PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers

Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry

(2017) Le Ying et al.   Journal of Translational Medicine

Fully automated 5-plex fluorescent immunohistochemistry with tyramide signal amplification and same species antibodies

(2017) Wenjun Zhang et al.   LABORATORY INVESTIGATION

A Four-Factor Immunoscore System That Predicts Clinical Outcome for Stage II/III Gastric Cancer

(2017) Ti Wen et al.   Cancer Immunology Research

Gastric adenocarcinoma

(2017) Jaffer A. Ajani et al.   Nature Reviews Disease Primers

Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)

(2016) J. M. Kim et al.   ANNALS OF ONCOLOGY

Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma

(2016) Elizabeth D Thompson et al.   GUT

Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial

(2016) Kei Muro et al.   LANCET ONCOLOGY

The clinicopathological and prognostic significance of PD-L1 expression in gastric cancer: a meta-analysis of 10 studies with 1,901 patients

(2016) Minghui Zhang et al.   Scientific Reports

Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)

(2015) Claudia Allemani et al.   LANCET

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

(2015) Anthony J. Sadler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New immunotherapies targeting the PD-1 pathway

(2015) Jordan M. Chinai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Is PD-L1 Expression a Biomarker of Response?

(2015)   Cancer Discovery

Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer

(2015) Yi Qing et al.   Drug Design Development and Therapy

Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens

(2015) Marina K Baine et al.   Oncotarget

Consensus nomenclature for CD8+T cell phenotypes in cancer

(2015) Lionel Apetoh et al.   OncoImmunology

Correlation between infiltration of FOXP3+ regulatory T cells and expression of B7-H1 in the tumor tissues of gastric cancer

(2014) Jingying Hou et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Multiplexed immunohistochemistry, imaging, and quantitation: A review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis

(2014) Edward C. Stack et al.   METHODS

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

ATF3 Suppresses Metastasis of Bladder Cancer by Regulating Gelsolin-Mediated Remodeling of the Actin Cytoskeleton

(2013) X. Yuan et al.   CANCER RESEARCH

Tumor-Reactive CD8+ T Cells in Metastatic Gastrointestinal Cancer Refractory to Chemotherapy

(2013) S. Turcotte et al.   CLINICAL CANCER RESEARCH

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

(2012) R. J. deLeeuw et al.   CLINICAL CANCER RESEARCH

Increased PD-1 expression on CD4+ and CD8+ T cells is involved in immune evasion in gastric cancer

(2012) Hiroaki Saito et al.   JOURNAL OF SURGICAL ONCOLOGY

Expression of tumour-specific antigens underlies cancer immunoediting

(2012) Michel DuPage et al.   NATURE

CD4+CD25+CD127low/− regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression

(2009) Li-Song Shen et al.   CLINICAL IMMUNOLOGY

Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner

(2009) Xiang-Liang Yuan et al.   CLINICAL IMMUNOLOGY

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

(2008) Paul Salama et al.   JOURNAL OF CLINICAL ONCOLOGY