitive training and transcranial direct current stimulation (tDCS) have a small but significant effect on attention/working memory, but only small and non-significant effects on global cognition and language. However, the results are limited by small sample sizes and inconsistent findings, and more data are needed to confirm the efficacy.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychiatry
Stefanie Russman Block, Luke J. Norman, Xiaoxi Zhang, Kristin A. Mannella, Huan Yang, Mike Angstadt, James L. Abelson, Joseph A. Himle, Stephan F. Taylor, Kate D. Fitzgerald
Summary: This study found that cortical-subcortical hyperconnectivity related to affective-behavioral integration and cortical network hypoconnectivity related to cognitive control are present in OCD patients. The objective was to examine whether these connectivity patterns predict treatment response. The results showed that ERP produced greater decreases in symptom scores compared to SMT. Decreased connectivity between vmPFC and subcortical regions, especially in unmedicated participants, was associated with ERP.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Takakuni Suzuki, Pan Gu, Tyler B. Grove, Taeah Hammond, Kelsey M. Collins, Preetha Pamidighantam, Paul D. Arnold, Stephan F. Taylor, Yanni Liu, William J. Gehring, Gregory L. Hanna, Ivy F. Tso
Summary: This study found that individuals with pediatric OCD exhibit abnormally enhanced midfrontal theta activity during response monitoring compared to healthy controls. This enhancement may reflect abnormal neurophysiological mechanisms underlying pediatric OCD.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Katrina R. Ellis, Athena Koumoutzis, Jordan P. Lewis, Zhiyong Lin, Yuanjin Zhou, William J. Chopik, Richard Gonzalez
Summary: This study presents a framework for conceptualizing caregiver collaboration and an index that captures variation in collaboration among multiple caregivers. The results show that larger care networks enable more collaboration, especially among those caring for Black or Hispanic care recipients and those caring for recipients with probable dementia. The discussion explores the implications of caregiver collaboration for outcomes of caregivers and recipients.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Letter
Psychiatry
Molly Simmonite, Beier Yao, Robert C. Welsh, Stephan F. Taylor
SCHIZOPHRENIA RESEARCH
(2023)
Article
Geriatrics & Gerontology
Kira S. Birditt, Angela Turkelson, Sarah Javaid, Richard Gonzalez, Toni Antonucci
Summary: This study examines the links between exposure to life event stress, daily stress exposure, and cardiovascular reactivity among Black and White individuals. The findings suggest that the trajectories of life event stress can influence daily stress exposure and cardiovascular reactivity, and these links may vary by race.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Clinical Neurology
Beier Yao, Pan Gu, Carly A. Lasagna, Scott Peltier, Stephan F. Taylor, Ivy F. Tso, Katharine N. Thakkar
Summary: Interoception, the processing and interpretation of bodily signals by the brain, is essential for basic survival and emotional functioning. This study investigated the anatomical connectivity of an interoception network in individuals with schizophrenia and found altered structural connectivity compared to healthy controls. The findings suggest that altered interoception may play a role in the illness mechanisms of schizophrenia, particularly in relation to emotional deficits.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Psychiatry
Jiwon Lee, Kenya Costa-Dookhan, Kristoffer Panganiban, Nicole MacKenzie, Quinn Casuccio Treen, Araba Chintoh, Gary Remington, Daniel J. J. Mueller, Sanjeev Sockalingam, Philip Gerretsen, Marcos Sanches, Alla Karnovsky, Kathleen A. Stringer, Vicki L. L. Ellingrod, Ivy F. F. Tso, Stephan F. F. Taylor, Sri Mahavir Agarwal, Margaret K. K. Hahn, Kristen M. M. Ward
Summary: Psychosis spectrum disorders (PSDs) and other severe mental illnesses like bipolar disorder are associated with intrinsic metabolic abnormalities. Antipsychotics (APs), the main treatment for PSDs, can lead to additional metabolic issues including weight gain. This study used metabolomic profiles to identify biomarkers and explore the mechanisms of PSDs and AP-induced weight gain. The findings suggest that specific fatty acids may serve as biomarkers for PSDs and early predictors of AP-induced weight gain. These findings have important clinical implications for identifying individuals at risk and developing targeted treatments.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Analay Perez, Michael D. Fetters, John W. Creswell, Mark Scerbo, Frederick W. Kron, Richard Gonzalez, Lawrence An, Masahito Jimbo, Predrag Klasnja, Timothy C. Guetterman
Summary: This study aims to enhance a conceptual model that incorporates technology to examine verbal and nonverbal components of communication and develop a nonverbal assessment for virtual simulation. The study uses a multistage mixed methods design, collects quantitative and qualitative data, and conducts grounded theory qualitative interviews. The results of this study are important for improving patient-provider communication and can be applied to medication safety, informed consent processes, patient instructions, and treatment adherence.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Psychiatry
Ricardo E. Carrion, Andrea M. Auther, Danielle Mclaughlin, Steven Adelsheim, Cynthia Z. Burton, Cameron S. Carter, Tara Niendam, J. Daniel Ragland, Tamara G. Sale, Stephan F. Taylor, Ivy F. Tso, William R. McFarlane, Barbara A. Cornblatt
Summary: The association between cannabis use and psychosis is inconsistent, especially in individuals at clinical high risk for psychosis. However, this study found that continuous cannabis use in CHR youth was associated with improved neurocognition and social functioning over time, as well as decreased medication usage. Surprisingly, clinical symptoms also improved despite the decrease in medication.
PSYCHIATRY RESEARCH
(2023)
Article
Neurosciences
Elana R. Goldenkoff, Joseph A. Deluisi, Danielle P. Destiny, Taraz G. Lee, Katherine J. Michon, James A. Brissenden, Stephan F. Taylor, Thad A. Polk, Michael Vesia
Summary: This study investigates the interaction between stimulation and brain state by applying intermittent theta burst stimulation to the parietal cortex. The results show that parietal stimulation during a behavioral manipulation can increase the excitability of downstream motor cortex and improve motor performance, compared to stimulation during rest.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Psychology, Social
Esra Ascigil, Anna Luerssen, Richard Gonzalez, Amie M. Gordon
Summary: This research used machine learning to identify the key factors contributing to changes in relationship satisfaction during the pandemic. Relationship processes were found to be the most important predictors, explaining up to 70% of the variance in satisfaction. Appreciation of one's partner and satisfaction with quality time spent together consistently emerged as top predictors of satisfaction. Longitudinal analysis further showed that appreciation and satisfaction with quality time were associated with high and relatively stable relationship satisfaction over time.
SOCIAL AND PERSONALITY PSYCHOLOGY COMPASS
(2023)