Article
Acoustics
Paul Christopher Lyon, Christophoros Mannaris, Michael Gray, Robert Carlisle, Fergus Gleeson, David Cranston, Feng Wu, Constantin C. Coussios
Summary: LTSLs are designed to release chemotherapy agents under mild hyperthermia conditions. By utilizing ultrasound-guided FUS systems, it is possible to rapidly induce and sustain mild hyperthermia in large tissue volumes, showing promise for successful application in drug delivery and cancer treatment.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Martina Capozza, Rachele Stefania, Valentina Dinatale, Valeria Bitonto, Laura Conti, Cristina Grange, Renata Skovronova, Enzo Terreno
Summary: A PSMA-targeted NIRF dye was developed as an intraoperative tool for improving tumour margin delineation and cancer therapy. The dye exhibited high affinity and specificity towards PCa cells and accurately highlighted tumour margins. In addition, the dye had the capability of PDT to kill residual cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yoon-Seok Kim, Min Jung Ko, Hyungwon Moon, Wonchul Sim, Ae Shin Cho, Gio Gil, Hyun Ryoung Kim
Summary: Ultrasound-responsive liposomes were fabricated for the delivery of anticancer drugs, and the study demonstrated that this system can release drugs and suppress tumor growth.
Article
Chemistry, Multidisciplinary
Natasha D. Sheybani, Victoria R. Breza, Soumen Paul, Katelyenn S. McCauley, Stuart S. Berr, G. Wilson Miller, Kiel D. Neumann, Richard J. Price
Summary: Phagocytic immunotherapies, such as CD47 blockade, have shown promise in treating glioblastoma (GB). Overcoming the challenges posed by the blood brain/tumor barriers (BBB/BTB) for mCD47 delivery through focused ultrasound (FUS) is crucial. Timing of antibody injection relative to FUS BBB/BTB disruption is essential for optimal mCD47 access to gliomas. Repeat sessions of FUS can significantly constrain tumor outgrowth and extend survival in glioma-bearing mice, making mCD47 delivery with FUS a promising therapeutic strategy for GB therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biotechnology & Applied Microbiology
Yaotai Wang, Zhong Zhang, Li Ren, Yong Luo, Qi Wang, Jianzhong Zou
Summary: This study aims to construct bio-targeted oxygen production probes consisting of Bifidobacterium that naturally target the hypoxia region of the tumor and multi-functional oxygen-producing nanoparticles equipped with IR780, perfluorohexane (PFH), CBP (carboplatin), and oxygen. The probes are expected to achieve targeted and synergistic focused ultrasound ablation surgery (FUAS) therapy and dual-mode imaging to mediate tumor diagnosis and treatment. The strategy can potentially alleviate tumor hypoxia, avoid tumor drug resistance, improve the effect of chemotherapy, and provide the foundation for future tumor therapy progress.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ko-Ting Chen, Wen-Yen Chai, Ya-Jui Lin, Chia-Jung Lin, Pin-Yuan Chen, Hong-Chieh Tsai, Chiung-Yin Huang, John S. Kuo, Hao-Li Liu, Kuo-Chen Wei
Summary: Focused ultrasound (FUS) with microbubbles can transiently open the blood-brain barrier (BBB) to increase therapeutic agent penetration, benefiting recurrent glioblastoma (rGBM) treatment. A pilot trial using a neuronavigation combined with a manually operated frameless FUS system for rGBM patients established safety and feasibility, with dose-dependent BBB-opening effect observed. Additionally, FUS-induced immune modulation was demonstrated to convert the immunosuppressive tumor microenvironment into an immunostimulatory one at a higher but safe dosage.
Article
Chemistry, Analytical
Dimitrios A. Diamantis, Adamantia Agalou, Maria Chatziathanasiadou, Georgios S. Markopoulos, Sofia Bellou, Zoi Kanaki, Timothy Crook, Nelofer Syed, Theodoros Rampias, Apostolos Klinakis, Evangelos Kolettas, Dimitris Beis, Andreas G. Tzakos
Summary: Biotin-Yellow, a tumor-targeting fluorescent and colorimetric probe, shows unprecedented turn-on near-infrared fluorescence properties and can effectively recognize and discriminate cancer cells. It is also capable of real-time bioimaging tracking of upregulated biothiol activity in cancer cells, as validated in zebrafish and mice xenografts.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Clinical Neurology
Raul Martinez-Fernandez, Sujitha Mahendran, Jose Angel Pineda-Pardo, Lukas L. Imbach, Jorge U. Manez-Miro, Fabian Buechele, Marta del Alamo, Rafael Rodriguez-Rojas, Frida Hernandez-Fernandez, Beat Werner, Michele Matarazzo, Ignacio Obeso, Lain H. Gonzalez-Quarante, Gunther Deuschl, Lennart Stieglitz, Christian R. Baumann, Jose A. Obeso
Summary: Unilateral magnetic resonance-guided focused ultrasound (FUS) thalamotomy is effective for treating medically refractory essential tremor (ET). The feasibility, safety, and efficacy of bilateral staged FUS thalamotomy for ET were explored in this study, showing promising results in improving voice and head tremor.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anastasia Antoniou, Nikolas Evripidou, Leonidas Georgiou, Antreas Chrysanthou, Cleanthis Ioannides, Christakis Damianou
Summary: This study presents the development and evaluation of a tumor-bearing tissue phantom model for testing MRgFUS ablation protocols and equipment. The results suggest that the proposed tumor phantom model is a simple and inexpensive tool for preclinical MRgFUS ablation studies.
Article
Materials Science, Multidisciplinary
Amirhossein Omidvar, Edmond Cretu, Robert Rohling, Mark Cresswell, Antony J. Hodgson
Summary: Conventional ultrasound transducers are limited in their applications due to their short and rigid nature, especially in musculoskeletal imaging. This paper introduces a process for fabricating flexible polymer-based CMUTs, which show promising results in terms of functionality and performance. The findings demonstrate the potential of these flexible CMUT arrays in diagnosing musculoskeletal conditions and justify further development in this area.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Acoustics
Yun Zhou, Xiang Ji, Jianmei Niu, Taotao Sun, Zhaoxia Qian, Yuhong Li, Jiangjing Yuan, Qiong Fan, Qianwen Huang, Jingfeng Bai, Yudong Wang
Summary: This study demonstrates the feasibility of ultrasound-guided high-intensity focused ultrasound for devascularization of uterine fibroids, with significant reduction in fibroid volume and improvement in symptoms and quality of life. No serious adverse events were observed, suggesting the need for further studies on safety and efficacy.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yuanli Luo, Bin Qiao, Chao Yang, Ping Zhang, Zhuoyan Xie, Jin Cao, Anyu Yang, Qinyanqiu Xiang, Haitao Ran, Zhigang Wang, Lan Hao, Yang Cao, Zhiyi Zhou, Jianli Ren
Summary: This study introduces a novel therapeutic modality based on ultrasonic cavitation effect to facilitate hypoxia-tolerant sonodynamic therapy (SDT) for inducing hypoxic tumor death. The tLyP-1 functionalized liposomes can achieve active tumor homing and effective deep-penetrating into hypoxic tumors.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Multidisciplinary Sciences
Bar Glickstein, Ramona Aronovich, Yi Feng, Tali Ilovitsh
Summary: Low pressure histotripsy has been developed to achieve precise and large-volume mechanical lesions in tissues with reduced pressure threshold. By integrating a rotating imaging transducer and a low frequency therapeutic transducer, the vaporization and detonation of nanodroplets are achieved, resulting in circular lesions.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Dezhuang Ye, Jinyun Yuan, Yaoheng Yang, Yimei Yue, Zhongtao Hu, Siaka Fadera, Hong Chen
Summary: This study investigates the potential of focused ultrasound-mediated intranasal delivery (FUSIN) in delivering adeno-associated viral (AAV) vectors to the brain. The results show that FUSIN achieves safe and efficient delivery to spatially targeted brain locations and is comparable to established delivery methods.
Article
Oncology
Lapo Bonosi, Silvia Marino, Umberto Emanuele Benigno, Sofia Musso, Felice Buscemi, Kevin Giardina, Rosamaria Gerardi, Lara Brunasso, Roberta Costanzo, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Glioblastoma (GB) is a highly aggressive and difficult-to-treat brain tumor. Sonodynamic therapy (SDT) and magnetic resonance focused ultrasound (MRgFUS) have shown promise in treating GB. SDT uses ultrasound waves and a sonosensitizer to selectively damage cancer cells, while MRgFUS delivers high-intensity ultrasound waves to target tumors and enhance drug delivery. This review explores the potential of SDT as a novel therapeutic strategy for GB, discussing its principles, mechanisms, and preclinical and clinical studies. SDT and MRgFUS have the potential to be complementary treatment modalities for GB, but further research is needed to optimize their parameters and determine their safety and efficacy in humans.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Neuroimaging
Ana Paula Narata, Fernando Moura, Ignacio Larrabide, Rene Chapot, Christophe Cognard, Anne-Christine Januel, Stephane Velasco, Ayache Bouakaz, Frederic Patat, Alberto Marzo
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2020)
Editorial Material
Acoustics
Weibao Qiu, Ayache Bouakaz, Elisa E. Konofagou, Hairong Zheng
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Review
Acoustics
Weibao Qiu, Ayache Bouakaz, Elisa E. Konofagou, Hairong Zheng
Summary: The emergence of new ultrasound technologies has improved our understanding of brain functions and provided new opportunities for the treatment of brain diseases. With novel ultrasound imaging techniques, high-resolution cerebral flow images with high sensitivity can be acquired, bringing new hope for the diagnosis and therapy of brain diseases.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Nanoscience & Nanotechnology
Dui Qin, Lei Zhang, Hongrui Zhu, Junjie Chen, Daocheng Wu, Ayache Bouakaz, Mingxi Wan, Yi Feng
Summary: A highly efficient nanodroplet with multiple capabilities was developed for cancer therapy, showing advantages in high photothermal conversion efficiency, enhanced US imaging, and acoustic cavitation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Acoustics
Tarik Iazourene, Hanaa Malloul, Rasha M. Noureddine, Edward Oujagir, Jean-Michel Escoffre, Ayache Bouakaz
Summary: Ultrasound neurostimulation (USNS) is an emerging treatment approach for neuropsychiatric and neurodegenerative disorders, offering noninvasive modulation of brain activity with good spatial specificity. This preclinical study aimed to elucidate the effects of various ultrasound parameters on USNS efficiency, particularly in targeting the motor cortex. The results showed that peak negative pressure and focal spot diameter were closely linked to USNS efficacy, and the study confirmed these findings using immunohistochemistry.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Oncology
Suzanne Dufresne, Cindy Richard, Arthur Dieumegard, Luz Orfila, Gregory Delpon, Sophie Chiavassa, Brice Martin, Laurent Rouviere, Jean-Michel Escoffre, Edward Oujagir, Baudouin Denis de Senneville, Ayache Bouakaz, Nathalie Rioux-Leclercq, Vincent Potiron, Amelie Rebillard
Summary: Physical activity is being increasingly integrated into cancer patient care to improve survival outcomes, but its specific impact on radiotherapy efficiency remains unclear. Different modalities of physical activity have varying effects on tumor growth, suggesting that the anti-cancer benefits may depend on the type of exercise.
Article
Pharmacology & Pharmacy
Laurent Auboire, Damien Fouan, Jean-Marc Gregoire, Frederic Ossant, Camille Plag, Jean-Michel Escoffre, Ayache Bouakaz
Summary: The study aimed to evaluate the impact of STL on the acoustic and elastic properties of blood clots. Results showed that STL alone or in combination with rtPA can lead to clot hardening and an increase in sound speed.
Review
Pharmacology & Pharmacy
Jean-Michel Escoffre, Najib Sekkat, Edward Oujagir, Sylvie Bodard, Coralie Mousset, Antoine Presset, Romain Chautard, Jean Ayoub, Thierry Lecomte, Ayache Bouakaz
Summary: The combination of microbubbles and ultrasound is a promising method for enhancing intratumor chemotherapeutic uptake while reducing systemic adverse effects. Current studies have mainly focused on subcutaneous models of digestive cancers, but further evaluation is needed in relevant preclinical animal models and clinical trials to provide solid evidence.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Acoustics
Xiaoyang Qiao, Yu Wen, Jianjun Yu, Ayache Bouakaz, Yujin Zong, Mingxi Wan
Summary: Intracranial blood pressure is an important indicator reflecting the status of blood vessels, but current estimation methods are invasive. Subharmonic-aided pressure estimation is a promising technique for estimating cardiac pressures. This study aims to optimize transcranial subharmonic-aided pressure estimation technique by investigating the relationship between subharmonic signals and middle cerebral artery pressure. The experiment results show that using freshly prepared SonoVue and appropriate acoustic output levels can achieve better subharmonic sensitivity.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Neurosciences
Antoine Presset, Sylvie Bodard, Antoine Lefevre, Anais Millet, Edward Oujagir, Camille Dupuy, Tarik Iazourene, Ayache Bouakaz, Patrick Emond, Jean-Michel Escoffre, Lydie Nadal-Desbarats
Summary: Microbubble-assisted ultrasound is a promising method to increase the permeability of the blood-brain barrier. This study used multimodal metabolomics approaches to investigate the metabolic processes following acoustically-mediated BBB opening in vivo. The findings revealed specific and sequential metabolic kinetics in the surrounding area of the target region.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Acoustics
Francois Avry, Coralie Mousset, Edward Oujagir, Ayache Bouakaz, Valerie Gouilleux-gruart, Rose-anne Thepault, Sylvaine Renault, Sylviane Marouillat, Laurent Machet, Jean-michel Escoffrea
Summary: Technological developments in ultrasound imaging and ultrasound contrast agents have improved diagnostic confidence and led to the emergence of sonoporation as a non-invasive and targeted method for drug delivery in melanoma.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Naoual Atia, Amir Benzaoui, Sebastien Jacques, Madina Hamiane, Kaouther El Kourd, Ayache Bouakaz, Abdeldjalil Ouahabi
Summary: Segmentation of brain tumor images from MRI is a challenging task due to the varied shapes of tumors and the intensity variations in MRI images. This paper proposes a three-step approach to address this issue. Firstly, a pre-processing step is applied to remove the skull bone from the image. Secondly, a particle swarm optimization algorithm is used to find the optimal block containing the brain lesion. Finally, the K-means clustering algorithm is applied for tumor classification. The proposed methodology achieves impressive performance compared to competing approaches, as demonstrated through extensive experimental analysis. The segmentation of brain tumor images is an important research topic in medical imaging, and this paper presents a novel method to improve the detection and understanding of such abnormalities.
Article
Pharmacology & Pharmacy
Sandrine Kerneis, Jean-Michel Escoffre, John J. Galvin, Ayache Bouakaz, Antoine Presset, Corentin Alix, Edward Oujagir, Antoine Lefevre, Patrick Emond, Helene Blasco, David Bakhos
Summary: Sonoporation using microbubble-assisted ultrasound is a safe method to increase the permeability of the biological barrier. In this study, sonoporation of the round window membrane in a sheep model did not cause any damage to the inner ear. The results suggest that this method could improve the delivery of therapeutics to the inner ear.
Article
Engineering, Biomedical
Fangyuan Cao, Jingjing Zhang, Dapeng Li, Mengke Wang, Chunhao Lai, Tianqi Xu, Ayache Bouakaz, Pengyu Ren, Mingxi Wan, Jie Han, Siyuan Zhang
Summary: By applying noninvasive ultrasound (US) neuromodulation to stimulate the solitary tract nucleus (NTS) of spontaneously hypertensive rats (SHRs), blood pressure (BP) can be regulated effectively. After two months of US stimulation, systolic blood pressure decreased significantly. US stimulation inhibited the pathological process of target organs, enhanced neuronal activities in relevant brain regions, and did not cause brain tissue damage. This study demonstrates the potential of using US stimulation of NTS as a therapeutic intervention for lowering BP in SHRs.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Dapeng Li, Zhiwei Cui, Shanshan Xu, Tianqi Xu, Shan Wu, Ayache Bouakaz, Mingxi Wan, Siyuan Zhang
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2020)
