Review
Oncology
Lin Qian, Fan Zhang, Miao Yin, Qunying Lei
Summary: Metabolic remodeling is a key feature in cancer development, leading malignant cells to favor specialized fermentation. Targeted cancer therapies based on reprogramming nutrient or metabolite metabolism have gained substantial attention, as well as the management of nutrient availability becoming more appealing.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Maria Chiara De Santis, Luca Gozzelino, Jean Piero Margaria, Andrea Costamagna, Edoardo Ratto, Federico Gulluni, Enza Di Gregorio, Erica Mina, Nicla Lorito, Marina Bacci, Rossano Lattanzio, Gianluca Sala, Paola Cappello, Francesco Novelli, Elisa Giovannetti, Caterina Vicentini, Silvia Andreani, Pietro Delfino, Vincenzo Corbo, Aldo Scarpa, Paolo Ettore Porporato, Andrea Morandi, Emilio Hirsch, Miriam Martini
Summary: This study reveals that loss of PI3K-C2 gamma in pancreatic ductal adenocarcinoma (PDAC) leads to hyperactivation of mTORC1 pathway and rewiring of glutamine metabolism, increasing tumor aggressiveness. Furthermore, PI3K-C2 gamma knockout tumors fail to adapt to metabolic stress induced by glutamine depletion, resulting in cell death. These findings suggest that targeting mTORC1 and glutamine metabolism may be a potential strategy for personalized treatment in PDAC with PI3K-C2 gamma loss.
Article
Environmental Sciences
Linchen He, Xinyan Hu, Drew B. Day, Meilin Yan, Yanbo Teng, Xing (Lucy) Liu, Erik Yan, Jianbang Xiang, Xinghua Qiu, Jinhan Mo, Yinping Zhang, Junfeng (Jim) Zhang, Jicheng Gong
Summary: Exposure to certain nitro-PAHs may affect glucose homeostasis, partly resulting from the depletion of insulin-stimulating amino acids.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Zuzanna Tracz-Gaszewska, Adrian Sowka, Pawel Dobrzyn
Summary: This study reveals the impact of SCD1 on glucose and lipid metabolism in colorectal cancer cells and its significant role in promoting cancer development and progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zeinab Ghasemishahrestani, Larissa Maura Melo Mattos, Tatiana Martins Tilli, Andre Luis Souza dos Santos, Marcos Dias Pereira
Summary: Cancer cell energy metabolism is focused on bioenergetic and biosynthetic pathways to meet the requirements of rapid proliferation, potentially influenced by genetic reprogramming. Enzymes crucial for cellular energy are targets of oncogenes and tumor suppressor proteins, with new therapeutic strategies aiming to disrupt cancer cell metabolism and genetic reprogramming.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Ying Yang, Jiaxing He, Bo Zhang, Zhansheng Zhang, Guozhan Jia, Shiqi Liu, Tao Wu, Xianli He, Nan Wang
Summary: SLC25A1 is significantly upregulated in CRC, associated with poor survival in patients, and reprograms energy metabolism through two mechanisms to promote CRC growth. It serves as a potential diagnostic marker and therapeutic target in CRC.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Bo Zhang, Yuzhou Wan, Xuefeng Zhou, Haojun Zhang, Hailing Zhao, Liang Ma, Xi Dong, Meihua Yan, Tingting Zhao, Ping Li
Summary: This study investigated the relationship between serum metabolites and gut microbiota in the progression of diabetic kidney disease (DKD). The results showed significant alterations in serum metabolites and the composition and function of gut microbiota in DKD. The study also identified potential metabolic and microbial targets for the treatment of DKD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Samia Mora, Patrick R. Lawler, Nancy R. Cook, Paul M. Ridker, Julie E. Buring, I-Min Lee, JoAnn E. Manson, Deirdre K. Tobias
Summary: The study found that higher plasma BCAA concentrations are associated with adverse profiles of biomarkers of inflammation and dyslipidemia, reflecting poorer cardiometabolic health.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jaewang Lee, Daiha Shin, Jong-Lyel Roh
Summary: Cancer disrupts lipid metabolism, leading to altered metabolism intermediates and contributing to abnormal growth and metastasis. The shift in lipid metabolism towards an increased presence of polyunsaturated fatty acids (PUFAs) in membrane phospholipids (PLs) also causes resistance to cancer therapy. The vulnerability of cancer cells to lipid peroxidation (LPO) and subsequent ferroptosis, a new form of regulated cell death, depends on adaptive lipidome remodeling, LPO patterns, and LPO scavenging ability. Understanding the molecular basis of altered lipid metabolism in cancer may offer new opportunities for overcoming cancer resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Zhiqiang Wang, Zhou Lu, Shengli Lin, Jie Xia, Ziwen Zhong, Zhangjuan Xie, Yun Xing, Jingbo Qie, Mengxia Jiao, Yifan Li, Haoyu Wen, Pengyuan Zhao, Dan Zhang, Pinghong Zhou, Jiawen Qian, Feifei Luo, Luman Wang, Hongxiu Yu, Jie Liu, Jie Gu, Ronghua Liu, Yiwei Chu
Summary: A subset of B cells expressing leucine-tRNA-synthase-2 (LARS2) with a transforming growth factor-beta 1 (TGF-beta 1) regulatory feature has been identified in both mouse and human colorectal cancer (CRC). These cells exhibit a leucine nutrient preference and are located outside the tertiary lymphoid structure. They are associated with colorectal hyperplasia and shortened survival in CRC patients. A leucine diet can induce the generation of LARS B cells, while deletion of Lars2 gene or leucine blockage can repress CRC immunoevasion. Mechanistically, LARS2 regulates mitochondrial nicotinamide adenine dinucleotide (NAD(+)) regeneration and oxidative metabolism, involving the NAD-dependent protein deacetylase sirtuin-1 (SIRT1).
Review
Pharmacology & Pharmacy
Rishi Rajesh, Reham Atallah, Thomas Baernthaler
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder of unknown origin and the most common interstitial lung disease. It is characterized by the accumulation of extracellular matrix (ECM) proteins, leading to compromised lung function. Metabolic dysregulation has been implicated in disease progression, and understanding metabolic pathways in IPF may provide potential therapeutic targets.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Fisheries
Shuaibo Li, Zhigang Yang, Hongyan Tian, Shengjie Ren, Wuxiao Zhang, Aimin Wang
Summary: Understanding the effects of dietary nutrient ratios on crayfish health and growth can help improve aquaculture production. This study found that an optimal carbohydrate-to-lipid ratio promoted growth performance in red swamp crayfish.
AQUACULTURE REPORTS
(2022)
Review
Oncology
Hong Yan, Ronan Talty, Oladimeji Aladelokun, Marcus Bosenberg, Caroline H. Johnson
Summary: Colorectal cancer (CRC) is a major cause of cancer deaths globally, with frequently mutated genes such as APC, TP53, KRAS and BRAF. The current treatment options face challenges of recurrence, drug resistance, and toxicity. Recent studies suggest that targeting ferroptosis, an iron-dependent and lipid peroxide-driven form of regulated cell death, may be a promising strategy for CRC treatment. However, further research is needed to understand the mechanisms of ferroptosis initiation, propagation, and resistance in CRC.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Arnaud Germain, Ludovic Giloteaux, Geoffrey E. Moore, Susan M. Levine, John K. Chia, Betsy A. Keller, Jared Stevens, Carl J. Franconi, Xiangling Mao, Dikoma C. Shungu, Andrew Grimson, Maureen R. Hanson
Summary: Post-exertional malaise (PEM) is a prominent symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). By monitoring plasma metabolites, this study found significant differences in metabolic response and recovery pattern between ME/CFS patients and healthy control participants after two maximal exercise tests. Glutamate metabolism was identified as a crucial factor in the metabolic disruptions that lead to PEM.
Article
Biochemistry & Molecular Biology
Pegah Bagheri, Khang Hoang, Anthony A. Fung, Sahran Hussain, Lingyan Shi
Summary: Oxidative imbalance is crucial in the progression of many diseases, with AAA being able to increase oxidative stress. The study utilized DO-SRS and 2PEF microscopy to visualize metabolic changes in HeLa cells under excess AAA conditions, revealing alterations in de novo lipogenesis, protein synthesis, and lipid ratios.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Plant Sciences
Shuwen Han, Qing Zhou, Jin Liu, Miao Da
Summary: The research explored the community structure and diversity of fungi on the surface of saffron corms with different growth characteristics, revealing differences in fungal composition and abundance among corms with varying growth features. Understanding the fungal diversity on corm surfaces may provide valuable insights for enhancing germination and blooming of saffron corms.
Review
Genetics & Heredity
Zhuang Jing, Yang Xi, Jin Yin, Han Shuwen
Summary: Colorectal cancer (CRC) is a common malignancy worldwide with piwi-interacting RNAs (piRNAs), a type of non-coding RNA, being closely linked to its occurrence and development. Studies have shown that piRNAs regulate CRC by modulating multiple molecular signaling pathways, suggesting their potential as molecular targets for CRC treatment.
Article
Cell Biology
Zuo Fei, Yin Lijuan, Zhuang Jing, Yang Xi, Pan Yuefen, Han Shuwen
Summary: This study identified 85 genes associated with both HCC progression and ferroptosis, revealing their involvement in crucial pathways like negative regulation of ERK cascades and NAD biosynthesis. Key genes such as CDC20 and HSPB1 were found to play central roles, with ATF3 and HLF identified as potential regulators. Survival analysis also highlighted 26 genes significantly correlated with overall survival in HCC patients.
Article
Biotechnology & Applied Microbiology
Miao Da, Hao Jiang, Yangyang Xie, Weili Jin, Shuwen Han
Summary: Exosomal lncRNAs play a crucial role in regulating cancer progression, angiogenesis, and chemotherapy resistance, with potential applications in cancer diagnosis, treatment, and prognosis. Exosomal lncRNAs can transmit different phenotypic patterns to neighboring cells, serving as a new medium for cancer behavior.
ONCOTARGETS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Miao Da, Jing Zhuang, Yani Zhou, Quan Qi, Shuwen Han
Summary: The abnormally expressed long non-coding RNA (lncRNA) TUG1 plays a critical role in regulating gene expression in malignant tumors, making it a potential clinical biomarker or therapeutic target for cancer. This review provides a basis for new research directions in cancer prevention, diagnosis, and treatment involving lncRNA TUG1.
MOLECULAR MEDICINE
(2021)
Article
Oncology
Zhang Yan, Yin Lijuan, Wu Yinhang, Jin Yin, Xu Jiamin, Wu Wei, Pan Yuefen, Han Shuwen
Summary: This study screened and analyzed the RNAs associated with activated memory CD4 T cells and CD8 T cells in liver cancer, and found that these T cell-related RNAs may be associated with the prognosis of liver cancer.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Liang Dong, Xi Yang, Yangyanqiu Wang, Yin Jin, Qing Zhou, Gong Chen, Shuwen Han
Summary: Our study identified key genes involved in the anticolon cancer response of CD8+ T cells through the regulation of cholesterol metabolism, with APOE expression significantly impacting CRC patient prognosis and pathologic features. The distribution of CD8+ T cells was found to be related to APOE expression levels.
JOURNAL OF ONCOLOGY
(2021)
Article
Oncology
Shen Junjun, Wang Yangyanqiu, Zhuang Jing, Pu Jie, Chu Jian, Pan Yuefen, Han Shuwen
Summary: High PD-1 expression is associated with high immune infiltration in breast cancer patients and is correlated with prolonged survival time. This study screened genes closely associated with PD-1, immune infiltration, and survival prognosis, and developed a prognostic model.
Review
Microbiology
Wu Yinhang, Wu Wei, Zhuang Jing, Zhou Qing, Zhou Yani, Wang Yangyanqiu, Han Shuwen
Summary: This study suggests that the occurrence of colorectal cancer is closely related to gut micro-organisms, and the micro-organisms can promote or inhibit the development of colorectal cancer by binding to toll-like receptors. This finding has important implications for future tumor immunotherapy and targeted therapy.
FUTURE MICROBIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Han Shuwen, Ding Kefeng
Summary: This review presents the interactions between phages and bacteria in the human intestinal tract, as well as their roles in disease pathogenesis and treatment.
Article
Oncology
Shuwen Han, Yangyanqiu Wang, Jian Chu, Boyang Hu, Gong Gong, Jing Zhuang
Summary: This study found that sodium butyrate (NaB) is a metabolite that affects the efficacy of oxaliplatin (OXA). NaB and OXA can synergistically inhibit the proliferation, migration, and invasion of colorectal cancer cells and promote cell apoptosis. This suggests that NaB has the potential to become a new clinical adjuvant in colorectal cancer chemotherapy.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Cell Biology
Xi Yang, Jing Zhuang, Weilong Song, Wangjie Shen, Wei Wu, Hong Shen, Shuwen Han
Summary: The mitochondrial-associated membrane (MAM) is a platform that promotes communication between the endoplasmic reticulum (ER) and mitochondria. It plays a crucial role in various physiological processes and its dysregulation can impact cancer cell fate. This review summarizes the structure of MAM and the functions of MAM-resident proteins in tumorigenesis, and discusses the mechanisms by which natural compounds induce cancer cell apoptosis through ER stress.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Biochemical Research Methods
Boyang Hu, Yangyanqiu Wang, Wenting Rui, Chenxin Yan, Jian Chu, Zhanbo Qu, Yanjun Yao, Qiang Yan, Shuwen Han
Summary: HCI is a research tool that allows automated imaging and analysis of cells while maintaining their structural and functional integrity. It is widely used in cutting-edge areas of medical research and has attracted great interest from researchers. This article provides a brief explanation of HCI, describes the history of optical imaging and the birth of HCI, and discusses its experimental methods. It also highlights the directions of its application in protein localization changes, gene identification, chemical and genetic analysis, microbiology, and drug discovery, while discussing the challenges and future directions of HCI. The application and optimization of HCI are expected to be further explored.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
Yinhang Wu, Jing Zhuang, Qi Zhang, Xingming Zhao, Gong Chen, Shugao Han, Boyang Hu, Wei Wu, Shuwen Han
Summary: Aging is a factor that affects the gut microbiota composition and is related to colorectal cancer (CRC). By analyzing metagenomic data sets of healthy individuals and CRC patients, significant differences in gut microbiota composition were found among different age groups. Furthermore, prediction models for age and CRC risk were constructed and showed good performance.
Article
Oncology
Yinhang Wu, Jing Zhuang, Jie Zhou, Yin Jin, Xinyue Wu, Yifei Song, Zhiqing Fan, Wei Wu, Shuwen Han
Summary: This study screened differential intestinal bacteria associated with lymph node metastasis in colorectal cancer and constructed a prediction model. The results showed that certain differential bacteria were not associated with lymph node metastasis in colorectal cancer. In the prediction model, the RF model had the highest prediction accuracy in the discovery set, while the SVM model had the highest prediction accuracy in the test set.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
