Article
Cell Biology
Georgia Margioula-Siarkou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Kosmas Margaritis, Eleftherios Vavoulidis, Giuseppe Gullo, Maria Alexandratou, Konstantinos Dinas, Alexandros Sotiriadis, Georgios Mavromatidis
Summary: Preeclampsia, a leading cause of maternal and fetal morbidity and mortality, involves dysfunction of the placenta leading to imbalance of angiogenic and anti-angiogenic factors. Endoglin and soluble endoglin play significant roles in the pathophysiology of preeclampsia by interfering with signaling pathways that regulate angiogenesis and endothelial function. Further research is needed to explore the potential prognostic, diagnostic, and therapeutic implications of these molecules in clinical management of preeclampsia.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
David B. Seifer, Geralyn Lambert-Messerlian, Glenn E. Palomaki, Robert M. Silver, Corette Parker, Carol J. Rowland Hogue, Barbara J. Stoll, George R. Saade, Robert L. Goldenberg, Donald J. Dudley, Radek Bukowski, Halit Pinar, Uma M. Reddy
Summary: This study found that women with preeclampsia at the time of delivery have higher levels of maternal anti-angiogenic factors and may have lower levels of maternal serum vitamin D.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Immunology
Nagarjuna Sivaraj, Bunga Papa Kusuma, L. V. Simhachalam Kutikuppala, K. Vijaya Rachel, Vijaya Sirisha Balaga, Samhitha Gundakaram
Summary: This study found that the polymorphism of TNFSF11 (rs2200287 and rs2148072) gene is associated with preeclampsia, with the G allele of variant rs2200287 and the C allele of variant rs2148072 being significantly increased in the preeclamptic group.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Peripheral Vascular Disease
Anna Kivioja, Elli Toivonen, Jaakko Tyrmi, Sanni Ruotsalainen, Samuli Ripatti, Heini Huhtala, Tiina Jaaskelainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Tanja Saarela, Hannele Laivuori
Summary: The study found that the polygenic risk score for blood pressure (BP-PRS) is associated with an increased risk of preeclampsia and its severe subtypes, with women with high BP-PRS presenting higher blood pressure values during pregnancy.
Review
Biochemistry & Molecular Biology
Wenwen Wei, Xin Wang, Yuanzhong Zhou, Xuejun Shang, Hongsong Yu
Summary: Pregnancy-induced hypertension (PIH) is a severe pregnancy complication that can lead to maternal mortality. Various genetic factors have been shown to play an important role in the occurrence and development of PIH. This review summarizes the genetic risk factors involved in the renin-angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks that may contribute to the pathogenesis of PIH.
Article
Biochemistry & Molecular Biology
Lucia Perez-Roque, Elena Nunez-Gomez, Alicia Rodriguez-Barbero, Carmelo Bernabeu, Jose M. Lopez-Novoa, Miguel Pericacho
Summary: Preeclampsia is a pregnancy-specific disease characterized by hypertension, with its etiopathogenesis related to abnormal placentation and the release of soluble factors. High plasma levels of soluble endoglin (sEng) may serve as an early diagnostic and prognostic biomarker for the disease, impacting the pathophysiology of preeclampsia significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Haiyan Chu, Anastasia Sacharidou, An Nguyen, Chun Li, Ken L. Chambliss, Jane E. Salmon, Yu-Min Shen, Julie Lo, Gustavo W. Leone, Joachim Herz, David Y. Hui, Denise K. Marciano, Vikki M. Abrahams, Bryony Natale, Alina P. Montalbano, Xue Xiao, Lin Xu, David R. Natale, Philip W. Shaul, Chieko Mineo
Summary: In this study, it was found that antiphospholipid antibodies (aPL) can induce preeclampsia by influencing placental trophoblast function and endangering the fetus. The results suggest that aPL affect preeclampsia by altering gene expression related to preeclampsia through the regulation of PP2A protein phosphatase activity. Overall, the findings indicate that the impact of aPL on trophoblast cells is crucial for the development of preeclampsia, involving modulation of various signaling pathways.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Obstetrics & Gynecology
Ahmed Mohamedain, Duria A. Rayis, Nadiah AlHabardi, Ishag Adam
Summary: The study demonstrated that previous spontaneous abortion reduced the risk of developing preeclampsia, while women with a history of preeclampsia had a higher risk of recurrence.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Cell Biology
Melanie Young, Ming Tang, Huika Li, Derek J. Richard, Donald S. A. McLeod, Michael C. d'Emden, Kerry Richard
Summary: Preeclampsia is a life-threatening condition caused by poor placentation during pregnancy. The study suggests that transthyretin, a thyroid hormone binding protein, binds to soluble endoglin (sEng) and enhances its uptake by hepatocytes. This finding may lead to potential treatment options for reducing sEng-induced vascular dysfunction.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Laura J. Slade, Milly Wilson, Hiten D. Mistry, Jeffrey N. Bone, Natalie A. Bello, Maya Blackman, Nuhaat Syeda, Peter von Dadelszen, Laura A. Magee
Summary: There is a relationship between the blood pressure thresholds defined by the 2017 American College of Cardiology and American Heart Association and adverse pregnancy outcomes. Blood pressure thresholds of 140 mm Hg (systolic) and 90 mm Hg (diastolic) from 20 weeks of gestation can effectively identify women at increased risk of adverse pregnancy outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Victoria A. deMartelly, John Dreixler, Avery Tung, Ariel Mueller, Sarah Heimberger, Abid A. Fazal, Heba Naseem, Roberto Lang, Eric Kruse, Megan Yamat, Joey P. Granger, Bhavisha A. Bakrania, Javier Rodriguez-Kovacs, Sarosh Rana, Sajid Shahul
Summary: The study found that in women with a history of preeclampsia, levels of activin A and global longitudinal strain remained elevated 10 years postpartum, and were associated with the deterioration of cardiac structure and function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Obstetrics & Gynecology
Samantha G. Bromfield, Qinli Ma, Andrea DeVries, Tiffany Inglis, Aliza S. Gordon
Summary: This study evaluated the association between hypertensive disorders during pregnancy and adverse outcomes for neonates and mothers. It also identified risk factors for the progression of milder hypertensive disorders to more severe conditions. The findings showed that mothers and neonates with preeclampsia or superimposed preeclampsia had higher risks of adverse outcomes compared to those without hypertension.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
Fatemeh Mazlum, Behrouz Gharesi-Fard, Hossein Hadinedoushan, Yousef Bakhshizadeh Ghashti
Summary: The study revealed an association between IL-32 gene polymorphism and serum levels of IL-32 with susceptibility to preeclampsia (PE). Higher frequencies of CT, TT genotypes, and T allele for rs4786370 were found in PE patients, along with a significant increase in serum IL-32 level.
HYPERTENSION IN PREGNANCY
(2021)
Review
Obstetrics & Gynecology
Lingli Li, Luping Liu, YuYue Xu
Summary: A meta-analysis explored the potential relationship between hypertensive disease during pregnancy and placenta accreta, finding that hypertensive disease during pregnancy was associated with a lower prevalence of placenta accreta.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
K. J. Gray, V. P. Kovacheva, H. Mirzakhani, A. C. Bjonnes, B. Almoguera, M. L. Wilson, S. A. Ingles, C. J. Lockwood, H. Hakonarson, T. F. McElrath, J. C. Murray, E. R. Norwitz, S. A. Karumanchi, B. T. Bateman, B. J. Keating, R. Saxena
Summary: The study found that genetic predisposition increases the risk of developing pre-eclampsia, especially in relation to elevated diastolic blood pressure and body mass index. Conversely, genetic variations associated with elevated alkaline phosphatase were found to be protective.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Statistics & Probability
Yingda Jiang, Chi-Yang Chiu, Qi Yan, Wei Chen, Michael B. Gorin, Yvette P. Conley, M'hamed Lajmi Lakhal-Chaieb, Richard J. Cook, Christopher Amos, Alexander F. Wilson, Joan E. Bailey-Wilson, Francis J. McMahon, Ana Vazquez, Ao Yuan, Xiaogang Zhong, Momiao Xiong, Daniel E. Weeks, Ruzong Fan
Summary: Genetics plays a significant role in age-related macular degeneration (AMD) and the study utilized a new generalized functional linear mixed model (GFLMM) to test for gene-based association in AMD families. Significant associations were found with known AMD genes CFH and ARMS2, while suggestive signals were observed in genes like ASAH1, CLEC6A, TMEM63C, and SGSM1. The GFLMM-based statistics provided a new tool for conducting family-based genetic studies of complex diseases.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2021)
Article
Nursing
Komal Singh, Huangshen Cao, Christine Miaskowski, Yvette P. Conley, Marilyn Hammer, Fay Wright, Jon D. Levine, Kord M. Kober
Summary: This study aimed to evaluate perturbed biological pathways associated with endocytosis and apoptosis in oncology patients, and found that inflammation of the GI mucosa induced by chemotherapy may lead to initiation of endocytotic and apoptotic processes in the gut, which are associated with the occurrence of chemotherapy-induced nausea.
BIOLOGICAL RESEARCH FOR NURSING
(2021)
Article
Orthopedics
Katherine A. Burns, Lynn M. Robbins, Angela R. LeMarr, Amber L. Childress, Diane J. Morton, William C. Schroer, Melissa L. Wilson
Summary: This study found that patients who took celecoxib after shoulder surgery had significantly lower opioid use at 3 and 6 weeks postoperatively. Using a multimodal pain control approach, celecoxib was effective in reducing opioid consumption in patients undergoing shoulder arthroplasty.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Oncology
Rafael Diaz, Kord M. Kober, Carol Viele, Bruce A. Cooper, Steven M. Paul, Marilyn Hammer, Fay Wright, Yvette P. Conley, Jon D. Levine, Christine Miaskowski
Summary: Chemotherapy-induced diarrhea (CID) is a common symptom that occurs in 50 to 80% of patients. This study identified four distinct diarrhea profiles among 1133 patients: none (58.3%), decreasing (22.0%), increasing (5.2%), and high (14.5%). Patients in the high class had lower functional status, worse comorbidity profile, were more likely to have gastrointestinal cancer, and receive chemotherapy on a 14-day cycle compared to the none class.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Nursing
Monica A. Wagner, Susan W. Wesmiller, Meaghan Maydick, Lisa M. Gawron, Frances M. Peterson-Burch, Yvette P. Conley
Summary: Integrating omics into non-pharmacological intervention research helps understand response variability and discover genes associated with intervention effectiveness. This study found nine genes related to response, indicating potential targets for future investigations using omic approaches in non-pharmacological interventions.
BIOLOGICAL RESEARCH FOR NURSING
(2021)
Article
Clinical Neurology
Jordan Lam, Justin Lee, Marcus Williams, Melanie Cohn, Melissa Wilson, Catherine Mark, Nasrin Esnaashari, Andrew Petkus, Jennifer Hui, Danielle Feigenbaum, Mark Liker, Charles Y. Liu, Brian Lee, Darrin J. Lee
Summary: The study evaluated the acute effects of theta frequency bilateral STN stimulation on executive function in Parkinson's disease patients, showing significant improvement in episodic category fluency compared to gamma frequency stimulation. However, there were no significant differences between stimulation frequencies in other tests.
Article
Nutrition & Dietetics
Angie W. Huang, Min Wei, Sara Caputo, Melissa L. Wilson, Joseph Antoun, William C. Hsu
Summary: The study showed that consuming a 200-calorie fasting-mimicking diet (FMD) bar does not interfere with physiological ketogenesis associated with overnight fasting, indicating it could facilitate the practice of time-restricted eating or intermittent fasting.
Article
Orthopedics
Katherine A. Burns, Lynn M. Robbins, Angela R. LeMarr, Kathleen Fortune, Diane J. Morton, Melissa L. Wilson
Summary: The study aimed to investigate the impact of predefined modifiable risk factors (MRFs) on total encounter charges, hospital length of stay (LOS), related emergency department (ED) visits and charges, and related hospital readmissions within 90 days after shoulder arthroplasty. Results showed that anemia, malnutrition, and obesity independently contributed to higher charges after shoulder arthroplasty, while anemia, malnutrition, and uncontrolled diabetes were associated with longer hospital stays.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2022)
Article
Orthopedics
Peyton Keeling, Brian A. Schneiderman, Conrad Lu, Melissa L. Wilson, Thomas P. Schmalzried
Summary: This study analyzed the periprosthetic tissues of TKA patients and compared the CD4+ and CD8+ lymphocyte subsets with LTT and histology results. The results showed that there was no relationship between lymphocyte subsets and LTT results or ALVAL scores on a case-by-case basis. Therefore, lymphocyte subsets cannot diagnose immune failure in TKA.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Oncology
Nisa Fraser, Melissa L. Wilson, Randall Y. Chan
Summary: We conducted a retrospective cohort study to investigate the social and logistic factors contributing to the delay in seeking immediate emergency care for neutropenic fever in pediatric hematology-oncology patients. From 2015 to 2020, we analyzed patients who presented for fever in the setting of neutropenia to our emergency department or clinic. Patients with a history of at least 2 prior admissions for neutropenic fever were more likely to wait for a second fever before seeking care. No other significant associations were observed.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Tiffany Xiu Zhen Lim, Trevor A. Pickering, Richard H. Lee, Isabella Hauptman, Melissa L. Wilson
Summary: This study aimed to synthesize epidemiologic literature on the association between preeclampsia (PE), attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and epilepsy. The results showed that intrauterine exposure to PE increased the risk of ADHD, ASD, and epilepsy. However, it is unclear whether the true association is with pre-term birth. This is the first meta-analysis to quantify the association between PE and epilepsy.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Luanda Grazette, Jeffrey S. Tran, Nadine K. Zawadzki, Roy S. Zawadzki, Jennifer M. McLeod, Michael W. Fong, Melissa L. Wilson, Ofer Havakuk, Joel W. Hay
Summary: This study found that patterns of continuous outpatient inotrope infusion therapy (COIIT) use varied by region, and these differences were associated with clinical outcomes.
IJC HEART & VASCULATURE
(2022)
Article
Health Care Sciences & Services
Margaret English, Fatimata Sanogo, Rebecca Trotzky-Sirr, Todd Schneberk, Melissa Lee Wilson, Jeffrey Riddell
Summary: The study found that most medical students at a US medical school have worked in a carceral health setting during their time in school. It was observed that increased exposure to carceral medicine education, hours worked in a jail, and substance abuse training led to improved knowledge and attitudes towards justice-involved patients among medical students. Moreover, knowledge and attitudes towards justice-involved patients tended to increase as students progressed through their years of medical school, indicating a need for formal curriculum to address this issue.
Article
Oncology
Mei R. Fu, Bradley E. Aouizerat, Gary Yu, Yvette Conley, Deborah Axelrod, Amber A. Guth, Jean-Pierre Gagner, Jeanna M. Qiu, David Zagzag
Summary: The study aimed to identify lymphedema symptom patterns and their association with phenotypic characteristics and biomarkers using latent class analysis (LCA). Three distinct lymphedema symptom classes were identified at 8 weeks and 12 months post-surgery, with participants more likely to be in the severe symptom classes at 12 months post-surgery if they had specific phenotypic characteristics and biomarker levels. Pre-surgery levels of IL1-a, IL-6, IL-8, and VEGF were associated with the severe symptom class at 8 weeks post-surgery, suggesting predictive value for lymphedema symptoms.
CURRENT BREAST CANCER REPORTS
(2021)
