Article
Obstetrics & Gynecology
K. Phan, Y. H. Gomez, J. Gorgui, A. El-Messidi, R. Gagnon, H. A. Abenhaim, E. Rahme, S. S. Daskalopoulou
Summary: This study aimed to evaluate the ability of arterial stiffness parameters to predict pre-eclampsia early compared with peripheral blood pressure, uterine artery Doppler, and established angiogenic biomarkers. The results showed that arterial stiffness predicted pre-eclampsia more accurately than blood pressure, ultrasound indices, and angiogenic biomarkers.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Sport Sciences
Murat Karabulut, Margarita Bitting, Jorge Bejar
Summary: The study aimed to determine the effects of various aerobic training protocols on arterial compliance and hemodynamic responses. The findings suggest that the duration and intensity of exercise play a crucial role in improving arterial elasticity, systemic vascular resistance, and total vascular impedance. Additionally, exercising for 20 minutes with blood flow restriction at 40% V?o(2)max may yield similar modifications in pulse wave velocity as seen after 60 minutes of exercise at 65% V?o(2)max.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Review
Biochemistry & Molecular Biology
Victoria E. de Knegt, Paula L. Hedley, Jorgen K. Kanters, Ida N. Thagaard, Lone Krebs, Michael Christiansen, Ulrik Lausten-Thomsen
Summary: Leptin plays a crucial role in regulating pregnancy-related functions and its dysregulation during pregnancy can lead to pre-eclampsia and restricted fetal growth. The regulatory mechanisms involving leptin in pre-eclampsia are specific to each situation, and the dysregulation of leptin likely affects fetal growth through complex interactions with parallel pregnancy systems throughout pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Seong-Joon Lee, Jin Soo Lee, Min Kim, So Young Park, Ji Hyun Park, Bumhee Park, Woo Sang Jung, Jin Wook Choi, Ji Man Hong
Summary: This study investigated the effects of endothelial function and arterial stiffness on CCAD using FMD and PWV measurements. The results showed that preserved endothelial function was associated with spontaneous arterial healing, while higher arterial stiffness was associated with ischemic presentation.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kaido Paapstel, Jaak Kals
Summary: Arterial stiffness is an early detectable sign of vascular wall alterations and is an independent predictor of cardiovascular events and death. Metabolomics can be used to study the metabolic intermediates and products associated with arterial stiffness, providing insights for personalized cardiovascular risk assessment and treatment selection.
Article
Engineering, Biomedical
Tadeusz Sondej, Iwona Jannasz, Krzysztof Sieczkowski, Andrzej Dobrowolski, Karolina Obia, Tomasz Targowski, Robert Olszewski
Summary: The study validated a new device for multi-site arterial PWV measurement using PPG sensors, with the reference device being SphygmoCor XCEL, according to ASG recommendations. Through experiments on 108 subjects, it was found that there was a high correlation between multi-site PWV and cfPWV, with the best results obtained when the proximal PPG sensor was placed on the head.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Ophthalmology
Jihei Sara Lee, Hyoung Won Bae, Sungeun Park, Chan Yun Kim, Sang Yeop Lee
Summary: The study aimed to determine the association between arterial stiffness predicted by brachial-ankle pulse wave velocity (PWV) and structural progression in early open-angle glaucoma. The results showed that high PWV was associated with macular ganglion cell-inner plexiform layer (mGCIPL) loss preceding peripapillary retinal nerve fiber layer (ppRNFL) loss.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Medicine, General & Internal
Yan-Feng Zhou, Yanxiu Wang, Guodong Wang, Zhen Zhou, Shuohua Chen, Tingting Geng, Yan-Bo Zhang, Yi Wang, Jun-Xiang Chen, An Pan, Shouling Wu
Summary: This study aimed to investigate the association between statin use and progression of arterial stiffness in Chinese adults with high atherosclerotic risk. The results showed that statin use was associated with lower baseline baPWV and slower progression of baPWV.
Article
Endocrinology & Metabolism
Zheng-Wei Chen, Chien-Ting Pan, Che-Wei Liao, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Shuo-Meng Wang, Ching-Chu Lu, Jeff S. Chueh, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Lin
Summary: This study compared the reversal of arterial stiffness in surgically and medically treated PA patients and identified predictors of effective medical treatment. The findings showed that adrenalectomy and medically treated PA patients with unsuppressed plasma renin activity (PRA) had an improvement in arterial stiffness.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Acoustics
J. Semmler, C. Garcia-Gonzalez, A. Sanchez Sierra, M. Gallardo Arozena, K. H. Nicolaides, M. Charakida
Summary: In fetuses of mothers who subsequently developed pre-eclampsia, there were notable differences in cardiac morphology and function compared to those from normotensive pregnancies. These differences included a more globular right ventricle, reduced right ventricular systolic contractility, and reduced left ventricular diastolic function. Additionally, other markers such as mean arterial pressure, soluble fms-like tyrosine kinase-1, and serum placental growth factor showed differences between the two groups, indicating possible implications for impaired placentation and fetal hypoxia-induced redistribution in pregnancies that develop pre-eclampsia.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Acoustics
C. A. Cluver, L. Bergman, J. Bergkvist, H. Imberg, L. Geerts, D. R. Hall, B. W. Mol, S. Tong, S. P. Walker
Summary: This study assessed whether coexisting fetal growth restriction (FGR) influences pregnancy latency and maternal and perinatal outcomes in women with preterm pre-eclampsia. The results showed that FGR is associated with shorter pregnancy latency, more emergency Cesarean deliveries, fewer successful inductions of labor, and increased rates of neonatal morbidity and mortality.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Peripheral Vascular Disease
Ryan J. Pewowaruk, Claudia Korcarz, James H. Stein, David Bluemke, Yacob Tedla, Adam D. Gepner
Summary: This study compared the associations of several arterial stiffness calculations in a large, multiethnic cohort and found that different methods of calculating local arterial stiffness largely gave equivalent results, indicating that the variety of different arterial stiffness calculations in use do not cause inconsistent findings.
JOURNAL OF HYPERTENSION
(2023)
Article
Obstetrics & Gynecology
Vaeochan Govender, Thinagrin D. Naidoo, Serantha Foolchand
Summary: The feasibility of using ductus venosus Doppler (DVD) to time delivery in early-onset fetal growth restriction (FGR) and pre-eclampsia was assessed in this study. The results showed that abnormal DVD was associated with increased perinatal morbidity and mortality, as well as increased risk of placental abruption.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Enrico Ferrazzi, Paolo Beretta, Stefano Bianchi, Irene Cetin, Paolo Guarnerio, Anna Locatelli, Anna Maria Marconi, Mario Giuseppe Meroni, Giulia Pavone, Armando Pintucci, Federico Prefumo, Valeria Savasi, Arsenio Spinillo, Beatrice Tassis, Patrizia Vergani, Michele Vignali, Fabio Parazzini, Carlo La Vecchia
Summary: Universal testing for pregnant women during the COVID-19 pandemic is suggested as a useful strategy. During the study period, 3.1% of pregnant women tested positive for SARS-Cov-2, a significantly higher proportion than estimated by health authorities. Among the positive cases, 44.9% had symptoms or reported close contact with positive patients.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Editorial Material
Obstetrics & Gynecology
Daniela Di Martino, Francesca Chiaffarino, Luisa Patane, Federico Prefumo, Patrizia Vergani, Sara Ornaghi, Valeria Savasi, Arsenio Spinillo, Antonella Cromi, Francesco D'Ambrosi, Beatrice Tassis, Enrico Iurlaro, Fabio Parazzini, Enrico Ferrazzi
Summary: A study of 250 pregnant women showed that obesity was the main determinant of severe COVID-19 illness in cases of asymptomatic, non-severe, or severe SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
F. D'Ambrosi, G. Rossi, C. M. Soldavini, I. F. Carbone, G. E. Cetera, N. Cesano, M. Di Maso, E. Ferrazzi
Summary: This study found that fetal right ventricular filling time was significantly shorter in pregnancies affected by gestational diabetes, indicating that fetal right cardiac function may be affected even when the diabetes is well controlled. Left ventricular filling time was also shorter in the GD group, although the difference was not significant.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Editorial Material
Obstetrics & Gynecology
Alessandro Ciavarella, Roberta Erra, Maria Abbattista, Enrico Iurlaro, Massimo Boscolo-Anzoletti, Manuela Wally Ossola, Fabio Mosca, Enrico Ferrazzi, Flora Peyvandi, Ida Martinelli
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Beatrice M. G. Tassis, Marta Ruggiero, Alice Ronchi, Ilaria G. Ramezzana, Giulia Bischetti, Enrico Iurlaro, Francesco D'Ambrosi, Fabrizio Ciralli, Fabio Mosca, Enrico M. Ferrazzi
Summary: This study compared the outcomes of consecutive pregnant women managed expectantly in an Italian academic hospital with those reported in the ARRIVE trial. The results showed that expectant management achieved better maternal and perinatal outcomes, indicating that the findings of the ARRIVE trial may not be applicable to the general population.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Claudia Giavoli, Enrico Iurlaro, Valentina Morelli, Giulia Rodari, Andrea Ronchi, Carlo Pietrasanta, Lorenza Pugni, Daniela Tubiolo, Paolo Properzi, Antonio Pesenti, Giovanna Mantovani, Enrico Ferrazzi, Maura Arosio
Summary: This case describes a pregnant woman with Covid-19 acute infection and non-classical congenital adrenal hyperplasia (NCAH) who required prompt care and treatment in a specialized hospital setting. The involvement of a multidisciplinary team ensured the well-being of both the mother and the newborn, as well as protection for all healthcare workers involved.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pediatrics
Jole Costanza, Margherita Camanni, Maria Maddalena Ferrari, Valentina De Cosmi, Silvia Tabano, Laura Fontana, Tatjana Radaelli, Giulia Privitera, Daniela Alberico, Patrizia Colapietro, Silvia Motta, Silvia Sirchia, Tamara Stampalija, Chiara Tabasso, Paola Roggero, Fabio Parazzini, Fabio Mosca, Enrico Ferrazzi, Silvano Bosari, Monica Miozzo, Carlo Agostoni
Summary: In a study of 503 women with uncomplicated pregnancies, maternal pre-pregnancy body mass index (BMI), gestational weight gain (GWG), and placental weight were found to be independently correlated with neonatal birth weight. However, maternal nutrition during pregnancy was not found to be associated with birth weight.
PEDIATRIC RESEARCH
(2022)
Editorial Material
Obstetrics & Gynecology
Giulia E. Cetera, Francesco D'Ambrosi, Enrico Iurlaro, Nicola Cesano, Ilma F. Carbone, Stefano De Marinis, Enrico Ferrazzi
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Environmental Sciences
Sara Molgora, Emanuela Saita, Maurizio Barbieri Carones, Enrico Ferrazzi, Federica Facchin
Summary: Postpartum depression is a common issue for mothers worldwide and is associated with anxiety disorders and parenting stress. This study aimed to describe the psychological status of mothers up to 12 months postpartum and identify predictors of depressive symptoms at 12 months postpartum. The findings highlight the importance of stable programs for mothers in the first year postpartum, and ensuring a positive childbirth experience to reduce potential long-term consequences.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Daniela Denis Di Martino, Laura Avagliano, Enrico Ferrazzi, Federica Fuse, Vittoria Sterpi, Marco Parasiliti, Tamara Stampalija, Sara Zullino, Antonio Farina, Gaetano Pietro Bulfamante, Matteo Di Maso, Francesco D'Ambrosi
Summary: This study found a higher prevalence of placental maternal vascular malperfusion in HDP-FGR and early FGR groups, which were associated with abnormal feto-placental Doppler parameters. In contrast, HDP-AGA fetus and late FGR presented more heterogeneous placental lesions not severe enough to cause feto-placental Doppler anomalies. These findings suggest potential preventive nutritional approaches for pregnant women with predisposing factors for HDP-AGA fetuses and late FGR.
Article
Nutrition & Dietetics
Chiara Maria Soldavini, Gabriele Piuri, Gabriele Rossi, Paola Antonia Corsetto, Linda Benzoni, Valeria Maggi, Giulia Privitera, Angela Spadafranca, Angela Maria Rizzo, Enrico Ferrazzi
Summary: This study aimed to assess the impact of nutraceutical supplements on patients with gestational diabetes mellitus (GD) and to explore anthropometric, metabolic, and inflammatory parameters as biomarkers for identifying individuals requiring pharmacological treatment. The results showed no significant differences in metabolic, inflammatory, and antioxidant parameters between the group receiving nutraceutical supplements and the placebo group. However, triglyceride concentration and AA/EPA ratio appear to be biomarkers for higher inflammatory levels and patients with GD who require pharmacological treatment.
Article
Nutrition & Dietetics
Daniela Di Martino, Mattia Cappelletti, Marta Tondo, Katia Basello, Camilla Garbin, Attilio Speciani, Enrico Ferrazzi
Summary: This study investigated the impact of SARS-CoV-2 infection on pregnant women and its relationship with overweight, obesity, and gestational diabetes. The findings showed that infected individuals had higher levels of advanced glycation end-products and glycated albumin, leading to premature delivery and impaired fetal growth.
Review
Acoustics
Moira Barbieri, Daniela Denis Di Martino, Enrico Mario Ferrazzi, Tamara Stampalija
Summary: Placental blood supply to the fetus can be measured by evaluating the umbilical vein blood flow. Despite its potential application in healthcare, the umbilical vein blood flow volume is still used only in research setting. One of the reasons is a concern regarding its reproducibility, partly due to technology issues. Nowadays, technology improvements make this evaluation accurate and reproducible. The aim of this review is to refresh basic elements of the physiology of umbilical vein blood flow and its analysis. Its evaluation in normal and abnormal fetal growth is also discussed.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Review
Medicine, General & Internal
Moira Barbieri, Giulia Zamagni, Ilaria Fantasia, Lorenzo Monasta, Leila Lo Bello, Mariachiara Quadrifoglio, Giuseppe Ricci, Gianpaolo Maso, Monica Piccoli, Daniela Denis Di Martino, Enrico Mario Ferrazzi, Tamara Stampalija
Summary: The objectives of this study were to review the available umbilical vein blood flow volume (UV-Q) reference ranges in uncomplicated pregnancies and compare them with UV-Q values obtained from a local cohort. Literature in English was reviewed according to PRISMA guidelines. Original articles were grouped based on UV sampling sites and formulae used to compute UV-Q. The UV-Q values were derived from formulae or tables presented by authors. A prospective observational study of uncomplicated singleton pregnancies was conducted to compare UV-Q with the systematic review results. Overall, there was a substantial heterogeneity in reported UV-Q central values, but values overlapped when using the same sampling methodology and formulae. The study suggests that UV-Q assessment is accurate and reproducible when adhering to the same methodology, encouraging further investigation on clinical applications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesco D'Ambrosi, Luisa Ronzoni, Roberta Villa, Stefano De Marinis, Giulia Emily Cetera, Chiara Maria Soldavini, Enrico Ferrazzi
Summary: Rubinstein-Taybi syndrome is a rare genetic disorder with challenging prenatal diagnosis. Ultrasonographic examination can increase the sensitivity of prenatal diagnosis for this condition.
JOURNAL OF ULTRASOUND
(2022)