Article
Allergy
Jonathan M. Gaffin, Carter R. Petty, Ronald L. Sorkness, Loren C. Denlinger, Brenda R. Phillips, Ngoc P. Ly, Benjamin Gaston, Kristie Ross, Anne Fitzpatrick, Leonard B. Bacharier, Mark D. DeBoer, W. Gerald Teague, Sally E. Wenzel, Sima Ramratnam, Elliot Israel, David T. Mauger, Wanda Phipatanakul
Summary: This study aimed to identify phenotypic factors associated with FEV1 in children with asthma. The results showed that baseline FENO, response to triamcinolone acetonide, and bronchodilator reversibility were associated with FEV1. Additionally, age, obesity, and exacerbation frequency predicted FEV1 over time. There was also a significant interaction between age and sex, with boys experiencing more significant effects of exacerbation frequency on FEV1 compared to girls.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Nursing
Hadassah Joann Ramachandran, Ying Jiang, Coral Hui Shan, Wilson Wai San Tam, Wenru Wang
Summary: The study found that swimming has positive effects on lung function and asthma control in children under 18 years old, but the potential adverse effects on asthma remain unclear. Future research should be adequately powered and consider cumulative exposures to chlorine by-products and other potential confounders.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Review
Medicine, General & Internal
Shuangtao Xing, Shijie Feng, Dan Zeng
Summary: This study compared the effects of different types of exercise on pulmonary function in adult patients with asthma through Network Meta-analysis. The results showed that breathing training, aerobic training, relaxation training, yoga training, and breathing combined with aerobic training significantly improved Forced Expiratory Volume in the first second (FEV1) levels; aerobic training, breathing training, yoga training, and breathing combined with aerobic training improved Forced Vital Capacity (FVC) levels; breathing training, aerobic training, relaxation training, yoga training, and breathing combined with aerobic training improved Peak Expiratory Flow (PEF) levels; breathing training, aerobic training, and yoga training improved Forced Expiratory Volume in the first second/Forced Vital Capacity (FEV1/FVC) levels.
ANNALS OF MEDICINE
(2023)
Article
Critical Care Medicine
Michael C. Peters, Mark L. Schiebler, Juan Carlos Cardet, Mats W. Johansson, Ronald Sorkness, Mark D. DeBoer, Eugene R. Bleecker, Deborah A. Meyers, Mario Castro, Kaharu Sumino, Serpil C. Erzurum, Matthew C. Tattersall, Joe G. Zein, Annette T. Hastie, Wendy Moore, Bruce D. Levy, Elliot Israel, Brenda R. Phillips, David T. Mauger, Sally E. Wenzel, Merritt L. Fajt, Suneil K. Koliwad, Loren C. Denlinger, Prescott G. Woodruff, Nizar N. Jarjour, John Fahy
Summary: This study demonstrates that insulin resistance (IR) is common in asthma and is associated with lower lung function, accelerated decline of lung function, and suboptimal responses to bronchodilator and corticosteroid treatments.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Nayely Reyes Noriega, Blanca E. Del-Rio-Navarro, Arturo Berber, Sergio de Jesus Romero Tapia, Dario Jorge Mario Molina Diaz
Summary: Obesity and asthma, especially in industrialized nations, are significant global health concerns. Obesity negatively affects lung function and the respiratory system due to metabolic and immunological issues. Research suggests that obese asthma patients exhibit diminished lung function compared to non-obese asthmatics, which can be attributed to mechanical factors such as fat loading on the diaphragm and central adiposity. This combination of mechanical, environmental, and inflammatory factors can contribute to the obesity-related asthma phenotype, characterized by severe symptoms, poor response to treatment, decreased lung function, and reduced quality of life from an early age.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Allergy
Yang-Ching Chen, Yen-Tsung Huang, Wen-Harn Pan, Yungling L. Lee
Summary: The association between obesity and asthma is mainly mediated by impaired pulmonary function, low physical fitness, and early puberty. Interventions promoting physical fitness and pulmonary function may effectively reduce the risk of asthma caused by obesity.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Allergy
Samidi Navaratna, Marie J. Estcourt, John Burgess, Nilakshi Waidyatillake, Elizabeth Enoh, Adrian J. Lowe, Rachel Peters, Jennifer Koplin, Shyamali C. Dhamage, Caroline J. Lodge
Summary: The study found that childhood vaccination with commonly administered vaccines was not associated with increased risk of later allergic disease. Vaccination with BCG and measles vaccines were associated with a reduced risk of eczema.
Article
Allergy
Yang-Ching Chen, Yen-Tsung Huang, Wen-Harn Pan, Yungling L. Lee
Summary: The study found that the association between obesity and asthma is mainly mediated through impaired pulmonary function, low physical fitness, and early puberty. Results suggest that interventions promoting physical fitness and pulmonary function may effectively reduce obesity-induced asthma risk.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Environmental Sciences
Tarik Karramass, Chalana Sol, Kurunthachalam Kannan, Leonardo Trasande, Vincent Jaddoe, Liesbeth Duijts
Summary: This study aimed to investigate the potential effects of fetal exposure to bisphenols and phthalates on respiratory and immune system development in children, as well as respiratory health. The results showed no strong associations between maternal urine concentrations of bisphenols and phthalates during pregnancy and lung function and asthma in children at age 13 years.
ENVIRONMENTAL POLLUTION
(2023)
Article
Allergy
Yang-Ching Chen, Ming-Wei Su, Ben M. Brumpton, Yungling L. Lee, Omer Kalayci
Summary: Using a Mendelian randomization design, this study found that obesity, SDB, and poor sleep quality were associated with childhood asthma, with sleep quality showing the largest effect. Prospective survival analysis revealed that obesity was the highest risk factor for incident asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Tzu-Ning Wen, Hsueh-Chun Lin, Kuo-Wei Yeh, Jing-Long Huang, Li-Chi Chiang
Summary: A web-based self-health management system, eAsthmaCare, was developed as an intervention for asthmatic children. The study found that eAsthmaCare intervention can improve childhood asthma symptoms, particularly in relation to sleeping condition and cough symptoms. However, there was no statistically significant improvement in lung function.
JOURNAL OF MEDICAL SYSTEMS
(2022)
Article
Respiratory System
Mohammad Talaei, Pauline M. Emmett, Raquel Granell, Hossein Tabatabaeian, Kate Northstone, Anna Bergstrom, Seif O. Shaheen
Summary: A study found that different dietary patterns in childhood are associated with lung function and incident asthma in adolescence. A 'health-conscious' diet was positively associated with lung function, while a diet high in processed food was negatively associated with lung function. However, there was no significant association between a 'traditional' diet and lung function or incident asthma.
RESPIRATORY RESEARCH
(2023)
Article
Immunology
Renyu Ruan, Xiangmin Deng, Xiaoyan Dong, Qi Wang, Xiaoling Lv, Caijuan Si
Summary: A meta-analysis was conducted to confirm the potential diagnostic value of lung microbiota markers for lung diseases, which showed promising results but further large-scale clinical studies are needed for validation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Nikos Stratakis, Erika Garcia, Aruna Chandran, Tingju Hsu, Akram Alshawabkeh, Izzuddin M. Aris, Judy L. Aschner, Carrie Breton, Allison Burbank, Carlos A. Jr Jr Camargo, Kecia N. Carroll, Zhanghua Chen, Erika C. Claud, Dana Dabelea, Anne L. Dunlop, Amy J. Elliott, Assiamira Ferrara, Jody M. Ganiban, James E. Gern, Diane R. Gold, William A. Gower, Irva Hertz-Picciotto, Margaret R. Karagas, Catherine J. Karr, Barry Lester, Leslie D. Leve, Augusto A. Litonjua, Yunin Ludena, Cindy T. McEvoy, Rachel L. Miller, Noel T. Mueller, Thomas G. O'Connor, Emily Oken, T. Michael O'Shea, Frederica Perera, Joseph B. Stanford, Katherine Rivera-Spoljaric, Andrew Rundle, Leonardo Trasande, Rosalind J. Wright, Yue Zhang, Yeyi Zhu, Kiros Berhane, Frank Gilliland, Lida Chatzi
Summary: This study found an association between childhood asthma and obesity, suggesting that asthma may contribute to the development of obesity in children. Additionally, the use of asthma medication was found to reduce this association.
Article
Environmental Sciences
Alicia Abellan, Sara M. Mensink-Bout, Raquel Garcia-Esteban, Andrea Beneito, Leda Chatzi, Talita Duarte-Salles, Mariana F. Fernandez, Judith Garcia-Aymerich, Berit Granum, Carmen Iniguez, Vincent W. V. Jaddoe, Kurunthachalam Kannan, Aitana Lertxundi, Maria-Jose Lopez-Espinosa, Claire Philippat, Amrit K. Sakhi, Susana Santos, Valerie Siroux, Jordi Sunyer, Leonardo Trasande, Marina Vafeiadi, Fernando Vela-Soria, Tiffany C. Yang, Carlos Zabaleta, Martine Vrijheid, Liesbeth Duijts, Maribel Casas
Summary: This study found that in utero exposure to BPA may increase the odds of asthma and wheeze in school-age girls. The associations of BPF and BPS with respiratory outcomes were inconsistent in overall and sex-stratified analyses.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Pediatrics
Joel Reiter, Maya Ramagopal, Alex Gileles-Hillel, Erick Forno
Summary: Asthma and sleep disorders are common in children and often coexist, with one potentially influencing the other. Children with asthma may experience complaints of poor sleep quality, insomnia, and daytime sleepiness, while also having higher rates of parasomnias. The bidirectional interaction between sleep-related breathing disorders and asthma may worsen each condition, emphasizing the importance of considering both when managing asthma in children.
PEDIATRIC PULMONOLOGY
(2022)
Article
Pediatrics
Maria Forero Molina, William Okoniewski, Sandeep Puranik, Shean Aujla, Juan C. Celedon, Allyson Larkin, Erick Forno
Summary: This study reviewed the electronic health records of a severe asthma clinic in a children's hospital, finding that children with severe asthma had high morbidity and healthcare utilization. The study also showed that patients with a history of hospital admissions for asthma were more likely to be nonwhite and highly atopic and have lower lung function. Following enrollment in a multidisciplinary clinic, the frequency of severe exacerbations decreased.
PEDIATRIC PULMONOLOGY
(2022)
Meeting Abstract
Pediatrics
Erick Forno
PEDIATRIC PULMONOLOGY
(2022)
Article
Allergy
Michael S. Freedman, Erick Forno
Summary: This study aimed to identify early predictive factors associated with pediatric intensive care unit (PICU) admission. The study found that higher heart rates and respiratory rates, and lower SpO2 within the first hour of emergency department (ED) presentation were independently associated with PICU admission. A binary predictive index using 1-hour vitals accurately predicted PICU admission, and in combination with a secondary standardized clinical asthma distress score, the positive predictive value increased significantly.
Article
Allergy
Esther Herrera-Luis, Victor E. Ortega, Elizabeth J. Ampleford, Yang Yie Sio, Raquel Granell, Emmely de Roos, Natalie Terzikhan, Ernesto Elorduy Vergara, Natalia Hernandez-Pacheco, Javier Perez-Garcia, Elena Martin-Gonzalez, Fabian Lorenzo-Diaz, Simone Hashimoto, Paul Brinkman, Andrea L. Jorgensen, Qi Yan, Erick Forno, Susanne J. Vijverberg, Ryan Lethem, Antonio Espuela-Ortiz, Mario Gorenjak, Celeste Eng, Ruperto Gonzalez-Perez, Jose M. Hernandez-Perez, Paloma Poza-Guedes, Olaia Sardon, Paula Corcuera, Greg A. Hawkins, Annalisa Marsico, Thomas Bahmer, Klaus F. Rabe, Gesine Hansen, Matthias Volkmar Kopp, Raimon Rios, Maria Jesus Cruz, Francisco-Javier Gonzalez-Barcala, Jose Maria Olaguibel, Vicente Plaza, Santiago Quirce, Glorisa Canino, Michelle Cloutier, Victoria Del Pozo, Jose R. Rodriguez-Santana, Javier Korta-Murua, Jesus Villar, Uros Potocnik, Camila Figueiredo, Michael Kabesch, Somnath Mukhopadhyay, Munir Pirmohamed, Daniel B. Hawcutt, Erik Melen, Colin N. Palmer, Steve Turner, Anke H. Maitland-van der Zee, Erika von Mutius, Juan C. Celedon, Guy Brusselle, Fook Tim Chew, Eugene Bleecker, Deborah Meyers, Esteban G. Burchard, Maria Pino-Yanes
Summary: This multi-ancestry study identified novel suggestive regulatory loci for asthma exacerbations, located in genomic regions participating in inflammation and host defense, revealing the genetic basis of asthma exacerbations.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Editorial Material
Critical Care Medicine
Erick Forno, Paul D. Robinson
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Franziska J. Rosser, Scott D. Rothenberger, Yueh-Ying Han, Erick Forno, Juan C. Celedon
Summary: This study examined the effects of adding the Air Quality Index and recommendations to asthma action plans for children with asthma. The results showed that adding the Air Quality Index led to improved asthma control, but may decrease outdoor activity.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Critical Care Medicine
Nirav R. Bhakta, Christian Bime, David A. Kaminsky, Meredith C. McCormack, Neeta Thakur, Sanja Stanojevic, Aaron D. Baugh, Lundy Braun, Stephanie Lovinsky-Desir, Rosemary Adamson, Jonathan Witonsky, Robert A. Wise, Sean D. Levy, Robert Brown, Erick Forno, Robyn T. Cohen, Meshell Johnson, John Balmes, Yolanda Mageto, Cathryn T. Lee, Refiloe Masekela, Daniel J. Weiner, Charlie G. Irvin, Erik R. Swenson, Margaret Rosenfeld, Richard M. Schwartzstein, Anurag Agrawal, Enid Neptune, Juan P. Wisnivesky, Victor E. Ortega, Peter Burney
Summary: The use of race and ethnicity in pulmonary function test (PFT) interpretation is being questioned due to concerns of perpetuating false fixed differences between races and masking the effects of differential exposures. The American Thoracic Society (ATS) recommended replacing race and ethnicity-specific reference equations with race-neutral average equations, accompanied by a broader re-evaluation of how PFTs are used in clinical, employment, and insurance decisions. Further research and education are also recommended to better understand the impact of this change and improve the evidence for PFT use.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Allergy
Amanda Gutwein, Yueh-Ying Han, Angel Colon-Semidey, Maria Alvarez, Edna Acosta-Perez, Erick Forno, Glorisa Canino, Andrea Apter, Juan C. Celedon
Summary: This study investigates the association between low parental numeracy and childhood asthma exacerbations. The results show that persistently low parental numeracy is associated with asthma exacerbations in Puerto Rican youth. However, there is no significant correlation between low numeracy and changes in lung function.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Pediatrics
Kristina Gaietto, Yueh-Ying Han, Erick Forno, Edna Acosta-Perez, Anna Marsland, Gregory E. Miller, Franziska J. Rosser, Wei Chen, Glorisa Canino, Juan C. Celedon
Summary: Exposure to violence (ETV) and violence-related distress are associated with an increased risk of asthma in children and adolescents with high Th2 immunity. These findings suggest that ETV and violence-related distress may be important determinants of asthma in youth with high Th2 immunity.
PEDIATRIC PULMONOLOGY
(2023)
Article
Multidisciplinary Sciences
Raimon Rios, Thiago Magalhaes da Silva, Agostino Strina, Erick Forno, Ryan Costa, Juan C. Celedon, Mauricio L. Barreto, Camila Alexandrina Figueiredo
Summary: Genetic variants in filaggrin (FLG) are associated with eczema, and the association is modified by African ancestry. The T allele of SNP rs6587666 in FLG is negatively associated with eczema, and this association is influenced by the degree of African ancestry.
Review
Pediatrics
Carlos E. E. Rodriguez-Martinez, Monica P. P. Sossa-Briceno, Erick Forno
Summary: The objective of this review was to systematically identify and evaluate the composite predictive models developed for predicting which children are at high risk for future asthma exacerbations or asthma deterioration. A total of 17 composite predictive models were identified, of which 41.2% fulfilled all the quality criteria. These models can help clinicians identify high-risk children and target specific interventions to prevent exacerbations or deterioration of asthma.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Kristina Gaietto, Nicholas Bergum, Franziska Rosser, Oliver Snyder, Natalia Acevedo-Torres, Leigh Anne DiCicco, Gabriella Butler, Sherry Rauenswinter, Jennifer Iagnemma, David Wolfson, Yueh-Ying Han, Traci M. Kazmerski, Erick Forno
Summary: This study aimed to determine the association of COVID-19 variant waves with asthma exacerbations in children. The proportion of children with asthma experiencing an asthma exacerbation was higher during the Omicron wave compared to prior waves. These findings provide additional support for vaccination and prevention efforts.
PEDIATRIC PULMONOLOGY
(2023)
Meeting Abstract
Critical Care Medicine
M. Yue, Z. Xu, F. J. Rosser, Y. Han, W. Chen, E. Forno, J. C. Celedon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Respiratory System
Erick Forno, Diego D. Brandenburg, Jose A. Castro-Rodriguez, Carlos A. Celis-Preciado, Fernando Holguin, Christopher Licskai, Stephanie Lovinsky-Desir, Marcia Pizzichini, Alejandro Teper, Connie Yang, Juan C. Celedon
Summary: Asthma in the Americas has different prevalence, morbidity, and mortality rates across the region. There is a need for research and health policies to improve the prevention, diagnosis, and management of pediatric and adult asthma. Attention should be given to regional differences in resources and risk factors, including indoor pollutants, tobacco use, and psychosocial stress.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
