A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

(2017) Monika Raab et al.   Nature Communications

Non-T cell activation linker (NTAL) proteolytic cleavage as a terminator of activatory intracellular signals

(2016) Mikel M. Arbulo-Echevarria et al.   JOURNAL OF LEUKOCYTE BIOLOGY

What Scales the T Cell Response?

(2016) Viveka Mayya et al.   TRENDS IN IMMUNOLOGY

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

(2016) Neel H Shah et al.   eLife

Early T Cell Activation: Integrating Biochemical, Structural, and Biophysical Cues

(2015) Bernard Malissen et al.   Annual Review of Immunology

GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production

(2015) Mahmood Yousif Bilal et al.   Frontiers in Immunology

Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes

(2014) Noemi Cruz-Orcutt et al.   CELLULAR SIGNALLING

Identification of functional, short-lived isoform of linker for activation of T cells (LAT)

(2014) M Kłossowicz et al.   GENES AND IMMUNITY

Th2 Lymphoproliferative Disorder of LatY136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3+ Regulatory T Cells

(2014) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor–independent TCR signaling hub

(2014) Romain Roncagalli et al.   NATURE IMMUNOLOGY

T Cell Activation Results in Conformational Changes in the Src Family Kinase Lck to Induce Its Activation

(2013) A. Stirnweiss et al.   Science Signaling

The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion

(2012) Antonio García-Blesa et al.   BIOCHEMICAL JOURNAL

Assessment of caspase mediated degradation of linker for activation of T cells (LAT) at a single cell level

(2012) Mikołaj Kłossowicz et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A negatively charged domain of LAT mediates its interaction with the active form of Lck

(2011) Panagiotis S. Kabouridis et al.   MOLECULAR MEMBRANE BIOLOGY

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

T Cell Receptor Signal Initiation Induced by Low-Grade Stimulation Requires the Cooperation of LAT in Human T Cells

(2010) Shen Dong et al.   PLoS One

T Cell Receptor Signaling Kinetics Takes the Stage

(2010) Y. Sykulev   Science Signaling

Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell Receptor

(2009) Michael Mingueneau et al.   IMMUNITY

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling

(2009) Gudrun Strauss et al.   JOURNAL OF EXPERIMENTAL MEDICINE