Article
Immunology
Daniele Mauro, Sotiria Manou-Stathopoulou, Felice Rivellese, Elisabetta Sciacca, Katriona Goldmann, Victoria Tsang, Isabelle Lucey-Clayton, Sara Pagani, Farah Alam, Debasish Pyne, Ravindra Rajakariar, Patrick A. Gordon, James Whiteford, Michele Bombardieri, Costantino Pitzalis, Myles J. Lewis
Summary: Study finds that UBE2L3 plays a critical role in TLR7-mediated NF-??B activation in Systemic Lupus Erythematosus (SLE). Inhibition of UBE2L3 by Dimethyl Fumarate (DMF) can effectively suppress TLR7-induced NF-??B activation, B cell differentiation, and autoantibody production in SLE. This suggests that UBE2L3 inhibition could be a potential therapeutic strategy for SLE by repurposing DMF.
JOURNAL OF AUTOIMMUNITY
(2023)
Review
Immunology
Swayanka Biswas, Katja Bieber, Rudolf Armin Manz
Summary: IL-10 is a cytokine that has pleiotropic effects on immune cells, including both suppressive and activating functions. It plays a dual role in Systemic lupus Erythematosus (SLE), inhibiting pro-inflammatory effector functions while also promoting extrafollicular antibody response. IL-10 is produced by B cells, myeloid cells, and certain T cell subsets, and it drives B cell responses, proliferation, class switching, and plasma cell formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Urology & Nephrology
Na Kang, Xiaohang Liu, Xujie You, Wenbo Sun, Kabeer Haneef, Xiaolin Sun, Wanli Liu
Summary: Aberrant B-cell activation is closely linked to the pathogenesis of SLE, with dysregulations of B-cell receptor (BCR), toll-like receptor (TLR), and B-cell activating factor receptor (BAFF-R) pathways being common factors. Targeting these aberrant signaling pathways has shown promise in alleviating clinical symptoms of SLE, emphasizing the importance of identifying new drug targets for future therapeutic strategies.
Article
Pharmacology & Pharmacy
Yi Zhang, FengQi Zhang, YiNi Gao, MeiJiao Wang, Yan Gao, HaiChang Li, Jing Sun, ChengPing Wen, ZhiJun Xie
Summary: Through experimental evidence, it has been found that triptolide (TP) exerts therapeutic effects on SLE by regulating miR-146a expression, inhibiting the TLR7/NF-kappa B signaling pathway, and affecting B cell activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Yusuke Takeshima, Yukiko Iwasaki, Masahiro Nakano, Yuta Narushima, Mineto Ota, Yasuo Nagafuchi, Shuji Sumitomo, Tomohisa Okamura, Keith Elkon, Kazuyoshi Ishigaki, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto, Keishi Fujio
Summary: This study revealed the importance of oxidative phosphorylation/mitochondrial dysfunction in SLE memory B cells through transcriptomic, epigenomic, and genomic analysis. The PRDX6 gene was identified as a key driver in SLE B cells. Furthermore, the OXPHOS signature was associated with type I IFN signaling-related genes and correlated with SLE organ damage and specific clinical phenotypes.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yong-Fei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Yu Lung Lau, Ken Yamaji, Zhengwei Zhu, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Kazuhiko Yamamoto, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao, Yong Cui, Sang-Cheol Bae
Summary: By combining genome-wide association studies and transcriptome-wide association studies, we identified candidate genes associated with systemic lupus erythematosus and discovered a strong association between the CD83 gene and SLE. We also identified 276 gene candidates at the 110 SLE loci and demonstrated a regulatory effect of a putative causal variant on the ACAP1 gene.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Immunology
Qian Chen, Jie Wang, Mengmeng Xiang, Yilun Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This review summarizes the potential links between ferroptosis and systemic lupus erythematosus (SLE), elucidates the role of ferroptosis in SLE pathogenesis, and proposes a new therapeutic strategy for SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
George Anthony Robinson, Meredyth G. Ll. Wilkinson, Chris Wincup
Summary: Upregulation of cellular energy metabolism plays a crucial role in the immune response of SLE. The latest research has found a close connection between abnormal mitochondrial function, lipid metabolism, and mTOR signaling with the immunological phenomenon observed in SLE. These findings have important implications for future therapeutic options in managing the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Jae Il Shin, Keum Hwa Lee, Seoyeon Park, Jae Won Yang, Hyung Ju Kim, Kwanhyuk Song, Seungyeon Lee, Hyeyoung Na, Yong Jun Jang, Ju Yun Nam, Soojin Kim, Chaehyun Lee, Chanhee Hong, Chohwan Kim, Minhyuk Kim, Uichang Choi, Jaeho Seo, Hyunsoo Jin, BoMi Yi, Se Jin Jeong, Yeon Ook Sheok, Haedong Kim, Sangmin Lee, Sangwon Lee, Young Soo Jeong, Se Jin Park, Ji Hong Kim, Andreas Kronbichler
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with various manifestations, including pleuropulmonary involvement. The precise mechanism of pleuropulmonary involvement in SLE is not well-understood, but type 1 interferons, immune complexes, and neutrophils likely play important roles. There are multiple types of pleuropulmonary involvement, and various diagnostic tools and immunosuppressive therapies are used. However, specific therapies for pleuropulmonary involvement in SLE remain limited.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
May Yee Choi, Ann Elaine Clarke, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Ken Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, Karen H. Costenbader, Marvin J. Fritzler
Summary: In a longitudinal analysis of a large international incident SLE cohort, three ANA assays demonstrated high positivity rates and commutability. However, over a 5-year follow-up, there was a modest variation in ANA assay performance.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
May Yee Choi, Irene Chen, Ann Elaine Clarke, Marvin J. Fritzler, Katherine A. Buhler, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Alan Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, David Sontag, Karen H. Costenbader
Summary: A novel longitudinal clustering technique was used to analyze comprehensive autoantibody data from a large, well-characterised, multinational inception SLE cohort, in order to determine predictive profiles of clinical outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Pharmacology & Pharmacy
Xirui Guo, Xuerong Yang, Qi Li, Xiaoyan Shen, Huiyun Zhong, Yong Yang
Summary: Systemic lupus erythematosus (SLE) is a chronic diffuse connective tissue illness characterized by multisystem and multiorgan involvement. Intake of probiotics alters the composition of the gut microbiome, contributing to prevent the progression of SLE and alleviate symptoms in animal models. Probiotics supplementation may serve as a potentially novel approach in the treatment of SLE.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Rheumatology
Hilde Julie T. Lien, Tina T. Pedersen, Bente Jakobsen, Arnar Flatberg, Konika Chawla, Pal Saetrom, Mona H. Fenstad
Summary: The study compared cellular composition and peripheral blood gene expression in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and healthy pregnancies. The results showed distinct RA, SLE, and pregnancy signatures that were not attributed to medication or disease activity. The study supports the need for close postpartum follow-up of patients with SLE and highlights the importance of cell-type adjustment in gene expression analysis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Madhu Ramaswamy, Raj Tummala, Katie Streicher, Andre Nogueira da Costa, Philip Z. Brohawn
Summary: Systemic lupus erythematosus (SLE) presents a challenging treatment landscape due to its multifaceted etiology and complex immunopathogenesis. While targeting the B-cell pathway has limitations, recent approval of anifrolumab, a type I interferon-blocking antibody, highlights the therapeutic potential of targeting the dysregulated interferon pathway in SLE patients. Further research into the pleiotropic biology of interferons and their intersection with SLE disease pathology will be crucial for the development of effective targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jacob T. Jackson, Kristy O'Donnell, Amanda Light, Wilford Goh, Nicholas D. Huntington, David M. Tarlinton, Matthew P. McCormack
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Review
Cell Biology
David Tarlinton
IMMUNOLOGY AND CELL BIOLOGY
(2020)
Article
Immunology
Dragos C. Dasoveanu, Hyeung Ju Park, Catherine L. Ly, William D. Shipman, Susan Chyou, Varsha Kumar, David Tarlinton, Burkhard Ludewig, Babak J. Mehrara, Theresa T. Lu
SCIENCE IMMUNOLOGY
(2020)
Review
Immunology
Marcus J. Robinson, Rosela H. Webster, David M. Tarlinton
IMMUNOLOGICAL REVIEWS
(2020)
Article
Multidisciplinary Sciences
Ashley P. Ng, Hannah D. Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy M. Johanson, Michael Sze Yuan Low, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Andrew J. Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D. Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A. Dawson, Rhys S. Allan, Marco J. Herold, Kelly Rogers, David M. Tarlinton, Gordon K. Smyth, Melissa J. Davis, Stephen L. Nutt, Warren S. Alexander
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Yu Kato, Thiago M. Steiner, Hae-Young Park, Rohan O. Hitchcock, Ali Zaid, Jyh Liang Hor, Sapna Devi, Gayle M. Davey, David Vremec, Kirsteen M. Tullett, Peck S. Tan, Fatma Ahmet, Scott N. Mueller, Sylvie Alonso, David M. Tarlinton, Hidde L. Ploegh, Tsuneyasu Kaisho, Lynette Beattie, Jonathan H. Manton, Daniel Fernandez-Ruiz, Ken Shortman, Mireille H. Lahoud, William R. Heath, Irina Caminschi
JOURNAL OF IMMUNOLOGY
(2020)
Editorial Material
Immunology
Isaak Quast, David Tarlinton
Summary: Immunological memory is crucial for protecting against reinfection, with antibodies produced by B cells playing a key role in this defense mechanism. Understanding how B cell memory is generated, its efficacy, and persistence, particularly in response to SARS-CoV-2, is essential for achieving protective immunity through vaccination.
Letter
Hematology
Winston Zheng, Michael Sze Yuan Low
ANNALS OF HEMATOLOGY
(2022)
Editorial Material
Immunology
Marcus James Robinson, Isaak Quast, David Mathew Tarlinton
Summary: B cells reprogram complement to enhance germinal center responses. However, when B cell C3 activity is restricted, germinal centers collapse leading to impaired outputs.
Editorial Material
Hematology
Paul Bao Duy La, Michael Sze Yuan Low
Article
Multidisciplinary Sciences
Dimitra Zotos, Isaak Quast, Connie S. N. Li-Wai-Suen, Craig I. McKenzie, Marcus J. Robinson, Andrey Kan, Gordon K. Smyth, Philip D. Hodgkin, David M. Tarlinton
Summary: IL-21 plays a crucial role in promoting cell cycle progression within the germinal centre (GC) light zone, facilitating release from the G1 cell cycle stage. This cytokine is essential for establishing normal zone representation and preventing cell accumulation in the G1 cell cycle stage in the GC LZ, highlighting its importance in antibody affinity maturation.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Alexandra R. Dvorscek, Craig McKenzie, Marcus J. Robinson, Zhoujie Ding, Catherine Pitt, Kristy O'Donnell, Dimitra Zotos, Robert Brink, David M. Tarlinton, Isaak Quast
Summary: IL-21 acts as a key regulator in the initial B cell response, accelerating cell cycle progression and fueling cyclic re-entry of B cells, thereby promoting plasma cell differentiation.
Editorial Material
Immunology
Isaak Quast, David Tarlinton
Summary: A new study reveals a novel protein immunization strategy that enhances the durability of germinal centers and improves immunological outcomes by delivering the protein slowly over a 12-day period.
Article
Immunology
Adam K. Wade-Vallance, Zhiyong Yang, Jeremy B. Libang, Marcus J. Robinson, David M. Tarlinton, Christopher D. C. Allen
Summary: Wade-Vallance et al. demonstrate that the binding of antigen or antibody to the B cell receptor triggers apoptosis in IgE plasma cells. This mechanism is relevant to allergic disease and its treatment through endogenous IgE regulation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Editorial Material
Immunology
Zhoujie Ding, David Tarlinton
Summary: BALT, formed in the lung during infancy and declining over childhood, plays a role in localized immune reactions against airway infections, including the production of germinal center-like B cells specific for respiratory pathogens.
