Article
Plant Sciences
Xin Xiong, Chuanqi Huang, Fuqian Wang, Junli Dong, Dan Zhang, Jie Jiang, Yan Feng, Bin Wu, Tingting Xie, Lu Cheng
Summary: The Qingxue jiedu Formulation (QF) has been clinically used for over 5 centuries to treat various skin inflammation, and its anti-AD activity is attributed to inhibiting the STAT3, MAPK, and NF-kappa B signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Allergy
Inge Kortekaas Krohn, Fariza Mishaal Saiema Badloe, Nadine Herrmann, Laura Maintz, Shauni De Vriese, Johannes Ring, Jan CK-CARE Study Group, Thomas Bieber, Jan Gutermuth
Summary: Autoreactive IgE antibodies to self-peptides within the epidermis have been identified in patients with atopic dermatitis (AD). The presence of IgE autoantibodies seems to be associated with atopic comorbidities and environmental factors. These findings suggest the potential value of IgE autoantibodies as a predictive biomarker for the course of AD and the atopic march.
Article
Medicine, Research & Experimental
Songwen Ren, You Gao, Luanjin Wang, Ce Qiu, Lingtao Yang, Li Li, Yueyue Xiao, Nengming Xiao, Lixin Liao, Zhenghong Zuo, Chunyan Yang, Chengyong He
Summary: The study demonstrated that Sacran could alleviate symptoms in AD mice, reduce skin inflammation induced by DNCB, potentially through inhibiting Th2 cell activation and decreasing IgE release.
Article
Chemistry, Multidisciplinary
Vanessa F. C. Dartora, Julia Sapienza Passos, Blanca Osorio, Ruei-Chun Hung, Michael Nguyen, Aijun Wang, Alyssa Panitch
Summary: In this study, a cell-penetrating MK2 inhibitor peptide YARA was loaded into hollow thermo-responsive nanoparticles and further incorporated into chitosan hydrogels to improve the local delivery and anti-inflammatory activity of the drug for treating atopic dermatitis.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Mariam M. Amin, Hossam M. Elkady
Summary: This study investigated the sensitization to aeroallergens in 132 patients with atopic dermatitis and found that multiple aeroallergens can worsen the severity of the disease.
Article
Allergy
Noora Ottman, Mauricio Barrientos-Somarribas, Nanna Fyhrquist, Helen Alexander, Lukas Wisgrill, Peter Olah, Sophia Tsoka, Dario Greco, Francesca Levi-Schaffer, Vassili Soumelis, Jens M. Schroeder, Juha Kere, Frank O. Nestle, Jonathan Barker, Annamari Ranki, Antti Lauerma, Bernhard Homey, Bjorn Andersson, Harri Alenius
Summary: This study found that different skin sites in atopic dermatitis (AD) patients have microbial heterogeneity, with distinct gene expression profiles between lesional and nonlesional skin. Keratinization dominates the transcriptomic signatures in the posterior thigh, while lipid metabolism is dominant in the upper back.
Article
Immunology
Youngae Lee, Jang-Hee Oh, Na Li, Hyun-Jae Jang, Kyung-Seop Ahn, Sei-Ryang Oh, Dong Hun Lee, Jin Ho Chung
Summary: SFII demonstrated anti-inflammatory effects in atopic dermatitis therapy, effectively suppressing inflammation, cytokine production, and cell infiltration, indicating therapeutic potential.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pei-Yun Shih, Chia-Jung Li, Su-Boon Yong
Summary: Atopic dermatitis is a chronic inflammatory skin disease characterized by immune function imbalance and impaired epidermal barrier function. The JAK/STAT signaling pathway plays a critical role in its pathogenesis, and JAK inhibitors offer a novel therapeutic approach.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Mirjana Bakic, Vesna Karanikolic
Summary: This study compared serum biomarkers of oxidative stress in patients with psoriasis and atopic dermatitis, finding that catalase exhibited good diagnostic accuracy in distinguishing between the two diseases. The results suggest the potential use of antioxidants as a therapeutic strategy for these skin inflammatory diseases.
Article
Immunology
Tina De Bruyn Carlier, Fariza Mishaal Saiema Badloe, Johannes Ring, Jan Gutermuth, Inge Kortekaas Krohn
Summary: Atopic dermatitis is a chronic inflammatory skin disease that develops in early childhood and is associated with food allergy, with immune reactions potentially leading to autoimmune processes. The exact mechanisms of IgE-mediated autoimmunity and self-reactive T cells in the pathophysiology of AD are still unclear.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Allergy
Lihua Luo, Yang Luo, Jing Xu, Ronghui Zhu, Jinghua Wu, Xiao Liu, Wei Li, Xu Yao
Summary: Epicutaneous sensitization is an important route for IgE production, and the origin of IgE in atopic dermatitis (AD) and psoriasis is heterogeneous. Skin inflammation may contribute to the increased production of natural IgE, with isotype-switching from IgG-expressing B cells potentially being a major source of IgE in these inflammatory skin diseases.
Article
Agriculture, Dairy & Animal Science
Morena Di Tommaso, Alessia Luciani, Paolo Emidio Crisi, Marica Beschi, Paolo Rosi, Francesca Rocconi, Arianna Miglio
Summary: Canine atopic dermatitis (CAD) is a pruritic allergic skin disease associated with IgE-mediated hypersensitivity. The present study used Serum Allergen-Specific IgE test (SAT) to identify relevant environmental allergens in atopic dogs living in Northern Italy, primarily house dust mites, Rumex acetosa pollen, and grasses. Specific panels for geographical areas should be considered and re-evaluated at time intervals.
Article
Immunology
Tomofumi Numata, Shunsuke Takahagi, Kaori Ishii, Satoshi Morioke, Takanobu Kan, Hayato Mizuno, Yuhki Yanase, Tomoko Kawaguchi, Akio Tanaka, Michihiro Hide
Summary: This study investigates the immunological changes of type-I hypersensitivity to sweat antigen in patients with well-controlled atopic dermatitis (AD). The results suggest that even with 52-96 weeks of treatment, the hyperreactivity of basophils against sweat antigen does not decrease in AD patients, indicating persistent basophil hyperreactivity to sweat antigen over a year or longer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Chieh-Chen Huang, Yuan-Hsin Lo, Yu-Jou Hsu, Yuan-Bin Cheng, Chia-Chi Kung, Cher-Wei Liang, Der-Chen Chang, Kang-Ling Wang, Chi-Feng Hung
Summary: Atopic dermatitis (AD, eczema) is a common skin condition that primarily affects children and adults, but current treatments have limited effectiveness and side effects. This study investigated the potential use of epi-oxyzoanthamine, a bioactive compound derived from Formosan zoanthid, for treating AD. In vitro and in vivo experiments showed that epi-oxyzoanthamine inhibited cytokine expression and reduced skin inflammation, indicating its potential as an alternative treatment for AD. Overall, the study highlights the importance of exploring new therapies for atopic dermatitis.
Article
Dermatology
Khalaf Kridin, Ralf J. Ludwig
Summary: In this retrospective cohort study, patients with acne treated with isotretinoin had a lower risk of depression compared to those treated with oral antibiotics, but a comparable risk of major depressive disorder. The risk of suicidal attempts was similar between the two groups, but patients under isotretinoin had a higher risk of suicidal ideation. Patients under isotretinoin also had a lower risk of post-traumatic stress disorder, anxiety, bipolar disorder, schizophrenia, and adjustment disorder. The study suggests that isotretinoin may confer a lower risk of several psychiatric comorbidities.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Letter
Dermatology
Katharina Boch, Henner Zirpel, Diamant Thaci, Noor Mruwat, Detlef Zillikens, Ralf J. Ludwig, Khalaf Kridin
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Immunology
Katja Bieber, Jennifer E. Hundt, Xinhua Yu, Marc Ehlers, Frank Petersen, Christian M. Karsten, Jorg Koehl, Khalaf Kridin, Kathrin Kalies, Anika Kasprick, Stephanie Goletz, Jens Y. Humrich, Rudolf A. Manz, Axel Kuenstner, Christoph M. Hammers, Reza Akbarzadeh, Hauke Busch, Christian D. Sadik, Tanja Lange, Hanna Grasshoff, Alexander M. Hackel, Jeanette Erdmann, Inke Koenig, Walter Raasch, Mareike Becker, Anja Kerstein-Staehle, Peter Lamprecht, Gabriela Riemekasten, Enno Schmidt, Ralf J. Ludwig
Summary: Approximately 5% of the world-wide population is affected by autoimmune diseases, which are still difficult to treat and have a significant economic impact. The progression from harmless to inflammatory autoimmune disease conditions is a key factor. Biomarkers that can predict this progression would be highly impactful. Factors such as genetics, environment, and lifestyle choices may influence the progression from benign to inflammatory autoimmune conditions. Research is needed to define and modulate autoimmune predisease.
AUTOIMMUNITY REVIEWS
(2023)
Letter
Dermatology
Khalaf Kridin, Noor Mruwat, Diamant Thaci, Ralf J. Ludwig
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Veterinary Sciences
Veronika Hartmann, William V. J. Hariton, Siavash Rahimi, Christoph M. Hammers, Ralf J. Ludwig, Eliane J. Mueller, Jennifer E. Hundt
Summary: Pemphigus is a severe autoimmune bullous disease that targets adhesion proteins desmoglein 3 and/or desmoglein 1. Current treatment involves systemic immunosuppression, and drug development focuses on B cells, autoantibodies, and tissue pathology. A human skin organ culture (HSOC) model has been established as an alternative to animal models for studying pemphigus, replicating key features of the disease.
LABORATORY ANIMALS
(2023)
Article
Dermatology
Khalaf Kridin, Noor Mruwat, Ralf J. Ludwig
Summary: Patients with pemphigus who were treated with rituximab had a lower risk of long-term cardiovascular and metabolic outcomes compared with those receiving first-line corticosteroid-sparing agents. Rituximab may be particularly preferred in patients with preexisting cardiovascular and metabolic risk factors.
Article
Immunology
Khalaf Kridin, Artem Vorobyev, Cristian Papara, David A. De Luca, Katja Bieber, Ralf J. Ludwig
Summary: Identification of risk factors and sequelae of diseases is crucial for primary prevention and disease management. This study used TriNetX to identify risk factors and sequelae of the rare autoimmune disease EBA. The findings revealed chronic inflammatory diseases, especially lupus erythematosus and lichen planus, as the highest risk factors for EBA development and metabolic and cardiovascular diseases, and thrombosis as the most common sequelae after EBA diagnosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Immunology
Jennifer E. Hundt, Markus H. Hoffmann, Kyle T. Amber, Ralf J. Ludwig
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Maria Shoykhet, Orsela Dervishi, Philipp Menauer, Matthias Hiermaier, Sina Moztarzadeh, Colin Osterloh, Ralf J. Ludwig, Tatjana Williams, Brenda Gerull, Stefan Kaab, Sebastian Clauss, Dominik Schuettler, Jens Waschke, Sunil Yeruva
Summary: Arrhythmogenic cardiomyopathy (AC) is a familial heart disease caused by impaired desmosome turnover, and stabilizing desmosome integrity through EGFR and ROCK inhibition may offer new treatment options. In this study, EGFR inhibition enhanced cardiomyocyte cohesion and increased DSG2 recruitment and binding at cell borders. Additionally, EGFR inhibition led to the upregulation of ROCK, and ROCK inhibition abolished the effects of EGFR inhibition on desmosome assembly and cardiomyocyte cohesion. These findings suggest that targeting EGFR and ROCK could be potential therapeutic strategies for AC.
Article
Biochemistry & Molecular Biology
Ulrike Raap, Maren M. M. Limberg, Khalaf Kridin, Ralf J. J. Ludwig
Summary: Autoimmune bullous skin diseases (AIBDs), such as bullous pemphigoid (BP) and pemphigus, are characterized by autoantibodies targeting structural proteins. Pruritus is common in patients with BP and pemphigus, and can be the sole symptom in some cases. The temporal relationship between pruritus and AIBDs is unclear, and the presence of pruritus in other AIBDs is also unknown.
Review
Medicine, General & Internal
Cristian Papara, David A. De Luca, Katja Bieber, Artem Vorobyev, Ralf J. Ludwig
Summary: Morphea, also known as localized scleroderma, is a chronic inflammatory connective tissue disorder that affects both adults and children. It is characterized by inflammation and fibrosis of the skin and underlying soft tissue, and in certain cases, can also affect surrounding structures. The etiology of morphea is still unknown, but genetic predisposition, vascular dysregulation, T(H)1/T(H)2 imbalance, cytokines, and certain environmental factors may contribute to its development. Proper assessment of disease activity and prompt initiation of treatment are crucial to prevent permanent damage.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
David A. De Luca, Cristian Papara, Artem Vorobyev, Hernan Staiger, Katja Bieber, Diamant Thaci, Ralf J. Ludwig
Summary: Lichen sclerosus (LS) is an inflammatory mucocutaneous condition primarily affecting postmenopausal women, with unknown etiology. LS is associated with factors such as hormonal status, trauma, and autoimmune diseases. LS pathogenesis involves genetic predisposition, immune-mediated mechanisms, tissue remodeling genes, and oxidative stress. LS presents as chronic whitish atrophic patches with itching and soreness in the genital and anal regions. Treatment options include topical corticosteroids and calcineurin inhibitors. LS is a common dermatological disease with an incompletely understood pathogenesis and limited treatment options.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Ralf J. Ludwig, Esther von Stebut
Summary: The epidemiology and clinical presentation of inflammatory dermatoses vary considerably between people with different colors of skin. It is important to know the epidemiology and recognize key clinical characteristics of these diseases in patients with skin of color (SOC) in order to provide excellent dermatological care for all patients.
Article
Dermatology
Stefan Tukaj, Katja Bieber, Wiebke Pruessmann, Jasper N. Pruessmann, Enno Schmidt, Detlef Zillikens, Ralf J. Ludwig, Michael Kasperkiewicz
Summary: Healthy individuals with BP autoantibody reactivity have abnormal vitamin D levels and a specific cytokine profile.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
Khalaf Kridin, Keren Lyakhovitsky, Erez Onn, Anna Lyakhovitsky, Ralf Ludwig, Orly Weinstein, Arnon D. Cohen
Summary: There is a bidirectional association between vitiligo and psoriasis.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)