Article
Clinical Neurology
Takaki Inui, Shin-ichi Haginomori, Yoshinaga Kajimoto, Tatsuro Kuriyama, Takeo Shirai, Ichita Kinoshita, Michitoshi Araki, Ryo Kawata
Summary: This study investigated the effects of excessive cerebrospinal fluid retention on the peripheral vestibular function and inner ear fluid in patients with idiopathic normal pressure hydrocephalus (iNPH). The results showed that one-fourth of the patients had obvious saccular dysfunction, and excessive CSF accumulation could propagate to the endolymph and perilymph.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Kuei-You Lin, Fu-Shan Jaw, Yi-Ho Young
Summary: This study investigated the resonance effect of the frontal sinus on oVEMP recordings and found that frontal sinus volume and inflammation can affect oVEMP responses. When the frontal sinus volume is >1.91 mL, Fpz-oVEMP displays larger reflex amplitude than Fz-oVEMP. Frontal sinusitis may lower the response rate of Fpz-oVEMP compared to Fz-oVEMP.
Article
Endocrinology & Metabolism
Jinying Zhang, Lichao Ye, Xuefeng Bai, Yali Huang, Jiayu Lin, Huapin Huang
Summary: Diabetic peripheral neuropathy may lead to vestibular dysfunction, and VEMP can be a useful tool for assessing vestibular impairment in these patients.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Otorhinolaryngology
Canset Aydin, Ovsen Onay, Elif Ilkay Tezcan, Zuhal Askar, Ali Ozdek
Summary: The study found that chirp stimuli resulted in higher VEMP response rates for both cVEMP and oVEMP testing compared to tone burst stimuli. Chirp stimuli also led to higher p1n1 and rectified amplitudes, and shorter p1 and n1 latencies for cVEMP, as well as higher n1p1 amplitudes and shorter n1 and p1 latencies for oVEMP.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Medicine, General & Internal
Kuei-You Lin, Fu-Shan Jaw, Yi-Ho Young
Summary: This study investigated the effect of resonance on ocular vestibular-evoked myogenic potential (oVEMP) by altering the air-material ratios in a dummy model and measuring acceleration magnitude. The results suggest that both the percentage of air volume and the density of filling media contribute to the resonance effect, enhancing the elicitation of oVEMP through primary bone vibration and secondary resonance effect.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Clinical Neurology
Emma C. Argaet, Belinda Y. C. Kwok, Justine Bradley, Allison S. Young, Benjamin Nham, Zeljka Calic, Rachael L. Taylor, Jacob M. Pogson, Nicole Reid, Jonathan H. K. Kong, Sean Flanagan, Gabor M. Halmagyi, Sally M. Rosengren, Miriam S. Welgampola
Summary: This study aimed to investigate the relationship between two widely used otolith function tests, Subjective Visual Horizontal (SVH) and Vestibular Evoked Myogenic Potentials (VEMP). A retrospective analysis of 301 patients showed that SVH had a significant moderate correlation with bone-conducted oVEMP, and a weak correlation with air-conducted cVEMP. This finding supports the hypothesis of a common utricular origin for both SVH and oVEMPs.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura Froehlich, Maira Wilke, Stefan K. Plontke, Torsten Rahne
Summary: This study evaluated the effectiveness of different bone conduction transducers in eliciting cervical and ocular vestibular evoked myogenic potentials in healthy subjects. Results showed that the B81 transducer placed on the mastoid had the highest VEMP response rates, while the lowest response rates were found with the B81 on the forehead.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
M. Geraldine Zuniga, Angela Schell, Benjamin G. Engst, John P. Carey
Summary: The study aimed to develop an oVEMP protocol that reduces discomfort and increases safety without compromising reliability, comparing experimental protocols with only 40 or 20 stimuli to the standard protocol of 100 stimuli.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Clinical Neurology
Sarah Hosli, Dominik Straumann
Summary: The study indicates that the relationships among oVEMPs, SVV, and BCR in assessing utricular function are complex, with no correlation between oVEMP and SVV, and a high correlation between SVV and BCR.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Feray Gulec Uyaroglu, Roza Ucar, Ahmet Acarer, Nese Celebisoy
Summary: In this study, cervical vestibular-evoked myogenic potentials (cVEMPs) were studied in essential tremor (ET) patients to explore the interaction between the tremor network and the vestibular neural pathways. The results showed that cVEMP responses were affected in ET patients, which could be caused by dysfunctional structures or pathways responsible for ET, or an additional disorder of vestibular information processing in these patients.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Onur Akan, Guler Berkiten, Belgin Tutar, Semih Karaketir, Omur Biltekin Tuna
Summary: The study revealed impaired vestibular function in diabetic patients, characterized by prolonged latencies and decreased amplitudes in both cVEMP and oVEMP, as well as significantly higher asymmetry ratios in cVEMP. The nonresponse rate was significantly higher in the DPN group compared to controls, with the sensory-motor PNP subgroup showing the highest nonresponse rate in oVEMP. These findings suggest that vestibular testing may be a valuable diagnostic tool for early detection of neurovascular degeneration in diabetes mellitus patients with polyneuropathy.
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Zhuo Xu, Zhilin Wang, Bo Zhong, Minjiao Wang, Xiaoqin Fan, Cuncun Ren, Meihao Qi, Ying Lin, Dingjun Zha
Summary: This study aimed to investigate the influence of aging on ocular vestibular-evoked myogenic potential (oVEMP) response rates and recording parameters. The study found that response rates and amplitudes declined with aging, while thresholds increased and N1 latencies were prolonged. Bone-conducted vibration (BCV) showed fewer risks of absent oVEMP response and acquired higher amplitudes, lower thresholds, and shorter N1 and P1 latencies compared to air conduction stimuli (ACS). B81-BCV stimulation is more effective and safer to elicit oVEMPs, and it should be recommended when ACS fails in the clinic, particularly in the elderly population.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Lilian Felipe, Jeremy A. Shelton
Summary: The study evaluated subclinical cervical abnormalities in the vestibulospinal pathway in subjects with history of concussion, finding higher latency scores in groups with history and symptoms of concussion. Abnormal cVEMP patterns were found in groups with history or symptoms of concussion, supporting the positive impact of cVEMP in evaluating athletes for concussion processes.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Shuo-Yen Hsu, Yi-Ho Young
Summary: This study devised a novel test for assessing the cervico-ocular reflex (COR) system using head vibration (h-COR) or neck vibration (n-COR) methods. The results showed that the head vibration method (h-COR test) is superior for assessing the COR system.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Audiology & Speech-Language Pathology
Tarryn Marisca Reddy, Barbara Heinze, Leigh Biagio-de Jager, Leen Maes
Summary: The narrowband CE-Chirp stimulation at 500 Hz shows the highest response rate, shortest latencies, and largest amplitudes for c&oVEMPs, indicating its potential as a reliable stimulus for clinical measurement.
INTERNATIONAL JOURNAL OF AUDIOLOGY
(2023)
Article
Engineering, Biomedical
Bozica Kovacevic, Melissa Jones, Corina Ionescu, Daniel Walker, Susbin Wagle, Jacqueline Chester, Thomas Foster, Daniel Brown, Momir Mikov, Armin Mooranian, Hani Al-Salami
Summary: Endogenous bile acids serve as lipid stabilizers, aiding the uptake of lipophilic nutrients through micelle formation and saponification effects, with various applications in pharmaceutical sciences. Their unique physico-chemical profile allows them to modulate immune cell signaling pathways and provide potential clinical therapies for cardio-metabolic disorders. In addition, their antioxidant, anti-inflammatory, and immunosuppressant properties make them effective in reducing blood pressure and alleviating hypertension, while also enhancing the immunogenicity of encapsulated cells for bioartificial organ transplantations.
Article
Biophysics
Sajad Abolpour Moshizi, Christopher John Pastras, Rajni Sharma, M. A. Parvez Mahmud, Rachel Ryan, Amir Razmjou, Mohsen Asadnia
Summary: Balance disorders are a common problem that affects approximately 30% of the population. Various treatment methods, including the vestibular prosthesis, stem cell regeneration, and gene therapies, are being explored. Artificial hair cell sensors show great promise as a new technology.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Nanoscience & Nanotechnology
Afsaneh Kashizadeh, Christopher Pastras, Navid Rabiee, Masoud Mohseni-Dargah, Payal Mukherjee, Mohsen Asadnia
Summary: Meniere's disease is a progressive inner ear disorder that can affect both ears, with unknown etiology posing challenges to effective treatments. Nanomaterials show promise in novel diagnostic and therapeutic applications for MD, but there are crucial challenges that need to be addressed for their use in middle ear disorders. Recommendations for improving the performance of nanomaterials in MD theragnostic applications are provided for future directions.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Otorhinolaryngology
Young Joon Seo, Dae Bo Shim, Arazu Sharif, Zeke Samson, Ryu Takechi, Daniel Brown
Summary: This study identified significant differences in cochlea microvessel size between a diabetic mouse model and normal mice. The diabetic mice had thicker and larger proximal-SMA vessel walls and diameters compared to control mice, potentially leading to increased blood viscosity or vascular insufficiency, exacerbating hearing loss in type 2 diabetes mellitus.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ahmed Gedawy, Giuseppe Luna, Jorge Martinez, Daniel Brown, Hani Al-Salami, Crispin R. Dass
Summary: A novel gliclazide-loaded elastomeric carbohydrate pharmaceutical vehicle was developed using a siliconized alginate platform. The microcapsules loaded with gliclazide showed excellent encapsulation efficiency (>92.13% +/- 0.76) and sustained drug release. The use of tetraethyl orthosilicate (TEOS) crosslinking improved the mechanical durability of the microcapsules.
Article
Multidisciplinary Sciences
Christopher J. Pastras, Ian S. Curthoys, Richard D. Rabbitt, Daniel J. Brown
Summary: To understand the mechanisms responsible for vestibular afferent sensitivity to transient bone conducted vibration, simultaneous measurements of stimulus-evoked vestibular compound action potentials (vCAPs), utricular macula velocity, and vestibular microphonics (VMs) were performed in anesthetized guinea pigs. The findings indicate that synchronized vestibular afferent responses are not universally sensitive to linear jerk, but rather to other kinematic elements. The results provide insights into the mechanical and neural mechanisms underlying synchronized action potentials in these sensitive afferents, with clinical relevance for understanding rapid compensatory reflex responses.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Christopher J. Pastras, Nastaran Gholami, Skyler Jennings, Hong Zhu, Wu Zhou, Daniel J. Brown, Ian S. Curthoys, Richard D. Rabbitt
Summary: This study presents a mathematical model of utricular mechanics and vestibular compound action potential generation (vCAP) in response to clinically relevant levels of auditory-frequency air conducted sound and bone conducted vibration. The model was validated and applied to predict blast-induced hair bundle shear, with results predicting acute mechanical damage to bundles immediately upon exposure.
FRONTIERS IN NEUROLOGY
(2023)
Article
Education, Scientific Disciplines
Daniel Brown, Tanya Uebergang, Nicole Masters, Michelle Towstoless, Alan Hayes, Deanne H. Hryciw, Louise Lexis, Kathy Tangalakis
Summary: This article aims to unpack the core concept of substance movement within the human body, providing guidance for physiology teaching in tertiary education institutes in Australia. The concept introduces fundamental knowledge of the driving factors and applies them in physiological contexts. The importance of understanding this concept is widely acknowledged, but its difficulty varies among educators. The complexity of this concept is due to the underlying physical forces, and organizing it into subthemes can help prioritize learning activities.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Education, Scientific Disciplines
Kathy Tangalakis, Louise Lexis, Deanne H. Hryciw, Michelle Towstoless, Anthony J. Bakker, Elizabeth Beckett, Daniel Brown, Melissa Cameron, Julia Choate, Lisa Chopin, Matthew B. Cooke, Tracy Douglas, Suzanne Estaphan, Sarah Etherington, Voula Gaganis, Andrew Moorhouse, Christian Moro, Tamara Paravicini, Ben Perry, Ruben Phillips, Christopher Scott, Gabrielle Todd, Tanya Uebergang, Glenn Wadley, Matthew Watt, Alan Hayes
Summary: Consensus has been reached on the core concepts of physiology in Australia through the Delphi method, and these concepts will be integrated into the curricula of Australian universities. The core concepts include Cell Membrane, Cell-Cell Communication, Movement of Substances, Structure and Function, Homeostasis, Integration, and Physiological Adaptation.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Multidisciplinary Sciences
Kady J. Braack, Tylah Miles, Farah Amat, Daniel J. Brown, Marcus D. Atlas, Jafri Kuthubutheen, Wilhelmina H. A. M. Mulders, Cecilia M. Prele
Summary: Cochlear implants help people with profound hearing loss understand speech and perceive sounds. Fibrotic scar tissue around the implanted electrode may limit the benefits of cochlear implants. This study used x-ray micro computed tomography (μCT) to measure and visualize the extent of fibrosis in a guinea pig model of cochlear implantation.
Review
Environmental Sciences
Masoud Mohseni-Dargah, Zahra Falahati, Christopher Pastras, Khosro Khajeh, Payal Mukherjee, Amir Razmjou, Sebastian Stefani, Mohsen Asadnia
Summary: Meniere's disease is a severe inner ear condition characterized by debilitating symptoms such as vertigo, hearing loss, tinnitus, and aural fullness. The underlying mechanisms, including the excessive buildup of endolymph fluid in the inner ear, are not fully understood. Current treatment strategies focus on symptom management, as there are no definitive cures.
ENVIRONMENTAL RESEARCH
(2023)
Article
Audiology & Speech-Language Pathology
Ian S. Curthoys, Ann M. Burgess, Leonardo Manzari, Christopher J. Pastras
Summary: A study found that a single test measuring oVEMP n10 to 4000 Hz stimuli can provide a definitive diagnosis of semicircular canal dehiscence (SCD) with high sensitivity and specificity. However, some studies have reported slightly lower sensitivity and specificity values for the 4000 Hz test. The study suggests that the rise time of the stimulus is important for detecting oVEMP n10 at 4000 Hz, and shorter rise times are preferred for clinical VEMP testing.
AUDIOLOGY RESEARCH
(2022)
Review
Health Care Sciences & Services
Leonardo Manzari, Sara De Angelis, Alessandro Antonio Princi, Giovanni Galeoto, Marco Tramontano
Summary: This review explores the potential clinical application of the suppression head impulse paradigm (SHIMP) in patients with unilateral and bilateral vestibulopathy. The results suggest that SHIMP could be a useful tool for diagnosing VOR alteration in patients with acute and chronic vestibulopathy.