Review
Food Science & Technology
Mahdieh Golzarand, Asma Salari-Moghaddam, Parvin Mirmiran
Summary: This study conducted a systematic review and dose-response meta-analysis on the association between alcohol intake and overweight/obesity, revealing that heavy alcohol drinkers have higher odds of overweight, overweight/obesity, and abdominal obesity in cross-sectional studies compared to non- or light alcohol drinkers, with no significant association found in cohort studies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Environmental Sciences
Linling Yu, Hong Mei, Da Shi, Xing Wang, Man Cheng, Lieyang Fan, Yang Xiao, Ruyi Liang, Bin Wang, Meng Yang, Weihong Chen
Summary: This study aimed to investigate the effects of caffeine exposure on children's health. The findings suggest that higher caffeine consumption is associated with increased risks of obesity and overweight, as well as higher BMI z-scores and waist circumference. The relationship between caffeine exposure and adverse adiposity outcomes is more significant in children aged 6-11 years compared to those aged 12-19 years.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, General & Internal
Johanna M. Jaakkola, Suvi P. Rovio, Katja Pahkala, Jorma Viikari, Tapani Ronnemaa, Antti Jula, Harri Niinikoski, Juha Mykkanen, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Terho Lehtimaki, Olli T. Raitakari
Summary: Childhood exposure to parental smoking is positively associated with increased risk of overweight/obesity and central obesity over the life-course, as indicated by the data from the two longitudinal cohort studies.
ANNALS OF MEDICINE
(2021)
Article
Medicine, General & Internal
Robyn E. Wootton, Rebecca B. Lawn, Maria C. Magnus, Jorien L. Treur, Elizabeth C. Corfield, Pal R. Njolstad, Ole A. Andreassen, Deborah A. Lawlor, Marcus R. Munafo, Siri E. Haberg, George Davey Smith, Ted Reichborn-Kjennerud, Per Magnus, Alexandra Havdahl
Summary: Advice to improve fertility includes reducing alcohol and caffeine consumption, achieving a healthy weight, and quitting smoking. However, observational evidence used to inform these recommendations is often biased by confounding factors.
Article
Public, Environmental & Occupational Health
Edith E. Schermer, Peter M. Engelfriet, Anneke Blokstra, W. M. Monique Verschuren, H. Susan J. Picavet
Summary: The study found changing trends in health-related lifestyle factors over 30 years at both population and individual levels, emphasizing the importance of individual-level changes in predicting potential changes in health-related lifestyles.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Health Care Sciences & Services
Getu Gamo Sagaro, Ulrico Angeloni, Claudia Marotta, Giulio Nittari, Giovanni Rezza, Andrea Silenzi, Gopi Battineni, Francesco Amenta
Summary: This study aims to estimate the pooled prevalence of major cardiovascular disease (CVD) risk factors among seafarers. The results showed that smoking, hypertension, overweight, obesity, diabetes mellitus, and alcohol consumption were prevalent among seafarers. These findings can guide shipping companies and other responsible bodies in preventing CVD risk factors among seafarers.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Tsuneaki Kenzaka, Shinsuke Yahata, Ken Goda, Ayako Kumabe, Momoka Kamada, Masanobu Okayama
Summary: The study found that routine activities on the day of influenza vaccination did not significantly affect the vaccine efficacy, but engaging in strenuous exercise on the vaccination day may lead to systemic adverse reactions. Lifestyle-related activities had no impact on the occurrence of adverse reactions.
Article
Clinical Neurology
Rune A. Aa Hoglund, Haakon E. Meyer, Hein Stigum, Oivind Torkildsen, Nina Grytten, Trygve Holmoy, Ola Nakken
Summary: This study found that high BMI in individuals aged 14 to 24 was associated with an increased risk of developing multiple sclerosis (MS) later in life, with the risk no longer present for those over 30 years old.
Article
Medicine, General & Internal
Lone B. Enebo, Kasper K. Berthelsen, Martin Kankam, Michael T. Lund, Domenica M. Rubino, Altynai Satylganova, David C. W. Lau
Summary: The study aimed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the combination of Cagrilintide and Semaglutide for weight management. Results showed that concomitant treatment with Cagrilintide and Semaglutide was well tolerated with an acceptable safety profile. Larger and longer trials are needed to fully assess the efficacy and safety of this treatment combination.
Review
Oncology
Shira Zelber-Sagi, Mazen Noureddin, Oren Shibolet
Summary: This review emphasizes the importance of defining modifiable risk factors for hepatocellular carcinoma (HCC) and suggests that healthy lifestyle habits, such as maintaining a healthy weight, following a healthy diet, avoiding smoking and excessive alcohol consumption, and engaging in physical activity, can potentially prevent HCC. The composition of the diet, including the consumption of n-3 polyunsaturated fatty acids, fish, poultry, vegetables, and fiber, is also important in reducing HCC risk. On the other hand, the consumption of red meat, saturated fat, cholesterol, and sugar is associated with an increased risk of HCC. Multiple studies support the beneficial effect of physical activity in reducing HCC risk. Smoking and alcohol consumption can lead to liver fibrosis and liver cancer, and their combined use further increases the risk. Therefore, comprehensive lifestyle interventions targeting diverse cohorts of liver disease patients are needed to prevent HCC.
Article
Oncology
Xiangwei Li, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Lina Jansen
Summary: The results of this case-control study suggest that cumulative lifetime excess weight plays a greater role in the risk of colorectal cancer than estimated by traditional BMI measurements at a single point in time.
Article
Endocrinology & Metabolism
Zhenqiu Liu, Chunqing Lin, Chen Suo, Renjia Zhao, Li Jin, Tiejun Zhang, Xingdong Chen
Summary: The study suggests that metabolic dysfunction-associated fatty liver disease (MAFLD) is closely associated with an increased risk of multiple cancers, with the effect varying by cancer site. This finding highlights the importance of prioritizing the prevention and management of MAFLD in current cancer prevention strategies.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Public, Environmental & Occupational Health
Dace S. Svikis, Pamela M. Dillon, Steven E. Meredith, Leroy R. Thacker, Kathryn Polak, Alexis C. Edwards, David Pomm, Danielle Dick, Kenneth Kendler
Summary: This study examined the associations between coffee and energy drink (ED) consumption and alcohol, tobacco, and other drug use, as well as alcohol use problems and parental substance abuse and mental health problems in college freshmen. The findings showed that there were significant associations between caffeine use groups and alcohol dependence symptoms, drug use, smoking, and familial risk factors. The response pattern was consistent, with the ED + Co group most likely to endorse these behaviors and risk factors, followed by the Co group, and the NoCE group least likely to endorse them.
Article
Medicine, General & Internal
Felix Teufel, Jacqueline A. Seiglie, Pascal Geldsetzer, Michaela Theilmann, Maja E. Marcus, Cara Ebert, William Andres Lopez Arboleda, Kokou Agoudavi, Glennis Andall-Brereton, Krishna K. Aryal, Brice Wilfried Bicaba, Garry Brian, Pascal Bovet, Maria Dorobantu, Mongal Singh Gurung, David Guwatudde, Corine Houehanou, Dismand Houinato, Jutta M. Adelin Jorgensen, Gibson B. Kagaruki, Khem B. Karki, Demetre Labadarios, Joao S. Martins, Mary T. Mayige, Roy Wong McClure, Joseph Kibachio Mwangi, Omar Mwalim, Bolormaa Norov, Sarah Crooks, Farshad Farzadfar, Sahar Saeedi Moghaddam, Bahendeka K. Silver, Lela Sturua, Chea Stanford Wesseh, Andrew C. Stokes, Utibe R. Essien, Jan-Walter De Neve, Rifat Atun, Justine I. Davies, Sebastian Vollmer, Till W. Barnighausen, Mohammed K. Ali, James B. Meigs, Deborah J. Wexler, Jennifer Manne-Goehler
Summary: The prevalence of overweight, obesity, and diabetes is increasing rapidly in low-income and middle-income countries, with BMI affecting the risk of diabetes, but there are significant regional variations in this association.
Article
Multidisciplinary Sciences
Dong-Woo Lim, Ga-Ram Yu, Jai-Eun Kim, Won-Hwan Park
Summary: This study aims to investigate the effect and underlying mechanism of a novel herbal combination, EH-CS, on obesity treatment. Network pharmacology analysis and adipocyte experiments showed that the combination of EH and CS can synergistically reduce adipocyte adiposity and control unexpected effects of EH treatment.
Article
Obstetrics & Gynecology
Mette Jorgensen Langergaard, Andreas Ernst, Nis Brix, Anne Gaml-Sorensen, Sandra S. Tottenborg, Jens Peter E. Bonde, Gunnar Toft, Karin S. Hougaard, Cecilia H. Ramlau-Hansen
Summary: This study found that later maternal age at menarche was associated with impaired semen characteristics, lower testes volume, and altered levels of reproductive hormones in sons. However, earlier maternal age at menarche was not strongly associated with reproductive outcomes in sons. These findings may suggest a shared heritability or underlying epigenetic profile of reproductive health, but the exact mechanism remains unknown.
HUMAN REPRODUCTION
(2023)
Article
Andrology
Anne Gaml-Sorensen, Nis Brix, Birgit Bjerre Hoyer, Sandra Sogaard Tottenborg, Karin Sorig Hougaard, Jens Peter Ellekilde Bonde, Pernille Jul Clemmensen, Andreas Ernst, Linn Hakonsen Arendt, Sjurdur Frodi Olsen, Charlotta Granstrom, Tine Brink Henriksen, Gunnar Toft, Cecilia Host Ramlau-Hansen
Summary: This study aimed to investigate the association between maternal folate intake during pregnancy and markers of fecundity in young men. The results showed that lower maternal folate intake was associated with lower sperm count and testes volume in adult men, but also with a lower proportion of non-progressive and immotile spermatozoa. Further investigation is needed to determine if this affects the ability to achieve pregnancy.
Article
Andrology
Mette Moller Dornfeldt, Anne-Marie Nybo Andersen, Karin Sorig Hougaard, Cecilia Host Ramlau-Hansen, Gunnar Toft, Jens Peter Ellekilde Bonde, Katia Keglberg Haervig, Kajsa Ugelvig Petersen, Ane Berger Bungum Kofoed, Laura Deen, Sandra Sogaard Tottenborg
Summary: A study found no strong associations between maternal fever during pregnancy and male reproductive health in young men, including timing, duration, and temperature of the fever. Concurrent use of antipyretics and antibiotics did not modify the association.
Article
Cardiac & Cardiovascular Systems
Louise F. Udholm, Linn H. Arendt, Ulla B. Knudsen, Cecilia H. Ramlau-Hansen, Vibeke E. Hjortdal
Summary: This study evaluated the fertility of men and women with congenital heart disease (CHD) and found that those with simple or moderate CHD were not at an increased risk of infertility compared to the general population. However, individuals with CHD were more likely to be childless, but those who became parents had the same number of children as parents without CHD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Obstetrics & Gynecology
Kristina Rantzau Saxov, Katrine Strandberg-Larsen, Sofie G. Pristed, Niels Henrik Bruun, Ulrik Schioler Kesmodel
Summary: According to a precautionary principle, it is recommended that pregnant women and women trying to conceive abstain from alcohol consumption. This dose-response meta-analysis aimed to examine the association between alcohol consumption and binge drinking and the risk of miscarriage in the first and second trimesters. The results showed no dose-dependent association between miscarriage risk and alcohol consumption, but further research is recommended to fill the research gap regarding miscarriage and binge drinking.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Public, Environmental & Occupational Health
Henriette Knold Rossau, Ingrid Maria Susanne Nilsson, Marianne Busck-Rasmussen, Claus Thorn Ekstrom, Anne Kristine Gadeberg, Jonas Cuzulan Hirani, Katrine Strandberg-Larsen, Sarah Fredsted Villadsen
Summary: In this study, a cluster-randomised trial is conducted within the Danish Municipal Health Visiting Programme to evaluate the effectiveness of an adapted intervention. The intervention is evaluated using survey and register data, and a comprehensive evaluation approach is taken including process evaluation, realist evaluation, and health economic evaluation. The aim is to improve breastfeeding rates and provide guidance for future efforts.
Review
Obstetrics & Gynecology
Marie Brond, Kjerstine Breintoft, Axel Forman, Tine Brink Henriksen, Cecilia Host Ramlau-Hansen, Dorte Rytter, Linn Hakonsen Arendt
Summary: This study systematically reviewed and meta-analyzed the association between measures of fetal growth and preterm birth and the risk of endometriosis and adenomyosis in adult life. The results showed that low birthweight and preterm birth were associated with an increased risk of endometriosis, but the evidence for adenomyosis was limited. The findings suggest a potential early programming effect of endometriosis, but further research is needed.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Medicine, General & Internal
Anders Schram, Hanne Irene Jensen, Maria Gamborg, Morten Lindhard, Jan Rolfing, Gunhild Kjaergaard-Andersen, Magnus Bie, Rune Dall Jensen
Summary: This study investigated the relationship between simulation-based team training and sick leave. The results showed that employees who received simulation-based team training had a significantly lower sick leave rate, suggesting that this training method could serve as a protective factor against sick leave. However, it is important to note that other factors may have influenced sick leave during the study period.
Article
Oncology
Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A. S. Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R. van Meel, Janine F. Felix, Vincent W. V. Jaddoe, Paul D. Yousefi, Cecilia H. Ramlau-Hansen, Caroline L. Relton, Elmar W. Tobi, Anne P. Starling, Ivana V. Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A. Salas, Mariona Bustamante, Susan L. Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Roeder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M. Page, Maria Magnus, Dereje D. Jima, Cathrine Hoyo, Rachel L. Maguire, Tuomas Kvist, Darina Czamara, Katri Raikkonen, Tong Gong, Vilhelmina Ullemar, Sheryl L. Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K. Murphy, Siri E. Haberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Regine P. M. Steegers-Theunissen, Ellen A. Nohr, Thorkild I. A. Sorensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S. Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M. Daniele Fallin, Edwina Yeung, Carrie V. Breton, Berthold Koletzko, Nina Holland, Joseph L. Wiemels, Erik Melen, Gemma C. Sharp, Matt J. Silver, Faisal Rezwan, John W. Holloway
Summary: This study found significant associations between DNA methylation and birth season at birth and in childhood. The differential methylation regions (DMRs) identified were related to genes involved in tumorigenesis, psychiatric/neurological disorders, inflammation, and immunity. Furthermore, the associations between birth season and DNA methylation were influenced by birth latitude, particularly in higher latitude regions.
CLINICAL EPIGENETICS
(2023)
Review
Public, Environmental & Occupational Health
Pernille Jul Clemmensen, Jorg Schullehner, Nis Brix, Torben Sigsgaard, Leslie Thomas Stayner, Henrik Albert Kolstad, Cecilia Host Ramlau-Hansen
Summary: Recently, several epidemiological studies have investigated the potential health effects of prenatal exposure to nitrate, even at levels below the current drinking water standard. The reviewed studies showed indications of increased risk of preterm delivery, lower birth weight, birth defects, and childhood cancer related to prenatal nitrate exposure. However, more studies are needed to confirm these findings and explore the impact of other factors such as water consumption and diet.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2023)
Review
Public, Environmental & Occupational Health
Mette J. Langergaard, Andreas Ernst, Nis Brix, Lea L. H. Lunddorf, Cecilia H. Ramlau-Hansen
Summary: The purpose of this study is to review recent epidemiological studies published from 2017 to 2022 on the potential associations between prenatal exposure to parental lifestyle factors, diseases, and medication use and pubertal development in sons. The reviewed studies found that maternal pre-pregnancy obesity and smoking during pregnancy may be associated with earlier pubertal development in sons, while the association between paternal obesity and timing of puberty was less clear. Maternal alcohol consumption may be associated with later pubertal development in sons. Maternal gestational diabetes mellitus was associated with faster pubertal development in terms of growth, but no association was found with other markers of pubertal timing. Recent studies also reported earlier timing of puberty in sons born to mothers with hyperthyroidism and mothers accidentally using oral contraceptives during early pregnancy. No other explored prenatal exposures were associated with pubertal development in sons.
CURRENT EPIDEMIOLOGY REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Marcella Broccia, Anders Munch, Bo Molholm Hansen, Kathrine Kold Sorensen, Thomas Larsen, Katrine Strandberg-Larsen, Thomas Alexander Gerds, Christian Torp-Pedersen, Ulrik Schioler Kesmodel
Summary: This Danish study investigated the morbidity risk in children exposed to heavy prenatal alcohol and found an increased risk of various diseases and health problems, particularly related to brain function, behavioral disorders, infections, and neonatal conditions. The findings highlight the importance of addressing prenatal alcohol exposure as a key public health issue and emphasizing pre-conceptional care.
LANCET PUBLIC HEALTH
(2023)
Article
Obstetrics & Gynecology
Anne Gaml-Sorensen, Anne Hjorth Thomsen, Sandra Sogaard Tottenborg, Nis Brix, Karin Sorig Hougaard, Gunnar Toft, Siri Eldevik Haberg, Mikko Myrskyla, Jens Peter Bonde, Cecilia Host Ramlau-Hansen
Summary: The maternal pre-pregnancy BMI was associated with altered reproductive hormone profile in young adult sons, characterized by higher levels of estradiol, LH, and free androgen index, and lower levels of sex hormone-binding globulin. The effects of maternal pre-pregnancy BMI on hormone levels may be partly mediated by sons' birthweight, fat mass, and BMI.
HUMAN REPRODUCTION
(2023)
Meeting Abstract
Psychiatry
A. Nakamura, L. Broseus, J. Tost, D. Vaiman, S. Martins, K. Keyes, K. Bonello, M. Fekom, K. Strandberg-Larsen, A. -L. Sutter-Dallay, M. Melchior, B. Heude, J. Lepeule
EUROPEAN PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Marcella Broccia, Bo Molholm Hansen, Julie Marie Winckler, Thomas Larsen, Katrine Strandberg-Larsen, Christian Torp-Pedersen, Ulrik Schioler Kesmodel
Summary: Heavy prenatal alcohol exposure is associated with adverse obstetric and birth outcomes, with high proportions of maternal low educational level, psychiatric disease, and lifestyle risk behaviors. These findings highlight the need for holistic public health programs and policy attention on improving pre-conceptional care and antenatal care.
LANCET PUBLIC HEALTH
(2023)
