Article
Hematology
Dalia E. Gaddis, Lindsey E. Padgett, Runpei Wu, Anh Nguyen, Chantel McSkimming, Huy Q. Dinh, Daniel J. Araujo, Angela M. Taylor, Coleen A. McNamara, Catherine C. Hedrick
Summary: The study found dysregulated expression of metabolism genes in CD4 T cells from atherosclerotic mice, and impaired glucose uptake, proliferation, and activation in these cells. Furthermore, a reduction in naive CD4 T cells and their proliferative capacity was observed in subjects with high cardiovascular disease, highlighting the dysfunction in CD4 T-cell metabolism and immune responses during atherosclerosis. Targeting metabolic pathways within naive CD4 T cells could offer novel therapeutic approaches for improving CD4 T-cell responses against atheroprogression.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Kim K. B. Clemmensen, Annemarie Koster, Johannes T. H. Nielen, Pieter C. Dagnelie, Coen D. A. Stehouwer, Hans Bosma, Anke Wesselius, Kristine Faerch, Simone J. P. M. Eussen
Summary: The timing of sleep, physical activity, and dietary intake varies between weekends and weekdays, potentially leading to impaired glucose and lipid regulation on Mondays. This study found that fasting glucose, insulin, and triglyceride concentrations were slightly higher on Mondays compared to other weekdays. There was a pronounced association between Monday and insulin concentrations in men, but not in women. The associations with glucose and triglycerides were only seen in individuals with known type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Emily A. Rosenberg, Ellen W. Seely, Kaitlyn James, Marti D. Soffer, Stacey Nelson, Jacinda M. Nicklas, Camille E. Powe
Summary: The study found no association between carbohydrate intake and post-OGTT glucose levels among postpartum individuals. Therefore, dietary preparation prior to the OGTT may not be necessary in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Shaofeng Huo, Liang Sun, Geng Zong, Xia Shen, He Zheng, Qianlu Jin, Huaixing Li, Huiyong Yin, Xu Lin
Summary: This study aimed to characterize plasma metabolomic profiles during an oral glucose tolerance test (OGTT) in Chinese individuals with different glycemic statuses. The results showed distinct metabolite responses in individuals with type 2 diabetes (T2D), with certain metabolites significantly higher at 2 hours post-OGTT. Differences in metabolite levels were also observed between T2D, prediabetes, and normal glucose subjects, suggesting potential implications for glucose homeostasis.
Article
Endocrinology & Metabolism
Lewin Small, Amy Ehrlich, Jo Iversen, Stephen P. Ashcroft, Kajetan Trost, Thomas Moritz, Bolette Hartmann, Jens J. Holst, Jonas T. Treebak, Juleen R. Zierath, Romain Barres
Summary: The study compares the effect of different routes of glucose administration (oral and intraperitoneal) on glucose and insulin kinetics during a glucose tolerance test in mice. The results show that intraperitoneal glucose administration resulted in significantly elevated blood glucose levels, but had a lesser effect on insulin and incretin hormone levels compared to oral administration.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Vasudha Ahuja, Pasi Aronen, T. A. Pramodkumar, Helen Looker, Angela Chetrit, Aini H. Bloigu, Auni Juutilainen, Cristina Bianchi, Lucia La Sala, Ranjit Mohan Anjana, Rajendra Pradeepa, Ulagamadesan Venkatesan, Sarvanan Jebarani, Viswanathan Baskar, Teresa Vanessa Fiorentino, Patrick Timpel, Ralph A. DeFronzo, Antonio Ceriello, Stefano Del Prato, Muhammad Abdul-Ghani, Sirkka Keinanen-Kiukaanniemi, Rachel Dankner, Peter H. Bennett, William C. Knowler, Peter Schwarz, Giorgio Sesti, Rie Oka, Viswanathan Mohan, Leif Groop, Jaakko Tuomilehto, Samuli Ripatti, Michael Bergman, Tiinamaija Tuomi
Summary: The 1-h PG of >= 11.6 mmol/L during OGTT has good sensitivity and specificity for detecting type 2 diabetes. Prescreening with a diabetes-specific risk calculator is suggested to reduce the proportion of false-positive cases, with further studies needed for other ethnic groups and complication risk assessment.
Article
Agriculture, Dairy & Animal Science
Abigail R. Rathert-Williams, Carlee M. Salisbury, Amanda K. Lindholm-Perry, Adel Pezeshki, David L. Lalman, Andrew P. Foote
Summary: Increased propionate may decrease dry matter intake and insulin sensitivity in finishing steers.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Oncology
Jara Palomero, Carla Panisello, Maria Lozano-Rabella, Ricky Tirtakasuma, Judit Diaz-Gomez, Daniela Grases, Helena Pasamar, Laura Arregui, Eduard Dorca Duch, Esther Guerra Fernandez, Ana Vivancos, Carlos E. de Andrea, Ignacio Melero, Jordi Ponce, August Vidal, Josep Maria Piulats, Xavier Matias-Guiu, Alena Gros
Summary: Our study investigates the prevalence, phenotype, specificity and prognostic value of tumor infiltrating lymphocytes (TILs) in endometrial cancer (EC). We found that CD8(+)TILs expressing high levels of PD-1 and CD39 were associated with tumor reactivity and improved patient survival. The co-expression of inhibitory and activation markers on PD-1(hi) CD4(+) T cells was also observed, which accumulated antitumor T cells and correlated with prolonged survival in EC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Agriculture, Dairy & Animal Science
Elin Manell, Patricia Hedenqvist, Marianne Jensen-Waern
Summary: Animal models are crucial in biomedical research for developing new treatments. Refinement of animal models is necessary to ensure ethical and reliable research data. This publication describes improvements in training techniques for pigs in an oral glucose tolerance test model, aiding researchers in successful training and adhering to the 3Rs principles.
Article
Cell Biology
Carlos van der Putten, Ester B. M. Remmerswaal, Matty L. Terpstra, Nelly D. van der Bom, Jesper Kers, Ineke J. M. ten Berge, Suzanne E. Geerlings, Rene A. W. van Lier, Frederike J. Bemelman, Michiel C. van Aalderen
Summary: In this study, the researchers aimed to investigate the presence and function of T-RM cells in healthy and allograft kidney tissue by analyzing the phenotype and function of T cells through multichannel flow cytometry. The results showed that kidney tissue samples contained a significant number of CD8 and CD4 T cells that were more actively cycling, expressed specific markers CXCR3 and CXCR6, produced higher levels of IFN gamma, and displayed polyfunctionality compared to circulating T cells.
Article
Cardiac & Cardiovascular Systems
Viola Zywicki, Paola Capozza, Paolo Caravelli, Stefano Del Prato, Raffaele De Caterina
Summary: Impaired glucose tolerance (IGT) has been associated with adverse cardiovascular outcomes. This study found that among non-diabetic ACS patients, only those with elevated 1-hour and 2-hour plasma glucose levels had more severe myocardial injury and longer hospitalization. 1-hour plasma glucose is important in assessing post-ACS cardiac risk.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniela Vejrazkova, Marketa Vankova, Petra Lukasova, Martin Hill, Josef Vcelak, Andrea Tura, Denisa Chocholova, Bela Bendlova
Summary: The shape of glycemic curve during OGTT predicts impaired glucose homeostasis and metabolic syndrome. Men are more likely to have biphasic curves, while women are more likely to have triphasic curves. Monophasic curves are associated with higher risk of impaired glucose regulation and metabolic syndrome.
Article
Immunology
Ainsley Lockhart, Aubrey Reed, Tiago Rezende de Castro, Calvin Herman, Maria Cecilia Campos Canesso, Daniel Mucida
Summary: The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4(+) T cells. Combining antigenically defined diets with gnotobiotic models, the study shows that both food and microbiota have distinct effects on the profile and T cell receptor repertoire of intestinal CD4(+) T cells. The response of CD4(+) T cells to food is disrupted by inflammatory challenge, but protection against food allergy is associated with Treg clonal expansion and decreased proinflammatory gene expression.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Feng Yu Kuo, Kai-Chun Cheng, Yingxiao Li, Juei-Tang Cheng
Summary: The oral glucose tolerance test (OGTT) is widely used for diagnosing impaired glucose tolerance and type 2 diabetes, as well as studying glucose utilization and insulin sensitivity. Recent clinical practice recommendations include using 30-min or 1-h post-glucose load glycemia. In basic research, the incremental area under the curve is not suitable for studies involving animals receiving repeated or chronic treatment.
WORLD JOURNAL OF DIABETES
(2021)
Article
Medicine, Research & Experimental
Sara Gonzalez-Rodriguez, Seila Lorenzo-Herrero, Christian Sordo-Bahamonde, Agustin Hidalgo, Segundo Gonzalez, Luis Menendez, Ana Baamonde
Summary: The study found that CCL4-induced hyperalgesia is related to the desensitization of CCR5 in CD4(+) T-cells and to the release of IL-16 from CD8(+) lymphocytes.
Article
Endocrinology & Metabolism
Koki Chiba, Hiroshi Nomoto, Akinobu Nakamura, Kyu Yong Cho, Kumiko Yamashita, Yui Shibayama, Aika Miya, Hiraku Kameda, Yoshio Kurihara, Shin Aoki, Tatsuya Atsumi, Hideaki Miyoshi
Summary: This study found that SGLT2 inhibitors have good efficacy and safety in patients with type 1 diabetes, significantly decreasing glycated hemoglobin and body weight, reducing insulin dose, improving day-to-day glucose variability, and increasing the time spent in the target glucose range.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Aika Miya, Akinobu Nakamura, Takahisa Handa, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, So Nagai, Hideaki Miyoshi, Tatsuya Atsumi
Summary: The study identified a CV of 40 as the threshold that distinguishes unstable glucose variability and hypoglycemia from stable GV in Japanese outpatients with type 2 diabetes. Impaired insulin secretion might affect the stability of glucose variability.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Aika Miya, Akinobu Nakamura, Kyu Yong Cho, Shinichiro Kawata, Hiroshi Nomoto, So Nagai, Hajime Sugawara, Shinji Taneda, Kazuhisa Tsuchida, Kazuno Omori, Hiroki Yokoyama, Jun Takeuchi, Shin Aoki, Yoshio Kurihara, Tatsuya Atsumi, Hideaki Miyoshi
Summary: The study found that compared to switching from a dipeptidyl peptidase-4 inhibitor to a sodium-glucose cotransporter 2 inhibitor, combination therapy with both types of inhibitors may be a better option for improving daily glucose variability in patients with impaired endogenous insulin secretion.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Kyu Yong Cho, Akinobu Nakamura, Kazuno Omori, Takahiro Takase, Aika Miya, Kohei Yamamoto, Hiroshi Nomoto, Hiraku Kameda, Shinji Taneda, Yoshio Kurihara, Shin Aoki, Tatsuya Atsumi, Hideaki Miyoshi
Summary: Dapagliflozin may be more beneficial than pioglitazone for patients with NAFLD, and improvements in FLI are closely related to glycemic control.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Arina Miyoshi, Hiraku Kameda, So Nagai, Akinobu Nakamura, Aika Miya, Takahiro Takase, Tatsuya Atsumi, Hideaki Miyoshi
Summary: This study included 48 patients divided into four groups, and the results showed that switching to Dmab from BP or SERM is beneficial in preventing osteoporosis progression in postmenopausal patients with type 2 diabetes mellitus.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Kyu Yong Cho, Hiroshi Nomoto, Akinobu Nakamura, Shinichiro Kawata, Hajime Sugawara, Jun Takeuchi, So Nagai, Kazuno Omori, Kazuhisa Tsuchida, Aika Miya, Ikumi Shigesawa, Kenichi Tsuchida, Shingo Yanagiya, Hiraku Kameda, Hiroki Yokoyama, Shinji Taneda, Yoshio Kurihara, Shin Aoki, Naoki Nishimoto, Tatsuya Atsumi, Hideaki Miyoshi
Summary: Combining sodium-glucose cotransporter 2 inhibitor with dipeptidyl peptidase-4 inhibitor improved the quality of glycemic variability and reduced postprandial hyperglycemia compared with each monotherapy.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Takahisa Handa, Akinobu Nakamura, Aika Miya, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, So Nagai, Narihito Yoshioka, Hideaki Miyoshi, Tatsuya Atsumi
Summary: Among elderly patients with type 2 diabetes, the coefficient of variation (CV) is the most appropriate index that best reflects TBR >= 1% among the glycemic variability (GV) indices examined. Clinical characteristics including HbA1c and C-peptide index were not independent markers for TBR >= 1% in the multivariate logistic regression analysis, while all three GV indices showed significant associations with TBR >= 1%.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Multidisciplinary Sciences
Aika Miya, Akinobu Nakamura, Takahisa Handa, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, So Nagai, Yoichi M. Ito, Hideaki Miyoshi, Tatsuya Atsumi
Summary: In patients with type 2 diabetes, there is a negative log-linear relationship between fasting C-peptide levels and glycemic variability, with low C-peptide levels being a predictor of high glycemic variability. Endogenous insulin secretion contributes to glycemic variability depending on the extent of insulin secretion impairment. Fasting C-peptide may serve as a useful indicator of glycemic variability instability in type 2 diabetes.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Yuka Takahashi, Hiraku Kameda, Aika Miya, Hiroshi Nomoto, Kyu Yong Cho, Akinobu Nakamura, Hiroki Nishimura, Hirokazu Kimura, Masaru Suzuki, Satoshi Konno, Ai Shimizu, Yoshihiro Matsuno, Michinari Okamoto, Hiroaki Motegi, Naoko Iwata, Haruki Fujisawa, Atsushi Suzuki, Yoshihisa Sugimura, Hideaki Miyoshi, Tatsuya Atsumi
Summary: The purpose of this study was to explore the clinical significance of anti-rabphilin-3A antibody for the differential diagnosis of lymphocytic panhypophysitis. A case analysis of a 58-year-old Japanese man revealed lymphocytic panhypophysitis comorbid with sarcoidosis. Biopsies of the hilar lymph nodes and anterior pituitary confirmed the diagnosis, and the detection of anti-rabphilin-3A antibody played an important role in the differential diagnosis.
Article
Endocrinology & Metabolism
Koki Chiba, Hiraku Kameda, Aika Miya, Hiroshi Nomoto, Kyu Yong Cho, Akinobu Nakamura, Shigeki Jin, Kotaro Matoba, Hideaki Miyoshi, Tatsuya Atsumi
Article
Endocrinology & Metabolism
Yuki Oe, Hiroshi Nomoto, Akinobu Nakamura, Saki Kuwabara, Yuka Takahashi, Ayano Yasui, Rimi Izumihara, Aika Miya, Hiraku Kameda, Kyu Yong Cho, Tatsuya Atsumi, Hideaki Miyoshi
Summary: This study investigated the effect of switching from a combination of basal insulin and a DPP-4 inhibitor to insulin degludec/liraglutide (IDegLira) on glycemic variability in patients with type 2 diabetes. The results showed that switching to IDegLira significantly improved glycemic variability and other indices. IDegLira might be beneficial for patients being treated with low-dose basal insulin.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Geriatrics & Gerontology
Aika Miya, Akinobu Nakamura, Isao Yokota, Kyu Yong Cho, Hiraku Kameda, Hiroshi Nomoto, Takahiro Takase, Kazuno Omori, Mayuko Ono, So Nagai, Shinji Taneda, Hideaki Miyoshi, Tatsuya Atsumi
Summary: The achievement of individualized target HbA1c based on the DASC-8 assessment in elderly patients with diabetes is low, and certain patient characteristics may act as barriers to reaching the target HbA1c.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Letter
Geriatrics & Gerontology
Yuri Ofuji, Hiroshi Nomoto, Aika Miya, Hiraku Kameda, Kyu Yong Cho, Akinobu Nakamura, Hideaki Miyoshi, Tatsuya Atsumi
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Aika Miya, Akinobu Nakamura, Yuka Suzuki, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Yoichi M. Ito, So Nagai, Hideaki Miyoshi, Tatsuya Atsumi
Summary: This study evaluated the contribution of body fat mass and serum adiponectin concentration to glucose variability stability in people with impaired and preserved endogenous insulin secretion in type 2 diabetes. The results showed that in those with preserved endogenous insulin secretion, glucose variability was not related to abdominal fat area. However, in those with impaired endogenous insulin secretion, glucose variability was significantly related to small abdominal visceral fat area and small subcutaneous fat area. There was no significant relationship between serum adiponectin concentration and continuous glucose monitoring-related variables.
DIABETES OBESITY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Hiroshi Nomoto, Yuka Takahashi, Yoshinari Takano, Hiroki Yokoyama, Kazuhisa Tsuchida, So Nagai, Aika Miya, Hiraku Kameda, Kyu Yong Cho, Akinobu Nakamura, Tatsuya Atsumi
Summary: This subanalysis suggests that switching from conventional glucagon-like peptide-1 receptor agonists to once-weekly semaglutide may be beneficial for individuals with NAFLD complicated with T2DM. The improvement in fatty liver index (FLI) was greater in those who switched from dulaglutide and significantly correlated with older age and lower baseline FLI.