4.7 Article

The regioselective synthesis of 2-phosphinoylindoles via Rh(III)-catalyzed C-H activation

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 1, Pages 88-91

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7qo00746a

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Funding

  1. National Natural Science Foundation of China [21372121, 21672108, 21421062]
  2. Natural Science Foundation of Tianjin [16JCZDJC31700]

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The redox-neutral annulation of N-nitrosoanilines with 1-alkynylphosphine oxides under rhodium catalysis was achieved. This step-economical protocol affords 2-phosphinoylindoles in excellent regioselectivity with good functional group tolerance.

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