Review
Immunology
John T. Anderson, Juthaporn Cowan, Antonio Condino-Neto, Donald Levy, Subhransu Prusty
Summary: Accurate and timely diagnosis of PID is crucial for patient QoL and outcomes, with adults generally experiencing longer diagnostic delays. Treatment burden is not the biggest impact on QoL, and the cost of PID is high, with support for national registries playing a major role in delayed diagnosis.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Klaus Warnatz, Stephen Jolles, Carlo Agostini, Fabrizio Vianello, Michael Borte, Claire Bethune, Sofia Grigoriadou, Alex Richter, Rashmi Jain, David M. Lowe, Constance Katelaris, Cinzia Milito, Matthew C. Cook
Summary: The study compared the impact of immunoglobulin treatment administered via pump or rapid push injection, with findings showing that rapid push had more frequent administrations but lower total time expenditure and some costs, and performed better in some aspects of quality of life and treatment interference.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Elissaveta Naumova, Spaska Lesichkova, Veneta Milenova, Petya Yankova, Marianna Murdjeva, Snezhina Mihailova
Summary: Significant progress has been made in the recognition of primary immune deficiencies (PIDs) in Bulgaria since joining the collaborative program. The establishment of an Expert Centre and a national register has greatly intensified the diagnosis and registration of PID patients. The epidemiological report based on the register provides important information about the nature of primary immunodeficiency diseases in the country.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lucia Pacillo, Giuliana Giardino, Donato Amodio, Carmela Giancotta, Beatrice Rivalta, Gioacchino Andrea Rotulo, Emma Concetta Manno, Cristina Cifaldi, Giuseppe Palumbo, Claudio Pignata, Paolo Palma, Paolo Rossi, Andrea Finocchi, Caterina Cancrini
Summary: Primary Immunodeficiencies (PID) are rare congenital disorders of the immune system, with Autoimmune cytopenia (AIC) being the most common autoimmune manifestation. Treatment of AIC in PID patients is challenging due to its chronic and relapsing nature, as well as resistance to first line therapies. Targeted therapies based on pathogenic mechanisms and immunological phenotypes show promise, but further research is needed. Prospective studies are necessary to define treatment response and predicting/stratifying biomarkers for patients with AIC and PID.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Martine Pergent, Filomeen Haerynck, Levi Hoste, Ann Gardulf
Summary: During the Sars-CoV-2 pandemic, patients with primary immunodeficiency or inborn errors of immunity and their families expressed great concern about this novel virus. This study investigated reasons for COVID-19 vaccination hesitancy and the occurrence and management of adverse events (AEs) in this patient population. The results showed that almost half of the patients had hesitancy towards COVID-19 vaccination, highlighting the need for international guidelines and education programs. The types of AEs were similar to healthy individuals, but more frequent AEs were reported, emphasizing the importance of clinical studies and registration of AEs related to COVID-19 vaccines in this population. It was concluded that patients with PID can be advised to be vaccinated against COVID-19 according to national guidelines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Elena E. Perez, Jacques Hebert, Anne K. Ellis, Oral Alpan, William R. Lumry, Ralph Shapiro, Daniel Suez, J. Fernando Mandujano, Richard L. Wasserman
Summary: The study demonstrated that GC5107 is an effective, safe, and well-tolerated treatment for patients with primary immunodeficiency in preventing serious bacterial infections. One acute serious bacterial infection occurred during the 12-month study period, with low incidence rates of other infections and hospitalizations. The medication was well-tolerated with few adverse events reported.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Niraj C. Patel, Troy Torgerson, Monica S. Thakar, M. Elizabeth M. Younger, Panida Sriaroon, Tamara C. Pozos, Rebecca H. Buckley, David Morris, Diana Vilkama, Jennifer Heimall
Summary: A retrospective study on 37 infants and children with primary immunodeficiency diseases who received hematopoietic cell transplant found that Hizentra (R) is a safe and effective treatment option post-transplant.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Zhaoyang Li, Kristin Follman, Ed Freshwater, Frank Engler, Leman Yel
Summary: This study developed an integrated population PK model to analyze the pharmacokinetics of immunoglobulin G (IgG) in different treatment methods. The model adequately described IgG PK profiles and identified covariate effects. This model provides a framework for future investigations in different dosing regimens and patient populations.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Paulina Mertowska, Konrad Smolak, Sebastian Mertowski, Ewelina Grywalska
Summary: This study aims to understand the role of Toll-like receptors (TLRs) in common variable immunodeficiency (CVID) and chronic lymphocytic leukemia (CLL), and the results indicate that the expression of TLRs is significantly increased in patients with immunodeficiency compared to healthy individuals, highlighting the importance of TLRs in the development of immunodeficiencies.
Article
Immunology
Michael Borte, Leif G. G. Hanitsch, Nizar Mahlaoui, Maria Fasshauer, Dorte Huscher, Matthaios Speletas, Maria Dimou, Marta Kamieniak, Corinna Hermann, David Pittrow, Cinzia Milito
Summary: The FIGARO study aims to provide insights on the real-world utilization and tolerability of fSCIG for PID and SID patients. This prospective, multicenter study analyzed medical records, charts, and diaries of patients receiving fSCIG treatment for at least 1 year. The results showed that fSCIG is a feasible, well-tolerated treatment option with good infection control for both PID and SID patients.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Miroslav Mihajlovic, Jelena Simic, Milan Marinkovic, Vladan Kovacevic, Aleksandar Kocijancic, Nebojsa Mujovic, Tatjana S. Potpara
Summary: This study explored sex-specific determinants of treatment burden in AF patients. Females had significantly higher treatment burden compared to males. Approximately 2 in 5 females and 1 in 5 males reported a treatment burden of >= 59 points, which is considered unacceptable for patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Health Care Sciences & Services
Kerstin Wohlleber, Patrick Heger, Pascal Probst, Christoph Engel, Markus K. Diener, Andre L. Mihaljevic
Summary: Patient-reported outcomes, including health-related quality of life (HRQoL), play a crucial role in oncological research. However, the validation of HRQoL instruments for liver cancer patients is lacking, with sparse studies comparing treatment options. This systematic review aimed to identify and assess HRQoL tools for primary liver cancer, highlighting the need for further research to enable meaningful comparisons between treatment options.
QUALITY OF LIFE RESEARCH
(2021)
Article
Immunology
Hanna Haberstroh, Aleksandra Hirsch, Sigune Goldacker, Norbert Zessack, Klaus Warnatz, Bodo Grimbacher, Ulrich Salzer
Summary: The purpose of this study was to assess the suitability of measuring immunoglobulin G (IgG) from dried blood spots (DBSs) using nephelometry as a remote monitoring method for patients with primary immunodeficiencies (PID). The results showed that IgG levels measured from DBS samples were lower than those measured in serum, but there was a high degree of correlation between the two.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Hematology
Ursula Holzer, Michaela Doering, Thomas Eichholz, Martin Ebinger, Manon Queudeville, Dominik Turkiewicz, Klaus Schwarz, Rupert Handgretinger, Peter Lang, Jacek Toporski
Summary: The study compared the outcomes of HSCT from HLA-matched unrelated or related donors and mismatched related haploidentical donors in patients with PIDs, finding differences in transplant success rate and GVHD incidence. However, haploidentical HSCT remains a viable option for some patients with life-threatening conditions and urgent need for treatment.
TRANSPLANTATION AND CELLULAR THERAPY
(2021)
Article
Gastroenterology & Hepatology
Yansheng Liu, Siyuan Tian, Gui Jia, Zheyi Han, Changcun Guo, Yulong Shang, Ying Han
Summary: The HRQoL of Chinese patients with PBC was significantly impaired depending on sex, age, and body mass index. Age and albumin level were significantly associated with the improvement of itch and fatigue, respectively. Therefore, treatment and support aimed at these two factors can be provided to improve the HRQoL of patients.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Review
Psychology, Clinical
Katharina Sophie Vogt, Paul Norman
PSYCHOLOGY AND PSYCHOTHERAPY-THEORY RESEARCH AND PRACTICE
(2019)
Article
Health Care Sciences & Services
Susan Baxter, Maxine Johnson, Duncan Chambers, Anthea Sutton, Elizabeth Goyder, Andrew Booth
BMC MEDICAL RESEARCH METHODOLOGY
(2019)
Article
Obstetrics & Gynecology
Sophia McDougall, Katharina S. Vogt, Anna Wilkinson, Jonathan Skull, Georgina L. Jones
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2020)
Review
Medicine, General & Internal
Duncan Chambers, Anna Cantrell, Susan Baxter, Janette Turner, Andrew Booth
Review
Health Care Sciences & Services
Duncan Chambers, Anna Cantrell, Andrew Booth
Summary: This study aimed to identify service development interventions aimed at improving awareness of safeguarding in health and social care settings. Promising initiatives include liaison nurses and assessment clinics, but overall evidence quality was low.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Education & Educational Research
Katharina Sophie Vogt, John Stephenson, Paul Norman
Summary: This study compared two self-affirmation manipulations on the impact on university students and found that these interventions did not significantly reduce alcohol consumption in this population.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2023)
Article
Psychology, Clinical
Katharina Sophie Vogt, Michela Harper, Bethany Leigh Griffin
Summary: Research findings suggest that Drunkorexia is mainly driven by concerns about appearance, seeking value for money, and habitual factors. The study concludes that Drunkorexia is more like a Food and Alcohol Disturbance rather than an eating or substance disorder. 18-26-year-olds are identified as a high-risk group for Drunkorexia and its negative health-related consequences.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2022)
Review
Information Science & Library Science
Anna Cantrell, Andrew Booth, Duncan Chambers
Summary: This study investigated the utility of citation searching in a case study of urgent and emergency care reconfiguration. The results showed that citation searching was necessary to identify all included studies in this case. WOS was more efficient for citation searching, while GS required additional time to remove non-English studies and locate abstracts.
HEALTH INFORMATION AND LIBRARIES JOURNAL
(2022)
Article
Oncology
Georgina L. Jones, Rachael H. Moss, Frances Darby, Neda Mahmoodi, Bob Phillips, Jane Hughes, Katharina S. Vogt, Diana M. Greenfield, Grete Brauten-Smith, Jacqui Gath, Tonia Campbell, Daniel Stark, Galina Velikova, John A. Snowden, Ellissa Baskind, Mariano Mascerenhas, Daniel Yeomanson, Jonathan Skull, Sheila Lane, Hilary L. Bekker, Richard A. Anderson
Summary: This study developed and tested a novel patient decision aid to support women in making fertility preservation treatment decisions after a cancer diagnosis. The resource was found to be acceptable and useful by both cancer patients and healthcare professionals, leading to better informed care plans. However, practical difficulties emerged during its implementation in routine care.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nursing
Katharina Sophie Vogt, Ruth Simms-Ellis, Angela Grange, Megan Elizabeth Griffiths, Rebecca Coleman, Reema Harrison, Nathan Shearman, Claire Horsfield, Luke Budworth, Jayne Marran, Judith Johnson
Summary: This paper examines the problem of critical care nurses intending to leave their roles and the impact of poor wellbeing on healthcare systems. It suggests that evidence-based interventions focusing on resilience and organisational change can address the workforce crisis.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Psychology, Clinical
Katharina Sophie Vogt, Judith Johnson, Mark Conner, Christopher J. Armitage, Chris Keyworth
Summary: This study aimed to examine the impact of the COVID-19 pandemic on the delivery of opportunistic health behavior change interventions in the UK's National Health Service. The findings identified barriers such as staffing pressures and poor internet connectivity, but also enablers such as video consultations. The results suggest that remote consultations may facilitate the delivery of opportunistic behavior change interventions, but staffing levels need improvement.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Medicine, Research & Experimental
K. S. Vogt, A. Grange, J. Johnson, J. Marran, L. Budworth, R. Coleman, R. Simms-Ellis
Summary: This study aims to assess the feasibility of delivering a psychological coaching program remotely and to preliminarily evaluate whether it can increase critical care nurses' confidence and resilience in coping with adverse events. The results will help determine if a remote version of the coaching program can be provided and evaluated, and will indicate its association with increased confidence, resilience, and well-being.
PILOT AND FEASIBILITY STUDIES
(2022)
Article
Social Sciences, Interdisciplinary
Duncan Chambers, Andrew Booth, Mark Rodgers, Louise Preston, Jane Dalton, Elizabeth Goyder, Sian Thomas, Gillian Parker, Andrew Street, Alison Eastwood
Summary: The study aimed to describe and evaluate the interactions between review teams and evidence users in the UK. The findings highlighted the barriers and facilitators to the impact of such programs on the uptake and use of research evidence by decision makers.
Article
Psychiatry
Bethany Leigh Griffin, Katharina Sophie Vogt
Summary: The study found no significant differences in compensatory behaviors related to alcohol consumption among students, non-students, and previous students. Low body esteem and high sensation seeking tendencies were identified as significant predictors of Drunkorexia. This complex behavior cannot be solely classified as an eating disorder or substance abuse disorder, indicating the need for further research and interventions involving non-student populations.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2021)
Meeting Abstract
Oncology
Georgina Jones, Frances Darby, Rachael Moss, Kathy Vogt, Jonathan Skull, Galina Velikova, Diana Greenfield, Hilary Bekker, Neda Mahmoodi, John Snowden, Daniel Yeomanson, Jacqui Gath, Bob Phillips, Sheila Lane, Richard Anderson
BREAST CANCER RESEARCH AND TREATMENT
(2020)